Novel polynucleotides and method of use thereof

ABSTRACT

The present invention is directed to novel polynucleotides and to polypeptides encoded thereby. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

FIELD OF THE INVENTION

[0001] The present invention relates generally to the identification and isolation of novel nucleic acid molecules which constitute at least a portion of full-length cDNA molecules that encode human polypeptides.

BACKGROUND OF THE INVENTION

[0002] Extracellular proteins play important roles in, among other things, the formation, differentiation and maintenance of multicellular organisms. The fate of many individual cells, e.g., proliferation, migration, differentiation, or interaction with other cells, is typically governed by information received from other cells and/or the immediate environment. This information is often transmitted by secreted polypeptides (for instance, mitogenic factors, survival factors, cytotoxic factors, differentiation factors, neuropeptides, and hormones) which are, in turn, received and interpreted by diverse cell receptors or membrane-bound proteins. These secreted polypeptides or signaling molecules normally pass through the cellular secretory pathway to reach their site of action in the extracellular environment.

[0003] Secreted proteins have various industrial applications, including as pharmaceuticals, diagnostics, biosensors and bioreactors. Most protein drugs available at present, such as thrombolytic agents, interferons, interleukins, erythropoietins, colony stimulating factors, and various other cytokines, are secretory proteins. Their receptors, which are membrane proteins, also have potential as therapeutic or diagnostic agents. Efforts are being undertaken by both industry and academia to identify new, native secreted proteins. Many efforts are focused on the screening of mammalian recombinant DNA libraries to identify the coding sequences for novel secreted proteins. Examples of screening methods and techniques are described in the literature [see, for example, Klein et al., Proc. Natl. Acad. Sci., 93:7108-7113 (1996); U.S. Pat. No. 5,536,637)].

[0004] Membrane-bound proteins and receptors can play important roles in, among other things, the formation, differentiation and maintenance of multicellular organisms. The fate of many individual cells, e.g., proliferation, migration, differentiation, or interaction with other cells, is typically governed by information received from other cells and/or the immediate environment. This information is often transmitted by secreted polypeptides (for instance, mitogenic factors, survival factors, cytotoxic factors, differentiation factors, neuropeptides, and hormones) which are, in turn, received and interpreted by diverse cell receptors or membrane-bound proteins. Such membrane-bound proteins and cell receptors include, but are not limited to, cytokine receptors, receptor kinases, receptor phosphatases, receptors involved in cell-cell interactions, and cellular adhesin molecules like selectins and integrins. For instance, transduction of signals that regulate cell growth and differentiation is regulated in part by phosphorylation of various cellular proteins. Protein tyrosine kinases, enzymes that catalyze that process, can also act as growth factor receptors. Examples include fibroblast growth factor receptor and nerve growth factor receptor.

[0005] Membrane-bound proteins and receptor molecules have various industrial applications, including as pharmaceutical and diagnostic agents. Receptor immunoadhesins, for instance, can be employed as therapeutic agents to block receptor-ligand interactions. The membrane-bound proteins can also be employed for screening of potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction. Efforts are being undertaken by both industry and academia to identify new, native receptor or membrane-bound proteins. Many efforts are focused on the screening of mammalian recombinant DNA libraries to identify the coding sequences for novel receptor or membrane-bound proteins.

[0006] Recently, significant progress has been made in identifying and isolating unique nucleic acid moelcules which encode all or a portion of many mammalian proteins. We herein describe the identification and characterization of novel polynucleotides which constitute at least partial cDNA molecules that encode various human polypeptides.

SUMMARY OF THE INVENTION

[0007] Novel polynucleotides have been identified and isolated which constitute at least partial cDNA molecules that encode human polypeptides.

[0008] In one embodiment, the invention provides an isolated nucleic acid molecule comprising any one of the nucleic acid sequences shown in the accompanying figures, or the complement thereof, or polynucleotide variants of those nucleic acid sequences as defined below.

[0009] In another embodiment, the invention provides an isolated nucleic acid molecule consisting essentially of any one of the nucleic acid sequences shown in the accompanying figures, or the complement thereof, or polynucleotide variants of those nucleic acid sequences as defined below.

[0010] In another embodiment, the invention provides an isolated nucleic acid molecule consisting of any one of the nucleic acid sequences shown in the accompanying figures, or the complement thereof, or polynucleotide variants of those nucleic acid sequences as defined below.

[0011] In yet another embodiment, the invention provides an isolated nucleic acid molecule that comprises a nucleotide sequence having at least about 80% sequence identity, preferably at least about 81% sequence identity, more preferably at least about 82% sequence identity, yet more preferably at least about 83% sequence identity, yet more preferably at least about 84% sequence identity, yet more preferably at least about 85% sequence identity, yet more preferably at least about 86% sequence identity, yet more preferably at least about 87% sequence identity, yet more preferably at least about 88% sequence identity, yet more preferably at least about 89% sequence identity, yet more preferably at least about 90% sequence identity, yet more preferably at least about 91% sequence identity, yet more preferably at least about 92% sequence identity, yet more preferably at least about 93% sequence identity, yet more preferably at least about 94% sequence identity, yet more preferably at least about 95% sequence identity, yet more preferably at least about 96% sequence identity, yet more preferably at least about 97% sequence identity, yet more preferably at least about 98% sequence identity and yet more preferably at least about 99% sequence identity to (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).

[0012] In another aspect, the isolated nucleic acid molecule consists essentially of a nucleotide sequence having at least about 80% sequence identity, preferably at least about 81% sequence identity, more preferably at least about 82% sequence identity, yet more preferably at least about 83% sequence identity, yet more preferably at least about 84% sequence identity, yet more preferably at least about 85% sequence identity, yet more preferably at least about 86% sequence identity, yet more preferably at least about 87% sequence identity, yet more preferably at least about 88% sequence identity, yet more preferably at least about 89% sequence identity, yet more preferably at least about 90% sequence identity, yet more preferably at least about 91% sequence identity, yet more preferably at least about 92% sequence identity, yet more preferably at least about 93% sequence identity, yet more preferably at least about 94% sequence identity, yet more preferably at least about 95% sequence identity, yet more preferably at least about 96% sequence identity, yet more preferably at least about 97% sequence identity, yet more preferably at least about 98% sequence identity and yet more preferably at least about 99% sequence identity to (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).

[0013] In yet another aspect, the isolated nucleic acid molecule consists of a nucleotide sequence having at least about 80% sequence identity, preferably at least about 81% sequence identity, more preferably at least about 82% sequence identity, yet more preferably at least about 83% sequence identity, yet more preferably at least about 84% sequence identity, yet more preferably at least about 85% sequence identity, yet more preferably at least about 86% sequence identity, yet more preferably at least about 87% sequence identity, yet more preferably at least about 88% sequence identity, yet more preferably at least about 89% sequence identity, yet more preferably at least about 90% sequence identity, yet more preferably at least about 91% sequence identity, yet more preferably at least about 92% sequence identity, yet more preferably at least about 93% sequence identity, yet more preferably at least about 94% sequence identity, yet more preferably at least about 95% sequence identity, yet more preferably at least about 96% sequence identity, yet more preferably at least about 97% sequence identity, yet more preferably at least about 98% sequence identity and yet more preferably at least about 99% sequence identity to (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).

[0014] In another embodiment, the invention concerns an isolated nucleic acid molecule which comprises a nucleotide sequence that hybridizes to (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a). Preferably, hybridization occurs under stringent hybridization and wash conditions. Also, it is preferred that the isolated nucleic acid molecule is fully complementary to (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).

[0015] In yet another embodiment, the present invention provides an isolated nucleic acid molecule which comprises at least about 10 consecutive nucleotides contained within (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a) which may find use as, for example, hybridizing oligonucleotide probes or for encoding polypeptide fragments that may optionally comprise a binding site for an antibody. In particular aspects, the isolated nucleic acid molecule is from about 10 to about 1000, about 10 to about 900, about 10 to about 800, about 10 to about 700, about 10 to about 600, about 10 to about 500, about 10 to about 400, about 10 to about 300, about 10 to about 200, about 10 to about 100, about 10 to about 90, about 10 to about 80, about 10 to about 70, about 10 to about 60, about 10 to about 50, about 10 to about 40, about 10 to about 30 or about 10 to about 20 nucleotides in length, where the term “about” means the referenced nucleotide sequence length plus or minus 10% of that referenced length. In yet other aspects, the isolated nucleic acid molecule comprises at least about 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 or 100 consecutive nucleotides contained within (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).

[0016] The present invention is also directed to a method of using an oligonucleotide probe having a nucleotide sequence derived from a nucleic acid molecule described herein for detecting the presence of and/or obtaining a full-length mammalian cDNA molecule from a mammalian cDNA library which encodes a mammalian polypeptide. Preferably, the mammal is human. The methods comprise the step of screening a mammalian cDNA library with one or more of the herein described oligonucleotides to detect the presence of a full-length cDNA and, optionally, obtaining the full-length cDNA from that library.

[0017] In another embodiment, the invention provides a vector comprising any of the isolated nucleic acid molecules described herein or their variants.

[0018] A host cell comprising such a vector is also provided. By way of example, the host cells may be CHO cells, E. coli, or yeast. A process for producing polypeptides is further provided and comprises culturing the host cells under conditions suitable for expression of a polypeptide and recovering the polypeptide from the cell culture.

[0019] In another embodiment, the invention provides isolated polypeptides encoded by any of the isolated nucleic acids described herein, wherein thise polypeptides are herein designated as SRT polypeptides.

[0020] In yet another embodiment, the invention provides antibodies which specifically bind to a polypeptide encoded by a nucleic acid molecule described herein. Preferably, the antibodies are monoclonal antibodies.

BRIEF DESCRIPTION OF THE DRAWINGS

[0021]FIG. 1 shows a nucleotide sequence (SEQ ID NO:1) designated herein as DNA8284.

[0022]FIG. 2 shows a nucleotide sequence (SEQ ID NO:2) designated herein as DNA8328.

[0023]FIG. 3 shows a nucleotide sequence (SEQ ID NO:3) designated herein as DNA8350.

[0024]FIG. 4 shows a nucleotide sequence (SEQ ID NO:4) designated herein as DNA8369.

[0025]FIG. 5 shows a nucleotide sequence (SEQ ID NO:5) designated herein as DNA8377.

[0026]FIG. 6 shows a nucleotide sequence (SEQ ID NO:6) designated herein as DNA8456.

[0027]FIG. 7 shows a nucleotide sequence (SEQ ID NO:7) designated herein as DNA8555.

[0028]FIG. 8 shows a nucleotide sequence (SEQ ID NO:8) designated herein as DNA8576.

[0029]FIG. 9 shows a nucleotide sequence (SEQ ID NO:9) designated herein as DNA9383.

[0030]FIG. 10 shows a nucleotide sequence (SEQ ID NO:10) designated herein as DNA9840.

[0031]FIG. 11 shows a nucleotide sequence (SEQ ID NO:11) designated herein as DNA10028.

[0032]FIG. 12 shows a nucleotide sequence (SEQ ID NO:12) designated herein as DNA10072.

[0033]FIG. 13 shows a nucleotide sequence (SEQ ID NO:13) designated herein as DNA10242.

[0034]FIG. 14 shows a nucleotide sequence (SEQ ID NO:14) designated herein as DNA10281.

[0035]FIG. 15 shows a nucleotide sequence (SEQ ID NO:15) designated herein as DNA12628.

[0036]FIG. 16 shows a nucleotide sequence (SEQ ID NO:16) designated herein as DNA12646.

[0037]FIG. 17 shows a nucleotide sequence (SEQ ID NO:17) designated herein as DNA12655.

[0038]FIG. 18 shows a nucleotide sequence (SEQ ID NO:18) designated herein as DNA12660.

[0039]FIG. 19 shows a nucleotide sequence (SEQ ID NO:19) designated herein as DNA12668.

[0040]FIG. 20 shows a nucleotide sequence (SEQ ID NO:20) designated herein as DNA12726.

[0041]FIG. 21 shows a nucleotide sequence (SEQ ID NO:21) designated herein as DNA12728.

[0042]FIG. 22 shows a nucleotide sequence (SEQ ID NO:22) designated herein as DNA12729.

[0043]FIG. 23 shows a nucleotide sequence (SEQ ID NO:23) designated herein as DNA12732.

[0044]FIG. 24 shows a nucleotide sequence (SEQ ID NO:24) designated herein as DNA12733.

[0045]FIG. 25 shows a nucleotide sequence (SEQ ID NO:25) designated herein as DNA12741.

[0046]FIG. 26 shows a nucleotide sequence (SEQ ID NO:26) designated herein as DNA12742.

[0047]FIG. 27 shows a nucleotide sequence (SEQ ID NO:27) designated herein as DNA 12747.

[0048]FIG. 28 shows a nucleotide sequence (SEQ ID NO:28) designated herein as DNA12752.

[0049]FIG. 29 shows a nucleotide sequence (SEQ ID NO:29) designated herein as DNA 12797.

[0050]FIG. 30 shows a nucleotide sequence (SEQ ID NO:30) designated herein as DNA12801.

[0051]FIG. 31 shows a nucleotide sequence (SEQ ID NO:31) designated herein as DNA12802.

[0052]FIG. 32 shows a nucleotide sequence (SEQ ID NO:32) designated herein as DNA12817.

[0053]FIG. 33 shows a nucleotide sequence (SEQ ID NO:33) designated herein as DNA12819.

[0054]FIG. 34 shows a nucleotide sequence (SEQ ID NO:34) designated herein as DNA12829.

[0055]FIG. 35 shows a nucleotide sequence (SEQ ID NO:35) designated herein as DNA12830.

[0056]FIG. 36 shows a nucleotide sequence (SEQ ID NO:36) designated herein as DNA12834.

[0057]FIG. 37 shows a nucleotide sequence (SEQ ID NO:37) designated herein as DNA12837.

[0058]FIG. 38 shows a nucleotide sequence (SEQ ID NO:38) designated herein as DNA12840.

[0059]FIG. 39 shows a nucleotide sequence (SEQ ID NO:39) designated herein as DNA12841.

[0060]FIG. 40 shows a nucleotide sequence (SEQ ID NO:40) designated herein as DNA 12844.

[0061]FIG. 41 shows a nucleotide sequence (SEQ ID NO:41) designated herein as DNA 12846.

[0062]FIG. 42 shows a nucleotide sequence (SEQ ID NO:42) designated herein as DNA12850.

[0063]FIG. 43 shows a nucleotide sequence (SEQ ID NO:43) designated herein as DNA 12865.

[0064]FIG. 44 shows a nucleotide sequence (SEQ ID NO:44) designated herein as DNA12867.

[0065]FIG. 45 shows a nucleotide sequence (SEQ ID NO:45) designated herein as DNA12884.

[0066]FIG. 46 shows a nucleotide sequence (SEQ ID NO:46) designated herein as DNA 12889.

[0067]FIG. 47 shows a nucleotide sequence (SEQ ID NO:47) designated herein as DNA12891.

[0068]FIG. 48 shows a nucleotide sequence (SEQ ID NO:48) designated herein as DNA12900.

[0069]FIG. 49 shows a nucleotide sequence (SEQ ID NO:49) designated herein as DNA12922.

[0070]FIG. 50 shows a nucleotide sequence (SEQ ID NO:50) designated herein as DNA12946.

[0071]FIG. 51 shows a nucleotide sequence (SEQ ID NO:51) designated herein as DNA12967.

[0072]FIG. 52 shows a nucleotide sequence (SEQ ID NO:52) designated herein as DNA12974.

[0073]FIG. 53 shows a nucleotide sequence (SEQ ID NO:53) designated herein as DNA12982.

[0074]FIG. 54 shows a nucleotide sequence (SEQ ID NO:54) designated herein as DNA12983.

[0075]FIG. 55 shows a nucleotide sequence (SEQ ID NO:55) designated herein as DNA12991.

[0076]FIG. 56 shows a nucleotide sequence (SEQ ID NO:56) designated herein as DNA12998.

[0077]FIG. 57 shows a nucleotide sequence (SEQ ID NO:57) designated herein as DNA12999.

[0078]FIG. 58 shows a nucleotide sequence (SEQ ID NO:58) designated herein as DNA13101.

[0079]FIG. 59 shows a nucleotide sequence (SEQ ID NO:59) designated herein as DNA13104.

[0080]FIG. 60 shows a nucleotide sequence (SEQ ID NO:60) designated herein as DNA13110.

[0081]FIG. 61 shows a nucleotide sequence (SEQ ID NO:61) designated herein as DNA13114.

[0082]FIG. 62 shows a nucleotide sequence (SEQ ID NO:62) designated herein as DNA13115.

[0083]FIG. 63 shows a nucleotide sequence (SEQ ID NO:63) designated herein as DNA13116.

[0084]FIG. 64 shows a nucleotide sequence (SEQ ID NO:64) designated herein as DNA13118.

[0085]FIG. 65 shows a nucleotide sequence (SEQ ID NO:65) designated herein as DNA13124.

[0086]FIG. 66 shows a nucleotide sequence (SEQ ID NO:66) designated herein as DNA13132.

[0087]FIG. 67 shows a nucleotide sequence (SEQ ID NO:67) designated herein as DNA13133.

[0088]FIG. 68 shows a nucleotide sequence (SEQ ID NO:68) designated herein as DNA13146.

[0089]FIG. 69 shows a nucleotide sequence (SEQ ID NO:69) designated herein as DNA13152.

[0090]FIG. 70 shows a nucleotide sequence (SEQ ID NO:70) designated herein as DNA13156.

[0091]FIG. 71 shows a nucleotide sequence (SEQ ID NO:71) designated herein as DNA13163.

[0092]FIG. 72 shows a nucleotide sequence (SEQ ID NO:72) designated herein as DNA13185.

[0093]FIG. 73 shows a nucleotide sequence (SEQ ID NO:73) designated herein as DNA 13992.

[0094]FIG. 74 shows a nucleotide sequence (SEQ ID NO:74) designated herein as DNA 14523.

[0095]FIG. 75 shows a nucleotide sequence (SEQ ID NO:75) designated herein as DNA 14656.

[0096]FIG. 76 shows a nucleotide sequence (SEQ ID NO:76) designated herein as DNA14938.

[0097]FIG. 77 shows a nucleotide sequence (SEQ ID NO:77) designated herein as DNA15172.

[0098]FIG. 78 shows a nucleotide sequence (SEQ ID NO:78) designated herein as DNA15618.

[0099]FIG. 79 shows a nucleotide sequence (SEQ ID NO:79) designated herein as DNA16546.

[0100]FIG. 80 shows a nucleotide sequence (SEQ ID NO:80) designated herein as DNA16669.

[0101]FIG. 81 shows a nucleotide sequence (SEQ ID NO:81) designated herein as DNA 17244.

[0102]FIG. 82 shows a nucleotide sequence (SEQ ID NO:82) designated herein as DNA18382.

[0103]FIG. 83 shows a nucleotide sequence (SEQ ID NO:83) designated herein as DNA18444.

[0104]FIG. 84 shows a nucleotide sequence (SEQ ID NO:84) designated herein as DNA18649.

[0105]FIG. 85 shows a nucleotide sequence (SEQ ID NO:85) designated herein as DNA19597.

[0106]FIG. 86 shows a nucleotide sequence (SEQ ID NO:86) designated herein as DNA19601.

[0107]FIG. 87 shows a nucleotide sequence (SEQ ID NO:87) designated herein as DNA21386.

[0108]FIG. 88 shows a nucleotide sequence (SEQ ID NO:88) designated herein as DNA22868.

[0109]FIG. 89 shows a nucleotide sequence (SEQ ID NO:89) designated herein as DNA23694.

[0110]FIG. 90 shows a nucleotide sequence (SEQ ID NO:90) designated herein as DNA24050.

[0111]FIG. 91 shows a nucleotide sequence (SEQ ID NO:91) designated herein as DNA24074.

[0112]FIG. 92 shows a nucleotide sequence (SEQ ID NO:92) designated herein as DNA24787.

[0113]FIG. 93 shows a nucleotide sequence (SEQ ID NO:93) designated herein as DNA28242.

[0114]FIG. 94 shows a nucleotide sequence (SEQ ID NO:94) designated herein as DNA28254.

[0115]FIG. 95 shows a nucleotide sequence (SEQ ID NO:95) designated herein as DNA31751.

[0116]FIG. 96 shows a nucleotide sequence (SEQ ID NO:96) designated herein as DNA32922.

[0117]FIG. 97 shows a nucleotide sequence (SEQ ID NO:97) designated herein as DNA33439.

[0118]FIG. 98 shows a nucleotide sequence (SEQ ID NO:98) designated herein as DNA34508.

[0119]FIG. 99 shows a nucleotide sequence (SEQ ID NO:99) designated herein as DNA34807.

[0120]FIG. 100 shows a nucleotide sequence (SEQ ID NO:100) designated herein as DNA34832.

[0121]FIG. 101 shows a nucleotide sequence (SEQ ID NO:101) designated herein as DNA36223.

[0122]FIG. 102 shows a nucleotide sequence (SEQ ID NO:102) designated herein as DNA36240.

[0123]FIG. 103 shows a nucleotide sequence (SEQ ID NO:103) designated herein as DNA36490.

[0124]FIG. 104 shows a nucleotide sequence (SEQ ID NO:104) designated herein as DNA36516.

[0125]FIG. 105 shows a nucleotide sequence (SEQ ID NO:105) designated herein as DNA36533.

[0126]FIG. 106 shows a nucleotide sequence (SEQ ID NO:106) designated herein as DNA36538.

[0127]FIG. 107 shows a nucleotide sequence (SEQ ID NO:107) designated herein as DNA36788.

[0128]FIG. 108 shows a nucleotide sequence (SEQ ID NO:108) designated herein as DNA36818.

[0129]FIG. 109 shows a nucleotide sequence (SEQ ID NO:109) designated herein as DNA36868.

[0130]FIG. 110 shows a nucleotide sequence (SEQ ID NO:110) designated herein as DNA37393.

[0131]FIG. 111 shows a nucleotide sequence (SEQ ID NO:111) designated herein as DNA27588.

[0132]FIG. 112 shows a nucleotide sequence (SEQ ID NO:112) designated herein as DNA37602.

[0133]FIG. 113 shows a nucleotide sequence (SEQ ID NO:113) designated herein as DNA37642.

[0134]FIG. 114 shows a nucleotide sequence (SEQ ID NO:114) designated herein as DNA37676.

[0135]FIG. 115 shows a nucleotide sequence (SEQ ID NO:115) designated herein as DNA37721.

[0136]FIG. 116 shows a nucleotide sequence (SEQ ID NO:116) designated herein as DNA37759.

[0137]FIG. 117 shows a nucleotide sequence (SEQ ID NO:117) designated herein as DNA37857.

[0138]FIG. 118 shows a nucleotide sequence (SEQ ID NO:118) designated herein as DNA37937.

[0139]FIG. 119 shows a nucleotide sequence (SEQ ID NO:119) designated herein as DNA38037.

[0140]FIG. 120 shows a nucleotide sequence (SEQ ID NO:120) designated herein as DNA38050.

[0141]FIG. 121 shows a nucleotide sequence (SEQ ID NO:121) designated herein as DNA38053.

[0142]FIG. 122 shows a nucleotide sequence (SEQ ID NO:122) designated herein as DNA38312.

[0143]FIG. 123 shows a nucleotide sequence (SEQ ID NO:123) designated herein as DNA38360.

[0144]FIG. 124 shows a nucleotide sequence (SEQ ID NO:124) designated herein as DNA38600.

[0145]FIG. 125 shows a nucleotide sequence (SEQ ID NO:125) designated herein as DNA38720.

[0146]FIG. 126 shows a nucleotide sequence (SEQ ID NO:126) designated herein as DNA38727.

[0147]FIG. 127 shows a nucleotide sequence (SEQ ID NO:127) designated herein as DNA38731.

[0148]FIG. 128 shows a nucleotide sequence (SEQ ID NO:128) designated herein as DNA38810.

[0149]FIG. 129 shows a nucleotide sequence (SEQ ID NO:129) designated herein as DNA38814.

[0150]FIG. 130 shows a nucleotide sequence (SEQ ID NO:130) designated herein as DNA39378.

[0151]FIG. 131 shows a nucleotide sequence (SEQ ID NO:131) designated herein as DNA40050.

[0152]FIG. 132 shows a nucleotide sequence (SEQ ID NO:132) designated herein as DNA40375.

[0153]FIG. 133 shows a nucleotide sequence (SEQ ID NO:133) designated herein as DNA40382.

[0154]FIG. 134 shows a nucleotide sequence (SEQ ID NO:134) designated herein as DNA40394.

[0155]FIG. 135 shows a nucleotide sequence (SEQ ID NO:135) designated herein as DNA40461.

[0156]FIG. 136 shows a nucleotide sequence (SEQ ID NO:136) designated herein as DNA40735.

[0157]FIG. 137 shows a nucleotide sequence (SEQ ID NO:137) designated herein as DNA40736.

[0158]FIG. 138 shows a nucleotide sequence (SEQ ID NO:138) designated herein as DNA40738.

[0159]FIG. 139 shows a nucleotide sequence (SEQ ID NO:139) designated herein as DNA40739.

[0160]FIG. 140 shows a nucleotide sequence (SEQ ID NO:140) designated herein as DNA41144.

[0161]FIG. 141 shows a nucleotide sequence (SEQ ID NO:141) designated herein as DNA41161.

[0162]FIG. 142 shows a nucleotide sequence (SEQ ID NO:142) designated herein as DNA41186.

[0163]FIG. 143 shows a nucleotide sequence (SEQ ID NO:143) designated herein as DNA41250.

[0164]FIG. 144 shows a nucleotide sequence (SEQ ID NO:144) designated herein as DNA41284.

[0165]FIG. 145 shows a nucleotide sequence (SEQ ID NO:145) designated herein as DNA41303.

[0166]FIG. 146 shows a nucleotide sequence (SEQ ID NO:146) designated herein as DNA41326.

[0167]FIG. 147 shows a nucleotide sequence (SEQ ID NO:147) designated herein as DNA41444.

[0168]FIG. 148 shows a nucleotide sequence (SEQ ID NO:148) designated herein as DNA41445.

[0169]FIG. 149 shows a nucleotide sequence (SEQ ID NO:149) designated herein as DNA41452.

[0170]FIG. 150 shows a nucleotide sequence (SEQ ID NO:150) designated herein as DNA41456.

[0171]FIG. 151 shows a nucleotide sequence (SEQ ID NO:151) designated herein as DNA41458.

[0172]FIG. 152 shows a nucleotide sequence (SEQ ID NO:152) designated herein as DNA41462.

[0173]FIG. 153 shows a nucleotide sequence (SEQ ID NO:153) designated herein as DNA41465.

[0174]FIG. 154 shows a nucleotide sequence (SEQ ID NO:154) designated herein as DNA41475.

[0175]FIG. 155 shows a nucleotide sequence (SEQ ID NO:155) designated herein as DNA41514.

[0176]FIG. 156 shows a nucleotide sequence (SEQ ID NO:156) designated herein as DNA41565.

[0177]FIG. 157 shows a nucleotide sequence (SEQ ID NO:157) designated herein as DNA41566.

[0178]FIG. 158 shows a nucleotide sequence (SEQ ID NO:158) designated herein as DNA41626.

[0179]FIG. 159 shows a nucleotide sequence (SEQ ID NO:159) designated herein as DNA41709.

[0180]FIG. 160 shows a nucleotide sequence (SEQ ID NO:160) designated herein as DNA41775.

[0181]FIG. 161 shows a nucleotide sequence (SEQ ID NO:161) designated herein as DNA41784.

[0182]FIG. 162 shows a nucleotide sequence (SEQ ID NO:162) designated herein as DNA42194.

[0183]FIG. 163 shows a nucleotide sequence (SEQ ID NO:163) designated herein as DNA42279.

[0184]FIG. 164 shows a nucleotide sequence (SEQ ID NO:164) designated herein as DNA42314.

[0185]FIG. 165 shows a nucleotide sequence (SEQ ID NO:165) designated herein as DNA42331.

[0186]FIG. 166 shows a nucleotide sequence (SEQ ID NO:166) designated herein as DNA42358.

[0187]FIG. 167 shows a nucleotide sequence (SEQ ID NO:167) designated herein as DNA42858.

[0188]FIG. 168 shows a nucleotide sequence (SEQ ID NO:168) designated herein as DNA42870.

[0189]FIG. 169 shows a nucleotide sequence (SEQ ID NO:169) designated herein as DNA42875.

[0190]FIG. 170 shows a nucleotide sequence (SEQ ID NO:170) designated herein as DNA43197.

[0191]FIG. 171 shows a nucleotide sequence (SEQ ID NO:171) designated herein as DNA43203.

[0192]FIG. 172 shows a nucleotide sequence (SEQ ID NO:172) designated herein as DNA43295.

[0193]FIG. 173 shows a nucleotide sequence (SEQ ID NO:173) designated herein as DNA43301.

[0194]FIG. 174 shows a nucleotide sequence (SEQ ID NO:174) designated herein as DNA43363.

[0195]FIG. 175 shows a nucleotide sequence (SEQ ID NO:175) designated herein as DNA43420.

[0196]FIG. 176 shows a nucleotide sequence (SEQ ID NO:176) designated herein as DNA443479.

[0197]FIG. 177 shows a nucleotide sequence (SEQ ID NO:177) designated herein as DNA43489.

[0198]FIG. 178 shows a nucleotide sequence (SEQ ID NO:178) designated herein as DNA43498.

[0199]FIG. 179 shows a nucleotide sequence (SEQ ID NO:179) designated herein as DNA43509.

[0200]FIG. 180 shows a nucleotide sequence (SEQ ID NO:180) designated herein as DNA43512.

[0201]FIG. 181 shows a nucleotide sequence (SEQ ID NO:181) designated herein as DNA43531.

[0202]FIG. 182 shows a nucleotide sequence (SEQ ID NO:182) designated herein as DNA43546.

[0203]FIG. 183 shows a nucleotide sequence (SEQ ID NO:183) designated herein as DNA43586.

[0204]FIG. 184 shows a nucleotide sequence (SEQ ID NO:184) designated herein as DNA43862.

[0205]FIG. 185 shows a nucleotide sequence (SEQ ID NO:185) designated herein as DNA43887.

[0206]FIG. 186 shows a nucleotide sequence (SEQ ID NO:186) designated herein as DNA43936.

[0207]FIG. 187 shows a nucleotide sequence (SEQ ID NO:187) designated herein as DNA43961.

[0208]FIG. 188 shows a nucleotide sequence (SEQ ID NO:188) designated herein as DNA43971.

[0209]FIG. 189 shows a nucleotide sequence (SEQ ID NO:189) designated herein as DNA44048.

[0210]FIG. 190 shows a nucleotide sequence (SEQ ID NO:190) designated herein as DNA44920.

[0211]FIG. 191 shows a nucleotide sequence (SEQ ID NO:191) designated herein as DNA44922.

[0212]FIG. 192 shows a nucleotide sequence (SEQ ID NO:192) designated herein as DNA44934.

[0213]FIG. 193 shows a nucleotide sequence (SEQ ID NO:193) designated herein as DNA44987.

[0214]FIG. 194 shows a nucleotide sequence (SEQ ID NO:194) designated herein as DNA45014.

[0215]FIG. 195 shows a nucleotide sequence (SEQ ID NO:195) designated herein as DNA45030.

[0216]FIG. 196 shows a nucleotide sequence (SEQ ID NO:196) designated herein as DNA45051.

[0217]FIG. 197 shows a nucleotide sequence (SEQ ID NO:197) designated herein as DNA45064.

[0218]FIG. 198 shows a nucleotide sequence (SEQ ID NO:198) designated herein as DNA45282.

[0219]FIG. 199 shows a nucleotide sequence (SEQ ID NO:199) designated herein as DNA45288.

[0220]FIG. 200 shows a nucleotide sequence (SEQ ID NO:200) designated herein as DNA45300.

[0221]FIG. 201 shows a nucleotide sequence (SEQ ID NO:201) designated herein as DNA45740.

[0222]FIG. 202 shows a nucleotide sequence (SEQ ID NO:202) designated herein as DNA45759.

[0223]FIG. 203 shows a nucleotide sequence (SEQ ID NO:203) designated herein as DNA45784.

[0224]FIG. 204 shows a nucleotide sequence (SEQ ID NO:204) designated herein as DNA45789.

[0225]FIG. 205 shows a nucleotide sequence (SEQ ID NO:205) designated herein as DNA45816.

[0226]FIG. 206 shows a nucleotide sequence (SEQ ID NO:206) designated herein as DNA45944.

[0227]FIG. 207 shows a nucleotide sequence (SEQ ID NO:207) designated herein as DNA45954.

[0228]FIG. 208 shows a nucleotide sequence (SEQ ID NO:208) designated herein as DNA45964.

[0229]FIG. 209 shows a nucleotide sequence (SEQ ID NO:209) designated herein as DNA45993.

[0230]FIG. 210 shows a nucleotide sequence (SEQ ID NO:210) designated herein as DNA46092.

[0231]FIG. 211 shows a nucleotide sequence (SEQ ID NO:211) designated herein as DNA46213.

[0232]FIG. 212 shows a nucleotide sequence (SEQ ID NO:212) designated herein as DNA46215.

[0233]FIG. 213 shows a nucleotide sequence (SEQ ID NO:213) designated herein as DNA46226.

[0234]FIG. 214 shows a nucleotide sequence (SEQ ID NO:214) designated herein as DNA46328.

[0235]FIG. 215 shows a nucleotide sequence (SEQ ID NO:215) designated herein as DNA47580.

[0236]FIG. 216 shows a nucleotide sequence (SEQ ID NO:216) designated herein as DNA47691.

[0237]FIG. 217 shows a nucleotide sequence (SEQ ID NO:217) designated herein as DNA47751.

[0238]FIG. 218 shows a nucleotide sequence (SEQ ID NO:218) designated herein as DNA47835.

[0239]FIG. 219 shows a nucleotide sequence (SEQ ID NO:219) designated herein as DNA47858.

[0240]FIG. 220 shows a nucleotide sequence (SEQ ID NO:220) designated herein as DNA47890.

[0241]FIG. 221 shows a nucleotide sequence (SEQ ID NO:221) designated herein as DNA47930.

[0242]FIG. 222 shows a nucleotide sequence (SEQ ID NO:222) designated herein as DNA47990.

[0243]FIG. 223 shows a nucleotide sequence (SEQ ID NO:223) designated herein as DNA48054.

[0244]FIG. 224 shows a nucleotide sequence (SEQ ID NO:224) designated herein as DNA48124.

[0245]FIG. 225 shows a nucleotide sequence (SEQ ID NO:225) designated herein as DNA48131.

[0246]FIG. 226 shows a nucleotide sequence (SEQ ID NO:226) designated herein as DNA48162.

[0247]FIG. 227 shows a nucleotide sequence (SEQ ID NO:227) designated herein as DNA48209.

[0248]FIG. 228 shows a nucleotide sequence (SEQ ID NO:228) designated herein as DNA48389.

[0249]FIG. 229 shows a nucleotide sequence (SEQ ID NO:229) designated herein as DNA48446.

[0250]FIG. 230 shows a nucleotide sequence (SEQ ID NO:230) designated herein as DNA48466.

[0251]FIG. 231 shows a nucleotide sequence (SEQ ID NO:231) designated herein as DNA48576.

[0252]FIG. 232 shows a nucleotide sequence (SEQ ID NO:232) designated herein as DNA48598.

[0253]FIG. 233 shows a nucleotide sequence (SEQ ID NO:233) designated herein as DNA48666.

[0254]FIG. 234 shows a nucleotide sequence (SEQ ID NO:234) designated herein as DNA48748.

[0255]FIG. 235 shows a nucleotide sequence (SEQ ID NO:235) designated herein as DNA48777.

[0256]FIG. 236 shows a nucleotide sequence (SEQ ID NO:236) designated herein as DNA48830.

[0257]FIG. 237 shows a nucleotide sequence (SEQ ID NO:237) designated herein as DNA49352.

[0258]FIG. 238 shows a nucleotide sequence (SEQ ID NO:238) designated herein as DNA49407.

[0259]FIG. 239 shows a nucleotide sequence (SEQ ID NO:239) designated herein as DNA49448.

[0260]FIG. 240 shows a nucleotide sequence (SEQ ID NO:240) designated herein as DNA49528.

[0261]FIG. 241 shows a nucleotide sequence (SEQ ID NO:241) designated herein as DNA49529.

[0262]FIG. 242 shows a nucleotide sequence (SEQ ID NO:242) designated herein as DNA49948.

[0263]FIG. 243 shows a nucleotide sequence (SEQ ID NO:243) designated herein as DNA49956.

[0264]FIG. 244 shows a nucleotide sequence (SEQ ID NO:244) designated herein as DNA49992.

[0265]FIG. 245 shows a nucleotide sequence (SEQ ID NO:245) designated herein as DNA50307.

[0266]FIG. 246 shows a nucleotide sequence (SEQ ID NO:246) designated herein as DNA50319.

[0267]FIG. 247 shows a nucleotide sequence (SEQ ID NO:247) designated herein as DNA50346.

[0268]FIG. 248 shows a nucleotide sequence (SEQ ID NO:248) designated herein as DNA50354.

[0269]FIG. 249 shows a nucleotide sequence (SEQ ID NO:249) designated herein as DNA50356.

[0270]FIG. 250 shows a nucleotide sequence (SEQ ID NO:250) designated herein as DNA50405.

[0271]FIG. 251 shows a nucleotide sequence (SEQ ID NO:251) designated herein as DNA50421.

[0272]FIG. 252 shows a nucleotide sequence (SEQ ID NO:252) designated herein as DNA50423.

[0273]FIG. 253 shows a nucleotide sequence (SEQ ID NO:253) designated herein as DNA50527.

[0274]FIG. 254 shows a nucleotide sequence (SEQ ID NO:254) designated herein as DNA50584.

[0275]FIG. 255 shows a nucleotide sequence (SEQ ID NO:255) designated herein as DNA50626.

[0276]FIG. 256 shows a nucleotide sequence (SEQ ID NO:256) designated herein as DNA50637.

[0277]FIG. 257 shows a nucleotide sequence (SEQ ID NO:257) designated herein as DNA50650.

[0278]FIG. 258 shows a nucleotide sequence (SEQ ID NO:258) designated herein as DNA50674.

[0279]FIG. 259 shows a nucleotide sequence (SEQ ID NO:259) designated herein as DNA50675.

[0280]FIG. 260 shows a nucleotide sequence (SEQ ID NO:260) designated herein as DNA50698.

[0281]FIG. 261 shows a nucleotide sequence (SEQ ID NO:261) designated herein as DNA50730.

[0282]FIG. 262 shows a nucleotide sequence (SEQ ID NO:262) designated herein as DNA50737.

[0283]FIG. 263 shows a nucleotide sequence (SEQ ID NO:263) designated herein as DNA51003.

[0284]FIG. 264 shows a nucleotide sequence (SEQ ID NO:264) designated herein as DNA51010.

[0285]FIG. 265 shows a nucleotide sequence (SEQ ID NO:265) designated herein as DNA51059.

[0286]FIG. 266 shows a nucleotide sequence (SEQ ID NO:266) designated herein as DNA51413.

[0287]FIG. 267 shows a nucleotide sequence (SEQ ID NO:267) designated herein as DNA51712.

[0288]FIG. 268 shows a nucleotide sequence (SEQ ID NO:268) designated herein as DNA51795.

[0289]FIG. 269 shows a nucleotide sequence (SEQ ID NO:269) designated herein as DNA52199.

[0290]FIG. 270 shows a nucleotide sequence (SEQ ID NO:270) designated herein as DNA52218.

[0291]FIG. 271 shows a nucleotide sequence (SEQ ID NO:271) designated herein as DNA52352.

[0292]FIG. 272 shows a nucleotide sequence (SEQ ID NO:272) designated herein as DNA54446.

[0293]FIG. 273 shows a nucleotide sequence (SEQ ID NO:273) designated herein as DNA54552.

[0294]FIG. 274 shows a nucleotide sequence (SEQ ID NO:274) designated herein as DNA54580.

[0295]FIG. 275 shows a nucleotide sequence (SEQ ID NO:275) designated herein as DNA54623.

[0296]FIG. 276 shows a nucleotide sequence (SEQ ID NO:276) designated herein as DNA54672.

[0297]FIG. 277 shows a nucleotide sequence (SEQ ID NO:277) designated herein as DNA54840.

[0298]FIG. 278 shows a nucleotide sequence (SEQ ID NO:278) designated herein as DNA54856.

[0299]FIG. 279 shows a nucleotide sequence (SEQ ID NO:279) designated herein as DNA54882.

[0300]FIG. 280 shows a nucleotide sequence (SEQ ID NO:280) designated herein as DNA54943.

[0301]FIG. 281 shows a nucleotide sequence (SEQ ID NO:281) designated herein as DNA54970.

[0302]FIG. 282 shows a nucleotide sequence (SEQ I) NO:282) designated herein as DNA55134.

[0303]FIG. 283 shows a nucleotide sequence (SEQ ID NO:283) designated herein as DNA55198.

[0304]FIG. 284 shows a nucleotide sequence (SEQ ID NO:284) designated herein as DNA55199.

[0305]FIG. 285 shows a nucleotide sequence (SEQ ID NO:285) designated herein as DNA55292.

[0306]FIG. 286 shows a nucleotide sequence (SEQ ID NO:286) designated herein as DNA55646.

[0307]FIG. 287 shows a nucleotide sequence (SEQ ID NO:287) designated herein as DNA56553.

[0308]FIG. 288 shows a nucleotide sequence (SEQ I) NO:288) designated herein as DNA56554.

[0309]FIG. 289 shows a nucleotide sequence (SEQ ID NO:289) designated herein as DNA56556.

[0310]FIG. 290 shows a nucleotide sequence (SEQ ID NO:290) designated herein as DNA56587.

[0311]FIG. 291 shows a nucleotide sequence (SEQ ID NO:291) designated herein as DNA56590.

[0312]FIG. 292 shows a nucleotide sequence (SEQ ID NO:292) designated herein as DNA56600.

[0313]FIG. 293 shows a nucleotide sequence (SEQ ID NO:293) designated herein as DNA56648.

[0314]FIG. 294 shows a nucleotide sequence (SEQ ID NO:294) designated herein as DNA56650.

[0315]FIG. 295 shows a nucleotide sequence (SEQ ID NO:295) designated herein as DNA56707.

[0316]FIG. 296 shows a nucleotide sequence (SEQ ID NO:296) designated herein as DNA56717.

[0317]FIG. 297 shows a nucleotide sequence (SEQ ID NO:297) designated herein as DNA58387.

[0318]FIG. 298 shows a nucleotide sequence (SEQ ID NO:298) designated herein as DNA58414.

[0319]FIG. 299 shows a nucleotide sequence (SEQ ID NO:299) designated herein as DNA58529.

[0320]FIG. 300 shows a nucleotide sequence (SEQ ID NO:300) designated herein as DNA59385.

[0321]FIG. 301 shows a nucleotide sequence (SEQ ID NO:301) designated herein as DNA59789.

[0322]FIG. 302 shows a nucleotide sequence (SEQ ID NO:302) designated herein as DNA60321.

[0323]FIG. 303 shows a nucleotide sequence (SEQ ID NO:303) designated herein as DNA60370.

[0324]FIG. 304 shows a nucleotide sequence (SEQ ID NO:304) designated herein as DNA60406.

[0325]FIG. 305 shows a nucleotide sequence (SEQ ID NO:305) designated herein as DNA60438.

[0326]FIG. 306 shows a nucleotide sequence (SEQ ID NO:306) designated herein as DNA60460.

[0327]FIG. 307 shows a nucleotide sequence (SEQ ID NO:307) designated herein as DNA60466.

[0328]FIG. 308 shows a nucleotide sequence (SEQ ID NO:308) designated herein as DNA60508.

[0329]FIG. 309 shows a nucleotide sequence (SEQ ID NO:309) designated herein as DNA60542.

[0330]FIG. 310 shows a nucleotide sequence (SEQ ID NO:310) designated herein as DNA60590.

[0331]FIG. 311 shows a nucleotide sequence (SEQ ID NO:311) designated herein as DNA61350.

[0332]FIG. 312 shows a nucleotide sequence (SEQ ID NO:312) designated herein as DNA61356.

[0333]FIG. 313 shows a nucleotide sequence (SEQ ID NO:313) designated herein as DNA61478.

[0334]FIG. 314 shows a nucleotide sequence (SEQ ID NO:314) designated herein as DNA61513.

[0335]FIG. 315 shows a nucleotide sequence (SEQ ID NO:315) designated herein as DNA61561.

[0336]FIG. 316 shows a nucleotide sequence (SEQ ID NO:316) designated herein as DNA61895.

[0337]FIG. 317 shows a nucleotide sequence (SEQ ID NO:317) designated herein as DNA61930.

[0338]FIG. 318 shows a nucleotide sequence (SEQ ID NO:318) designated herein as DNA61953.

[0339]FIG. 319 shows a nucleotide sequence (SEQ ID NO:319) designated herein as DNA62011.

[0340]FIG. 320 shows a nucleotide sequence (SEQ ID NO:320) designated herein as DNA62080.

[0341]FIG. 321 shows a nucleotide sequence (SEQ ID NO:321) designated herein as DNA62126.

[0342]FIG. 322 shows a nucleotide sequence (SEQ ID NO:322) designated herein as DNA62154.

[0343]FIG. 323 shows a nucleotide sequence (SEQ ID NO:323) designated herein as DNA62170.

[0344]FIG. 324 shows a nucleotide sequence (SEQ ID NO:324) designated herein as DNA62193.

[0345]FIG. 325 shows a nucleotide sequence (SEQ ID NO:325) designated herein as DNA62261.

[0346]FIG. 326 shows a nucleotide sequence (SEQ ID NO:326) designated herein as DNA62291.

[0347]FIG. 327 shows a nucleotide sequence (SEQ ID NO:327) designated herein as DNA62422.

[0348]FIG. 328 shows a nucleotide sequence (SEQ ID NO:328) designated herein as DNA62436.

[0349]FIG. 329 shows a nucleotide sequence (SEQ ID NO:329) designated herein as DNA62524.

[0350]FIG. 330 shows a nucleotide sequence (SEQ ID NO:330) designated herein as DNA62589.

[0351]FIG. 331 shows a nucleotide sequence (SEQ ID NO:331) designated herein as DNA63878.

[0352]FIG. 332 shows a nucleotide sequence (SEQ ID NO:332) designated herein as DNA64017.

[0353]FIG. 333 shows a nucleotide sequence (SEQ ID NO:333) designated herein as DNA64045.

[0354]FIG. 334 shows a nucleotide sequence (SEQ ID NO:334) designated herein as DNA64101.

[0355]FIG. 335 shows a nucleotide sequence (SEQ ID NO:335) designated herein as DNA64183.

[0356]FIG. 336 shows a nucleotide sequence (SEQ ID NO:336) designated herein as DNA64193.

[0357]FIG. 337 shows a nucleotide sequence (SEQ ID NO:337) designated herein as DNA64199.

[0358]FIG. 338 shows a nucleotide sequence (SEQ ID NO:338) designated herein as DNA64268.

[0359]FIG. 339 shows a nucleotide sequence (SEQ ID NO:339) designated herein as DNA64304.

[0360]FIG. 340 shows a nucleotide sequence (SEQ ID NO:340) designated herein as DNA64453.

[0361]FIG. 341 shows a nucleotide sequence (SEQ ID NO:341) designated herein as DNA64458.

[0362]FIG. 342 shows a nucleotide sequence (SEQ ID NO:342) designated herein as DNA64512.

[0363]FIG. 343 shows a nucleotide sequence (SEQ ID NO:343) designated herein as DNA64540.

[0364]FIG. 344 shows a nucleotide sequence (SEQ ID NO:344) designated herein as DNA64552.

[0365]FIG. 345 shows a nucleotide sequence (SEQ ID NO:345) designated herein as DNA64557.

[0366]FIG. 346 shows a nucleotide sequence (SEQ ID NO:346) designated herein as DNA64569.

[0367]FIG. 347 shows a nucleotide sequence (SEQ ID NO:347) designated herein as DNA64627.

[0368]FIG. 348 shows a nucleotide sequence (SEQ ID NO:348) designated herein as DNA64745.

[0369]FIG. 349 shows a nucleotide sequence (SEQ ID NO:349) designated herein as DNA64784.

[0370]FIG. 350 shows a nucleotide sequence (SEQ ID NO:350) designated herein as DNA65609.

[0371]FIG. 351 shows a nucleotide sequence (SEQ ID NO:351) designated herein as DNA65644.

[0372]FIG. 352 shows a nucleotide sequence (SEQ ID NO:352) designated herein as DNA65720.

[0373]FIG. 353 shows a nucleotide sequence (SEQ ID NO:353) designated herein as DNA65752.

[0374]FIG. 354 shows a nucleotide sequence (SEQ ID NO:354) designated herein as DNA65771.

[0375]FIG. 355 shows a nucleotide sequence (SEQ ID NO:355) designated herein as DNA65833.

[0376]FIG. 356 shows a nucleotide sequence (SEQ ID NO:356) designated herein as DNA65836.

[0377]FIG. 357 shows a nucleotide sequence (SEQ ID NO:357) designated herein as DNA65864.

[0378]FIG. 358 shows a nucleotide sequence (SEQ ID NO:358) designated herein as DNA65869.

[0379]FIG. 359 shows a nucleotide sequence (SEQ ID NO:359) designated herein as DNA65928.

[0380]FIG. 360 shows a nucleotide sequence (SEQ ID NO:360) designated herein as DNA66065.

[0381]FIG. 361 shows a nucleotide sequence (SEQ ID NO:361) designated herein as DNA66095.

[0382]FIG. 362 shows a nucleotide sequence (SEQ ID NO:362) designated herein as DNA66197.

[0383]FIG. 363 shows a nucleotide sequence (SEQ ID NO:363) designated herein as DNA66217.

[0384]FIG. 364 shows a nucleotide sequence (SEQ ID NO:364) designated herein as DNA66231.

[0385]FIG. 365 shows a nucleotide sequence (SEQ ID NO:365) designated herein as DNA66404.

[0386]FIG. 366 shows a nucleotide sequence (SEQ ID NO:366) designated herein as DNA66432.

[0387]FIG. 367 shows a nucleotide sequence (SEQ ID NO:367) designated herein as DNA67076.

[0388]FIG. 368 shows a nucleotide sequence (SEQ ID NO:368) designated herein as DNA68013.

[0389]FIG. 369 shows a nucleotide sequence (SEQ ID NO:369) designated herein as DNA68018.

[0390]FIG. 370 shows a nucleotide sequence (SEQ ID NO:370) designated herein as DNA68034.

[0391]FIG. 371 shows a nucleotide sequence (SEQ ID NO:371) designated herein as DNA68119.

[0392]FIG. 372 shows a nucleotide sequence (SEQ ID NO:372) designated herein as DNA68248.

[0393]FIG. 373 shows a nucleotide sequence (SEQ ID NO:373) designated herein as DNA68383.

[0394]FIG. 374 shows a nucleotide sequence (SEQ ID NO:374) designated herein as DNA68423.

[0395]FIG. 375 shows a nucleotide sequence (SEQ ID NO:375) designated herein as DNA68441.

[0396]FIG. 376 shows a nucleotide sequence (SEQ ID NO:376) designated herein as DNA68459.

[0397]FIG. 377 shows a nucleotide sequence (SEQ ID NO:377) designated herein as DNA68509.

[0398]FIG. 378 shows a nucleotide sequence (SEQ ID NO:378) designated herein as DNA68514.

[0399]FIG. 379 shows a nucleotide sequence (SEQ ID NO:379) designated herein as DNA68521.

[0400]FIG. 380 shows a nucleotide sequence (SEQ ID NO:380) designated herein as DNA68532.

[0401]FIG. 381 shows a nucleotide sequence (SEQ ID NO:381) designated herein as DNA68540.

[0402]FIG. 382 shows a nucleotide sequence (SEQ ID NO:382) designated herein as DNA68561.

[0403]FIG. 383 shows a nucleotide sequence (SEQ ID NO:383) designated herein as DNA68585.

[0404]FIG. 384 shows a nucleotide sequence (SEQ ID NO:384) designated herein as DNA69491.

[0405]FIG. 385 shows a nucleotide sequence (SEQ ID NO:385) designated herein as DNA70222.

[0406]FIG. 386 shows a nucleotide sequence (SEQ ID NO:386) designated herein as DNA70239.

[0407]FIG. 387 shows a nucleotide sequence (SEQ ID NO:387) designated herein as DNA70244.

[0408]FIG. 388 shows a nucleotide sequence (SEQ ID NO:388) designated herein as DNA70349.

[0409]FIG. 389 shows a nucleotide sequence (SEQ ID NO:389) designated herein as DNA70400.

[0410]FIG. 390 shows a nucleotide sequence (SEQ ID NO:390) designated herein as DNA70413.

[0411]FIG. 391 shows a nucleotide sequence (SEQ ID NO:391) designated herein as DNA70526.

[0412]FIG. 392 shows a nucleotide sequence (SEQ ID NO:392) designated herein as DNA70685.

[0413]FIG. 393 shows a nucleotide sequence (SEQ ID NO:393) designated herein as DNA70732.

[0414]FIG. 394 shows a nucleotide sequence (SEQ ID NO:394) designated herein as DNA72634.

[0415]FIG. 395 shows a nucleotide sequence (SEQ ID NO:395) designated herein as DNA72683.

[0416]FIG. 396 shows a nucleotide sequence (SEQ ID NO:396) designated herein as DNA72695.

[0417]FIG. 397 shows a nucleotide sequence (SEQ ID NO:397) designated herein as DNA72864.

[0418]FIG. 398 shows a nucleotide sequence (SEQ ID NO:398) designated herein as DNA73156.

[0419]FIG. 399 shows a nucleotide sequence (SEQ ID NO:399) designated herein as DNA73275.

[0420]FIG. 400 shows a nucleotide sequence (SEQ ID NO:400) designated herein as DNA74052.

[0421]FIG. 401 shows a nucleotide sequence (SEQ ID NO:401) designated herein as DNA74063.

[0422]FIG. 402 shows a nucleotide sequence (SEQ ID NO:402) designated herein as DNA74072.

[0423]FIG. 403 shows a nucleotide sequence (SEQ ID NO:403) designated herein as DNA74140.

[0424]FIG. 404 shows a nucleotide sequence (SEQ ID NO:404) designated herein as DNA74216.

[0425]FIG. 405 shows a nucleotide sequence (SEQ ID NO:405) designated herein as DNA74218.

[0426]FIG. 406 shows a nucleotide sequence (SEQ ID NO:406) designated herein as DNA74228.

[0427]FIG. 407 shows a nucleotide sequence (SEQ ID NO:407) designated herein as DNA74256.

[0428]FIG. 408 shows a nucleotide sequence (SEQ ID NO:408) designated herein as DNA75062.

[0429]FIG. 409 shows a nucleotide sequence (SEQ ID NO:409) designated herein as DNA76137.

[0430]FIG. 410 shows a nucleotide sequence (SEQ ID NO:410) designated herein as DNA76158.

[0431]FIG. 411 shows a nucleotide sequence (SEQ ID NO:411) designated herein as DNA77098.

[0432]FIG. 412 shows a nucleotide sequence (SEQ ID NO:412) designated herein as DNA77791.

[0433]FIG. 413 shows a nucleotide sequence (SEQ ID NO:413) designated herein as DNA77968.

[0434]FIG. 414 shows a nucleotide sequence (SEQ ID NO:414) designated herein as DNA77976.

[0435]FIG. 415 shows a nucleotide sequence (SEQ ID NO:415) designated herein as DNA78017.

[0436]FIG. 416 shows a nucleotide sequence (SEQ ID NO:416) designated herein as DNA78095.

[0437]FIG. 417 shows a nucleotide sequence (SEQ ID NO:417) designated herein as DNA78103.

[0438]FIG. 418 shows a nucleotide sequence (SEQ ID NO:418) designated herein as DNA78113.

[0439]FIG. 419 shows a nucleotide sequence (SEQ ID NO:419) designated herein as DNA78746.

[0440]FIG. 420 shows a nucleotide sequence (SEQ ID NO:420) designated herein as DNA78759.

[0441]FIG. 421 shows a nucleotide sequence (SEQ ID NO:421) designated herein as DNA78796.

[0442]FIG. 422 shows a nucleotide sequence (SEQ ID NO:422) designated herein as DNA79561.

[0443]FIG. 423 shows a nucleotide sequence (SEQ ID NO:423) designated herein as DNA79602.

[0444]FIG. 424 shows a nucleotide sequence (SEQ ID NO:424) designated herein as DNA79617.

[0445]FIG. 425 shows a nucleotide sequence (SEQ ID NO:425) designated herein as DNA79628.

[0446]FIG. 426 shows a nucleotide sequence (SEQ ID NO:426) designated herein as DNA79640.

[0447]FIG. 427 shows a nucleotide sequence (SEQ ID NO:427) designated herein as DNA79661.

[0448]FIG. 428 shows a nucleotide sequence (SEQ ID NO:428) designated herein as DNA79684.

[0449]FIG. 429 shows a nucleotide sequence (SEQ ID NO:429) designated herein as DNA79717.

[0450]FIG. 430 shows a nucleotide sequence (SEQ ID NO:430) designated herein as DNA79733.

[0451]FIG. 431 shows a nucleotide sequence (SEQ ID NO:431) designated herein as DNA79970.

[0452]FIG. 432 shows a nucleotide sequence (SEQ ID NO:432) designated herein as DNA80050.

[0453]FIG. 433 shows a nucleotide sequence (SEQ ID NO:433) designated herein as DNA80247.

[0454]FIG. 434 shows a nucleotide sequence (SEQ ID NO:434) designated herein as DNA80265.

[0455]FIG. 435 shows a nucleotide sequence (SEQ ID NO:435) designated herein as DNA80615.

[0456]FIG. 436 shows a nucleotide sequence (SEQ ID NO:436) designated herein as DNA80623.

[0457]FIG. 437 shows a nucleotide sequence (SEQ ID NO:437) designated herein as DNA80627.

[0458]FIG. 438 shows a nucleotide sequence (SEQ ID NO:438) designated herein as DNA81896.

[0459]FIG. 439 shows a nucleotide sequence (SEQ ID NO:439) designated herein as DNA81918.

[0460]FIG. 440 shows a nucleotide sequence (SEQ ID NO:440) designated herein as DNA81976.

[0461]FIG. 441 shows a nucleotide sequence (SEQ ID NO:441) designated herein as DNA82017.

[0462]FIG. 442 shows a nucleotide sequence (SEQ ID NO:442) designated herein as DNA82024.

[0463]FIG. 443 shows a nucleotide sequence (SEQ ID NO:443) designated herein as DNA82027.

[0464]FIG. 444 shows a nucleotide sequence (SEQ ID NO:444) designated herein as DNA82115.

[0465]FIG. 445 shows a nucleotide sequence (SEQ ID NO:445) designated herein as DNA82154.

[0466]FIG. 446 shows a nucleotide sequence (SEQ ID NO:446) designated herein as DNA82157.

[0467]FIG. 447 shows a nucleotide sequence (SEQ ID NO:447) designated herein as DNA82166.

[0468]FIG. 448 shows a nucleotide sequence (SEQ ID NO:448) designated herein as DNA82182.

[0469]FIG. 449 shows a nucleotide sequence (SEQ ID NO:449) designated herein as DNA82212.

[0470]FIG. 450 shows a nucleotide sequence (SEQ ID NO:450) designated herein as DNA82498.

[0471]FIG. 451 shows a nucleotide sequence (SEQ ID NO:451) designated herein as DNA82499.

[0472]FIG. 452 shows a nucleotide sequence (SEQ ID NO:452) designated herein as DNA82504.

[0473]FIG. 453 shows a nucleotide sequence (SEQ ID NO:453) designated herein as DNA82531.

[0474]FIG. 454 shows a nucleotide sequence (SEQ ID NO:454) designated herein as DNA82693.

[0475]FIG. 455 shows a nucleotide sequence (SEQ ID NO:455) designated herein as DNA82702.

[0476]FIG. 456 shows a nucleotide sequence (SEQ ID NO:456) designated herein as DNA82786.

[0477]FIG. 457 shows a nucleotide sequence (SEQ ID NO:457) designated herein as DNA82851.

[0478]FIG. 458 shows a nucleotide sequence (SEQ ID NO:458) designated herein as DNA82898.

[0479]FIG. 459 shows a nucleotide sequence (SEQ ID NO:459) designated herein as DNA82935.

[0480]FIG. 460 shows a nucleotide sequence (SEQ ID NO:460) designated herein as DNA82977.

[0481]FIG. 461 shows a nucleotide sequence (SEQ ID NO:461) designated herein as DNA82989.

[0482]FIG. 462 shows a nucleotide sequence (SEQ ID NO:462) designated herein as DNA83628.

[0483]FIG. 463 shows a nucleotide sequence (SEQ ID NO:463) designated herein as DNA83630.

[0484]FIG. 464 shows a nucleotide sequence (SEQ ID NO:464) designated herein as DNA83749.

[0485]FIG. 465 shows a nucleotide sequence (SEQ ID NO:465) designated herein as DNA83772.

[0486]FIG. 466 shows a nucleotide sequence (SEQ ID NO:466) designated herein as DNA83800.

[0487]FIG. 467 shows a nucleotide sequence (SEQ ID NO:467) designated herein as DNA83950.

[0488]FIG. 468 shows a nucleotide sequence (SEQ ID NO:468) designated herein as DNA84027.

[0489]FIG. 469 shows a nucleotide sequence (SEQ ID NO:469) designated herein as DNA84076.

[0490]FIG. 470 shows a nucleotide sequence (SEQ ID NO:470) designated herein as DNA84109.

[0491]FIG. 471 shows a nucleotide sequence (SEQ ID NO:471) designated herein as DNA85072.

[0492]FIG. 472 shows a nucleotide sequence (SEQ ID NO:472) designated herein as DNA85154.

[0493]FIG. 473 shows a nucleotide sequence (SEQ ID NO:473) designated herein as DNA85193.

[0494]FIG. 474 shows a nucleotide sequence (SEQ ID NO:474) designated herein as DNA85224.

[0495]FIG. 475 shows a nucleotide sequence (SEQ ID NO:475) designated herein as DNA85237.

[0496]FIG. 476 shows a nucleotide sequence (SEQ ID NO:476) designated herein as DNA85289.

[0497]FIG. 477 shows a nucleotide sequence (SEQ ID NO:477) designated herein as DNA85357.

[0498]FIG. 478 shows a nucleotide sequence (SEQ ID NO:478) designated herein as DNA85361.

[0499]FIG. 479 shows a nucleotide sequence (SEQ ID NO:479) designated herein as DNA85371.

[0500]FIG. 480 shows a nucleotide sequence (SEQ ID NO:480) designated herein as DNA86875.

[0501]FIG. 481 shows a nucleotide sequence (SEQ ID NO:481) designated herein as DNA86876.

[0502]FIG. 482 shows a nucleotide sequence (SEQ ID NO:482) designated herein as DNA86905.

[0503]FIG. 483 shows a nucleotide sequence (SEQ ID NO:483) designated herein as DNA86945.

[0504]FIG. 484 shows a nucleotide sequence (SEQ ID NO:484) designated herein as DNA86969.

[0505]FIG. 485 shows a nucleotide sequence (SEQ ID NO:485) designated herein as DNA87050.

[0506]FIG. 486 shows a nucleotide sequence (SEQ ID NO:486) designated herein as DNA87094.

[0507]FIG. 487 shows a nucleotide sequence (SEQ ID NO:487) designated herein as DNA87126.

[0508]FIG. 488 shows a nucleotide sequence (SEQ ID NO:488) designated herein as DNA87493.

[0509]FIG. 489 shows a nucleotide sequence (SEQ ID NO:489) designated herein as DNA87494.

[0510]FIG. 490 shows a nucleotide sequence (SEQ ID NO:490) designated herein as DNA87505.

[0511]FIG. 491 shows a nucleotide sequence (SEQ ID NO:491) designated herein as DNA87566.

[0512]FIG. 492 shows a nucleotide sequence (SEQ ID NO:492) designated herein as DNA87586.

[0513]FIG. 493 shows a nucleotide sequence (SEQ ID NO:493) designated herein as DNA87649.

[0514]FIG. 494 shows a nucleotide sequence (SEQ ID NO:494) designated herein as DNA89340.

[0515]FIG. 495 shows a nucleotide sequence (SEQ ID NO:495) designated herein as DNA89355.

[0516]FIG. 496 shows a nucleotide sequence (SEQ ID NO:496) designated herein as DNA89365.

[0517]FIG. 497 shows a nucleotide sequence (SEQ ID NO:497) designated herein as DNA89419.

[0518]FIG. 498 shows a nucleotide sequence (SEQ ID NO:498) designated herein as DNA89470.

[0519]FIG. 499 shows a nucleotide sequence (SEQ ID NO:499) designated herein as DNA89480.

[0520]FIG. 500 shows a nucleotide sequence (SEQ ID NO:500) designated herein as DNA89549.

[0521]FIG. 501 shows a nucleotide sequence (SEQ ID NO:501) designated herein as DNA89606.

[0522]FIG. 502 shows a nucleotide sequence (SEQ ID NO:502) designated herein as DNA89615.

[0523]FIG. 503 shows a nucleotide sequence (SEQ ID NO:503) designated herein as DNA89669.

[0524]FIG. 504 shows a nucleotide sequence (SEQ ID NO:504) designated herein as DNA89760.

[0525]FIG. 505 shows a nucleotide sequence (SEQ ID NO:505) designated herein as DNA89766.

[0526]FIG. 506 shows a nucleotide sequence (SEQ ID NO:506) designated herein as DNA89772.

[0527]FIG. 507 shows a nucleotide sequence (SEQ ID NO:507) designated herein as DNA89773.

[0528]FIG. 508 shows a nucleotide sequence (SEQ ID NO:508) designated herein as DNA89774.

[0529]FIG. 509 shows a nucleotide sequence (SEQ ID NO:509) designated herein as DNA89872.

[0530]FIG. 510 shows a nucleotide sequence (SEQ ID NO:510) designated herein as DNA89918.

[0531]FIG. 511 shows a nucleotide sequence (SEQ ID NO:511) designated herein as DNA89928.

[0532]FIG. 512 shows a nucleotide sequence (SEQ ID NO:512) designated herein as DNA89930.

[0533]FIG. 513 shows a nucleotide sequence (SEQ ID NO:513) designated herein as DNA91463.

[0534]FIG. 514 shows a nucleotide sequence (SEQ ID NO:514) designated herein as DNA91507.

[0535]FIG. 515 shows a nucleotide sequence (SEQ ID NO:515) designated herein as DNA93615.

[0536]FIG. 516 shows a nucleotide sequence (SEQ ID NO:516) designated herein as DNA94011.

[0537]FIG. 517 shows a nucleotide sequence (SEQ ID NO:517) designated herein as DNA94043.

[0538]FIG. 518 shows a nucleotide sequence (SEQ ID NO:518) designated herein as DNA94050.

[0539]FIG. 519 shows a nucleotide sequence (SEQ ID NO:519) designated herein as DNA94097.

[0540]FIG. 520 shows a nucleotide sequence (SEQ ID NO:520) designated herein as DNA94098.

[0541]FIG. 521 shows a nucleotide sequence (SEQ ID NO:521) designated herein as DNA94100.

[0542]FIG. 522 shows a nucleotide sequence (SEQ ID NO:522) designated herein as DNA94126.

[0543]FIG. 523 shows a nucleotide sequence (SEQ ID NO:523) designated herein as DNA94136.

[0544]FIG. 524 shows a nucleotide sequence (SEQ ID NO:524) designated herein as DNA94156.

[0545]FIG. 525 shows a nucleotide sequence (SEQ ID NO:525) designated herein as DNA94219.

[0546]FIG. 526 shows a nucleotide sequence (SEQ ID NO:526) designated herein as DNA94254.

[0547]FIG. 527 shows a nucleotide sequence (SEQ ID NO:527) designated herein as DNA94274.

[0548]FIG. 528 shows a nucleotide sequence (SEQ ID NO:528) designated herein as DNA94292.

[0549]FIG. 529 shows a nucleotide sequence (SEQ ID NO:529) designated herein as DNA94360.

[0550]FIG. 530 shows a nucleotide sequence (SEQ ID NO:530) designated herein as DNA94377.

[0551]FIG. 531 shows a nucleotide sequence (SEQ ID NO:531) designated herein as DNA94477.

[0552]FIG. 532 shows a nucleotide sequence (SEQ ID NO:532) designated herein as DNA94518.

[0553]FIG. 533 shows a nucleotide sequence (SEQ ID NO:533) designated herein as DNA94533.

[0554]FIG. 534 shows a nucleotide sequence (SEQ ID NO:534) designated herein as DNA95370.

[0555]FIG. 535 shows a nucleotide sequence (SEQ ID NO:535) designated herein as DNA97358.

[0556]FIG. 536 shows a nucleotide sequence (SEQ ID NO:536) designated herein as DNA97374.

[0557]FIG. 537 shows a nucleotide sequence (SEQ ID NO:537) designated herein as DNA97470.

[0558]FIG. 538 shows a nucleotide sequence (SEQ ID NO:538) designated herein as DNA97581.

[0559]FIG. 539 shows a nucleotide sequence (SEQ ID NO:539) designated herein as DNA97767.

[0560]FIG. 540 shows a nucleotide sequence (SEQ ID NO:540) designated herein as DNA97842.

[0561]FIG. 541 shows a nucleotide sequence (SEQ ID NO:541) designated herein as DNA97949.

[0562]FIG. 542 shows a nucleotide sequence (SEQ ID NO:542) designated herein as DNA97987.

[0563]FIG. 543 shows a nucleotide sequence (SEQ ID NO:543) designated herein as DNA97995.

[0564]FIG. 544 shows a nucleotide sequence (SEQ ID NO:544) designated herein as DNA98293.

[0565]FIG. 545 shows a nucleotide sequence (SEQ ID NO:545) designated herein as DNA98294.

[0566]FIG. 546 shows a nucleotide sequence (SEQ ID NO:546) designated herein as DNA98346.

[0567]FIG. 547 shows a nucleotide sequence (SEQ ID NO:547) designated herein as DNA98360.

[0568]FIG. 548 shows a nucleotide sequence (SEQ ID NO:548) designated herein as DNA98829.

[0569]FIG. 549 shows a nucleotide sequence (SEQ ID NO:549) designated herein as DNA101514.

[0570]FIG. 550 shows a nucleotide sequence (SEQ ID NO:550) designated herein as DNA101572.

[0571]FIG. 551 shows a nucleotide sequence (SEQ ID NO:551) designated herein as DNA101580.

[0572]FIG. 552 shows a nucleotide sequence (SEQ ID NO:552) designated herein as DNA101595.

[0573]FIG. 553 shows a nucleotide sequence (SEQ ID NO:553) designated herein as DNA101633.

[0574]FIG. 554 shows a nucleotide sequence (SEQ ID NO:554) designated herein as DNA101717.

[0575]FIG. 555 shows a nucleotide sequence (SEQ ID NO:555) designated herein as DNA101768.

[0576]FIG. 556 shows a nucleotide sequence (SEQ ID NO:556) designated herein as DNA107332.

[0577]FIG. 557 shows a nucleotide sequence (SEQ ID NO:557) designated herein as DNA43499.

[0578]FIG. 558 shows a nucleotide sequence (SEQ ID NO:558) designated herein as DNA45713.

[0579]FIG. 559 shows a nucleotide sequence (SEQ ID NO:559) designated herein as DNA46089.

[0580]FIG. 560 shows a nucleotide sequence (SEQ ID NO:560) designated herein as DNA68256.

[0581]FIG. 561 shows a nucleotide sequence (SEQ ID NO:561) designated herein as DNA70305.

[0582]FIG. 562 shows a nucleotide sequence (SEQ ID NO:562) designated herein as DNA82953.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0583] I. Definitions

[0584] The term “SRT polypeptide” when used herein encompasses “native sequence SRT polypeptides” and “SRT polypeptide variants” (which are further defined herein). “SRT” is a designation given to those polypeptides which are encoded by the nucleic acid molecules shown in the accompanying figures and variants thereof, nucleic acid molecules comprising the sequence shown in the accompanying figures and variants thereof as well as fragments of the above. The SRT polypeptides of the invention may be isolated from a variety of sources, such as from human tissue types or from another source, or prepared by recombinant and/or synthetic methods.

[0585] A “native sequence” SRT polypeptide comprises a polypeptide having the same amino acid sequence as the corresponding SRT polypeptide derived from nature. Such native sequence SRT polypeptides can be isolated from nature or can be produced by recombinant and/or synthetic means. The term “native sequence SRT polypeptide” specifically encompasses naturally-occurring truncated or secreted forms (e.g., an extracellular domain sequence), naturally-occurring variant forms (e.g., alternatively spliced forms) and naturally-occurring allelic variants of the polypeptide.

[0586] An SRT polypeptide “extracellular domain” or “ECD” refers to a form of the SRT polypeptide which is essentially free of the transmembrane and cytoplasmic domains. Ordinarily, an SRT polypeptide ECD will have less than about 1% of such transmembrane and/or cytoplasmic domains and preferably, will have less than about 0.5% of such domains. It will be understood that any transmembrane domain(s) identified for the SRT polypeptides of the present invention are identified pursuant to criteria routinely employed in the art for identifying that type of hydrophobic domain. The exact boundaries of a transmembrane domain may vary but most likely by no more than about 5 amino acids at either end of the domain as initially identified.

[0587] “Variant SRT polypeptide” means an active SRT polypeptide as defined below having at least about 80% amino acid sequence identity with the amino acid sequence of a specifically derived fragment of any other polypeptide which will be specifically recited. Such variant SRT polypeptides include, for instance, SRT polypeptides wherein one or more amino acid residues are added, or deleted, at the N- and/or C-terminus, as well as within one or more internal domains, of the full-length amino acid sequence. Ordinarily, a variant SRT polypeptide will have at least about 80% amino acid sequence identity, more preferably at least about 81% amino acid sequence identity, more preferably at least about 82% amino acid sequence identity, more preferably at least about 83% amino acid sequence identity, more preferably at least about 84% amino acid sequence identity, more preferably at least about 85% amino acid sequence identity, more preferably at least about 86% amino acid sequence identity, more preferably at least about 87% amino acid sequence identity, more preferably at least about 88% amino acid sequence identity, more preferably at least about 89% amino acid sequence identity, more preferably at least about 90% amino acid sequence identity, more preferably at least about 91% amino acid sequence identity, more preferably at least about 92% amino acid sequence identity, more preferably at least about 93% amino acid sequence identity, more preferably at least about 94% amino acid sequence identity, more preferably at least about 95% amino acid sequence identity, more preferably at least about 96% amino acid sequence identity, more preferably at least about 97% amino acid sequence identity, more preferably at least about 98% amino acid sequence identity and yet more preferably at least about 99% amino acid sequence identity with an SRT polypeptide encoded by a nucleic acid molecule shown in one of the accompanying figures or a specified fragment thereof. SRT variant polypeptides do not encompass the native SRT polypeptide sequence. Ordinarily, SRT variant polypeptides are at least about 10 amino acids in length, often at least about 20 amino acids in length, more often at least about 30 amino acids in length, more often at least about 40 amino acids in length, more often at least about 50 amino acids in length, more often at least about 60 amino acids in length, more often at least about 70 amino acids in length, more often at least about 80 amino acids in length, more often at least about 90 amino acids in length, more often at least about 100 amino acids in length, more often at least about 150 amino acids in length, more often at least about 200 amino acids in length, more often at least about 250 amino acids in length, more often at least about 300 amino acids in length, or more.

[0588] “Percent (%) amino acid sequence identity” with respect to the SRT polypeptide sequences identified herein is defined as the percentage of amino acid residues in a candidate sequence that are identical with the amino acid residues in a SRT sequence, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent sequence identity, and not considering any conservative substitutions as part of the sequence identity. Alignment for purpose s of determining percent amino acid sequence identity can be achieved in various ways that are within the skill in the art, for instance, using publicly available computer software such as BLAST, BLAST-2, ALIGN, ALIGN-2 or Megalign (DNASTAR) software. Those skilled in the art can determine appropriate parameters for measuring alignment, including any algorithms needed to achieve maximal alignment over the full-length of the sequences being compared. For purposes herein, however, % amino acid sequence identity values are obtained as described below by using the sequence comparison computer program ALIGN-2, wherein the complete source code for the ALIGN-2 program is provided in Table 1. The ALIGN-2 sequence comparison computer program was authored by Genentech, Inc. and the source code shown in Table 1 has been filed with user documentation in the U.S. Copyright Office, Washington D.C., 20559, where it is registered under U.S. Copyright Registration No. TXU510087. The ALIGN-2 program is publicly available through Genentech, Inc., South San Francisco, Calif. or may be compiled from the source code provided in Table 1. The ALIGN-2 program should be compiled for use on a UNIX operating system, preferably digital UNIX V4.0D. All sequence comparison parameters are set by the ALIGN-2 program and do not vary.

[0589] For purposes herein, the % amino acid sequence identity of a given amino acid sequence A to, with, or against a given amino acid sequence B (which can alternatively be phrased as a given amino acid sequence A that has or comprises a certain % amino acid sequence identity to, with, or against a given amino acid sequence B) is calculated as follows:

100 times the fraction X/Y

[0590] where X is the number of amino acid residues scored as identical matches by the sequence alignment program ALIGN-2 in that program's alignment of A and B, and where Y is the total number of amino acid residues in B. It will be appreciated that where the length of amino acid sequence A is not equal to the length of amino acid sequence B, the % amino acid sequence identity of A to B will not equal the % amino acid sequence identity of B to A. As examples of % amino acid sequence identity calculations, Tables 2 and 3 demonstrate how to calculate the % amino acid sequence identity of the amino acid sequence designated “Comparison Protein” to the amino acid sequence designated “PRO”.

[0591] Unless specifically stated otherwise, all % amino acid sequence identity values used herein are obtained as described above using the ALIGN-2 sequence comparison computer program. However, % amino acid sequence identity may also be determined using the sequence comparison program NCBI-BLAST2 (Altschul et al., Nucleic Acids Res. 25:3389-3402 (1997)). The NCBI-BLAST2 sequence comparison program may be downloaded from http://www.ncbi.nlm.nih.gov. NCBI-BLAST2 uses several search parameters, wherein all of those search parameters are set to default values including, for example, unmask=yes, strand=all, expected occurrences=10, minimum low complexity length=15/5, multi-pass e-value=0.01, constant for multi-pass=25, dropoff for final gapped alignment=25 and scoring matrix=BLOSUM62.

[0592] In situations where NCBI-BLAST2 is employed for amino acid sequence comparisons, the % amino acid sequence identity of a given amino acid sequence A to, with, or against a given amino acid sequence B (which can alternatively be phrased as a given amino acid sequence A that has or comprises a certain % amino acid sequence identity to, with, or against a given amino acid sequence B) is calculated as follows:

100 times the fraction X/Y

[0593] where X is the number of amino acid residues scored as identical matches by the sequence alignment program NCBI-BLAST2 in that program's alignment of A and B, and where Y is the total number of amino acid residues in B. It will be appreciated that where the length of amino acid sequence A is not equal to the length of amino acid sequence B, the % amino acid sequence identity of A to B will not equal the % amino acid sequence identity of B to A.

[0594] “SRT variant polynucleotide” or “SRT variant nucleic acid sequence” means a nucleic acid molecule which has at least about 80% nucleic acid sequence identity with any of the nucleic acid sequences shown in the accompanying figures or a specified fragment thereof. Ordinarily, a SRT variant polynucleotide will have at least about 80% nucleic acid sequence identity, more preferably at least about 81% nucleic acid sequence identity, more preferably at least about 82% nucleic acid sequence identity, more preferably at least about 83% nucleic acid sequence identity, more preferably at least about 84% nucleic acid sequence identity, more preferably at least about 85% nucleic acid sequence identity, more preferably at least about 86% nucleic acid sequence identity, more preferably at least about 87% nucleic acid sequence identity, more preferably at least about 88% nucleic acid sequence identity, more preferably at least about 89% nucleic acid sequence identity, more preferably at least about 90% nucleic acid sequence identity, more preferably at least about 91% nucleic acid sequence identity, more preferably at least about 92% nucleic acid sequence identity, more preferably at least about 93% nucleic acid sequence identity, more preferably at least about 94% nucleic acid sequence identity, more preferably at least about 95% nucleic acid sequence identity, more preferably at least about 96% nucleic acid sequence identity, more preferably at least about 97% nucleic acid sequence identity, more preferably at least about 98% nucleic acid sequence identity and yet more preferably at least about 99% nucleic acid sequence identity with any of the nucleic acid sequences shown in the accompanying figures or a specified fragment thereof. SRT polynucleotide variants do not encompass the native SRT nucleotide sequence.

[0595] Ordinarily, SRT variant polynucleotides are at least about 10 nucleotides in length, often at least about 15 nucleotides in length, often at least about 20 nucleotides in length, often at least about 25 nucleotides in length, often at least about 30 nucleotides in length, often at least about 35 nucleotides in length, often at least about 40 nucleotides in length, often at least about 45 nucleotides in length, often at least about 50 nucleotides in length, often at least about 55 nucleotides in length, often at least about 60 nucleotides in length, often at least about 65 nucleotides in length, often at least about 65 nucleotides in length, often at least about 70 nucleotides in length, often at least about 75 nucleotides in length, often at least about 80 nucleotides in length, often at least about 85 nucleotides in length, often at least about 90 nucleotides in length, often at least about 95 nucleotides in length, often at least about 100 nucleotides in length, or more.

[0596] “Percent (%) nucleic acid sequence identity” with respect to the SRT polypeptide-encoding nucleic acid sequences identified herein is defined as the percentage of nucleotides in a candidate sequence that are identical with the nucleotides in a SRT polypeptide-encoding nucleic acid sequence, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent sequence identity. Alignment for purposes of determining percent nucleic acid sequence identity can be achieved in various ways that are within the skill in the art, for instance, using publicly available computer software such as BLAST, BLAST-2, ALIGN, ALIGN-2 or Megalign (DNASTAR) software. Those skilled in the art can determine appropriate parameters for measuring alignment, including any algorithms needed to achieve maximal alignment over the full-length of the sequences being compared. For purposes herein, however, % nucleic acid sequence identity values are obtained as described below by using the sequence comparison computer program ALIGN-2, wherein the complete source code for the ALIGN-2 program is provided in Table 1. The ALIGN-2 sequence comparison computer program was authored by Genentech, Inc. and the source code shown in Table 1 has been filed with user documentation in the U.S. Copyright Office, Washington D.C., 20559, where it is registered under U.S. Copyright Registration No. TXU510087. The ALIGN-2 program is publicly available through Genentech, Inc., South San Francisco, Calif. or may be compiled from the source code provided in Table 1. The ALIGN-2 program should be compiled for use on a UNIX operating system, preferably digital UNIX V4.0D. All sequence comparison parameters are set by the ALIGN-2 program and do not vary.

[0597] For purposes herein, the % nucleic acid sequence identity of a given nucleic acid sequence C to, with, or against a given nucleic acid sequence D (which can alternatively be phrased as a given nucleic acid sequence C that has or comprises a certain % nucleic acid sequence identity to, with, or against a given nucleic acid sequence D) is calculated as follows:

100 times the fraction W/Z

[0598] where W is the number of nucleotides scored as identical matches by the sequence alignment program ALIGN-2 in that program's alignment of C and D, and where Z is the total number of nucleotides in D. It will be appreciated that where the length of nucleic acid sequence C is not equal to the length of nucleic acid sequence D, the % nucleic acid sequence identity of C to D will not equal the % nucleic acid sequence identity of D to C. As examples of % nucleic acid sequence identity calculations, Tables 4 and 5 demonstrate how to calculate the % nucleic acid sequence identity of the nucleic acid sequence designated “Comparison DNA” to the nucleic acid sequence designated “PRO-DNA”.

[0599] Unless specifically stated otherwise, all % nucleic acid sequence identity values used herein are obtained as described above using the ALIGN-2 sequence comparison computer program. However, % nucleic acid sequence identity may also be determined using the sequence comparison program NCBI-BLAST2 (Altschul et al., Nucleic Acids Res. 25:3389-3402 (1997)). The NCBI-BLAST2 sequence comparison program may be downloaded from http://www.ncbi.nlm.nih.gov. NCBI-BLAST2 uses several search parameters, wherein all of those search parameters are set to default values including, for example, unmask=yes, strand=all, expected occurrences=10, minimum low complexity length=15/5, multi-pass e-value=0.01, constant for multi-pass=25, dropoff for final gapped alignment=25 and scoring matrix=BLOSUM62.

[0600] In situations where NCBI-BLAST2 is employed for sequence comparisons, the % nucleic acid sequence identity of a given nucleic acid sequence C to, with, or against a given nucleic acid sequence D (which can alternatively be phrased as a given nucleic acid sequence C that has or comprises a certain % nucleic acid sequence identity to, with, or against a given nucleic acid sequence D) is calculated as follows:

100 times the fraction W/Z

[0601] where W is the number of nucleotides scored as identical matches by the sequence alignment program NCBI-BLAST2 in that program's alignment of C and D, and where Z is the total number of nucleotides in D. It will be appreciated that where the length of nucleic acid sequence C is not equal to the length of nucleic acid sequence D, the % nucleic acid sequence identity of C to D will not equal the % nucleic acid sequence identity of D to C.

[0602] In other embodiments, SRT variant polynucleotides are nucleic acid molecules that encode an active SRT polypeptide and which are capable of hybridizing, preferably under stringent hybridization conditions, to any of the nucleotide sequences shown in the accompanying figures or their complements. SRT variant polypeptides may be those that are encoded by a SRT variant polynucleotide.

[0603] The term “positives”, in the context of the amino acid sequence identity comparisons performed as described above, includes amino acid residues in the sequences compared that are not only identical, but also those that have similar properties. Amino acid residues that score a positive value to an amino acid residue of interest are those that are either identical to the amino acid residue of interest or are a preferred substitution (as defined in Table 6 below) of the amino acid residue of interest.

[0604] For purposes herein, the % value of positives of a given amino acid sequence A to, with, or against a given amino acid sequence B (which can alternatively be phrased as a given amino acid sequence A that has or comprises a certain % positives to, with, or against a given amino acid sequence B) is calculated as follows:

100 times the fraction X/Y

[0605] where X is the number of amino acid residues scoring a positive value as defined above by the sequence alignment program ALIGN-2 in that program's alignment of A and B, and where Y is the total number of amino acid residues in B. It will be appreciated that where the length of amino acid sequence A is not equal to the length of amino acid sequence B, the % positives of A to B will not equal the % positives of B to A.

[0606] “Isolated,” when used to describe the various polypeptides disclosed herein, means polypeptide that has been identified and separated and/or recovered from a component of its natural environment. Preferably, the isolated polypeptide is free of association with all components with which it is naturally associated. Contaminant components of its natural environment are materials that would typically interfere with diagnostic or therapeutic uses for the polypeptide, and may include enzymes, hormones, and other proteinaceous or non-proteinaceous solutes. In preferred embodiments, the polypeptide will be purified (1) to a degree sufficient to obtain at least 15 residues of N-terminal or internal amino acid sequence by use of a spinning cup sequenator, or (2) to homogeneity by SDS-PAGE under non-reducing or reducing conditions using Coomassie blue or, preferably, silver stain. Isolated polypeptide includes polypeptide in situ within recombinant cells, since at least one component of the SRT natural environment will not be present. Ordinarily, however, isolated polypeptide will be prepared by at least one purification step.

[0607] An “isolated” nucleic acid molecule encoding a SRT polypeptide is a nucleic acid molecule that is identified and separated from at least one contaminant nucleic acid molecule with which it is ordinarily associated in the natural source of the SRT-encoding nucleic acid. Preferably, the isolated nucleic is free of association with all components with which it is naturally associated. An isolated SRT-encoding nucleic acid molecule is other than in the form or setting in which it is found in nature. Isolated nucleic acid molecules therefore are distinguished from the SRT-encoding nucleic acid molecule as it exists in natural cells. However, an isolated nucleic acid molecule encoding a SRT polypeptide includes SRT-encoding nucleic acid molecules contained in cells that ordinarily express SRT where, for example, the nucleic acid molecule is in a chromosomal location different from that of natural cells.

[0608] The term “control sequences” refers to DNA sequences necessary for the expression of an operably linked coding sequence in a particular host organism. The control sequences that are suitable for prokaryotes, for example, include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers.

[0609] Nucleic acid is “operably linked” when it is placed into a functional relationship with another nucleic acid sequence. For example, DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion of the polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation. Generally, “operably linked” means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is accomplished by ligation at convenient restriction sites. If such sites do not exist, the synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice.

[0610] The term “antibody” is used in the broadest sense and specifically covers, for example, single anti-SRT monoclonal antibodies (including agonist, antagonist, and neutralizing antibodies), anti-SRT antibody compositions with polyepitopic specificity, single chain anti-SRT antibodies, and fragments of anti-SRT antibodies (see below). The term “monoclonal antibody” as used herein refers to an antibody obtained from a population of substantially homogeneous antibodies, i.e., the individual antibodies comprising the population are identical except for possible naturally-occurring mutations that may be present in minor amounts.

[0611] “Stringency” of hybridization reactions is readily determinable by one of ordinary skill in the art, and generally is an empirical calculation dependent upon probe length, washing temperature, and salt concentration. In general, longer probes require higher temperatures for proper annealing, while shorter probes need lower temperatures. Hybridization generally depends on the ability of denatured DNA to reanneal when complementary strands are present in an environment below their melting temperature. The higher the degree of desired homology between the probe and hybridizable sequence, the higher the relative temperature which can be used. As a result, it follows that higher relative temperatures would tend to make the reaction conditions more stringent, while lower temperatures less so. For additional details and explanation of stringency of hybridization reactions, see Ausubel et al., Current Protocols in Molecular Biology, Wiley Interscience Publishers, (1995).

[0612] “Stringent conditions” or “high stringency conditions”, as defined herein, may be identified by those that: (1) employ low ionic strength and high temperature for washing, for example 0.015 M sodium chloride/0.0015 M sodium citrate/0.1% sodium dodecyl sulfate at 50° C.; (2) employ during hybridization a denaturing agent, such as formamide, for example, 50% (v/v) formamide with 0.1% bovine serum albumin/0.1% Ficoll/0.1% polyvinylpyrrolidone/50 mM sodium phosphate buffer at pH 6.5 with 750 mM sodium chloride, 75 mM sodium citrate at 42° C.; or (3) employ 50% formamide, 5×SSC (0.75 M NaCl, 0.075 M sodium citrate), 50 mM sodium phosphate (pH 6.8), 0.1% sodium pyrophosphate, 5×Denhardt's solution, sonicated salmon sperm DNA (50 μg/ml), 0.1% SDS, and 10% dextran sulfate at 42° C., with washes at 42° C. in 0.2×SSC (sodium chloride/sodium citrate) and 50% formamide at 55° C., followed by a high-stringency wash consisting of 0.1×SSC containing EDTA at 55° C.

[0613] “Moderately stringent conditions” may be identified as described by Sambrook et al., Molecular Cloning: A Laboratory Manual, New York: Cold Spring Harbor Press, 1989, and include the use of washing solution and hybridization conditions (e.g., temperature, ionic strength and % SDS) less stringent that those described above. An example of moderately stringent conditions is overnight incubation at 37° C. in a solution comprising: 20% formamide, 5×SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), 5×Denhardt's solution, 10% dextran sulfate, and 20 mg/ml denatured sheared salmon sperm DNA, followed by washing the filters in 1×SSC at about 37-50° C. The skilled artisan will recognize how to adjust the temperature, ionic strength, etc. as necessary to accommodate factors such as probe length and the like.

[0614] The term “epitope tagged” when used herein refers to a chimeric polypeptide comprising a SRT polypeptide fused to a “tag polypeptide”. The tag polypeptide has enough residues to provide an epitope against which an antibody can be made, yet is short enough such that it does not interfere with activity of the polypeptide to which it is fused. The tag polypeptide preferably also is fairly unique so that the antibody does not substantially cross-react with other epitopes. Suitable tag polypeptides generally have at least six amino acid residues and usually between about 8 and 50 amino acid residues (preferably, between about 10 and 20 amino acid residues).

[0615] As used herein, the term “immunoadhesin” designates antibody-like molecules which combine the binding specificity of a heterologous protein (an “adhesin”) with the effector functions of immunoglobulin constant domains. Structurally, the immunoadhesins comprise a fusion of an amino acid sequence with the desired binding specificity which is other than the antigen recognition and binding site of an antibody (i.e., is “heterologous”), and an immunoglobulin constant domain sequence. The adhesin part of an immunoadhesin molecule typically is a contiguous amino acid sequence comprising at least the binding site of a receptor or a ligand. The immunoglobulin constant domain sequence in the immunoadhesin may be obtained from any immunoglobulin, such as IgG-1, IgG-2, IgG-3, or IgG-4 subtypes, IgA (including IgA-1 and IgA-2), IgE, IgD or IgM.

[0616] “Active” or “activity” for the purposes herein refers to form(s) of SRT which retain a biological and/or an immunological activity of native or naturally-occurring SRT, wherein “biological” activity refers to a biological function (either inhibitory or stimulatory) caused by a native or naturally-occurring SRT other than the ability to induce the production of an antibody against an antigenic epitope possessed by a native or naturally-occurring SRT and an “immunological” activity refers to the ability to induce the production of an antibody against an antigenic epitope possessed by a native or naturally-occurring SRT.

[0617] The term “antagonist” is used in the broadest sense, and includes any molecule that partially or fully blocks, inhibits, or neutralizes a biological activity of a native SRT polypeptide disclosed herein. In a similar manner, the term “agonist” is used in the broadest sense and includes any molecule that mimics a biological activity of a native SRT polypeptide disclosed herein. Suitable agonist or antagonist molecules specifically include agonist or antagonist antibodies or antibody fragments, fragments or amino acid sequence variants of native SRT polypeptides, peptides, small organic molecules, etc. Methods for identifying agonists or antagonists of a SRT polypeptide may comprise contacting a SRT polypeptide with a candidate agonist or antagonist molecule and measuring a detectable change in one or more biological activities normally associated with the SRT polypeptide.

[0618] “Treatment” refers to both therapeutic treatment and prophylactic or preventative measures, wherein the object is to prevent or slow down (lessen) the targeted pathologic condition or disorder. Those in need of treatment include those already with the disorder as well as those prone to have the disorder or those in whom the disorder is to be prevented.

[0619] “Chronic” administration refers to administration of the agent(s) in a continuous mode as opposed to an acute mode, so as to maintain the initial therapeutic effect (activity) for an extended period of time. “Intermittent” administration is treatment that is not consecutively done without interruption, but rather is cyclic in nature.

[0620] “Mammal” for purposes of treatment refers to any animal classified as a mammal, including humans, domestic and farm animals, and zoo, sports, or pet animals, such as dogs, cats, cattle, horses, sheep, pigs, goats, rabbits, etc. Preferably, the mammal is human.

[0621] Administration “in combination with” one or more further therapeutic agents includes simultaneous (concurrent) and consecutive administration in any order.

[0622] “Carriers” as used herein include pharmaceutically acceptable carriers, excipients, or stabilizers which are nontoxic to the cell or mammal being exposed thereto at the dosages and concentrations employed. Often the physiologically acceptable carrier is an aqueous pH buffered solution. Examples of physiologically acceptable carriers include buffers such as phosphate, citrate, and other organic acids; antioxidants including ascorbic acid; low molecular weight (less than about 10 residues) polypeptide; proteins, such as serum albumin, gelatin, or immunoglobulins; hydrophilic polymers such as polyvinylpyrrolidone; amino acids such as glycine, glutamine, asparagine, arginine or lysine; monosaccharides, disaccharides, and other carbohydrates including glucose, mannose, or dextrins; chelating agents such as EDTA; sugar alcohols such as mannitol or sorbitol; salt-forming counterions such as sodium; and/or nonionic surfactants such as TWEEN™, polyethylene glycol (PEG), and PLURONICS™.

[0623] “Antibody fragments” comprise a portion of an intact antibody, preferably the antigen binding or variable region of the intact antibody. Examples of antibody fragments include Fab, Fab′, F(ab′)₂, and Fv fragments; diabodies; linear antibodies (Zapata et al., Protein Eng. 8(10): 1057-1062 [1995]); single-chain antibody molecules; and multispecific antibodies formed from antibody fragments.

[0624] Papain digestion of antibodies produces two identical antigen-binding fragments, called “Fab” fragments, each with a single antigen-binding site, and a residual “Fc” fragment, a designation reflecting the ability to crystallize readily. Pepsin treatment yields an F(ab′)₂ fragment that has two antigen-combining sites and is still capable of cross-linking antigen.

[0625] “Fv” is the minimum antibody fragment which contains a complete antigen-recognition and -binding site. This region consists of a dimer of one heavy- and one light-chain variable domain in tight, non-covalent association. It is in this configuration that the three CDRs of each variable domain interact to define an antigen-binding site on the surface of the VH-VL dimer. Collectively, the six CDRs confer antigen-binding specificity to the antibody. However, even a single variable domain (or half of an Fv comprising only three CDRs specific for an antigen) has the ability to recognize and bind antigen, although at a lower affinity than the entire binding site.

[0626] The Fab fragment also contains the constant domain of the light chain and the first constant domain (CH1) of the heavy chain. Fab fragments differ from Fab′ fragments by the addition of a few residues at the carboxy terminus of the heavy chain CH1 domain including one or more cysteines from the antibody hinge region. Fab′-SH is the designation herein for Fab′ in which the cysteine residue(s) of the constant domains bear a free thiol group. F(ab′)₂ antibody fragments originally were produced as pairs of Fab′ fragments which have hinge cysteines between them. Other chemical couplings of antibody fragments are also known.

[0627] The “light chains” of antibodies (immunoglobulins) from any vertebrate species can be assigned to one of two clearly distinct types, called kappa and lambda, based on the amino acid sequences of their constant domains.

[0628] Depending on the amino acid sequence of the constant domain of their heavy chains, immunoglobulins can be assigned to different classes. There are five major classes of immunoglobulins: IgA, IgD, IgE, IgG, and IgM, and several of these may be further divided into subclasses (isotypes), e.g., IgG1, IgG2, IgG3, IgG4, IgA, and IgA2.

[0629] “Single-chain Fv” or “sFv” antibody fragments comprise the VH and VL domains of antibody, wherein these domains are present in a single polypeptide chain. Preferably, the Fv polypeptide further comprises a polypeptide linker between the VH and VL domains which enables the sFv to form the desired structure for antigen binding. For a review of sFv, see Pluckthun in The Pharmacology of Monoclonal Antibodies, vol. 113, Rosenburg and Moore eds., Springer-Verlag, New York, pp. 269-315 (1994).

[0630] The term “diabodies” refers to small antibody fragments with two antigen-binding sites, which fragments comprise a heavy-chain variable domain (VH) connected to a light-chain variable domain (VL) in the same polypeptide chain (VH-VL). By using a linker that is too short to allow pairing between the two domains on the same chain, the domains are forced to pair with the complementary domains of another chain and create two antigen-binding sites. Diabodies are described more fully in, for example, EP 404,097; WO 93/11161; and Hollinger et al., Proc. Natl. Acad. Sci. USA, 90:6444-6448 (1993).

[0631] An “isolated” antibody is one which has been identified and separated and/or recovered from a component of its natural environment. Contaminant components of its natural environment are materials which would interfere with diagnostic or therapeutic uses for the antibody, and may include enzymes, hormones, and other proteinaceous or nonproteinaceous solutes. In preferred embodiments, the antibody will be purified (1) to greater than 95% by weight of antibody as determined by the Lowry method, and most preferably more than 99% by weight, (2) to a degree sufficient to obtain at least 15 residues of N-terminal or internal amino acid sequence by use of a spinning cup sequenator, or (3) to homogeneity by SDS-PAGE under reducing or nonreducing conditions using Coomassie blue or, preferably, silver stain. Isolated antibody includes the antibody in situ within recombinant cells since at least one component of the antibody's natural environment will not be present. Ordinarily, however, isolated antibody will be prepared by at least one purification step.

[0632] An antibody that “specifically binds to” or is “specific for” a particular polypeptide or an epitope on a particular polypeptide is one that binds to that particular polypeptide or epitope on a particular polypeptide without substantially binding to any other polypeptide or polypeptide epitope.

[0633] The word “label” when used herein refers to a detectable compound or composition which is conjugated directly or indirectly to the antibody so as to generate a “labeled” antibody. The label may be detectable by itself (e.g. radioisotope labels or fluorescent labels) or, in the case of an enzymatic label, may catalyze chemical alteration of a substrate compound or composition which is detectable.

[0634] By “solid phase” is meant a non-aqueous matrix to which the antibody of the present invention can adhere. Examples of solid phases encompassed herein include those formed partially or entirely of glass (e.g., controlled pore glass), polysaccharides (e.g., agarose), polyacrylamides, polystyrene, polyvinyl alcohol and silicones. In certain embodiments, depending on the context, the solid phase can comprise the well of an assay plate; in others it is a purification column (e.g., an affinity chromatography column). This term also includes a discontinuous solid phase of discrete particles, such as those described in U.S. Pat. No. 4,275,149.

[0635] A “liposome” is a small vesicle composed of various types of lipids, phospholipids and/or surfactant which is useful for delivery of a drug (such as a SRT polypeptide or antibody thereto) to a mammal. The components of the liposome are commonly arranged in a bilayer formation, similar to the lipid arrangement of biological membranes.

[0636] A “small molecule” is defined herein to have a molecular weight below about 500 Daltons.

[0637] An “oligonucleotide” or “oligomer” is a stretch of nucleotide residues which has a sufficient number of bases to be used in a polymerase chain reaction (PCR). These sequences are based on (or designed from) genomic or cDNA sequences and may be used to amplify, confirm, or reveal the presence of an identical, similar or complementary DNA or RNA in a particular cell or tissue. Oligonucleotides or oligomers comprise portions of a DNA sequence having at least about 10 nucleotides as described above. Oligonucleotides may be chemically synthesized and may be used as probes.

[0638] “Probes” are nucleic acid sequences of variable length, preferably between about 10 and as many as about 6000 nucleotides, depending upon use. They are used in the detection of identical, similar or complementary nucleic acid sequences. Longer length probes are usually obtained from a natural or recombinant source, are highly specific and are often much slower to hybridize to a target nucleic acid than are oligomers. Probes may be single- or double-stranded and may be carefully designaed to have specificity in PCR, hybridization membrane-based, or ELISA-like technologies.

[0639] “Detectably labeled” with regard to a nucleic acid molecule of the present invention means that the molecule has attached thereto, either covalently or non-covalently, a compound which is detectable such as, for example, radionuclides, enzymes, fluorescent, chemi-luminescent, or chromogenic agents. Detectable labels associate with, establish the presence of, and may allow quantification of a particular nucleic or amino acid sequence.

[0640] A “portion” or “fragment” of a polynucleotide or nucleic acid molecule comprises all or any part of the nucleotide sequence having fewer nucleotides than about 6 kb, preferably fewer than about 1 kb which can be used as a probe. Such probes may be labelled with detectable labels using nick translation, Klenow fill-in reaction, PCR or other methods well known in the art. After pretesting to optimize reaction conditions and to eliminate false positives, nucleic acid probes may be used in Southern, Northern or in situ hybridizations to determine whether DNA or RNA encoding the protein is present in a biological sample, cell type, tissue, organ or organism.

TABLE 2 PRO XXXXXXXXXXXXXXX (Length = 15 amino acids) Comparison XXXXXYYYYYYY (Length = 12 amino acids) Protein % amino acid sequence identity = (the number of identically matching amino acid residues between the two polypeptide sequences as determined by ALIGN-2) divided by (the total number of amino acid residues of the PRO polypeptide) = 5 divided by 15 = 33.3%

[0641] TABLE 3 PRO XXXXXXXXXX (Length = 10 amino acids) Comparison XXXXXYYYYYYZZYZ (Length = 15 amino acids) Protein % amino acid sequence identity = (the number of identically matching amino acid residues between the two polypeptide sequences as determined by ALIGN-2) divided by (the total number of amino acid residues of the PRO polypeptide) = 5 divided by 10 = 50%

[0642] TABLE 4 PRO-DNA NNNNNNNNNNNNNN (Length = 14 nucleotides) Comparison DNA NNNNNNLLLLLLLLLL (Length = 16 nucleotides) % nucleic acid sequence identity = (the number of identically matching nucleotides between the two nucleic acid sequences as determined by ALIGN-2) divided by (the total number of nucleotides of the PRO-DNA nucleic acid sequence) = 6 divided by 14 = 42.9%

[0643] TABLE 5 PRO-DNA NNNNNNNNNNNN (Length = 12 nucleotides) Comparison DNA NNNNLLLVV (Length = 9 nucleotides) % nucleic acid sequence identity = (the number of identically matching nucleotides between the two nucleic acid sequences as determined by ALIGN-2) divided by (the total number of nucleotides of the PRO-DNA nucleic acid sequence) = 4 divided by 12 = 33.3%

[0644] II. Compositions and Methods of the Invention

[0645] A. Full-length SRT Polypeptides

[0646] The present invention provides newly identified and isolated polynucleotide sequences encoding at least a portion of full-length human polypeptides referred to in the present application as SRT polypeptides. In particular, cDNAs encoding at least a portion of SRT polypeptides have been identified and isolated, as disclosed in further detail in the Examples below. For sake of simplicity, in the present specification the polypeptides encoded by nucleic acid molecules disclosed herein as well as all further native homologues and variants included in the foregoing definition of SRT, will be referred to as “SRT”, regardless of their origin or mode of preparation.

[0647] B. SRT Polypeptide Variants

[0648] In addition to the native sequence SRT polypeptides described herein, it is contemplated that SRT variants can be prepared. SRT variants can be prepared by introducing appropriate nucleotide changes into the SRT DNA, and/or by synthesis of the desired SRT polypeptide. Those skilled in the art will appreciate that amino acid changes may alter post-translational processes of the SRT, such as changing the number or position of glycosylation sites or altering the membrane anchoring characteristics.

[0649] Variations in the native sequence SRT or in various domains of the SRT described herein, can be made, for example, using any of the techniques and guidelines for conservative and non-conservative mutations set forth, for instance, in U.S. Pat. No. 5,364,934. Variations may be a substitution, deletion or insertion of one or more codons encoding the SRT that results in a change in the amino acid sequence of the SRT as compared with the native sequence SRT. Optionally the variation is by substitution of at least one amino acid with any other amino acid in one or more of the domains of the SRT. Guidance in determining which amino acid residue may be inserted, substituted or deleted without adversely affecting the desired activity may be found by comparing the sequence of the SRT with that of homologous known protein molecules and minimizing the number of amino acid sequence changes made in regions of high homology. Amino acid substitutions can be the result of replacing one amino acid with another amino acid having similar structural and/or chemical properties, such as the replacement of a leucine with a serine, i.e., conservative amino acid replacements. Insertions or deletions may optionally be in the range of about 1 to 5 amino acids. The variation allowed may be determined by systematically making insertions, deletions or substitutions of amino acids in the sequence and testing the resulting variants for activity exhibited by the full-length or mature native sequence.

[0650] SRT polypeptide fragments are provided herein. Such fragments may be truncated at the N-terminus or C-terminus, or may lack internal residues, for example, when compared with a full-length native protein. Certain fragments lack amino acid residues that are not essential for a desired biological activity of the SRT polypeptide.

[0651] SRT fragments may be prepared by any of a number of conventional techniques. Desired peptide fragments may be chemically synthesized. An alternative approach involves generating SRT fragments by enzymatic digestion, e.g., by treating the protein with an enzyme known to cleave proteins at sites defined by particular amino acid residues, or by digesting the DNA with suitable restriction enzymes and isolating the desired fragment. Yet another suitable technique involves isolating and amplifying a DNA fragment encoding a desired polypeptide fragment, by polymerase chain reaction (PCR). Oligonucleotides that define the desired termini of the DNA fragment are employed at the 5′ and 3′ primers in the PCR. Preferably, SRT polypeptide fragments share at least one biological and/or immunological activity with the corresponding native SRT polypeptide.

[0652] In particular embodiments, conservative substitutions of interest are shown in Table 6 under the heading of preferred substitutions. If such substitutions result in a change in biological activity, then more substantial changes, denominated exemplary substitutions in Table 6, or as further described below in reference to amino acid classes, are introduced and the products screened. TABLE 6 Original Exemplary Preferred Residue Substitutions Substitutions Ala (A) val; leu; ile val Arg (R) lys; gln; asn lys Asn (N) gln; his; lys; arg gln Asp (D) glu glu Cys (C) ser ser Gln (Q) asn asn Glu (E) asp asp Gly (G) pro; ala ala His (H) asn; gln; lys; arg arg Ile (I) leu; val; met; ala; phe; leu norleucine Leu (L) norleucine; ile; val; ile met; ala; phe Lys (K) arg; gln; asn arg Met (M) leu; phe; ile leu Phe (F) leu; val; ile; ala; tyr leu Pro (P) ala ala Ser (S) thr thr Thr (T) ser ser Trp (W) tyr; phe tyr Tyr (Y) trp; phe; thr; ser phe Val (V) ile; leu; met; phe; ala; norleucine leu

[0653] Substantial modifications in function or immunological identity of the SRT polypeptide are accomplished by selecting substitutions that differ significantly in their effect on maintaining (a) the structure of the polypeptide backbone in the area of the substitution, for example, as a sheet or helical conformation, (b) the charge or hydrophobicity of the molecule at the target site, or (c) the bulk of the side chain. Naturally occurring residues are divided into groups based on common side-chain properties:

[0654] (1) hydrophobic: norleucine, met, ala, val, leu, ile;

[0655] (2) neutral hydrophilic: cys, ser, thr;

[0656] (3) acidic: asp, glu;

[0657] (4) basic: asn, gln, his, lys, arg;

[0658] (5) residues that influence chain orientation: gly, pro; and

[0659] (6) aromatic: trp, tyr, phe.

[0660] Non-conservative substitutions will entail exchanging a member of one of these classes for another class. Such substituted residues also may be introduced into the conservative substitution sites or, more preferably, into the remaining (non-conserved) sites.

[0661] The variations can be made using methods known in the art such as oligonucleotide-mediated (site-directed) mutagenesis, alanine scanning, and PCR mutagenesis. Site-directed mutagenesis [Carter et al., Nucl. Acids Res., 13:4331 (1986); Zoller et al., Nucl. Acids Res., 10:6487 (1987)], cassette mutagenesis [Wells et al., Gene, 34:315 (1985)], restriction selection mutagenesis [Wells et al., Philos. Trans. R. Soc. London SerA, 317:415 (1986)] or other known techniques can be performed on the cloned DNA to produce the SRT variant DNA.

[0662] Scanning amino acid analysis can also be employed to identify one or more amino acids along a contiguous sequence. Among the preferred scanning amino acids are relatively small, neutral amino acids. Such amino acids include alanine, glycine, serine, and cysteine. Alanine is typically a preferred scanning amino acid among this group because it eliminates the side-chain beyond the beta-carbon and is less likely to alter the main-chain conformation of the variant [Cunningham and Wells, Science, 244: 1081-1085 (1989)]. Alanine is also typically preferred because it is the most common amino acid. Further, it is frequently found in both buried and exposed positions [Creighton, The Proteins, (W. H. Freeman & Co., N.Y.); Chothia, J. Mol. Biol., 150:1 (1976)]. If alanine substitution does not yield adequate amounts of variant, an isoteric amino acid can be used.

[0663] C. Modifications of SRT Polypeptides

[0664] Covalent modifications of SRT polypeptides are included within the scope of this invention. One type of covalent modification includes reacting targeted amino acid residues of a SRT polypeptide with an organic derivatizing agent that is capable of reacting with selected side chains or the N- or C- terminal residues of the SRT. Derivatization with bifunctional agents is useful, for instance, for crosslinking SRT to a water-insoluble support matrix or surface for use in the method for purifying anti-SRT antibodies, and vice-versa. Commonly used crosslinking agents include, e.g., 1,1-bis(diazoacetyl)-2-phenylethane, glutaraldehyde, N-hydroxysuccinimide esters, for example, esters with 4-azidosalicylic acid, homobifunctional imidoesters, including disuccinimidyl esters such as 3,3′-dithiobis(succinimidylpropionate), bifunctional maleimides such as bis-N-maleimido-1,8-octane and agents such as methyl-3-[(p-azidophenyl)dithio]propioimidate.

[0665] Other modifications include deamidation of glutaminyl and asparaginyl residues to the corresponding glutamyl and aspartyl residues, respectively, hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of seryl or threonyl residues, methylation of the α-amino groups of lysine, arginine, and histidine side chains [T. E. Creighton, Proteins: Structure and Molecular Properties, W. H. Freeman & Co., San Francisco, pp. 79-86 (1983)], acetylation of the N-terminal amine, and amidation of any C-terminal carboxyl group.

[0666] Another type of covalent modification of the SRT polypeptide included within the scope of this invention comprises altering the native glycosylation pattern of the polypeptide. “Altering the native glycosylation pattern” is intended for purposes herein to mean deleting one or more carbohydrate moieties found in native sequence SRT (either by removing the underlying glycosylation site or by deleting the glycosylation by chemical and/or enzymatic means), and/or adding one or more glycosylation sites that are not present in the native sequence SRT. In addition, the phrase includes qualitative changes in the glycosylation of the native proteins, involving a change in the nature and proportions of the various carbohydrate moieties present.

[0667] Addition of glycosylation sites to the SRT polypeptide may be accomplished by altering the amino acid sequence. The alteration may be made, for example, by the addition of, or substitution by, one or more serine or threonine residues to the native sequence SRT (for O-linked glycosylation sites). The SRT amino acid sequence may optionally be altered through changes at the DNA level, particularly by mutating the DNA encoding the SRT polypeptide at preselected bases such that codons are generated that will translate into the desired amino acids.

[0668] Another means of increasing the number of carbohydrate moieties on the SRT polypeptide is by chemical or enzymatic coupling of glycosides to the polypeptide. Such methods are described in the art, e.g., in WO 87/05330 published Sep. 11, 1987, and in Aplin and Wriston, CRC Crit. Rev. Biochem., pp. 259-306 (1981).

[0669] Removal of carbohydrate moieties present on the SRT polypeptide maybe accomplished chemically or enzymatically or by mutational substitution of codons encoding for amino acid residues that serve as targets for glycosylation. Chemical deglycosylation techniques are known in the art and described, for instance, by Hakimuddin et al., Arch. Biochem. Biophys., 259:52 (1987) and by Edge et al., Anal. Biochem. 118:131 (1981). Enzymatic cleavage of carbohydrate moieties on polypeptides can be achieved by the use of a variety of endo- and exo-glycosidases as described by Thotakura et al., Meth. Enzymol., 138:350 (1987).

[0670] Another type of covalent modification of SRT comprises linking the SRT polypeptide to one of a variety of nonproteinaceous polymers, e.g., polyethylene glycol (PEG), polypropylene glycol, or polyoxyalkylenes, in the manner set forth in U.S. Pat. Nos. 4,640,835; 4,496,689; 4,301,144; 4,670,417; 4,791,192 or 4,179,337.

[0671] The SRT polypeptides of the present invention may also be modified in a way to form chimeric molecules comprising SRT fused to another, heterologous polypeptide or amino acid sequence.

[0672] In one embodiment, such a chimeric molecule comprises a fusion of the SRT with a tag polypeptide which provides an epitope to which an anti-tag antibody can selectively bind. The epitope tag is generally placed at the amino- or carboxyl- terminus of the SRT. The presence of such epitope-tagged forms of the SRT can be detected using an antibody against the tag polypeptide. Also, provision of the epitope tag enables the SRT to be readily purified by affinity purification using an anti-tag antibody or another type of affinity matrix that binds to the epitope tag. Various tag polypeptides and their respective antibodies are well known in the art. Examples include poly-histidine (poly-his) or poly-histidine-glycine (poly-his-gly) tags; the flu HA tag polypeptide and its antibody 12CA5 [Field et al., Mol. Cell. Biol., 8:2159-2165 (1988)]; the c-myc tag and the 8F9, 3C7, 6E10, G4, B7 and 9E10 antibodies thereto [Evan et al., Molecular and Cellular Biology, 5:3610-3616 (1985)]; and the Herpes Simplex virus glycoprotein D (gD) tag and its antibody [Paborsky et al., Protein Engineering, 3(6):547-553 (1990)]. Other tag polypeptides include the Flag-peptide [Hopp et al., BioTechnology, 6:1204-1210 (1988)]; the KT3 epitope peptide [Martin et al., Science, 255:192-194 (1992)]; an α-tubulin epitope peptide [Skinner et al., J. Biol. Chem., 266:15163-15166 (1991)]; and the T7 gene 10 protein peptide tag [Lutz-Freyermuth et al., Proc. Natl. Acad. Sci. USA, 87:6393-6397 (1990)].

[0673] In an alternative embodiment, the chimeric molecule may comprise a fusion of the SRT with an immunoglobulin or a particular region of an immunoglobulin. For a bivalent form of the chimeric molecule (also referred to as an “immunoadhesin”), such a fusion could be to the Fc region of an IgG molecule. The Ig fusions preferably include the substitution of a soluble (transmembrane domain deleted or inactivated) form of a SRT polypeptide in place of at least one variable region within an Ig molecule. In a particularly preferred embodiment, the immunoglobulin fusion includes the hinge, CH2 and CH3, or the hinge, CH1, CH2 and CH3 regions of an IgG1 molecule. For the production of immunoglobulin fusions see also U.S. Pat. No. 5,428,130 issued Jun. 27, 1995.

[0674] D. Preparation of SRT Polypeptides

[0675] The description below relates primarily to production of SRT by culturing cells transformed or transfected with a vector containing SRT nucleic acid. It is, of course, contemplated that alternative methods, which are well known in the art, may be employed to prepare SRT. For instance, the SRT sequence, or portions thereof, may be produced by direct peptide synthesis using solid-phase techniques [see, e.g., Stewart et al., Solid-Phase Peptide Synthesis, W. H. Freeman Co., San Francisco, Calif. (1969); Merrifield, J. Am. Chem. Soc., 85:2149-2154 (1963)]. In vitro protein synthesis may be performed using manual techniques or by automation. Automated synthesis may be accomplished, for instance, using an Applied Biosystems Peptide Synthesizer (Foster City, Calif.) using manufacturer's instructions. Various portions of the SRT may be chemically synthesized separately and combined using chemical or enzymatic methods to produce the full-length SRT.

[0676] 1. Isolation of DNA Encoding SRT

[0677] DNA encoding SRT may be obtained from a cDNA library prepared from tissue believed to possess the SRT mRNA and to express it at a detectable level. Accordingly, human SRT DNA can be conveniently obtained from a cDNA library prepared from human tissue, such as described in the Examples. The SRT-encoding gene may also be obtained from a genomic library or by known synthetic procedures (e.g., automated nucleic acid synthesis).

[0678] Libraries can be screened with probes (such as antibodies to the SRT or oligonucleotides of at least about 20-80 bases) designed to identify the gene of interest or the protein encoded by it, wherein those probes may be based upon the polynucleotide sequences shown in the accompanying figures. Screening the cDNA or genomic library with the selected probe may be conducted using standard procedures, such as described in Sambrook et al., Molecular Cloning: A Laboratory Manual (New York: Cold Spring Harbor Laboratory Press, 1989). An alternative means to isolate the gene encoding SRT is to use PCR methodology [Sambrook et al., supra; Dieffenbach et al., PCR Primer: A Laboratory Manual (Cold Spring Harbor Laboratory Press, 1995)].

[0679] The Examples below describe techniques for screening a cDNA library. The oligonucleotide sequences selected as probes should be of sufficient length and sufficiently unambiguous that false positives are minimized. The oligonucleotide is preferably labeled such that it can be detected upon hybridization to DNA in the library being screened. Methods of labeling are well known in the art, and include the use of radiolabels like ³²P-labeled ATP, biotinylation or enzyme labeling. Hybridization conditions, including moderate stringency and high stringency, are provided in Sambrook et al., supra.

[0680] Sequences identified in such library screening methods can be compared and aligned to other known sequences deposited and available in public databases such as GenBank or other private sequence databases. Sequence identity (at either the amino acid or nucleotide level) within defined regions of the molecule or across the full-length sequence can be determined using methods known in the art and as described herein.

[0681] Nucleic acid having protein coding sequence may be obtained by screening selected cDNA or genomic libraries using the deduced amino acid sequence disclosed herein for the first time, and, if necessary, using conventional primer extension procedures as described in Sambrook et al., supra, to detect precursors and processing intermediates of mRNA that may not have been reverse-transcribed into cDNA.

[0682] 2. Selection and Transformation of Host Cells

[0683] Host cells are transfected or transformed with expression or cloning vectors described herein for SRT production and cultured in conventional nutrient media modified as appropriate for inducing promoters, selecting transformants, or amplifying the genes encoding the desired sequences. The culture conditions, such as media, temperature, pH and the like, can be selected by the skilled artisan without undue experimentation. In general, principles, protocols, and practical techniques for maximizing the productivity of cell cultures can be found in Mammalian Cell Biotechnology: a Practical Approach, M. Butler, ed. (IRL Press, 199 1) and Sambrook et al., supra.

[0684] Methods of eukaryotic cell transfection and prokaryotic cell transformation are known to the ordinarily skilled artisan, for example, CaCl₂, CaPO₄, liposome-mediated and electroporation. Depending on the host cell used, transformation is performed using standard techniques appropriate to such cells. The calcium treatment employing calcium chloride, as described in Sambrook et al., supra, or electroporation is generally used for prokaryotes. Infection with Agrobacterium tumefaciens is used for transformation of certain plant cells, as described by Shaw et al., Gene, 23:315 (1983) and WO 89/05859 published Jun. 29, 1989. For mammalian cells without such cell walls, the calcium phosphate precipitation method of Graham and van der Eb, Virology, 52:456-457 (1978) can be employed. General aspects of mammalian cell host system transfections have been described in U.S. Pat. No. 4,399,216. Transformations into yeast are typically carried out according to the method of Van Solingen et al., J. Bact., 130:946 (1977) and Hsiao et al., Proc. Natl. Acad. Sci. (USA), 76:3829 (1979). However, other methods for introducing DNA into cells, such as by nuclear microinjection, electroporation, bacterial protoplast fusion with intact cells, or polycations, e.g., polybrene, polyornithine, may also be used. For various techniques for transforming mammalian cells, see Keown et al., Methods in Enzymology, 185:527-537 (1990) and Mansour et al., Nature, 336:348-352 (1988).

[0685] Suitable host cells for cloning or expressing the DNA in the vectors herein include prokaryote, yeast, or higher eukaryote cells. Suitable prokaryotes include but are not limited to eubacteria, such as Gram-negative or Gram-positive organisms, for example, Enterobacteriaceae such as E. coli. Various E. coli strains are publicly available, such as E. coli K12 strain MM294 (ATCC 31,446); E. coli X1776 (ATCC 31,537); E. coli strain W3110 (ATCC 27,325) and K5 772 (ATCC 53,635). Other suitable prokaryotic host cells include Enterobacteriaceae such as Escherichia, e.g., E. coli, Enterobacter, Erwinia, Klebsiella, Proteus, Salmonella, e.g., Salmonella typhimurium, Serratia, e.g., Serratia marcescans, and Shigella, as well as Bacilli such as B. subtilis and B. licheniformis (e.g., B. licheniformis 41P disclosed in DD 266,710 published Apr. 12, 1989), Pseudomonas such as P. aeruginosa, and Streptomyces. These examples are illustrative rather than limiting. Strain W3110 is one particularly preferred host or parent host because it is a common host strain for recombinant DNA product fermentations. Preferably, the host cell secretes minimal amounts of proteolytic enzymes. For example, strain W3110 may be modified to effect a genetic mutation in the genes encoding proteins endogenous to the host, with examples of such hosts including E. coli W3110 strain 1A2, which has the complete genotype tonA; E. coli W3110 strain 9E4, which has the complete genotype tonA ptr3; E. coli W3110 strain 27C7 (ATCC 55,244), which has the complete genotype tonA ptr3 phoA E15 (argF-lac)169 degP ompT kan^(r) ; E. coli W3110 strain 37D6, which has the complete genotype tonA ptr3 phoA E15 (argF-lac)169 degP ompT rbs7 ilvG kan^(r) ; E. coli W3110 strain 40B4, which is strain 37D6 with a non-kanamycin resistant degP deletion mutation; and an E. coli strain having mutant periplasmic protease disclosed in U.S. Pat. No. 4,946,783 issued Aug. 7, 1990. Alternatively, in vitro methods of cloning, e.g., PCR or other nucleic acid polymerase reactions, are suitable.

[0686] In addition to prokaryotes, eukaryotic microbes such as filamentous fungi or yeast are suitable cloning or expression hosts for SRT-encoding vectors. Saccharomyces cerevisiae is a commonly used lower eukaryotic host microorganism. Others include Schizosaccharomyces pombe (Beach and Nurse, Nature, 290: 140 [1981]; EP 139,383 published 2 May 1985); Kluyveromyces hosts (U.S. Pat. No. 4,943,529; Fleer et al., Bio/Technology, 9:968-975 (1991)) such as, e.g., K. lactis (MW98-8C, CBS683, CBS4574; Louvencourt et al., J. Bacteriol., 737 [1983]), K. fragilis (ATCC 12,424), K. bulgaricus (ATCC 16,045), K. wickeramii (ATCC 24,178), K. waltii (ATCC 56,500), K. drosophilarum (ATCC 36,906; Van den Berg et al., Bio/Technology, 8:135 (1990)), K. thermotolerans, and K. marxianus; yarrowia (EP 402,226); Pichia pastoris (EP 183,070; Sreekrishna et al., J. Basic Microbiol., 28:265-278 [1988]); Candida; Trichoderma reesia (EP 244,234); Neurospora crassa (Case et al., Proc. Natl. Acad. Sci. USA, 76:5259-5263 [1979]); Schwanniomyces such as Schwanniomyces occidentalis (EP 394,538 published Oct. 31, 1990); and filamentous fungi such as, e.g., Neurospora, Penicillium, Tolypocladium (WO 91/00357 published Jan. 10, 1991), and Aspergillus hosts such as A. nidulans (Ballance et al., Biochem. Biophys. Res. Commun., 112:284-289 [1983]; Tilburn et al., Gene, 26:205-221 [1983]; Yelton et al., Proc. Natl. Acad. Sci. USA, 81: 1470-1474 [1984]) and A. niger (Kelly and Hynes, EMBO J., 4:475-479 [1985]). Methylotropic yeasts are suitable herein and include, but are not limited to, yeast capable of growth on methanol selected from the genera consisting of Hansenula, Candida, Kloeckera, Pichia, Saccharomyces, Torulopsis, and Rhodotorula. A list of specific species that are exemplary of this class of yeasts may be found in C. Anthony, The Biochemistry of Methylotrophs, 269 (1982).

[0687] Suitable host cells for the expression of glycosylated SRT are derived from multicellular organisms. Examples of invertebrate cells include insect cells such as Drosophila S2 and Spodoptera Sf9, as well as plant cells. Examples of useful mammalian host cell lines include Chinese hamster ovary (CHO) and COS cells. More specific examples include monkey kidney CV1 line transformed by SV40 (COS-7, ATCC CRL 1651); human embryonic kidney line (293 or 293 cells subcloned for growth in suspension culture, Graham et al., J. Gen Virol., 36:59 (1977)); Chinese hamster ovary cells/-DHFR (CHO, Urlaub and Chasin, Proc. Natl. Acad. Sci. USA, 77:4216 (1980)); mouse sertoli cells (TM4, Mather, Biol. Reprod., 23:243-251 (1980)); human lung cells (WI38, ATCC CCL 75); human liver cells (Hep G2, HB 8065); and mouse mammary tumor (MMT 060562, ATCC CCL51). The selection of the appropriate host cell is deemed to be within the skill in the art.

[0688] 3. Selection and Use of a Replicable Vector

[0689] The nucleic acid (e.g., cDNA or genomic DNA) encoding SRT may be inserted into a replicable vector for cloning (amplification of the DNA) or for expression. Various vectors are publicly available. The vector may, for example, be in the form of a plasmid, cosmid, viral particle, or phage. The appropriate nucleic acid sequence may be inserted into the vector by a variety of procedures. In general, DNA is inserted into an appropriate restriction endonuclease site(s) using techniques known in the art. Vector components generally include, but are not limited to, one or more of a signal sequence, an origin of replication, one or more marker genes, an enhancer element, a promoter, and a transcription termination sequence. Construction of suitable vectors containing one or more of these components employs standard ligation techniques which are known to the skilled artisan.

[0690] The SRT may be produced recombinantly not only directly, but also as a fusion polypeptide with a heterologous polypeptide, which may be a signal sequence or other polypeptide having a specific cleavage site at the N-terminus of the mature protein or polypeptide. In general, the signal sequence may be a component of the vector, or it may be a part of the SRT-encoding DNA that is inserted into the vector. The signal sequence may be a prokaryotic signal sequence selected, for example, from the group of the alkaline phosphatase, penicillinase, lpp, or heat-stable enterotoxin II leaders. For yeast secretion the signal sequence may be, e.g., the yeast invertase leader, alpha factor leader (including Saccharomyces and Kluyveromyces α-factor leaders, the latter described in U.S. Pat. No. 5,010,182), or acid phosphatase leader, the C. albicans glucoamylase leader (EP 362,179 published Apr. 4, 1990), or the signal described in WO 90/13646 published Nov. 15, 1990. In mammalian cell expression, mammalian signal sequences may be used to direct secretion of the protein, such as signal sequences from secreted polypeptides of the same or related species, as well as viral secretory leaders.

[0691] Both expression and cloning vectors contain a nucleic acid sequence that enables the vector to replicate in one or more selected host cells. Such sequences are well known for a variety of bacteria, yeast, and viruses. The origin of replication from the plasmid pBR322 is suitable for most Gram-negative bacteria, the 2μ plasmid origin is suitable for yeast, and various viral origins (SV40, polyoma, adenovirus, VSV or BPV) are useful for cloning vectors in mammalian cells.

[0692] Expression and cloning vectors will typically contain a selection gene, also termed a selectable marker. Typical selection genes encode proteins that (a) confer resistance to antibiotics or other toxins, e.g., ampicillin, neomycin, methotrexate, or tetracycline, (b) complement auxotrophic deficiencies, or (c) supply critical nutrients not available from complex media, e.g., the gene encoding D-alanine racemase for Bacilli.

[0693] An example of suitable selectable markers for mammalian cells are those that enable the identification of cells competent to take up the SRT-encoding nucleic acid, such as DHFR or thymidine kinase. An appropriate host cell when wild-type DHFR is employed is the CHO cell line deficient in DHFR activity, prepared and propagated as described by Urlaub et al., Proc. Natl. Acad. Sci. USA, 77:4216 (1980). A suitable selection gene for use in yeast is the trp1 gene present in the yeast plasmid YRp7 [Stinchcomb et al., Nature, 282:39 (1979); Kingsman et al., Gene, 7:141 (1979); Tschemper et al., Gene, 10: 157 (1980)]. The trp1 gene provides a selection marker for a mutant strain of yeast lacking the ability to grow in tryptophan, for example, ATCC No. 44076 or PEP4-1 [Jones, Genetics, 85:12 (1977)].

[0694] Expression and cloning vectors usually contain a promoter operably linked to the SRT-encoding nucleic acid sequence to direct mRNA synthesis. Promoters recognized by a variety of potential host cells are well known. Promoters suitable for use with prokaryotic hosts include the β-lactamase and lactose promoter systems [Chang et al., Nature, 275:615 (1978); Goeddel et al., Nature, 281:544 (1979)], alkaline phosphatase, a tryptophan (trp) promoter system [Goeddel, Nucleic Acids Res., 8:4057 (1980); EP 36,776], and hybrid promoters such as the tac promoter [deBoer et al., Proc. Natl. Acad. Sci. USA, 80:21-25 (1983)]. Promoters for use in bacterial systems also will contain a Shine-Dalgarno (S.D.) sequence operably linked to the DNA encoding SRT.

[0695] Examples of suitable promoting sequences for use with yeast hosts include the promoters for 3-phosphoglycerate kinase [Hitzeman et al., J. Biol. Chem., 255:2073 (1980)] or other glycolytic enzymes [Hess et al., J. Adv. Enzyme Reg., 7:149 (1968); Holland, Biochemistry, 17:4900 (1978)], such as enolase, glyceraldehyde-3-phosphate dehydrogenase, hexokinase, pyruvate decarboxylase, phosphofructokinase, glucose-6-phosphate isomerase, 3-phosphoglycerate mutase, pyruvate kinase, triosephosphate isomerase, phosphoglucose isomerase, and glucokinase.

[0696] Other yeast promoters, which are inducible promoters having the additional advantage of transcription controlled by growth conditions, are the promoter regions for alcohol dehydrogenase 2, isocytochrome C, acid phosphatase, degradative enzymes associated with nitrogen metabolism, metallothionein, glyceraldehyde-3-phosphate dehydrogenase, and enzymes responsible for maltose and galactose utilization. Suitable vectors and promoters for use in yeast expression are further described in EP 73,657.

[0697] SRT transcription from vectors in mammalian host cells is controlled, for example, by promoters obtained from the genomes of viruses such as polyoma virus, fowlpox virus (UK 2,211,504 published Jul. 5, 1989), adenovirus (such as Adenovirus 2), bovine papilloma virus, avian sarcoma virus, cytomegalovirus, a retrovirus, hepatitis-B virus and Simian Virus 40 (SV40), from heterologous mammalian promoters, e.g., the actin promoter or an immunoglobulin promoter, and from heat-shock promoters, provided such promoters are compatible with the host cell systems.

[0698] Transcription of a DNA encoding the SRT by higher eukaryotes may be increased by inserting an enhancer sequence into the vector. Enhancers are cis-acting elements of DNA, usually about from 10 to 300 bp, that act on a promoter to increase its transcription. Many enhancer sequences are now known from mammalian genes (globin, elastase, albumin, α-fetoprotein, and insulin). Typically, however, one will use an enhancer from a eukaryotic cell virus. Examples include the SV40 enhancer on the late side of the replication origin (bp 100-270), the cytomegalovirus early promoter enhancer, the polyoma enhancer on the late side of the replication origin, and adenovirus enhancers. The enhancer may be spliced into the vector at a position 5′ or 3′ to the SRT coding sequence, but is preferably located at a site 5′ from the promoter.

[0699] Expression vectors used in eukaryotic host cells (yeast, fungi, insect, plant, animal, human, or nucleated cells from other multicellular organisms) will also contain sequences necessary for the termination of transcription and for stabilizing the mRNA. Such sequences are commonly available from the 5′ and, occasionally 3′, untranslated regions of eukaryotic or viral DNAs or cDNAs. These regions contain nucleotide segments transcribed as polyadenylated fragments in the untranslated portion of the mRNA encoding SRT.

[0700] Still other methods, vectors, and host cells suitable for adaptation to the synthesis of SRT in recombinant vertebrate cell culture are described in Gething et al., Nature, 293:620-625 (1981); Mantei et al., Nature, 281:40-46 (1979); EP 117,060; and EP 117,058.

[0701] 4. Detecting Gene Amplification/Expression

[0702] Gene amplification and/or expression may be measured in a sample directly, for example, by conventional Southern blotting, Northern blotting to quantitate the transcription of mRNA [Thomas, Proc. Natl. Acad. Sci. USA, 77:5201-5205 (1980)], dot blotting (DNA analysis), or in situ hybridization, using an appropriately labeled probe, based on the sequences provided herein. Alternatively, antibodies maybe employed that can recognize specific duplexes, including DNA duplexes, RNA duplexes, and DNA-RNA hybrid duplexes or DNA-protein duplexes. The antibodies in turn may be labeled and the assay may be carried out where the duplex is bound to a surface, so that upon the formation of duplex on the surface, the presence of antibody bound to the duplex can be detected.

[0703] Gene expression, alternatively, may be measured by immunological methods, such as immunohistochemical staining of cells or tissue sections and assay of cell culture or body fluids, to quantitate directly the expression of gene product. Antibodies useful for immunohistochemical staining and/or assay of sample fluids may be either monoclonal or polyclonal, and may be prepared in any mammal. Conveniently, the antibodies may be prepared against a native sequence SRT polypeptide or against a synthetic peptide based on the DNA sequences provided herein or against exogenous sequence fused to SRT DNA and encoding a specific antibody epitope.

[0704] 5. Purification of Polypeptide

[0705] Forms of SRT may be recovered from culture medium or from host cell lysates. If membrane-bound, it can be released from the membrane using a suitable detergent solution (e.g. Triton-X 100) or by enzymatic cleavage. Cells employed in expression of SRT can be disrupted by various physical or chemical means, such as freeze-thaw cycling, sonication, mechanical disruption, or cell lysing agents.

[0706] It may be desired to purify SRT from recombinant cell proteins or polypeptides. The following procedures are exemplary of suitable purification procedures: by fractionation on an ion-exchange column; ethanol precipitation; reverse phase HPLC; chromatography on silica or on a cation-exchange resin such as DEAE; chromatofocusing; SDS-PAGE; ammonium sulfate precipitation; gel filtration using, for example, Sephadex G-75; protein A Sepharose columns to remove contaminants such as IgG; and metal chelating columns to bind epitope-tagged forms of the SRT. Various methods of protein purification may be employed and such methods are known in the art and described for example in Deutscher, Methods in Enzymology, 182 (1990); Scopes, Protein Purification: Principles and Practice, Springer-Verlag, New York (1982). The purification step(s) selected will depend, for example, on the nature of the production process used and the particular SRT produced.

[0707] E. Uses for SRT Polynucleotides and Polypeptides

[0708] SRT nucleotide sequences (and/or their complements) disclosed herein have various applications in the art of molecular biology, including for example uses as hybridization probes, in chromosome and gene mapping, in tissue typing, disease tissue detection, in PCR technologies, in screening for new therapeutic molecules and in the generation of anti-sense RNA and DNA. SRT nucleic acid will also be useful for the preparation of SRT polypeptides by the recombinant techniques described herein.

[0709] The SRT polynucleotides disclosed herein, or portions thereof, may be used as hybridization probes for a cDNA library to isolate the full-length SRT cDNA or to isolate still other cDNAs (for instance, those encoding naturally-occurring variants of SRT or SRT from other species) which have a desired sequence identity to the SRT sequence of interest. Optionally, the length of the probes will be about 20 to about 50 bases. The hybridization probes may be derived from at least partially novel regions of the nucleotide sequences disclosed herein wherein those regions may be determined without undue experimentation or from genomic sequences including promoters, enhancer elements and introns of native sequence SRT. By way of example, a screening method will comprise isolating the coding region of the SRT gene using the known DNA sequence to synthesize a selected probe of about 40 bases. Hybridization probes may be labeled by a variety of labels, including radionucleotides such as ³²P or ³⁵S, or enzymatic labels such as alkaline phosphatase coupled to the probe via avidin/biotin coupling systems. Labeled probes having a sequence complementary to that of the SRT gene of the present invention can be used to screen libraries of human cDNA, genomic DNA or mRNA to determine which members of such libraries the probe hybridizes to. Hybridization techniques are described in further detail in the Examples below.

[0710] PCR as described in U.S. Pat. Nos. 4,683,195; 4,800,195; and 4,965,188 provides additional uses for oligonucleotides based upon the polynucleotide sequences disclosed in the accompanying figures. Such oligomers are generally chemically synthesized, but they may be of recombinant origin or a mixture of both. Oligomers generally comprise two nucleotide sequences, one with sense orientation (5′ to 3′) and one with antisense (3′ to 5′) employed under optimized conditions for identification of a specific gene or diagnostic use. The same two oligomers, nested sets of oligomers, or even a degenerate pool of oligomers may be employed under less stringent conditions for identification and/or quantitation of closely related DNA or RNA sequences.

[0711] Full length genes may be cloned utilizing partial nucleotide sequence and various methods known in the art. Gobinda et al. PCR Methods Applic. 2:318-322 (1993) disclose “restriction-site PCR” as a direct method which uses universal primers to retrieve unknown sequence adjacent to a known locus. First, genomic DNA is amplified in the presence of primer to linker and a primer specific to the known region. The amplified sequences are subjected to a second round of PCR with the same linker primer and another specific primer internal to the first one. Products of each round of PCR are transcribed with an appropriate RNA polymerase and sequenced using reverse transcriptase. Gobinda et al present data concerning Factor IX for which they identified a conserved stretch of 20 nucleotides in the 3′ noncoding region of the gene.

[0712] Inverse PCR is the first method to report successful acquisition of unknown sequences starting with primers based on a known region (Triglia et al., Nucleic Acids Res. 16:8186 (1988). The method uses several restriction enzymes to generate a suitable fragment in the known region of a gene. The fragment is then circularized by intramolecular ligation and used as a PCR template. Divergent primers are designed from the known region. The multiple rounds of restriction enzyme digestions and ligations that are necessary prior to PCR make the procedure slow and expensive (Gobinda et al, supra).

[0713] Capture PCR (Lagerstrom et al., PCR Methods Applic. 1:111-119 (1991) is a method for PCR amplification of DNA fragments adjacent to a known sequence in human and YAC DNA. As noted by Gobinda et al. (supra), capture PCR also requires multiple restriction enzyme digestions and ligations to place an engineered double-stranded sequence into an unknown portion of the DNA molecule before PCR. Although the restriction and ligation reactions are carried out simultaneously, the requirements for extension, immobilization and two rounds of PCR and purification prior to sequencing render the method cumbersome and time consuming.

[0714] Parker et al., Nucleic Acids Res. 19:3055-3060 (1991) teach walking PCR, a method for targeted gene walking which permits retrieval of unknown sequence. PromoterFinder™ is a new kit available from Clontech (Palo Alto, Calif.) which uses PCR and primers derived from p53 to walk in genomic DNA. Nested primers and special PromoterFinder libraries are used to detect upstream sequences such as promoters and regulatory elements. This process avoids the need to screen libraries and is useful in finding intron/exon junctions.

[0715] Another new PCR method, “Improved Method for Obtaining Full Length cDNA Sequences” (see U.S. Pat. No. 5,817,479, issued Oct. 6, 1998), employs XL-PCR (Perkin-Elmer, Foster City, Calif.) to amplify and extend partial nucleotide sequence into longer pieces of DNA. This method was developed to allow a single researcher to process multiple genes (up to 20 or more) at one time and to obtain an extended (possibly full-length) sequence within 6-10 days. This new method replaces methods which use labelled probes to screen plasmid libraries and allow one researcher to process only about 3-5 genes in 14-40 days.

[0716] In the first step, which can be performed in about two days, any two of a plurality of primers are designed and synthesized based on a known partial sequence. In step 2, which takes about six to eight hours, the sequence is extended by PCR amplification of a selected library. Steps 3 and 4, which take about one day, are purification of the amplified cDNA and its ligation into an appropriate vector. Step 5, which takes about one day, involves transforming and growing up host bacteria. In step 6, which takes approximately five hours, PCR is used to screen bacterial clones for extended sequence. The final steps, which take about one day, involve the preparation and sequencing of selected clones.

[0717] If the full length cDNA has not been obtained, the entire procedure is repeated using either the original library or some other preferred library. The preferred library may be one that has been size-selected to include only larger cDNAs or may consist of single or combined commercially available libraries, eg. lung, liver, heart and brain from Gibco/BRL (Gaithersburg, Md.). The cDNA library may have been prepared with oligo (dT) or random priming. Random primed libraries are preferred in that they will contain more sequences which contain 5′ ends of genes. A randomly primed library may be particularly useful if an oligo (dT) library does not yield a complete gene.

[0718] The nucleotide sequence for any particular polynucleotide shown in the accompanying figures can also be used to generate probes for mapping the native genomic sequence. The sequence may be mapped to a particular chromosome or to a specific region of the chromosome using well known techniques. These include in situ hybridization to chromosomal spreads (Verma et al., “Human Chromosomes: A Manual of Basic Techniques”, Pergamon Press, New York City, 1988), flow-sorted chromosomal preparations, or artificial chromosome constructions such as yeast artificial chromosomes (YACs), bacterial artificial chromosomes (BACs), bacterial P1 constructions or single chromosome cDNA libraries.

[0719] In situ hybridization of chromosomal preparations and physical mapping techniques such as linkage analysis using established chromosomal markers are invaluable in extending genetic maps. Examples of genetic maps can be found in the 1994 Genome Issue of Science (265:1981 f). Often the placement of a gene on the chromosome of another mammalian species may reveal associated markers even if the number or arm of a particular human chromosome is not known. New partial nucleotide sequences can be assigned to chromosomal arms, or parts thereof, by physical mapping. This provides valuable information to investigators searching for disease genes using positional cloning or other gene discovery techniques. Once a disease or syndrome, such as ataxia telangiectasia (AT), has been crudely localized by genetic linkage to a particular genomic region, for example, AT to 11q22-23 (Gatti et al., Nature 336:577-580 (1988), any sequences mapping to that area may represent genes for further investigation. The nucleotide sequences of the subject invention may also be used to detect differences in the chromosomal location of nucleotide sequences due to translocation, inversion, etc., between normal and carrier or affected individuals.

[0720] The partial nucleotide sequence encoding a particular SRT polypeptide may be used to produce an amino acid sequence using well known methods of recombinant DNA technology. The amino acid or peptide may be expressed in a variety of host cells, either prokaryotic or eukaryotic. Host cells may be from the same species from which the nucleotide sequence was derived or from a different species. Advantages of producing an amino acid sequence or peptide by recombinant DNA technology include obtaining adequate amounts for purification and the availability of simplified purification procedures.

[0721] Cells transformed with an SRT nucleotide sequence may be cultured under conditions suitable for the expression and recovery of peptide from cell culture as described above. The peptide produced by a recombinant cell may be secreted or may be contained intracellularly depending on the sequence itself and/or the vector used. In general, it is more convenient to prepare recombinant proteins in secreted form, and this is accomplished by ligating SRT to a recombinant nucleotide sequence which directs its movement through a particular prokaryotic or eukaryotic cell membrane. Other recombinant constructions may join SRT to nucleotide sequence encoding a polypeptide domain which will facilitate protein purification (Kroll et al., DNA Cell Biol. 12:441-53 (1993).

[0722] Other useful fragments of the SRT nucleic acids include antisense or sense oligonucleotides comprising a singe-stranded nucleic acid sequence (either RNA or DNA) capable of binding to target SRT mRNA (sense) or SRT DNA (antisense) sequences. Antisense or sense oligonucleotides, according to the present invention, comprise a fragment of the coding region of SRT DNA. Such a fragment generally comprises at least about 14 nucleotides, preferably from about 14 to 30 nucleotides. The ability to derive an antisense or a sense oligonucleotide, based upon a cDNA sequence encoding a given protein is described in, for example, Stein and Cohen (Cancer Res. 48:2659, 1988) and van der Krol et al. (BioTechniques 6:958, 1988).

[0723] Binding of antisense or sense oligonucleotides to target nucleic acid sequences results in the formation of duplexes that block transcription or translation of the target sequence by one of several means, including enhanced degradation of the duplexes, premature termination of transcription or translation, or by other means. The antisense oligonucleotides thus may be used to block expression of SRT proteins. Antisense or sense oligonucleotides further comprise oligonucleotides having modified sugar-phosphodiester backbones (or other sugar linkages, such as those described in WO 91/06629) and wherein such sugar linkages are resistant to endogenous nucleases. Such oligonucleotides with resistant sugar linkages are stable in vivo (i.e., capable of resisting enzymatic degradation) but retain sequence specificity to be able to bind to target nucleotide sequences.

[0724] Other examples of sense or antisense oligonucleotides include those oligonucleotides which are covalently linked to organic moieties, such as those described in WO 90/10048, and other moieties that increases affinity of the oligonucleotide for a target nucleic acid sequence, such as poly-(L-lysine). Further still, intercalating agents, such as ellipticine, and alkylating agents or metal complexes may be attached to sense or antisense oligonucleotides to modify binding specificities of the antisense or sense oligonucleotide for the target nucleotide sequence.

[0725] Antisense or sense oligonucleotides may be introduced into a cell containing the target nucleic acid sequence by any gene transfer method, including, for example, CaPO₄-mediated DNA transfection, electroporation, or by using gene transfer vectors such as Epstein-Barr virus. In a preferred procedure, an antisense or sense oligonucleotide is inserted into a suitable retroviral vector. A cell containing the target nucleic acid sequence is contacted with the recombinant retroviral vector, either in vivo or ex vivo. Suitable retroviral vectors include, but are not limited to, those derived from the murine retrovirus M-MuLV, N2 (a retrovirus derived from M-MuLV), or the double copy vectors designated DCT5A, DCT5B and DCT5C (see WO 90/13641).

[0726] Sense or antisense oligonucleotides also may be introduced into a cell containing the target nucleotide sequence by formation of a conjugate with a ligand binding molecule, as described in WO 91/04753. Suitable ligand binding molecules include, but are not limited to, cell surface receptors, growth factors, other cytokines, or other ligands that bind to cell surface receptors. Preferably, conjugation of the ligand binding molecule does not substantially interfere with the ability of the ligand binding molecule to bind to its corresponding molecule or receptor, or block entry of the sense or antisense oligonucleotide or its conjugated version into the cell.

[0727] Alternatively, a sense or an antisense oligonucleotide may be introduced into a cell containing the target nucleic acid sequence by formation of an oligonucleotide-lipid complex, as described in WO 90/10448. The sense or antisense oligonucleotide-lipid complex is preferably dissociated within the cell by an endogenous lipase.

[0728] The probes may also be employed in PCR techniques to generate a pool of sequences for identification of closely related SRT coding sequences.

[0729] Nucleotide sequences encoding an SRT can also be used to construct hybridization probes for mapping the gene which encodes that SRT and for the genetic analysis of individuals with genetic disorders. The nucleotide sequences provided herein may be mapped to a chromosome and specific regions of a chromosome using known techniques, such as in situ hybridization, linkage analysis against known chromosomal markers, and hybridization screening with libraries.

[0730] When the coding sequences for SRT encode a protein which binds to another protein (example, where the SRT is a receptor), the SRT can be used in assays to identify the other proteins or molecules involved in the binding interaction. By such methods, inhibitors of the receptor/ligand binding interaction can be identified. Proteins involved in such binding interactions can also be used to screen for peptide or small molecule inhibitors or agonists of the binding interaction. Also, the receptor SRT can be used to isolate correlative ligand(s). Screening assays can be designed to find lead compounds that mimic the biological activity of a native SRT or a receptor for SRT. Such screening assays will include assays amenable to high-throughput screening of chemical libraries, making them particularly suitable for identifying small molecule drug candidates. Small molecules contemplated include synthetic organic or inorganic compounds. The assays can be performed in a variety of formats, including protein-protein binding assays, biochemical screening assays, immunoassays and cell based assays, which are well characterized in the art.

[0731] Nucleic acids which encode SRT or its modified forms can also be used to generate either transgenic animals or “knock out” animals which, in turn, are useful in the development and screening of therapeutically useful reagents. A transgenic animal (e.g., a mouse or rat) is an animal having cells that contain a transgene, which transgene was introduced into the animal or an ancestor of the animal at a prenatal, e.g., an embryonic stage. A transgene is a DNA which is integrated into the genome of a cell from which a transgenic animal develops. In one embodiment, cDNA encoding SRT can be used to clone genomic DNA encoding SRT in accordance with established techniques and the genomic sequences used to generate transgenic animals that contain cells which express DNA encoding SRT. Methods for generating transgenic animals, particularly animals such as mice or rats, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866 and 4,870,009. Typically, particular cells would be targeted for SRT transgene incorporation with tissue-specific enhancers. Transgenic animals that include a copy of a transgene encoding SRT introduced into the germ line of the animal at an embryonic stage can be used to examine the effect of increased expression of DNA encoding SRT. Such animals can be used as tester animals for reagents thought to confer protection from, for example, pathological conditions associated with its overexpression. In accordance with this facet of the invention, an animal is treated with the reagent and a reduced incidence of the pathological condition, compared to untreated animals bearing the transgene, would indicate a potential therapeutic intervention for the pathological condition.

[0732] Alternatively, non-human homologues of SRT can be used to construct a SRT “knock out” animal which has a defective or altered gene encoding SRT as a result of homologous recombination between the endogenous gene encoding SRT and altered genomic DNA encoding SRT introduced into an embryonic stem cell of the animal. For example, cDNA encoding SRT can be used to clone genomic DNA encoding SRT in accordance with established techniques. A portion of the genomic DNA encoding SRT can be deleted or replaced with another gene, such as a gene encoding a selectable marker which can be used to monitor integration. Typically, several kilobases of unaltered flanking DNA (both at the 5′ and 3′ ends) are included in the vector [see e.g., Thomas and Capecchi, Cell, 51:503 (1987) for a description of homologous recombination vectors]. The vector is introduced into an embryonic stem cell line (e.g., by electroporation) and cells in which the introduced DNA has homologously recombined with the endogenous DNA are selected [see e.g., Li et al., Cell, 69:915 (1992)]. The selected cells are then injected into a blastocyst of an animal (e.g., a mouse or rat) to form aggregation chimeras [see e.g., Bradley, in Teratocarcinomas and Embryonic Stem Cells: A Practical Approach, E. J. Robertson, ed. (IRL, Oxford, 1987), pp. 113-152]. A chimeric embryo can then be implanted into a suitable pseudopregnant female foster animal and the embryo brought to term to create a “knock out” animal. Progeny harboring the homologously recombined DNA in their germ cells can be identified by standard techniques and used to breed animals in which all cells of the animal contain the homologously recombined DNA. Knockout animals can be characterized for instance, for their ability to defend against certain pathological conditions and for their development of pathological conditions due to absence of the SRT polypeptide.

[0733] Nucleic acid encoding the SRT polypeptides may also be used in gene therapy. In gene therapy applications, genes are introduced into cells in order to achieve in vivo synthesis of a therapeutically effective genetic product, for example for replacement of a defective gene. “Gene therapy” includes both conventional gene therapy where a lasting effect is achieved by a single treatment, and the administration of gene therapeutic agents, which involves the one time or repeated administration of a therapeutically effective DNA or mRNA. Antisense RNAs and DNAs can be used as therapeutic agents for blocking the expression of certain genes in vivo. It has already been shown that short antisense oligonucleotides can be imported into cells where they act as inhibitors, despite their low intracellular concentrations caused by their restricted uptake by the cell membrane. (Zamecnik et al., Proc. Natl. Acad. Sci. USA 83:4143-4146 [1986]). The oligonucleotides can be modified to enhance their uptake, e.g. by substituting their negatively charged phosphodiester groups by uncharged groups.

[0734] There are a variety of techniques available for introducing nucleic acids into viable cells. The techniques vary depending upon whether the nucleic acid is transferred into cultured cells in vitro, or in vivo in the cells of the intended host. Techniques suitable for the transfer of nucleic acid into mammalian cells in vitro include the use of liposomes, electroporation, microinjection, cell fusion, DEAE-dextran, the calcium phosphate precipitation method, etc. The currently preferred in vivo gene transfer techniques include transfection with viral (typically retroviral) vectors and viral coat protein-liposome mediated transfection (Dzau et al., Trends in Biotechnology 11, 205-210 [1993]). In some situations it is desirable to provide the nucleic acid source with an agent that targets the target cells, such as an antibody specific for a cell surface membrane protein or the target cell, a ligand for a receptor on the target cell, etc. Where liposomes are employed, proteins which bind to a cell surface membrane protein associated with endocytosis may be used for targeting and/or to facilitate uptake, e.g. capsid proteins or fragments thereof tropic for a particular cell type, antibodies for proteins which undergo internalization in cycling, proteins that target intracellular localization and enhance intracellular half-life. The technique of receptor-mediated endocytosis is described, for example, by Wu et al., J. Biol. Chem. 262, 4429-4432 (1987); and Wagner et al., Proc. Natl. Acad. Sci. USA 87, 3410-3414 (1990). For review of gene marking and gene therapy protocols see Anderson et al., Science 256, 808-813 (1992).

[0735] The SRT polypeptides described herein may also be employed as molecular weight markers for protein electrophoresis purposes.

[0736] The nucleic acid molecules encoding the SRT polypeptides or fragments thereof described herein are useful for chromosome identification. In this regard, there exists an ongoing need to identify new chromosome markers, since relatively few chromosome marking reagents, based upon actual sequence data are presently available. Each SRT nucleic acid molecule of the present invention can be used as a chromosome marker.

[0737] The SRT polypeptides and nucleic acid molecules of the present invention may also be used for tissue typing, wherein the SRT polypeptides of the present invention may be differentially expressed in one tissue as compared to another, for example in a diseased tissue versus a normal tissue. SRT nucleic acid molecules will find use for generating probes for PCR, Northern analysis, Southern analysis and Western analysis.

[0738] The SRT polypeptides described herein and antibodies thereagainst may also be employed as therapeutic agents. The SRT polypeptides of the present invention can be formulated according to known methods to prepare pharmaceutically useful compositions, whereby the SRT product hereof is combined in admixture with a pharmaceutically acceptable carrier vehicle. Therapeutic formulations are prepared for storage by mixing the active ingredient having the desired degree of purity with optional physiologically acceptable carriers, excipients or stabilizers (Remington's Pharmaceutical Sciences 16th edition, Osol, A. Ed. (1980)), in the form of lyophilized formulations or aqueous solutions. Acceptable carriers, excipients or stabilizers are nontoxic to recipients at the dosages and concentrations employed, and include buffers such as phosphate, citrate and other organic acids; antioxidants including ascorbic acid; low molecular weight (less than about 10 residues) polypeptides; proteins, such as serum albumin, gelatin or immunoglobulins; hydrophilic polymers such as polyvinylpyrrolidone, amino acids such as glycine, glutamine, asparagine, arginine or lysine; monosaccharides, disaccharides and other carbohydrates including glucose, mannose, or dextrins; chelating agents such as EDTA; sugar alcohols such as mannitol or sorbitol; salt-forming counterions such as sodium; and/or nonionic surfactants such as TWEEN™, PLURONICS™ or PEG.

[0739] The formulations to be used for in vivo administration must be sterile. This is readily accomplished by filtration through sterile filtration membranes, prior to or following lyophilization and reconstitution.

[0740] Therapeutic compositions herein generally are placed into a container having a sterile access port, for example, an intravenous solution bag or vial having a stopper pierceable by a hypodermic injection needle.

[0741] The route of administration is in accord with known methods, e.g. injection or infusion by intravenous, intraperitoneal, intracerebral, intramuscular, intraocular, intraarterial or intralesional routes, topical administration, or by sustained release systems.

[0742] Dosages and desired drug concentrations of pharmaceutical compositions of the present invention may vary depending on the particular use envisioned. The determination of the appropriate dosage or route of administration is well within the skill of an ordinary physician. Animal experiments provide reliable guidance for the determination of effective doses for human therapy. Interspecies scaling of effective doses can be performed following the principles laid down by Mordenti, J. and Chappell, W. “The use of interspecies scaling in toxicokinetics” In Toxicokinetics and New Drug Development, Yacobi et al., Eds., Pergamon Press, New York 1989, pp. 42-96.

[0743] When in vivo administration of a SRT polypeptide or agonist or antagonist thereof is employed, normal dosage amounts may vary from about 10 ng/kg to up to 100 mg/kg of mammal body weight or more per day, preferably about 1 μg/kg/day to 10 mg/kg/day, depending upon the route of administration. Guidance as to particular dosages and methods of delivery is provided in the literature; see, for example, U.S. Pat. Nos. 4,657,760; 5,206,344; or 5,225,212. It is anticipated that different formulations will be effective for different treatment compounds and different disorders, that administration targeting one organ or tissue, for example, may necessitate delivery in a manner different from that to another organ or tissue.

[0744] Where sustained-release administration of a SRT polypeptide is desired in a formulation with release characteristics suitable for the treatment of any disease or disorder requiring administration of the SRT polypeptide, microencapsulation of the SRT polypeptide is contemplated. Microencapsulation of recombinant proteins for sustained release has been successfully performed with human growth hormone (rhGH), interferon-(rhIFN- ), interleukin-2, and MN rgp120. Johnson et al., Nat. Med., 2:795-799 (1996); Yasuda, Biomed. Ther., 27:1221-1223 (1993); Hora et al., Bio/Technology 8:755-758 (1990); Cleland, “Design and Production of Single Immunization Vaccines Using Polylactide Polyglycolide Microsphere Systems,” in Vaccine Design: The Subunit and Adjuvant Approach, Powell and Newman, eds, (Plenum Press: New York, 1995), pp.439-462; WO 97/03692, WO 96/40072, WO 96/07399; and U.S. Pat. No. 5,654,010.

[0745] The sustained-release formulations of these proteins were developed using poly-lactic-coglycolic acid (PLGA) polymer due to its biocompatibility and wide range of biodegradable properties. The degradation products of PLGA, lactic and glycolic acids, can be cleared quickly within the human body. Moreover, the degradability of this polymer can be adjusted from months to years depending on its molecular weight and composition. Lewis, “Controlled release of bioactive agents from lactide/glycolide polymer,” in: M. Chasin and R. Langer (Eds.), Biodegradable Polymers as Drug Delivery Systems (Marcel Dekker: New York, 1990), pp.1-41.

[0746] This invention encompasses methods of screening compounds to identify those that mimic the SRT polypeptide (agonists) or prevent the effect of the SRT polypeptide (antagonists). Screening assays for antagonist drug candidates are designed to identify compounds that bind or complex with the SRT polypeptides encoded by the genes identified herein, or otherwise interfere with the interaction of the encoded polypeptides with other cellular proteins. Such screening assays will include assays amenable to high-throughput screening of chemical libraries, making them particularly suitable for identifying small molecule drug candidates.

[0747] The assays can be performed in a variety of formats, including protein-protein binding assays, biochemical screening assays, immunoassays, and cell-based assays, which are well characterized in the art.

[0748] All assays for antagonists are common in that they call for contacting the drug candidate with a SRT polypeptide encoded by a nucleic acid identified herein under conditions and for a time sufficient to allow these two components to interact.

[0749] In binding assays, the interaction is binding and the complex formed can be isolated or detected in the reaction mixture. In a particular embodiment, the SRT polypeptide encoded by the gene identified herein or the drug candidate is immobilized on a solid phase, e.g., on a microtiter plate, by covalent or non-covalent attachments. Non-covalent attachment generally is accomplished by coating the solid surface with a solution of the SRT polypeptide and drying. Alternatively, an immobilized antibody, e.g., a monoclonal antibody, specific for the SRT polypeptide to be immobilized can be used to anchor it to a solid surface. The assay is performed by adding the non-immobilized component, which may be labeled by a detectable label, to the immobilized component, e.g., the coated surface containing the anchored component. When the reaction is complete, the non-reacted components are removed, e.g., by washing, and complexes anchored on the solid surface are detected. When the originally non-immobilized component carries a detectable label, the detection of label immobilized on the surface indicates that complexing occurred. Where the originally non-immobilized component does not carry a label, complexing can be detected, for example, by using a labeled antibody specifically binding the immobilized complex.

[0750] If the candidate compound interacts with but does not bind to a particular SRT polypeptide encoded by a gene identified herein, its interaction with that polypeptide can be assayed by methods well known for detecting protein-protein interactions. Such assays include traditional approaches, such as, e.g., cross-linking, co-immunoprecipitation, and co-purification through gradients or chromatographic columns. In addition, protein-protein interactions can be monitored by using a yeast-based genetic system described by Fields and co-workers (Fields and Song, Nature (London), 340:245-246 (1989); Chien et al., Proc. Natl. Acad. Sci. USA, 88:9578-9582 (1991)) as disclosed by Chevray and Nathans, Proc. Natl. Acad. Sci. USA, 89: 5789-5793 (1991). Many transcriptional activators, such as yeast GAL4, consist of two physically discrete modular domains, one acting as the DNA-binding domain, the other one functioning as the transcription-activation domain. The yeast expression system described in the foregoing publications (generally referred to as the “two-hybrid system”) takes advantage of this property, and employs two hybrid proteins, one in which the target protein is fused to the DNA-binding domain of GAL4, and another, in which candidate activating proteins are fused to the activation domain. The expression of a GAL1-lacZ reporter gene under control of a GAL4-activated promoter depends on reconstitution of GALA activity via protein-protein interaction. Colonies containing interacting polypeptides are detected with a chromogenic substrate for β-galactosidase. A complete kit (MATCHMAKER™) for identifying protein-protein interactions between two specific proteins using the two-hybrid technique is commercially available from Clontech. This system can also be extended to map protein domains involved in specific protein interactions as well as to pinpoint amino acid residues that are crucial for these interactions.

[0751] Compounds that interfere with the interaction of a gene encoding a SRT polypeptide identified herein and other intra- or extracellular components can be tested as follows: usually a reaction mixture is prepared containing the product of the gene and the intra- or extracellular component under conditions and for a time allowing for the interaction and binding of the two products. To test the ability of a candidate compound to inhibit binding, the reaction is run in the absence and in the presence of the test compound. In addition, a placebo may be added to a third reaction mixture, to serve as positive control. The binding (complex formation) between the test compound and the intra- or extracellular component present in the mixture is monitored as described hereinabove. The formation of a complex in the control reaction(s) but not in the reaction mixture containing the test compound indicates that the test compound interferes with the interaction of the test compound and its reaction partner.

[0752] To assay for antagonists, the SRT polypeptide may be added to a cell along with the compound to be screened for a particular activity and the ability of the compound to inhibit the activity of interest in the presence of the SRT polypeptide indicates that the compound is an antagonist to the SRT polypeptide. Alternatively, antagonists may be detected by combining the SRT polypeptide and a potential antagonist with membrane-bound SRT polypeptide receptors or recombinant receptors under appropriate conditions for a competitive inhibition assay. The SRT polypeptide can be labeled, such as by radioactivity, such that the number of SRT polypeptide molecules bound to the receptor can be used to determine the effectiveness of the potential antagonist. The gene encoding the receptor can be identified by numerous methods known to those of skill in the art, for example, ligand panning and FACS sorting. Coligan et al., Current Protocols in Immun., 1(2): Chapter 5 (1991). Preferably, expression cloning is employed wherein polyadenylated RNA is prepared from a cell responsive to the SRT polypeptide and a cDNA library created from this RNA is divided into pools and used to transfect COS cells or other cells that are not responsive to the SRT polypeptide. Transfected cells that are grown on glass slides are exposed to labeled SRT polypeptide. The SRT polypeptide can be labeled by a variety of means including iodination or inclusion of a recognition site for a site-specific protein kinase. Following fixation and incubation, the slides are subjected to autoradiographic analysis. Positive pools are identified and sub-pools are prepared and re-transfected using an interactive sub-pooling and re-screening process, eventually yielding a single clone that encodes the putative receptor.

[0753] As an alternative approach for receptor identification, labeled SRT polypeptide can be photoaffinity-linked with cell membrane or extract preparations that express the receptor molecule. Cross-linked material is resolved by PAGE and exposed to X-ray film. The labeled complex containing the receptor can be excised, resolved into peptide fragments, and subjected to protein micro-sequencing. The amino acid sequence obtained from micro-sequencing would be used to design a set of degenerate oligonucleotide probes to screen a cDNA library to identify the gene encoding the putative receptor.

[0754] In another assay for antagonists, mammalian cells or a membrane preparation expressing the receptor would be incubated with labeled SRT polypeptide in the presence of the candidate compound. The ability of the compound to enhance or block this interaction could then be measured.

[0755] More specific examples of potential antagonists include an oligonucleotide that binds to the fusions of immunoglobulin with SRT polypeptide, and, in particular, antibodies including, without limitation, poly- and monoclonal antibodies and antibody fragments, single-chain antibodies, anti-idiotypic antibodies, and chimeric or humanized versions of such antibodies or fragments, as well as human antibodies and antibody fragments. Alternatively, a potential antagonist may be a closely related protein, for example, a mutated form of the SRT polypeptide that recognizes the receptor but imparts no effect, thereby competitively inhibiting the action of the SRT polypeptide.

[0756] Another potential SRT polypeptide antagonist is an antisense RNA or DNA construct prepared using antisense technology, where, e.g., an antisense RNA or DNA molecule acts to block directly the translation of mRNA by hybridizing to targeted mRNA and preventing protein translation. Antisense technology can be used to control gene expression through triple-helix formation or antisense DNA or RNA, both of which methods are based on binding of a polynucleotide to DNA or RNA. For example, the 5′ coding portion of the polynucleotide sequence, which encodes the mature SRT polypeptides herein, is used to design an antisense RNA oligonucleotide of from about 10 to 40 base pairs in length. A DNA oligonucleotide is designed to be complementary to a region of the gene involved in transcription (triple helix—see Lee et al., Nucl. Acids Res., 6:3073 (1979); Cooney et al., Science, 241: 456 (1988); Dervan et al., Science, 251:1360 (1991)), thereby preventing transcription and the production of the SRT polypeptide. The antisense RNA oligonucleotide hybridizes to the mRNA in vivo and blocks translation of the mRNA molecule into the SRT polypeptide (antisense—Okano, Neurochem., 56:560 (1991); Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression (CRC Press: Boca Raton, Fla., 1988). The oligonucleotides described above can also be delivered to cells such that the antisense RNA or DNA may be expressed in vivo to inhibit production of the SRT polypeptide. When antisense DNA is used, oligodeoxyribonucleotides derived from the translation-initiation site, e.g., between about −10 and +10 positions of the target gene nucleotide sequence, are preferred.

[0757] Potential antagonists include small molecules that bind to the active site, the receptor binding site, or growth factor or other relevant binding site of the SRT polypeptide, thereby blocking the normal biological activity of the SRT polypeptide. Examples of small molecules include, but are not limited to, small peptides or peptide-like molecules, preferably soluble peptides, and synthetic non-peptidyl organic or inorganic compounds.

[0758] Ribozymes are enzymatic RNA molecules capable of catalyzing the specific cleavage of RNA. Ribozymes act by sequence-specific hybridization to the complementary target RNA, followed by endonucleolytic cleavage. Specific ribozyme cleavage sites within a potential RNA target can be identified by known techniques. For further details see, e.g., Rossi, Current Biology, 4:469-471 (1994), and PCT publication No. WO 97/33551 (published Sep. 18, 1997).

[0759] Nucleic acid molecules in triple-helix formation used to inhibit transcription should be single-stranded and composed of deoxynucleotides. The base composition of these oligonucleotides is designed such that it promotes triple-helix formation via Hoogsteen base-pairing rules, which generally require sizeable stretches of purines or pyrimidines on one strand of a duplex. For further details see, e.g., PCT publication No. WO 97/33551, supra.

[0760] These small molecules can be identified by any one or more of the screening assays discussed hereinabove and/or by any other screening techniques well known for those skilled in the art.

[0761] F. Anti-SRT Polypeptide Antibodies

[0762] The present invention further provides anti-SRT antibodies. Exemplary antibodies include polyclonal, monoclonal, humanized, bispecific, and heteroconjugate antibodies.

[0763] 1. Polyclonal Antibodies

[0764] The anti-SRT antibodies may comprise polyclonal antibodies. Methods of preparing polyclonal antibodies are known to the skilled artisan. Polyclonal antibodies can be raised in a mammal, for example, by one or more injections of an immunizing agent and, if desired, an adjuvant. Typically, the immunizing agent and/or adjuvant will be injected in the mammal by multiple subcutaneous or intraperitoneal injections. The immunizing agent may include the SRT polypeptide or a fusion protein thereof. It may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. Examples of adjuvants which may be employed include Freund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate). The immunization protocol may be selected by one skilled in the art without undue experimentation.

[0765] 2. Monoclonal Antibodies

[0766] The anti-SRT antibodies may, alternatively, be monoclonal antibodies. Monoclonal antibodies may be prepared using hybridoma methods, such as those described by Kohler and Milstein, Nature, 256:495 (1975). In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent. Alternatively, the lymphocytes may be immunized in vitro.

[0767] The immunizing agent will typically include the SRT polypeptide or a fusion protein thereof. Generally, either peripheral blood lymphocytes (“PBLs”) are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell [Goding, Monoclonal Antibodies: Principles and Practice, Academic Press, (1986) pp. 59-103]. Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine and human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine (“HAT medium”), which substances prevent the growth of HGPRT-deficient cells.

[0768] Preferred immortalized cell lines are those that fuse efficiently, support stable high level expression of antibody by the selected antibody-producing cells, and are sensitive to a medium such as HAT medium. More preferred immortalized cell lines are murine myeloma lines, which can be obtained, for instance, from the Salk Institute Cell Distribution Center, San Diego, Calif. and the American Type Culture Collection, Manassas, Va. Human myeloma and mouse-human heteromyeloma cell lines also have been described for the production of human monoclonal antibodies [Kozbor, J. Immunol., 133:3001 (1984); Brodeur et al., Monoclonal Antibody Production Techniques and Applications, Marcel Dekker, Inc., New York, (1987) pp. 51-63].

[0769] The culture medium in which the hybridoma cells are cultured can then be assayed for the presence of monoclonal antibodies directed against SRT. Preferably, the binding specificity of monoclonal antibodies produced by the hybridoma cells is determined by immunoprecipitation or by an in vitro binding assay, such as radioimmunoassay (RIA) or enzyme-linked immunoabsorbent assay (ELISA). Such techniques and assays are known in the art. The binding affinity of the monoclonal antibody can, for example, be determined by the Scatchard analysis of Munson and Pollard, Anal. Biochem., 107:220 (1980).

[0770] After the desired hybridoma cells are identified, the clones may be subcloned by limiting dilution procedures and grown by standard methods [Goding, supra]. Suitable culture media for this purpose include, for example, Dulbecco's Modified Eagle's Medium and RPMI-1640 medium. Alternatively, the hybridoma cells may be grown in vivo as ascites in a mammal.

[0771] The monoclonal antibodies secreted by the subclones may be isolated or purified from the culture medium or ascites fluid by conventional immunoglobulin purification procedures such as, for example, protein A-Sepharose, hydroxylapatite chromatography, gel electrophoresis, dialysis, or affinity chromatography.

[0772] The monoclonal antibodies may also be made by recombinant DNA methods, such as those described in U.S. Pat. No. 4,816,567. DNA encoding the monoclonal antibodies of the invention can be readily isolated and sequenced using conventional procedures (e.g., by using oligonucleotide probes that are capable of binding specifically to genes encoding the heavy and light chains of murine antibodies). The hybridoma cells of the invention serve as a preferred source of such DNA. Once isolated, the DNA may be placed into expression vectors, which are then transfected into host cells such as simian COS cells, Chinese hamster ovary (CHO) cells, or myeloma cells that do not otherwise produce immunoglobulin protein, to obtain the synthesis of monoclonal antibodies in the recombinant host cells. The DNA also may be modified, for example, by substituting the coding sequence for human heavy and light chain constant domains in place of the homologous murine sequences [U.S. Pat. No. 4,816,567; Morrison et al., supra] or by covalently joining to the immunoglobulin coding sequence all or part of the coding sequence for a non-immunoglobulin polypeptide. Such a non-immunoglobulin polypeptide can be substituted for the constant domains of an antibody of the invention, or can be substituted for the variable domains of one antigen-combining site of an antibody of the invention to create a chimeric bivalent antibody.

[0773] The antibodies may be monovalent antibodies. Methods for preparing monovalent antibodies are well known in the art. For example, one method involves recombinant expression of immunoglobulin light chain and modified heavy chain. The heavy chain is truncated generally at any point in the Fc region so as to prevent heavy chain crosslinking. Alternatively, the relevant cysteine residues are substituted with another amino acid residue or are deleted so as to prevent crosslinking.

[0774] In vitro methods are also suitable for preparing monovalent antibodies. Digestion of antibodies to produce fragments thereof, particularly, Fab fragments, can be accomplished using routine techniques known in the art.

[0775] 3. Human and Humanized Antibodies

[0776] The anti-SRT antibodies of the invention may further comprise humanized antibodies or human antibodies. Humanized forms of non-human (e.g., murine) antibodies are chimeric immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab′, F(ab′)₂ or other antigen-binding subsequences of antibodies) which contain minimal sequence derived from non-human immunoglobulin. Humanized antibodies include human immunoglobulins (recipient antibody) in which residues from a complementary determining region (CDR) of the recipient are replaced by residues from a CDR of a non-human species (donor antibody) such as mouse, rat or rabbit having the desired specificity, affinity and capacity. In some instances, Fv framework residues of the human immunoglobulin are replaced by corresponding non-human residues. Humanized antibodies may also comprise residues which are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, the humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the FR regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin [Jones et al., Nature, 321:522-525 (1986); Riechmann et al., Nature, 332:323-329 (1988); and Presta, Curr. Op. Struct. Biol., 2:593-596 (1992)].

[0777] Methods for humanizing non-human antibodies are well known in the art. Generally, a humanized antibody has one or more amino acid residues introduced into it from a source which is non-human. These non-human amino acid residues are often referred to as “import” residues, which are typically taken from an “import” variable domain. Humanization can be essentially performed following the method of Winter and co-workers [Jones et al., Nature, 321:522-525 (1986); Riechmann et al., Nature, 332:323-327 (1988); Verhoeyen et al., Science, 239:1534-1536 (1988)], by substituting rodent CDRs or CDR sequences for the corresponding sequences of a human antibody. Accordingly, such “humanized” antibodies are chimeric antibodies (U.S. Pat. No. 4,816,567), wherein substantially less than an intact human variable domain has been substituted by the corresponding sequence from a non-human species. In practice, humanized antibodies are typically human antibodies in which some CDR residues and possibly some FR residues are substituted by residues from analogous sites in rodent antibodies.

[0778] Human antibodies can also be produced using various techniques known in the art, including phage display libraries [Hoogenboom and Winter, J. Mol. Biol., 227:381 (1991); Marks et al., J. Mol. Biol., 222:581 (1991)]. The techniques of Cole et al. and Boerner et al. are also available for the preparation of human monoclonal antibodies (Cole et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, p. 77 (1985) and Boerner et al., J. Immunol., 147(1):86-95 (1991)]. Similarly, human antibodies can be made by introducing of human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, for example, in U.S. Pat. Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in the following scientific publications: Marks et al., Bio/Technology 10, 779-783 (1992); Lonberg et al., Nature 368 856-859 (1994); Morrison, Nature 368, 812-13 (1994); Fishwild et al., Nature Biotechnology 14, 845-51 (1996); Neuberger, Nature Biotechnology 14, 826 (1996); Lonberg and Huszar, Intern. Rev. Immunol. 13 65-93 (1995).

[0779] 4. Bispecific Antibodies

[0780] Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens. In the present case, one of the binding specificities is for the SRT, the other one is for any other antigen, and preferably for a cell-surface protein or receptor or receptor subunit.

[0781] Methods for making bispecific antibodies are known in the art. Traditionally, the recombinant production of bispecific antibodies is based on the co-expression of two immunoglobulin heavy-chain/light-chain pairs, where the two heavy chains have different specificities [Milstein and Cuello, Nature, 305:537-539 (1983)]. Because of the random assortment of immunoglobulin heavy and light chains, these hybridomas (quadromas) produce a potential mixture of ten different antibody molecules, of which only one has the correct bispecific structure. The purification of the correct molecule is usually accomplished by affinity chromatography steps. Similar procedures are disclosed in WO 93/08829, published May 13, 1993, and in Traunecker et al., EMBO J., 10:3655-3659 (1991).

[0782] Antibody variable domains with the desired binding specificities (antibody-antigen combining sites) can be fused to immunoglobulin constant domain sequences. The fusion preferably is with an immunoglobulin heavy-chain constant domain, comprising at least part of the hinge, CH2, and CH3 regions. It is preferred to have the first heavy-chain constant region (CH1) containing the site necessary for light-chain binding present in at least one of the fusions. DNAs encoding the immunoglobulin heavy-chain fusions and, if desired, the immunoglobulin light chain, are inserted into separate expression vectors, and are co-transfected into a suitable host organism. For further details of generating bispecific antibodies see, for example, Suresh et al., Methods in Enzymology, 121:210 (1986).

[0783] According to another approach described in WO 96/27011, the interface between a pair of antibody molecules can be engineered to maximize the percentage of heterodimers which are recovered from recombinant cell culture. The preferred interface comprises at least a part of the CH3 region of an antibody constant domain. In this method, one or more small amino acid side chains from the interface of the first antibody molecule are replaced with larger side chains (e.g. tyrosine or tryptophan). Compensatory “cavities” of identical or similar size to the large side chain(s) are created on the interface of the second antibody molecule by replacing large amino acid side chains with smaller ones (e.g. alanine or threonine). This provides a mechanism for increasing the yield of the heterodimer over other unwanted end-products such as homodimers.

[0784] Bispecific antibodies can be prepared as full length antibodies or antibody fragments (e.g. F(ab′)₂ bispecific antibodies). Techniques for generating bispecific antibodies from antibody fragments have been described in the literature. For example, bispecific antibodies can be prepared can be prepared using chemical linkage. Brennan et al, Science 229:81 (1985) describe a procedure wherein intact antibodies are proteolytically cleaved to generate F(ab′)₂ fragments. These fragments are reduced in the presence of the dithiol complexing agent sodium arsenite to stabilize vicinal dithiols and prevent intermolecular disulfide formation. The Fab′ fragments generated are then converted to thionitrobenzoate (TNB) derivatives. One of the Fab′-TNB derivatives is then reconverted to the Fab′-thiol by reduction with mercaptoethylamine and is mixed with an equimolar amount of the other Fab′-TNB derivative to form the bispecific antibody. The bispecific antibodies produced can be used as agents for the selective immobilization of enzymes.

[0785] Fab′ fragments may be directly recovered from E. coli and chemically coupled to form bispecific antibodies. Shalaby et al., J. Exp. Med. 175:217-225 (1992) describe the production of a fully humanized bispecific antibody F(ab′)₂ molecule. Each Fab′ fragment was separately secreted from E. coli and subjected to directed chemical coupling in vitro to form the bispecific antibody. The bispecific antibody thus formed was able to bind to cells overexpressing the ErbB2 receptor and normal human T cells, as well as trigger the lytic activity of human cytotoxic lymphocytes against human breast tumor targets.

[0786] Various technique for making and isolating bispecific antibody fragments directly from recombinant cell culture have also been described. For example, bispecific antibodies have been produced using leucine zippers. Kostelny et al., J. Immunol. 148(5): 1547-1553 (1992). The leucine zipper peptides from the Fos and Jun proteins were linked to the Fab′ portions of two different antibodies by gene fusion. The antibody homodimers were reduced at the hinge region to form monomers and then re-oxidized to form the antibody heterodimers. This method can also be utilized for the production of antibody homodimers. The “diabody” technology described by Hollinger et al., Proc. Natl. Acad. Sci. USA 90:6444-6448 (1993) has provided an alternative mechanism for making bispecific antibody fragments. The fragments comprise a heavy-chain variable domain (V_(H)) connected to a light-chain variable domain (V_(L)) by a linker which is too short to allow pairing between the two domains on the same chain. Accordingly, the V_(H) and V_(L) domains of one fragment are forced to pair with the complementary V_(L) and V_(H) domains of another fragment, thereby forming two antigen-binding sites. Another strategy for making bispecific antibody fragments by the use of single-chain Fv (sFv) dimers has also been reported. See, Gruber et al., J. Immunol. 152:5368 (1994). Antibodies with more than two valencies are contemplated. For example, trispecific antibodies can be prepared. Tutt et al., J. Immunol. 147:60 (1991).

[0787] Exemplary bispecific antibodies may bind to two different epitopes on a given SRT polypeptide herein. Alternatively, an anti-SRT polypeptide arm may be combined with an arm which binds to a triggering molecule on a leukocyte such as a T-cell receptor molecule (e.g. CD2, CD3, CD28, or B7), or Fc receptors for IgG (FcγR), such as FcγRI (CD64), FcγRII (CD32) and FcγRIII (CD 16) so as to focus cellular defense mechanisms to the cell expressing the particular SRT polypeptide. Bispecific antibodies may also be used to localize cytotoxic agents to cells which express a particular SRT polypeptide. These antibodies possess a SRT-binding arm and an arm which binds a cytotoxic agent or a radionuclide chelator, such as EOTUBE, DPTA, DOTA, or TETA. Another bispecific antibody of interest binds the SRT polypeptide and further binds tissue factor (TF).

[0788] 5. Heteroconjugate Antibodies

[0789] Heteroconjugate antibodies are also within the scope of the present invention. Heteroconjugate antibodies are composed of two covalently joined antibodies. Such antibodies have, for example, been proposed to target immune system cells to unwanted cells [U.S. Pat. No. 4,676,980], and for treatment of HIV infection [WO 91/00360; WO 92/200373; EP 03089]. It is contemplated that the antibodies may be prepared in vitro using known methods in synthetic protein chemistry, including those involving crosslinking agents. For example, immunotoxins may be constructed using a disulfide exchange reaction or by forming a thioether bond. Examples of suitable reagents for this purpose include iminothiolate and methyl-4-mercaptobutyrimidate and those disclosed, for example, in U.S. Pat. No. 4,676,980.

[0790] 6. Effector Function Engineering

[0791] It may be desirable to modify the antibody of the invention with respect to effector function, so as to enhance, e.g., the effectiveness of the antibody in treating cancer. For example, cysteine residue(s) may be introduced into the Fc region, thereby allowing interchain disulfide bond formation in this region. The homodimeric antibody thus generated may have improved internalization capability and/or increased complement-mediated cell killing and antibody-dependent cellular cytotoxicity (ADCC). See Caron et al., J. Exp Med., 176: 1191-1195 (1992) and Shopes, J. Immunol., 148: 2918-2922 (1992). Homodimeric antibodies with enhanced anti-tumor activity may also be prepared using heterobifunctional cross-linkers as described in Wolff et al. Cancer Research, 53: 2560-2565 (1993). Alternatively, an antibody can be engineered that has dual Fc regions and may thereby have enhanced complement lysis and ADCC capabilities. See Stevenson et al, Anti-Cancer Drug Design, 3: 219-230 (1989).

[0792] 7. Immunoconjugates

[0793] The invention also pertains to immunoconjugates comprising an antibody conjugated to a cytotoxic agent such as a chemotherapeutic agent, toxin (e.g., an enzymatically active toxin of bacterial, fungal, plant, or animal origin, or fragments thereof), or a radioactive isotope (i.e., a radioconjugate).

[0794] Chemotherapeutic agents useful in the generation of such immunoconjugates have been described above. Enzymatically active toxins and fragments thereof that can be used include diphtheria A chain, nonbinding active fragments of diphtheria toxin, exotoxin A chain (from Pseudomonas aeruginosa), ricin A chain, abrin A chain, modeccin A chain, alpha-sarcin, Aleurites fordii proteins, dianthin proteins, Phytolaca americana proteins (PAPI, PAPII, and PAP-S), momordica charantia inhibitor, curcin, crotin, sapaonaria officinalis inhibitor, gelonin, mitogellin, restrictocin, phenomycin, enomycin, and the tricothecenes. A variety of radionuclides are available for the production of radioconjugated antibodies. Examples include ²¹²Bi, ¹³¹I, ¹³¹In, ⁹⁰Y, and ¹⁸⁶Re. Conjugates of the antibody and cytotoxic agent are made using a variety of bifunctional protein-coupling agents such as N-succinimidyl-3-(2-pyridyldithiol) propionate (SPDP), iminothiolane (IT), bifunctional derivatives of imidoesters (such as dimethyl adipimidate HCL), active esters (such as disuccinimidyl suberate), aldehydes (such as glutareldehyde), bis-azido compounds (such as bis (p-azidobenzoyl) hexanediamine), bis-diazonium derivatives (such as bis-(p-diazoniumbenzoyl)-ethylenediamine), diisocyanates (such as tolyene 2,6-diisocyanate), and bis-active fluorine compounds (such as 1,5-difluoro-2,4-dinitrobenzene). For example, a ricin immunotoxin can be prepared as described in Vitetta et al., Science, 238: 1098 (1987). Carbon-14-labeled 1-isothiocyanatobenzyl-3-methyldiethylene triaminepentaacetic acid (MX-DTPA) is an exemplary chelating agent for conjugation of radionucleotide to the antibody. See W094/11026.

[0795] In another embodiment, the antibody may be conjugated to a “receptor” (such streptavidin) for utilization in tumor pretargeting wherein the antibody-receptor conjugate is administered to the patient, followed by removal of unbound conjugate from the circulation using a clearing agent and then administration of a “ligand” (e.g., avidin) that is conjugated to a cytotoxic agent (e.g., a radionucleotide).

[0796] 8. Immunoliposomes

[0797] The antibodies disclosed herein may also be formulated as immunoliposomes. Liposomes containing the antibody are prepared by methods known in the art, such as described in Epstein et al., Proc. Natl. Acad. Sci. USA, 82: 3688 (1985); Hwang et al., Proc. Natl Acad. Sci. USA, 77: 4030 (1980); and U.S. Pat. Nos. 4,485,045 and 4,544,545. Liposomes with enhanced circulation time are disclosed in U.S. Pat. No. 5,013,556.

[0798] Particularly useful liposomes can be generated by the reverse-phase evaporation method with a lipid composition comprising phosphatidylcholine, cholesterol, and PEG-derivatized phosphatidylethanolamine (PEG-PE). Liposomes are extruded through filters of defined pore size to yield liposomes with the desired diameter. Fab′ fragments of the antibody of the present invention can be conjugated to the liposomes as described in Martin et al., J. Biol. Chem., 257: 286-288 (1982) via a disulfide-interchange reaction. A chemotherapeutic agent (such as Doxorubicin) is optionally contained within the liposome. See Gabizon et al., J. National Cancer Inst., 81(19): 1484 (1989).

[0799] 9. Pharmaceutical Compositions of Antibodies

[0800] Antibodies specifically binding a SRT polypeptide identified herein, as well as other molecules identified by the screening assays disclosed hereinbefore, can be administered for the treatment of various disorders in the form of pharmaceutical compositions.

[0801] If the SRT polypeptide is intracellular and whole antibodies are used as inhibitors, internalizing antibodies are preferred. However, lipofections or liposomes can also be used to deliver the antibody, or an antibody fragment, into cells. Where antibody fragments are used, the smallest inhibitory fragment that specifically binds to the binding domain of the target protein is preferred. For example, based upon the variable-region sequences of an antibody, peptide molecules can be designed that retain the ability to bind the target protein sequence. Such peptides can be synthesized chemically and/or produced by recombinant DNA technology. See, e.g., Marasco et al., Proc. Natl. Acad. Sci. USA, 90: 7889-7893 (1993). The formulation herein may also contain more than one active compound as necessary for the particular indication being treated, preferably those with complementary activities that do not adversely affect each other. Alternatively, or in addition, the composition may comprise an agent that enhances its function, such as, for example, a cytotoxic agent, cytokine, chemotherapeutic agent, or growth-inhibitory agent. Such molecules are suitably present in combination in amounts that are effective for the purpose intended.

[0802] The active ingredients may also be entrapped in microcapsules prepared, for example, by coacervation techniques or by interfacial polymerization, for example, hydroxymethylcellulose or gelatin-microcapsules and poly-(methylmethacylate) microcapsules, respectively, in colloidal drug delivery systems (for example, liposomes, albumin microspheres, microemulsions, nano-particles, and nanocapsules) or in macroemulsions. Such techniques are disclosed in Remington's Pharmaceutical Sciences, supra.

[0803] The formulations to be used for in vivo administration must be sterile. This is readily accomplished by filtration through sterile filtration membranes.

[0804] Sustained-release preparations may be prepared. Suitable examples of sustained-release preparations include semipermeable matrices of solid hydrophobic polymers containing the antibody, which matrices are in the form of shaped articles, e.g., films, or microcapsules. Examples of sustained-release matrices include polyesters, hydrogels (for example, poly(2-hydroxyethyl-methacrylate), or poly(vinylalcohol)), polylactides (U.S. Pat. No. 3,773,919), copolymers of L-glutamic acid and γ ethyl-L-glutamate, non-degradable ethylene-vinyl acetate, degradable lactic acid-glycolic acid copolymers such as the LUPRON DEPOT™ (injectable microspheres composed of lactic acid-glycolic acid copolymer and leuprolide acetate), and poly-D-(−)-3-hydroxybutyric acid. While polymers such as ethylene-vinyl acetate and lactic acid-glycolic acid enable release of molecules for over 100 days, certain hydrogels release proteins for shorter time periods. When encapsulated antibodies remain in the body for a long time, they may denature or aggregate as a result of exposure to moisture at 37° C., resulting in a loss of biological activity and possible changes in immunogenicity. Rational strategies can be devised for stabilization depending on the mechanism involved. For example, if the aggregation mechanism is discovered to be intermolecular S—S bond formation through thio-disulfide interchange, stabilization may be achieved by modifying sulfhydryl residues, lyophilizing from acidic solutions, controlling moisture content, using appropriate additives, and developing specific polymer matrix compositions.

[0805] G. Uses for anti-SRT Antibodies

[0806] The anti-SRT antibodies of the invention have various utilities. For example, anti-SRT antibodies may be used in diagnostic assays for SRT, e.g., detecting its expression in specific cells, tissues, or serum. Various diagnostic assay techniques known in the art may be used, such as competitive binding assays, direct or indirect sandwich assays and immunoprecipitation assays conducted in either heterogeneous or homogeneous phases [Zola, Monoclonal Antibodies: A Manual of Techniques, CRC Press, Inc. (1987) pp. 147-158]. The antibodies used in the diagnostic assays can be labeled with a detectable moiety. The detectable moiety should be capable of producing, either directly or indirectly, a detectable signal. For example, the detectable moiety may be a radioisotope, such as ³H, ¹⁴C, ³²P, ³⁵S, or ¹²⁵I, a fluorescent or chemiluminescent compound, such as fluorescein isothiocyanate, rhodamine, or luciferin, or an enzyme, such as alkaline phosphatase, beta-galactosidase or horseradish peroxidase. Any method known in the art for conjugating the antibody to the detectable moiety may be employed, including those methods described by Hunter et al., Nature, 144:945 (1962); David et al., Biochemistry, 13:1014 (1974); Pain et al., J. Immunol. Meth., 40:219 (1981); and Nygren, J. Histochem. and Cytochem., 30:407 (1982).

[0807] Anti-SRT antibodies also are useful for the affinity purification of SRT from recombinant cell culture or natural sources. In this process, the antibodies against SRT are immobilized on a suitable support, such a Sephadex resin or filter paper, using methods well known in the art. The immobilized antibody then is contacted with a sample containing the SRT to be purified, and thereafter the support is washed with a suitable solvent that will remove substantially all the material in the sample except the SRT, which is bound to the immobilized antibody. Finally, the support is washed with another suitable solvent that will release the SRT from the antibody.

[0808] The following examples are offered for illustrative purposes only, and are not intended to limit the scope of the present invention in any way.

[0809] All patent and literature references cited in the present specification are hereby incorporated by reference in their entirety.

EXAMPLES

[0810] Commercially available reagents referred to in the examples were used according to manufacturer's instructions unless otherwise indicated. The source of those cells identified in the following examples, and throughout the specification, by ATCC accession numbers is the American Type Culture Collection, Manassas, Va.

EXAMPLE 1 Isolation of SRT cDNAs

[0811] 1. Preparation of oligo dT primed cDNA library

[0812] mRNA was isolated from human tissue using reagents and protocols from Invitrogen, San Diego, Calif. (Fast Track 2). This RNA was used to generate an oligo dT primed cDNA library in the vector pRK5D using reagents and protocols from Life Technologies, Gaithersburg, Md. (Super Script Plasmid System). In this procedure, the double stranded cDNA was sized to greater than 1000 bp and the SalI/NotI linkered cDNA was cloned into Xhol/NotI cleaved vector. pRK5D is a cloning vector that has an sp6 transcription initiation site followed by an SfiI restriction enzyme site preceding the XhoI/NotI cDNA cloning sites.

[0813] 2. Preparation of random primed cDNA library

[0814] A secondary cDNA library was generated in order to preferentially represent the 5′ ends of the primary cDNA clones. Sp6 RNA was generated from the primary library (described above), and this RNA was used to generate a random primed cDNA library in the vector pSST-AMY.0 using reagents and protocols from Life Technologies (Super Script Plasmid System, referenced above). In this procedure the double stranded cDNA was sized to 500-1000 bp, linkered with blunt to NotI adaptors, cleaved with SfiI, and cloned into SfiI/NotI cleaved vector. pSST-AMY.0 is a cloning vector that has a yeast alcohol dehydrogenase promoter preceding the cDNA cloning sites and the mouse amylase sequence (the mature sequence without the secretion signal) followed by the yeast alcohol dehydrogenase terminator, after the cloning sites. Thus, cDNAs cloned into this vector that are fused in frame with the amylase sequence will lead to the secretion of amylase from appropriately transfected yeast colonies.

[0815] 3. Transformation and Detection

[0816] DNA from the library described in paragraph 2 above was chilled on ice to which was added electrocompetent DH10B bacteria (Life Technologies, 20 ml). The bacteria and vector mixture was then electroporated as recommended by the manufacturer. Subsequently, SOC media (Life Technologies, 1 ml) was added and the mixture was incubated at 37° C. for 30 minutes. The transformants were then plated onto 20 standard 150 mm LB plates containing ampicillin and incubated for 16 hours (37° C.). Positive colonies were scraped off the plates and the DNA was isolated from the bacterial pellet using standard protocols, e.g. CsCl-gradient. The purified DNA was then carried on to the yeast protocols below.

[0817] The yeast methods were divided into three categories: (1) Transformation of yeast with the plasmid/cDNA combined vector; (2) Detection and isolation of yeast clones secreting amylase; and (3) PCR amplification of the insert directly from the yeast colony and purification of the DNA for sequencing and further analysis.

[0818] The yeast strain used was HD56-5A (ATCC-90785). This strain has the following genotype: MAT alpha, ura3-52, leu2-3, leu2-112, his3-11, his3-15, MAL⁺, SUC⁺, GAL⁺. Preferably, yeast mutants can be employed that have deficient post-translational pathways. Such mutants may have translocation deficient alleles in sec71, sec72, sec62, with truncated sec71 being most preferred. Alternatively, antagonists (including antisense nucleotides and/or ligands) which interfere with the normal operation of these genes, other proteins implicated in this post translation pathway (e.g., SEC61p, SEC72p, SEC62p, SEC63p, TDJ1p or SSA1p-4p) or the complex formation of these proteins may also be preferably employed in combination with the amylase-expressing yeast.

[0819] Transformation was performed based on the protocol outlined by Gietz et al., Nucl. Acid. Res., 20:1425 (1992). Transformed cells were then inoculated from agar into YEPD complex media broth (100 ml) and grown overnight at 30° C. The YEPD broth was prepared as described in Kaiser et al., Methods in Yeast Genetics, Cold Spring Harbor Press, Cold Spring Harbor, N.Y., p. 207 (1994). The overnight culture was then diluted to about 2×10⁶ cells/ml (approx. OD₆₀₀=0.1) into fresh YEPD broth (500 ml) and regrown to 1×10⁷ cells/ml (approx. OD₆₀₀=0.4-0.5).

[0820] The cells were then harvested and prepared for transformation by transfer into GS3 rotor bottles in a Sorval GS3 rotor at 5,000 rpm for 5 minutes, the supernatant discarded, and then resuspended into sterile water, and centrifuged again in 50 ml falcon tubes at 3,500 rpm in a Beckman GS-6KR centrifuge. The supernatant was discarded and the cells were subsequently washed with LiAc/TE (10 ml, 10 mM Tris-HCl, 1 mM EDTA pH 7.5, 100 mM Li₂OOCCH₃), and resuspended into LiAc/TE (2.5 ml).

[0821] Transformation took place by mixing the prepared cells (100 μl) with freshly denatured single stranded salmon testes DNA (Lofstrand Labs, Gaithersburg, Md.) and transforming DNA (1 μg, vol.<10 μl) in microfuge tubes. The mixture was mixed briefly by vortexing, then 40% PEG/TE (600 μl, 40% polyethylene glycol-4000, 10 mM Tris-HCl, 1 mM EDTA, 100 mM Li₂OOCCH₃, pH 7.5) was added. This mixture was gently mixed and incubated at 30° C. while agitating for 30 minutes. The cells were then heat shocked at 42° C. for 15 minutes, and the reaction vessel centrifuged in a microfuge at 12,000 rpm for 5-10 seconds, decanted and resuspended into TE (500 μl, 10 mM Tris-HCl, 1 mM EDTA pH 7.5) followed by recentrifugation. The cells were then diluted into TE (1 ml) and aliquots (200 μl) were spread onto the selective media previously prepared in 150 mm growth plates (VWR).

[0822] Alternatively, instead of multiple small reactions, the transformation was performed using a single, large scale reaction, wherein reagent amounts were scaled up accordingly.

[0823] The selective media used was a synthetic complete dextrose agar lacking uracil (SCD-Ura) prepared as described in Kaiser et al., Methods in Yeast Genetics, Cold Spring Harbor Press, Cold Spring Harbor, N.Y., p. 208-210 (1994). Transformants were grown at 30° C. for 2-3 days.

[0824] The detection of colonies secreting amylase was performed by including red starch in the selective growth media. Starch was coupled to the red dye (Reactive Red-120, Sigma) as per the procedure described by Biely et al., Anal. Biochem., 172: 176-179 (1988). The coupled starch was incorporated into the SCD-Ura agar plates at a final concentration of 0.15% (w/v), and was buffered with potassium phosphate to a pH of 7.0 (50-100 mM final concentration).

[0825] The positive colonies were picked and streaked across fresh selective media (onto 150 mm plates) in order to obtain well isolated and identifiable single colonies. Well isolated single colonies positive for amylase secretion were detected by direct incorporation of red starch into buffered SCD-Ura agar. Positive colonies were determined by their ability to break down starch resulting in a clear halo around the positive colony visualized directly.

[0826] 4. Isolation of DNA by PCR Amplification

[0827] When a positive colony was isolated, a portion of it was picked by a toothpick and diluted into sterile water (30 μl) in a 96 well plate. At this time, the positive colonies were either frozen and stored for subsequent analysis or immediately amplified. An aliquot of cells (5 μl) was used as a template for the PCR reaction in a 25 μl volume containing: 0.5 μl Klentaq (Clontech, Palo Alto, Calif.); 4.0 μl 10 mM dNTP's (Perkin Elmer-Cetus); 2.5 μl Klentaq buffer (Clontech); 0.25 μl forward oligo 1; 0.25 μl reverse oligo 2; 12.5 μl distilled water. The sequence of the forward oligonucleotide 1 was:

[0828] 5′-TGTAAAACGACGGCCAGTTAAATAGACCTGCAATTATTAATCT-3′ (SEQ ID NO:563)

[0829] The sequence of reverse oligonucleotide 2 was:

[0830] 5′-CAGGAAACAGCTATGACCACCTGCACACCTGCAAATCCATT-3′ (SEQ ID NO:564)

[0831] PCR was then performed as follows: a. Denature 92° C., 5 minutes b. 3 cycles of: Denature 92° C., 30 seconds Anneal 59° C., 30 seconds Extend 72° C., 60 seconds c. 3 cycles of: Denature 92° C., 30 seconds Anneal 57° C., 30 seconds Extend 72° C., 60 seconds d. 25 cycles of: Denature 92° C., 30 seconds Anneal 55° C., 30 seconds Extend 72° C., 60 seconds e. Hold 4° C.

[0832] The underlined regions of the oligonucleotides disclosed above annealed to the ADH promoter region and the amylase region, respectively, and amplified a 307 bp region from vector pSST-AMY.0 when no insert was present. Typically, the first 18 nucleotides of the 5′ end of these oligonucleotides contained annealing sites for the sequencing primers. Thus, the total product of the PCR reaction from an empty vector was 343 bp. However, signal sequence-fused cDNA resulted in considerably longer nucleotide sequences.

[0833] Following the PCR, an aliquot of the reaction (5 μl) was examined by agarose gel electrophoresis in a 1% agarose gel using a Tris-Borate-EDTA (TBE) buffering system as described by Sambrook et al., supra. Clones resulting in a single strong PCR product larger than 400 bp were further analyzed by DNA sequencing after purification with a 96 Qiaquick PCR clean-up column (Qiagen Inc., Chatsworth, Calif.).

[0834] cDNA molecules isolated from this amylase screen are shown in FIGS. 1-562 (SEQ ID NOS: 1-562, respectively), wherein the nucleotides “N” and “X” represent any nucleotide. The cDNA libraries from which these cDNA molecules were obtained are as follows:

[0835] (a) Human liver tissue

[0836] FIGS. 1-19, 124 and 130.

[0837] (b) Human placenta tissue

[0838] FIGS. 20-73.

[0839] (c) Human retina tissue

[0840] FIGS. 74-75, 81, 107-108, 139-140 and 340-341.

[0841] (d) Human salivary gland tissue

[0842] FIGS. 76-78.

[0843] (e) Human umbilical vein endothelial cells

[0844] FIGS. 79-80, 97, 110, 245-252, 254-260, 263-265, 413-421, 433-437, 444-449, 454-456, 462-467, 477-478, 480-485, 492-493, 515 and 548.

[0845] (f) Human thyroid tissue

[0846] FIGS. 82-84, 90-91, 96, 109, 141-143 and 268.

[0847] (g) Human small intestine tissue

[0848] FIGS. 85-86, 144-161 and 267.

[0849] (h) Human colon carcinoma tissue

[0850]FIG. 87.

[0851] (i) Human lung endothelial cells

[0852]FIGS. 88 and 93-95.

[0853] Human hypothalamus tissue

[0854]FIG. 89.

[0855] (k) Human breast carcinoma tissue

[0856] FIGS. 92, 111-115, 206-213, 228-232, 269-270, 450-453, 534-547, 556 and 559.

[0857] (l) Human aortic endothelial cells

[0858] FIGS. 98-102, 125-129, 136-138, 216-217, 253, 261-262, 300-301, 327-330, 365-367 and 385-387.

[0859] (m) Human uterus tissue

[0860] FIGS. 103-106, 170-173, 176-183, 233-235, 238, 242-244, 266, 311-312 and 557.

[0861] (n) Human lung carcinoma tissue

[0862] FIGS. 106-108, 201-205, 221-227, 271-274, 334-339, 342-348, 350-351, 360-364, 372, 388-408, 411, 431-432, 479, 558 and 560-561.

[0863] (o) Human mammary epithelial cells

[0864] FIGS. 119-121, 214 and 316-320.

[0865] (p) Human chronic myelogenous leukemia tissue

[0866] FIGS. 122-123 and 131-135.

[0867] (q) Human spinal cord tissue

[0868] FIGS. 162, 167-169, 198-200, 236 and 315.

[0869] (r) Human fetal brain tissue

[0870] FIGS. 163-166, 174-175, 332-333, 422-430 and 494-502.

[0871] (s) Human fetal kidney tissue

[0872] FIGS. 184-197, 409-410 and 412.

[0873] (t) Human prostate tissue

[0874]FIGS. 215, 237, 239-241 and 349.

[0875] (u) Human mammary gland tissue

[0876] FIGS. 218-220, 275-276 and 331.

[0877] (v) Human adenocarcinoma tissue

[0878] FIGS. 277-299 and 302-310.

[0879] (w) Human fetal small intestine tissue

[0880] FIGS. 313-314.

[0881] (x) Human fetal lung tissue

[0882] FIGS. 321-326.

[0883] (y) Human testis tissue

[0884] FIGS. 352-359, 368-371, 377-384, 438-443, 457-461, 486-491, 513-514, 516-527 and 562.

[0885] (z) Human MCF-7 cells

[0886] FIGS. 373-376, 468-476, 503-512, 528-533 and 549-555.

EXAMPLE 2 Identification of Full-Length cDNA Molecules

[0887] Oligonucleotide probes may be generated from the sequence of any of the SRT polynucleotide sequences disclosed herein, including those shown in FIGS. 1 to 562 and used to screen human cDNA libraries prepared as described in paragraph 1 of Example 1 above. The cloning vector may be pRK5B (pRKSB is a precursor of pRK5D that does not contain the SfiI site; see, Holmes et al., Science 253:1278-1280 (1991)), and the cDNA size cut may be less than 2800 bp. The oligonucleotides probes may be synthesized: 1) to identify by PCR a cDNA library that contained the sequence of interest, and 2) for use as probes to isolate a clone of the full-length coding sequence for SRT. Forward and reverse PCR primers generally range from 20 to 30 nucleotides and are often designed to give a PCR product of about 100-1000 bp in length. The probe sequences are typically 40-55 bp in length. In order to screen several libraries for a full-length clone, DNA from the libraries may be screened by PCR amplification, as per Ausubel et al., Current Protocols in Molecular Biology, supra, with the PCR primer pair. A positive library may then be used to isolate clones encoding the gene of interest using the probe oligonucleotide and one of the primer pairs.

EXAMPLE 3 Use of SRT Polynucleotides as Hybridization Probes

[0888] The following method describes use of a nucleotide sequence encoding SRT as a hybridization probe.

[0889] DNA comprising the coding sequence of full-length or mature SRT is employed as a probe to screen for homologous DNAs (such as those encoding naturally-occurring variants of SRT) in human tissue cDNA libraries or human tissue genomic libraries.

[0890] Hybridization and washing of filters containing either library DNAs is performed under the following high stringency conditions. Hybridization of radiolabeled SRT-derived probe to the filters is performed in a solution of 50% formamide, 5×SSC, 0.1% SDS, 0.1% sodium pyrophosphate, 50 mM sodium phosphate, pH 6.8, 2×Denhardt's solution, and 10% dextran sulfate at 42° C. for 20 hours. Washing of the filters is performed in an aqueous solution of 0.1x SSC and 0.1% SDS at 42° C.

[0891] DNAs having a desired sequence identity with the DNA encoding full-length native sequence SRT can then be identified using standard techniques known in the art.

EXAMPLE 4 Expression of SRT in E. coli

[0892] This example illustrates preparation of an unglycosylated form of SRT by recombinant expression in E. coli.

[0893] The DNA sequence encoding SRT is initially amplified using selected PCR primers. The primers should contain restriction enzyme sites which correspond to the restriction enzyme sites on the selected expression vector. A variety of expression vectors may be employed. An example of a suitable vector is pBR322 (derived from E. coli; see Bolivar et al., Gene, 2:95 (1977)) which contains genes for ampicillin and tetracycline resistance. The vector is digested with restriction enzyme and dephosphorylated. The PCR amplified sequences are then ligated into the vector. The vector will preferably include sequences which encode for an antibiotic resistance gene, a trp promoter, a polyhis leader (including the first six STII codons, polyhis sequence, and enterokinase cleavage site), the SRT coding region, lambda transcriptional terminator, and an argu gene.

[0894] The ligation mixture is then used to transform a selected E. coli strain using the methods described in Sambrook et al., supra. Transformants are identified by their ability to grow on LB plates and antibiotic resistant colonies are then selected. Plasmid DNA can be isolated and confirmed by restriction analysis and DNA sequencing.

[0895] Selected clones can be grown overnight in liquid culture medium such as LB broth supplemented with antibiotics. The overnight culture may subsequently be used to inoculate a larger scale culture. The cells are then grown to a desired optical density, during which the expression promoter is turned on.

[0896] After culturing the cells for several more hours, the cells can be harvested by centrifugation. The cell pellet obtained by the centrifugation can be solubilized using various agents known in the art, and the solubilized SRT protein can then be purified using a metal chelating column under conditions that allow tight binding of the protein.

[0897] SRT may be expressed in E. coli in a poly-His tagged form, using the following procedure. The DNA encoding SRT is initially amplified using selected PCR primers. The primers will contain restriction enzyme sites which correspond to the restriction enzyme sites on the selected expression vector, and other useful sequences providing for efficient and reliable translation initiation, rapid purification on a metal chelation column, and proteolytic removal with enterokinase. The PCR-amplified, poly-His tagged sequences are then ligated into an expression vector, which is used to transform an E. coli host based on strain 52 (W3110 fuhA(tonA) lon galErpoHts(htpRts) clpP(lacIq). Transformants are first grown in LB containing 50 mg/ml carbenicillin at 30° C. with shaking until an O.D.600 of 3-5 is reached. Cultures are then diluted 50-100 fold into CRAP media (prepared by mixing 3.57 g (NH₄)₂SO₄, 0.71 g sodium citrate•2H2O, 1.07 g KCl, 5.36 g Difco yeast extract, 5.36 g Sheffield hycase SF in 500 mL water, as well as 110 mM MPOS, pH 7.3, 0.55% (w/v) glucose and 7 mM MgSO₄) and grown for approximately 20-30 hours at 30° C. with shaking. Samples are removed to verify expression by SDS-PAGE analysis, and the bulk culture is centrifuged to pellet the cells. Cell pellets are frozen until purification and refolding.

[0898]E. coli paste from 0.5 to 1 L fermentations (6-10 g pellets) is resuspended in 10 volumes (w/v) in 7 M guanidine, 20 mM Tris, pH 8 buffer. Solid sodium sulfite and sodium tetrathionate is added to make final concentrations of 0.1M and 0.02 M, respectively, and the solution is stirred overnight at 4° C. This step results in a denatured protein with all cysteine residues blocked by sulfitolization. The solution is centrifuged at 40,000 rpm in a Beckman Ultracentifuge for 30 min. The supernatant is diluted with 3-5 volumes of metal chelate column buffer (6 M guanidine, 20 mM Tris, pH 7.4) and filtered through 0.22 micron filters to clarify. The clarified extract is loaded onto a 5 ml Qiagen Ni-NTA metal chelate column equilibrated in the metal chelate column buffer. The column is washed with additional buffer containing 50 mM imidazole (Calbiochem, Utrol grade), pH 7.4. The protein is eluted with buffer containing 250 mM imidazole. Fractions containing the desired protein are pooled and stored at 4° C. Protein concentration is estimated by its absorbance at 280 nm using the calculated extinction coefficient based on its amino acid sequence.

[0899] The proteins are refolded by diluting the sample slowly into freshly prepared refolding buffer consisting of: 20 mM Tris, pH 8.6, 0.3 M NaCl, 2.5 M urea, 5 mM cysteine, 20 mM glycine and 1 mM EDTA. Refolding volumes are chosen so that the final protein concentration is between 50 to 100 micrograms/ml. The refolding solution is stirred gently at 4° C. for 12-36 hours. The refolding reaction is quenched by the addition of TFA to a final concentration of 0.4% (pH of approximately 3). Before further purification of the protein, the solution is filtered through a 0.22 micron filter and acetonitrile is added to 2-10% final concentration. The refolded protein is chromatographed on a Poros R1/H reversed phase column using a mobile buffer of 0.1% TFA with elution with a gradient of acetonitrile from 10 to 80%. Aliquots of fractions with A280 absorbance are analyzed on SDS polyacrylamide gels and fractions containing homogeneous refolded protein are pooled. Generally, the properly refolded species of most proteins are eluted at the lowest concentrations of acetonitrile since those species are the most compact with their hydrophobic interiors shielded from interaction with the reversed phase resin. Aggregated species are usually eluted at higher acetonitrile concentrations. In addition to resolving misfolded forms of proteins from the desired form, the reversed phase step also removes endotoxin from the samples.

[0900] Fractions containing the desired folded SRT polypeptide are pooled and the acetonitrile removed using a gentle stream of nitrogen directed at the solution. Proteins are formulated into 20 mM Hepes, pH 6.8 with 0.14 M sodium chloride and 4% mannitol by dialysis or by gel filtration using G25 Superfine (Pharmacia) resins equilibrated in the formulation buffer and sterile filtered.

EXAMPLE 5 Expression of SRT in Mammalian Cells

[0901] This example illustrates preparation of a potentially glycosylated form of SRT by recombinant expression in mammalian cells.

[0902] The vector, pRK5 (see EP 307,247, published Mar. 15, 1989), is employed as the expression vector. Optionally, the SRT DNA is ligated into pRK5 with selected restriction enzymes to allow insertion of the SRT DNA using ligation methods such as described in Sambrook et al., supra. The resulting vector is called pRK5-SRT.

[0903] In one embodiment, the selected host cells may be 293 cells. Human 293 cells (ATCC CCL 1573) are grown to confluence in tissue culture plates in medium such as DMEM supplemented with fetal calf serum and optionally, nutrient components and/or antibiotics. About 10 μg pRK5-SRT DNA is mixed with about 1 μg DNA encoding the VA RNA gene [Thimmappaya et al., Cell, 31:543 (1982)] and dissolved in 500 μl of 1 mM Tris-HCl, 0.1 mM EDTA, 0.227 M CaCl₂. To this mixture is added, dropwise, 500 μl of 50 mM HEPES (pH 7.35), 280 mM NaCl, 1.5 mM NaPO₄, and a precipitate is allowed to form for 10 minutes at 25° C. The precipitate is suspended and added to the 293 cells and allowed to settle for about four hours at 37° C. The culture medium is aspirated off and 2 ml of 20% glycerol in PBS is added for 30 seconds. The 293 cells are then washed with serum free medium, fresh medium is added and the cells are incubated for about 5 days.

[0904] Approximately 24 hours after the transfections, the culture medium is removed and replaced with culture medium (alone) or culture medium containing 200 μCi/ml ³⁵S-cysteine and 200 μCi/ml ³⁵S-methionine. After a 12 hour incubation, the conditioned medium is collected, concentrated on a spin filter, and loaded onto a 15% SDS gel. The processed gel may be dried and exposed to film for a selected period of time to reveal the presence of SRT polypeptide. The cultures containing transfected cells may undergo further incubation (in serum free medium) and the medium is tested in selected bioassays.

[0905] In an alternative technique, SRT may be introduced into 293 cells transiently using the dextran sulfate method described by Somparyrac et al., Proc. Natl. Acad. Sci., 12:7575 (1981). 293 cells are grown to maximal density in a spinner flask and 700 μg pRK5-SRT DNA is added. The cells are first concentrated from the spinner flask by centrifugation and washed with PBS. The DNA-dextran precipitate is incubated on the cell pellet for four hours. The cells are treated with 20% glycerol for 90 seconds, washed with tissue culture medium, and re-introduced into the spinner flask containing tissue culture medium, 5 μg/ml bovine insulin and 0.1 μg/ml bovine transferrin. After about four days, the conditioned media is centrifuged and filtered to remove cells and debris. The sample containing expressed SRT can then be concentrated and purified by any selected method, such as dialysis and/or column chromatography.

[0906] In another embodiment, SRT can be expressed in CHO cells. The pRK5-SRT can be transfected into CHO cells using known reagents such as CaPo₄ or DEAE-dextran. As described above, the cell cultures can be incubated, and the medium replaced with culture medium (alone) or medium containing a radiolabel such as ³⁵S-methionine. After determining the presence of SRT polypeptide, the culture medium may be replaced with serum free medium. Preferably, the cultures are incubated for about 6 days, and then the conditioned medium is harvested. The medium containing the expressed SRT can then be concentrated and purified by any selected method.

[0907] Epitope-tagged SRT may also be expressed in host CHO cells. The SRT may be subcloned out of the pRK5 vector. The subclone insert can undergo PCR to fuse in frame with a selected epitope tag such as a poly-his tag into a Baculovirus expression vector. The poly-his tagged SRT insert can then be subcloned into a SV40 driven vector containing a selection marker such as DHFR for selection of stable clones. Finally, the CHO cells can be transfected (as described above) with the SV40 driven vector. Labeling may be performed, as described above, to verify expression. The culture medium containing the expressed poly-His tagged SRT can then be concentrated and purified by any selected method, such as by Ni²⁺-chelate affinity chromatography.

[0908] SRT may also be expressed in CHO and/or COS cells by a transient expression procedure or in CHO cells by another stable expression procedure.

[0909] Stable expression in CHO cells is performed using the following procedure. The proteins are expressed as an IgG construct (immunoadhesin), in which the coding sequences for the soluble forms (e.g. extracellular domains) of the respective proteins are fused to an IgG1 constant region sequence containing the hinge, CH2 and CH2 domains and/or is a poly-His tagged form.

[0910] Following PCR amplification, the respective DNAs are subcloned in a CHO expression vector using standard techniques as described in Ausubel et al., Current Protocols of Molecular Biology, Unit 3.16, John Wiley and Sons (1997). CHO expression vectors are constructed to have compatible restriction sites 5′ and 3′ of the DNA of interest to allow the convenient shuttling of cDNA's. The vector used expression in CHO cells is as described in Lucas et al., Nucl. Acids Res. 24:9 (1774-1779 (1996), and uses the SV40 early promoter/enhancer to drive expression of the cDNA of interest and dihydrofolate reductase (DHFR). DHFR expression permits selection for stable maintenance of the plasmid following transfection.

[0911] Twelve micrograms of the desired plasmid DNA is introduced into approximately 10 million CHO cells using commercially available transfection reagents Superfect® (Quiagen), Dosper® or Fugene® (Boehringer Mannheim). The cells are grown as described in Lucas et al., supra. Approximately 3×10⁻⁷ cells are frozen in an ampule for further growth and production as described below.

[0912] The ampules containing the plasmid DNA are thawed by placement into water bath and mixed by vortexing. The contents are pipetted into a centrifuge tube containing 10 mLs of media and centrifuged at 1000 rpm for 5 minutes. The supernatant is aspirated and the cells are resuspended in 10 mL of selective media (0.2 μm filtered PS20 with 5% 0.2 μm diafiltered fetal bovine serum). The cells are then aliquoted into a 100 mL spinner containing 90 mL of selective media. After 1-2 days, the cells are transferred into a 250 mL spinner filled with 150 mL selective growth medium and incubated at 37° C. After another 2-3 days, 250 mL, 500 mL and 2000 mL spinners are seeded with 3×10⁵ cells/mL. The cell media is exchanged with fresh media by centrifugation and resuspension in production medium. Although any suitable CHO media may be employed, a production medium described in U.S. Pat. No. 5,122,469, issued Jun. 16, 1992 may actually be used. A 3L production spinner is seeded at 1.2×10⁶ cells/mL. On day 0, the cell number pH ie determined. On day 1, the spinner is sampled and sparging with filtered air is commenced. On day 2, the spinner is sampled, the temperature shifted to 33° C., and 30 mL of 500 g/L glucose and 0.6 mL of 10% antifoam (e.g., 35% polydimethylsiloxane emulsion, Dow Corning 365 Medical Grade Emulsion) taken. Throughout the production, the pH is adjusted as necessary to keep it at around 7.2. After 10 days, or until the viability dropped below 70%, the cell culture is harvested by centrifugation and filtering through a 0.22 μm filter. The filtrate was either stored at 4° C. or immediately loaded onto columns for purification.

[0913] For the poly-His tagged constructs, the proteins are purified using a Ni-NTA column (Qiagen). Before purification, imidazole is added to the conditioned media to a concentration of 5 mM. The conditioned media is pumped onto a 6 ml Ni-NTA column equilibrated in 20 mM Hepes, pH 7.4, buffer containing 0.3 M NaCl and 5 mM imidazole at a flow rate of 4-5 ml/min. at 4° C. After loading, the column is washed with additional equilibration buffer and the protein eluted with equilibration buffer containing 0.25 M imidazole. The highly purified protein is subsequently desalted into a storage buffer containing 10 mM Hepes, 0.14 M NaCl and 4% mannitol, pH 6.8, with a 25 ml G25 Superfine (Pharmacia) column and stored at −80° C.

[0914] Immunoadhesin (Fc-containing) constructs are purified from the conditioned media as follows. The conditioned medium is pumped onto a 5 ml Protein A column (Pharmacia) which had been equilibrated in 20 mM Na phosphate buffer, pH 6.8. After loading, the column is washed extensively with equilibration buffer before elution with 100 mM citric acid, pH 3.5. The eluted protein is immediately neutralized by collecting 1 ml fractions into tubes containing 275 μL of 1 M Tris buffer, pH 9. The highly purified protein is subsequently desalted into storage buffer as described above for the poly-His tagged proteins. The homogeneity is assessed by SDS polyacrylamide gels and by N-terminal amino acid sequencing by Edman degradation.

EXAMPLE 6 Expression of SRT in Yeast

[0915] The following method describes recombinant expression of SRT in yeast.

[0916] First, yeast expression vectors are constructed for intracellular production or secretion of SRT from the ADH2/GAPDH promoter. DNA encoding SRT and the promoter is inserted into suitable restriction enzyme sites in the selected plasmid to direct intracellular expression of SRT. For secretion, DNA encoding SRT can be cloned into the selected plasmid, together with DNA encoding the ADH2/GAPDH promoter, a native SRT signal peptide or other mammalian signal peptide, or, for example, a yeast alpha-factor or invertase secretory signal/leader sequence, and linker sequences (if needed) for expression of SRT.

[0917] Yeast cells, such as yeast strain AB110, can then be transformed with the expression plasmids described above and cultured in selected fermentation media. The transformed yeast supernatants can be analyzed by precipitation with 10% trichloroacetic acid and separation by SDS-PAGE, followed by staining of the gels with Coomassie Blue stain.

[0918] Recombinant SRT can subsequently be isolated and purified by removing the yeast cells from the fermentation medium by centrifugation and then concentrating the medium using selected cartridge filters. The concentrate containing SRT may further be purified using selected column chromatography resins.

EXAMPLE 7 Expression of SRT in Baculovirus-Infected Insect Cells

[0919] The following method describes recombinant expression of SRT in Baculovirus-infected insect cells.

[0920] The sequence coding for SRT is fused upstream of an epitope tag contained within a baculovirus expression vector. Such epitope tags include poly-his tags and immunoglobulin tags (like Fc regions of IgG). A variety of plasmids may be employed, including plasmids derived from commercially available plasmids such as pVL1393 (Novagen). Briefly, the sequence encoding SRT or the desired portion of the coding sequence of SRT such as the sequence encoding the extracellular domain of a transmembrane protein or the sequence encoding the mature protein if the protein is extracellular is amplified by PCR with primers complementary to the 5′ and 3′ regions. The 5′ primer may incorporate flanking (selected) restriction enzyme sites. The product is then digested with those selected restriction enzymes and subcloned into the expression vector.

[0921] Recombinant baculovirus is generated by co-transfecting the above plasmid and BaculoGold™ virus DNA (Pharmingen) into Spodoptera frugiperda (“Sf9”) cells (ATCC CRL 1711) using lipofectin (commercially available from GIBCO-BRL). After 4-5 days of incubation at 28° C., the released viruses are harvested and used for further amplifications. Viral infection and protein expression are performed as described by OReilley et al., Baculovirus expression vectors: A Laboratory Manual, Oxford: Oxford University Press (1994).

[0922] Expressed poly-his tagged SRT can then be purified, for example, by Ni²+-chelate affinity chromatography as follows. Extracts are prepared from recombinant virus-infected Sf9 cells as described by Rupert et al. Nature, 362:175-179 (1993). Briefly, Sf9 cells are washed, resuspended in sonication buffer (25 mL Hepes, pH 7.9; 12.5 mM MgCl₂; 0.1 mM EDTA; 10% glycerol; 0.1% NP-40; 0.4 M KCl), and sonicated twice for 20 seconds on ice. The sonicates are cleared by centrifugation, and the supernatant is diluted 50-fold in loading buffer (50 mM phosphate, 300 mM NaCl, 10% glycerol, pH 7.8) and filtered through a 0.45 μm filter. A Ni²⁺-NTA agarose column (commercially available from Qiagen) is prepared with a bed volume of 5 mL, washed with 25 mL of water and equilibrated with 25 mL of loading buffer. The filtered cell extract is loaded onto the column at 0.5 mL per minute. The column is washed to baseline A₂₈₀ with loading buffer, at which point fraction collection is started. Next, the column is washed with a secondary wash buffer (50 mM phosphate; 300 mM NaCl, 10% glycerol, pH 6.0), which elutes nonspecifically bound protein. After reaching A₂₈₀ baseline again, the column is developed with a 0 to 500 mM Imidazole gradient in the secondary wash buffer. One mL fractions are collected and analyzed by SDS-PAGE and silver staining or Western blot with Ni²⁺-NTA-conjugated to alkaline phosphatase (Qiagen). Fractions containing the eluted His₁₀-tagged SRT are pooled and dialyzed against loading buffer.

[0923] Alternatively, purification of the IgG tagged (or Fc tagged) SRT can be performed using known chromatography techniques, including for instance, Protein A or protein G column chromatography.

EXAMPLE 8 Preparation of Antibodies That Bind SRT

[0924] This example illustrates preparation of monoclonal antibodies which can specifically bind SRT.

[0925] Techniques for producing the monoclonal antibodies are known in the art and are described, for instance, in Goding, supra. Immunogens that may be employed include purified SRT, fusion proteins containing SRT, and cells expressing recombinant SRT on the cell surface. Selection of the immunogen can be made by the skilled artisan without undue experimentation.

[0926] Mice, such as Balb/c, are immunized with the SRT immunogen emulsified in complete Freund's adjuvant and injected subcutaneously or intraperitoneally in an amount from 1-100 micrograms. Alternatively, the immunogen is emulsified in MPL-TDM adjuvant (Ribi Immunochemical Research, Hamilton, Mont.) and injected into the animal's hind foot pads. The immunized mice are then boosted 10 to 12 days later with additional immunogen emulsified in the selected adjuvant. Thereafter, for several weeks, the mice may also be boosted with additional immunization injections. Serum samples may be periodically obtained from the mice by retro-orbital bleeding for testing in ELISA assays to detect anti-SRT antibodies.

[0927] After a suitable antibody titer has been detected, the animals “positive” for antibodies can be injected with a final intravenous injection of SRT. Three to four days later, the mice are sacrificed and the spleen cells are harvested. The spleen cells are then fused (using 35% polyethylene glycol) to a selected murine myeloma cell line such as P3X63AgU.1, available from ATCC, No. CRL 1597. The fusions generate hybridoma cells which can then be plated in 96 well tissue culture plates containing HAT (hypoxanthine, aminopterin, and thymidine) medium to inhibit proliferation of non-fused cells, myeloma hybrids, and spleen cell hybrids.

[0928] The hybridoma cells will be screened in an ELISA for reactivity against SRT. Determination of “positive” hybridoma cells secreting the desired monoclonal antibodies against SRT is within the skill in the art.

[0929] The positive hybridoma cells can be injected intraperitoneally into syngeneic Balb/c mice to produce ascites containing the anti-SRT monoclonal antibodies. Alternatively, the hybridoma cells can be grown in tissue culture flasks or roller bottles. Purification of the monoclonal antibodies produced in the ascites can be accomplished using ammonium sulfate precipitation, followed by gel exclusion chromatography. Alternatively, affinity chromatography based upon binding of antibody to protein A or protein G can be employed.

EXAMPLE 9 Purification of SRT Polypeptides Using Specific Antibodies

[0930] Native or recombinant SRT polypeptides may be purified by a variety of standard techniques in the art of protein purification. For example, pro-SRT polypeptide, mature SRT polypeptide, or pre-SRT polypeptide is purified by immunoaffinity chromatography using antibodies specific for the SRT polypeptide of interest. In general, an immunoaffinity column is constructed by covalently coupling the anti-SRT polypeptide antibody to an activated chromatographic resin.

[0931] Polyclonal immunoglobulins are prepared from immune sera either by precipitation with ammonium sulfate or by purification on immobilized Protein A (Pharmacia LKB Biotechnology, Piscataway, N.J.). Likewise, monoclonal antibodies are prepared from mouse ascites fluid by ammonium sulfate precipitation or chromatography on immobilized Protein A. Partially purified immunoglobulin is covalently attached to a chromatographic resin such as CnBr-activated SEPHAROSE™ (Pharmacia LKB Biotechnology). The antibody is coupled to the resin, the resin is blocked, and the derivative resin is washed according to the manufacturer's instructions.

[0932] Such an immunoaffinity column is utilized in the purification of SRT polypeptide by preparing a fraction from cells containing SRT polypeptide in a soluble form. This preparation is derived by solubilization of the whole cell or of a subcellular fraction obtained via differential centrifugation by the addition of detergent or by other methods well known in the art. Alternatively, soluble SRT polypeptide containing a signal sequence may be secreted in useful quantity into the medium in which the cells are grown.

[0933] A soluble SRT polypeptide-containing preparation is passed over the immunoaffinity column, and the column is washed under conditions that allow the preferential absorbance of SRT polypeptide (e.g., high ionic strength buffers in the presence of detergent). Then, the column is eluted under conditions that disrupt antibody/SRT polypeptide binding (e.g., a low pH buffer such as approximately pH 2-3, or a high concentration of a chaotrope such as urea or thiocyanate ion), and SRT polypeptide is collected.

EXAMPLE 10 Drug Screening

[0934] This invention is particularly useful for screening compounds by using SRT polypeptides or binding fragment thereof in any of a variety of drug screening techniques. The SRT polypeptide or fragment employed in such a test may either be free in solution, affixed to a solid support, borne on a cell surface, or located intracellularly. One method of drug screening utilizes eukaryotic or prokaryotic host cells which are stably transformed with recombinant nucleic acids expressing the SRT polypeptide or fragment. Drugs are screened against such transformed cells in competitive binding assays. Such cells, either in viable or fixed form, can be used for standard binding assays. One may measure, for example, the formation of complexes between SRT polypeptide or a fragment and the agent being tested. Alternatively, one can examine the diminution in complex formation between the SRT polypeptide and its target cell or target receptors caused by the agent being tested.

[0935] Thus, the present invention provides methods of screening for drugs or any other agents which can affect a SRT polypeptide-associated disease or disorder. These methods comprise contacting such an agent with an SRT polypeptide or fragment thereof and assaying (I) for the presence of a complex between the agent and the SRT polypeptide or fragment, or (ii) for the presence of a complex between the SRT polypeptide or fragment and the cell, by methods well known in the art. In such competitive binding assays, the SRT polypeptide or fragment is typically labeled. After suitable incubation, free SRT polypeptide or fragment is separated from that present in bound form, and the amount of free or uncomplexed label is a measure of the ability of the particular agent to bind to SRT polypeptide or to interfere with the SRT polypeptide/cell complex.

[0936] Another technique for drug screening provides high throughput screening for compounds having suitable binding affinity to a polypeptide and is described in detail in WO 84/03564, published on Sep. 13, 1984. Briefly stated, large numbers of different small peptide test compounds are synthesized on a solid substrate, such as plastic pins or some other surface. As applied to a SRT polypeptide, the peptide test compounds are reacted with SRT polypeptide and washed. Bound SRT polypeptide is detected by methods well known in the art. Purified SRT polypeptide can also be coated directly onto plates for use in the aforementioned drug screening techniques. In addition, non-neutralizing antibodies can be used to capture the peptide and immobilize it on the solid support.

[0937] This invention also contemplates the use of competitive drug screening assays in which neutralizing antibodies capable of binding SRT polypeptide specifically compete with a test compound for binding to SRT polypeptide or fragments thereof. In this manner, the antibodies can be used to detect the presence of any peptide which shares one or more antigenic determinants with SRT polypeptide.

EXAMPLE 11 Rational Drug Design

[0938] The goal of rational drug design is to produce structural analogs of biologically active polypeptide of interest (i.e., a SRT polypeptide) or of small molecules with which they interact, e.g., agonists, antagonists, or inhibitors. Any of these examples can be used to fashion drugs which are more active or stable forms of the SRT polypeptide or which enhance or interfere with the function of the SRT polypeptide in vivo (c.f., Hodgson, Bio/Technology, 9: 19-21 (1991)).

[0939] In one approach, the three-dimensional structure of the SRT polypeptide, or of an SRT polypeptide-inhibitor complex, is determined by x-ray crystallography, by computer modeling or, most typically, by a combination of the two approaches. Both the shape and charges of the SRT polypeptide must be ascertained to elucidate the structure and to determine active site(s) of the molecule. Less often, useful information regarding the structure of the SRT polypeptide may be gained by modeling based on the structure of homologous proteins. In both cases, relevant structural information is used to design analogous SRT polypeptide-like molecules or to identify efficient inhibitors. Useful examples of rational drug design may include molecules which have improved activity or stability as shown by Braxton and Wells, Biochemistry, 31:7796-7801 (1992) or which act as inhibitors, agonists, or antagonists of native peptides as shown by Athauda et al., J. Biochem., 113:742-746 (1993).

[0940] It is also possible to isolate a target-specific antibody, selected by functional assay, as described above, and then to solve its crystal structure. This approach, in principle, yields a pharmacore upon which subsequent drug design can be based. It is possible to bypass protein crystallography altogether by generating anti-idiotypic antibodies (anti-ids) to a functional, pharmacologically active antibody. As a mirror image of a mirror image, the binding site of the anti-ids would be expected to be an analog of the original receptor. The anti-id could then be used to identify and isolate peptides from banks of chemically or biologically produced peptides. The isolated peptides would then act as the pharmacore.

[0941] By virtue of the present invention, sufficient amounts of the SRT polypeptide may be made available to perform such analytical studies as X-ray crystallography. In addition, knowledge of the SRT polypeptide amino acid sequence provided herein will provide guidance to those employing computer modeling techniques in place of or in addition to x-ray crystallography.

[0942] The foregoing written specification is considered to be sufficient to enable one skilled in the art to practice the invention. The present invention is not to be limited in scope by the construct deposited, since the deposited embodiment is intended as a single illustration of certain aspects of the invention and any constructs that are functionally equivalent are within the scope of this invention. The deposit of material herein does not constitute an admission that the written description herein contained is inadequate to enable the practice of any aspect of the invention, including the best mode thereof, nor is it to be construed as limiting the scope of the claims to the specific illustrations that it represents. Indeed, various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description and fall within the scope of the appended claims.

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base <400> SEQUENCE: 2 acgttcgcgg ttcgaggtta gggccccgga agcccgcagt aattncacgt 50 nttcccgccc gnttccggcc ccccagtgcc gcccttcgcg ggccggaggc 100 gcgagtctgg gctttggcgc cttcgcagcc gcaggcgaca tcctctttcc 150 tagctaaagc cccaaacgcc caggtggctt cctgggagag cacggctgag 200 cctccgcctt cagatcagaa caggcagagc ctccaagggc ggcttgggcc 250 cagtgcctgc ttatcctgcc cgtctctcca cacttcttct ttccctgtcc 300 gttggagtcc attccttcct ggaaaagcca aagccgcgct cccctaagag 350 tcatgtgtta ctggattaat tgaaattctt gataggtaac agagttttat 400 catcagctta tgattgccta tgactagctc aaagttaagt tttaataaac 450 tagtaagtac aataaacctc attcctaaat acaaggaaaa gaactatata 500 atgaatactt gtctctatgc ccctctcgca tagataacaa taatttaggt 550 ttacctttaa atgaactgca tttaaatgaa attaatttaa atgattgttt 600 cacggcacag tttcatcaat ggtctacggt atcccttatt tatgtataca 650 tcagtttgta tacatctgta tctatgtatt tg 682 <210> SEQ ID NO 3 <211> LENGTH: 835 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 1, 6, 12, 27, 29-31, 49, 53, 56, 58, 61-62, 66, 68, 71, 74, 78-81, 85-86, 88, 91, 95, 98, 102, 105, 109, 111, 115, 126-127, 131, 139, 142, 146-147, 157, 163, 166, 169, 175, 177, 184, 196-197, 199, 210, 215, 217, 219, 222, 228, 234, 236, 238, 240-241, 244-245, 257, 260, 263, 271, 279, 287, 291-331, 335, 337, 345, 384, 392, 418, 438, 459, 465, 478, 499, 501, 507, 533, 562, 579, 587, 598, 616, 630, 656, 661, 667, 671, 684, 702, 746, 811, 824-835 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 3 nagaanggaa gngaaggagg aagaggngnn naagagggag gggaaaagng 50 ganggngnag nngagnangg nggnggannn naggnngnag naggnccnag 100 anggnaagng nttgnaagaa aggganngcc nggtaaaana gnaccnnccc 150 aagaagngat tanggnggnt tcctngntga aggntgtgga tcccanntnt 200 ttcccgggan ttatngntng gnaacaanat ttcnangngn nacnnaggca 250 aacaatnaan ttnccaaggt nttggtagna tttcccncgg nnnnnnnnnn 300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngatntnggg gtttntcccc 350 tttccccttc ccctttcccc accccggggg ttcnggttgg tnaagaaaaa 400 aaaaaaaaaa aagaattntg gcgcggcctc ggcggagntg gtgatcggct 450 ggtgcatant cggcntctta ctactggnta ttttggcatt ctgctggana 500 natgttngta aataccaaag tcggcgggaa agngaagttg tttccaccat 550 aacagcaatt tnttttttag caattgcant tatcacntca gcacttgnac 600 cagaggaaat attttnggtt tcttacatgn aaaatcaaaa tggtacattt 650 aaggantggg ntaatgntaa ngtcagcaga cagnttgagg acactgtatt 700 anacggttac tatactttat attctgttat attgttctgt gtgttnttct 750 ggatcccttt tgtctactta tattatgaag aaaaggatga tgatgatact 800 agtagatgta ntcaaattaa aacnnnnnnn nnnnn 835 <210> SEQ ID NO 4 <211> LENGTH: 491 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 181, 213, 251, 335, 345-346, 350, 357, 374, 381, 387, 398, 401, 403, 427, 442, 447, 451, 463, 481, 484, 486, 489 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 4 agtttgttaa aaataataat gccaataata tatgttattt aacgtatgtt 50 tataacagat gcacgcttat ttatacttat gtgtaagtga aataaatggc 100 aaaaatgata caaggcatag gaagaagaaa ttaggattat atgctatgta 150 agaagcagta tagtgttttt tgaaaataga nttgaattag ttggaaatcc 200 atattgaaaa ctntcgggca aacattttta aaaaataaaa aaatgatatg 250 ntaagaaaga agagaaaacg gaattacaca aaatgctcaa ttaaaaccac 300 aaaaggaagc aaaagtgtgg aaaacaaaaa ggggnacaaa gaatnnggcn 350 acaaacngca aacagtaaca attntggtaa ncattantcc aattatantt 400 ncnattactc taaatatcaa tgttttnaat atgtctattg tnagacngag 450 nttaccagag agnacacatt atataaggtc ngangngtng g 491 <210> SEQ ID NO 5 <211> LENGTH: 637 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 4, 12-13, 31, 37, 40, 43-44, 46, 50, 55, 64, 68, 78, 97, 114,124-125, 137, 148, 183, 185, 227, 233, 236, 238, 264, 266, 268, 276, 322, 325, 334, 340, 345, 417, 426, 428, 472, 474-475, 482-484, 500, 502-503, 509-510, 521, 540, 543, 558, 588-589, 594, 598, 606, 616, 631, 633 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 5 ttcnttgtca anngtttttg gttccccctt ntttccnggn ttnntntttn 50 ggaanaaaaa tttnaagnta taccaagnaa aaaattaaat tccaagnatt 100 ggattgaatt cccnggggat cttnnagaga tcccttngac tttgaccnaa 150 gggtccggct ttaggggaag aagttggtgt ttngntgggc cctggtactg 200 aagacgcgtt ccgggtagcc caaagangtt tcntantnac ccaaagcccc 250 gcacccgcct tttntntntt ttcttntggc aggatgaggc gtgcaggcct 300 gggtgaagga gtacttcctg gnaantatgg gaantatggn tatgntaata 350 gtgggtatag tgcctgtgaa gaagaaaatg agaggctcac tgaaagtttg 400 agaagcaaag taactgntat aaaatntntt tcccattgaa ataggccatg 450 aagttaaaac ccagaataaa tnannagcgg annnggatta aaaagacgan 500 tnnacaacnn tgattttgta ngtataacta tgggcataan tgnagatttt 550 ttccagangg agctaaacaa agatgttgtg agatatgnng aggntatnat 600 taattntcaa gtttgntcac ataggcgagc ntnaaac 637 <210> SEQ ID NO 6 <211> LENGTH: 969 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12-13, 25, 46, 49, 53, 64, 94, 118, 134, 140, 153, 155, 164, 172, 175, 177, 182, 184, 191, 210, 218, 221, 223-224, 240, 242, 250, 259, 266-267, 272, 276, 298, 305-306, 319, 339-340, 344, 346, 348, 353, 384, 397, 408, 432, 455, 457, 470, 474, 480, 502, 504, 519, 525, 559, 579, 597, 625, 629, 631, 634, 645, 649, 655, 657, 666, 670, 675, 681, 697, 768, 773, 776, 786, 788, 791, 794, 816, 819, 830, 859, 877, 879, 886, 895, 904, 910, 913, 918, 925, 927-946, 952, 956, 958, 962, 966, 968-969 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 6 cccctttttc cnnggttttt ttttnggaaa aaaatttcag gggtanccng 50 ggnaaaattt aaantccagg gtttgggggg atttccccgg ggtncttttg 100 gagttccttt ggacctgnaa caaagggttg gaantaaaan aaaaattaaa 150 aancngggtt tttnggggaa anttnanaat gngnttgggg ncaagaaaaa 200 tgggtttttn gggagggnaa ngnnggttca tttccaaatn gnaggggggn 250 aaaaatttna ggcttnnggg gnaggnggaa aaaaatttcg tagcctcnag 300 gttgnnattt ttaaacctnc agaaggtggc cagccccgnn tcancngntg 350 atnaaggcag atgggaaaag ggggatatgg ggtnataagg gtacctntca 400 cccttttnga aggaaaaaaa gtggtccaca gnatttttgt ttacccaagg 450 gtaananatg gaattttgtn gaanataggn gaatggtgag gcatttggaa 500 anangggggg gggtttttnt tgaanggggg agtaggggta tggtatttta 550 tgggaaaana gttttttggc actaaaccnt tttgaattac ctaatanatt 600 tatgtggaaa cctgtccttt ttttncagnt naanaaaaat ttttncccnt 650 gaaantnatt tttagnaagn atatnaaaag natttttttt ttcaagngtc 700 agaaaccttt tagcatcatt gaagttaaaa tgactgtcca taaacttttc 750 agaaatagta ggcatttnag gcnacnagat ttgtanangg natnttcata 800 gaattatacc agtganttna ccacctgaan cctcttggat cccgtaagca 850 ttctttgcna caaggaaggg aggtatncng ggtaantcct tgaanttttg 900 gacnggaacn atnacttnga atttnannnn nnnnnnnnnn nnnnnngccg 950 cngggncntt tntcgngnn 969 <210> SEQ ID NO 7 <211> LENGTH: 952 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 1, 3, 7, 23, 30, 38, 49, 53, 64, 68, 84, 90-92, 109, 130, 147, 152, 182, 198, 211, 221-222, 228, 239, 243, 255, 271, 300, 303, 308-309, 314, 322, 331, 337, 340, 345, 359, 377, 381, 385, 412, 422, 452, 463, 469, 475, 541, 547, 586, 777, 780-781, 784-787, 789, 798, 802-803, 825, 831, 838, 840, 853, 855, 863, 865, 872, 885, 889-890, 907, 921-952 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 7 ngntttngtt cccttttttc ccnggttttn tttttggnaa aaaaatttna 50 ggnttaaccc aggnaaanat taaattccaa gggntttggn nngaattccc 100 cgggggttnc ttttaggggt tcctttgacn ttgaaccaaa ggtttcnggc 150 cnggaggggg gggggaccgg ttttttcccc cngcgtttcc cccggggntg 200 ggggttgggg ngcccatttg nngaagtnag tggggaggng gantgggaac 250 ccggnagttt tggagaaagg naggttcctt ccttaaccct gggggttccn 300 ggngcccnng gagnggcagt tnggggaata ntgtttnagn ggttnggggg 350 gttttcctng ggtcccgcca agggggnggt ncttnataaa agggtgcctt 400 tttccccaca gnttccaggt cngagaggag ccgcaccgtc gggttggaga 450 tngcgcgcaa ggnggcttnt ggttnggatt tgccccgcat cggccacagg 500 aaaagcctgg tccctaggca cggttgtggt tcgagctttt ngttttntcg 550 aacattgagg tattcgctca gcccaccacg ttgtcntcgg ggttattagg 600 ccccagtcac aagccctatg atgttttcag acttcccagg tggagataag 650 gaaaatttta ctatttctgc agaacttctg ttgatgtaca gcattgtatt 700 tagcaacttc tgtgtagatc tgaaaataaa tacattacca attgttagtt 750 gcgtttttat taatataatt ttagagnagn ngannnngnt gttagacnta 800 cnnaggtaaa ttatgtggca ctttngcatt nttgttgntn catgttcccc 850 tgnantttgc ttngngattt cnatttattc caaantcann atagaatgta 900 atttccnaac ccacagtccg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 950 nn 952 <210> SEQ ID NO 8 <211> LENGTH: 752 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 4-6, 8, 11, 34, 37, 40, 87, 123, 125, 133-134, 138, 143, 147, 166, 171, 174, 199, 242, 263, 302, 305, 333, 363, 380, 423, 425, 463, 527, 534, 539, 547-548, 553, 556, 561, 583, 604, 607, 615, 618, 621, 624, 628, 638, 641-643, 646, 648, 654-655, 658, 660, 666, 674, 676, 679, 688-689, 704, 710-725, 727, 730, 735, 739, 741, 745, 747, 749, 751-752 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 8 ggannngntt ncaaaatggg atttttaacc aaantanggn agagaaaagt 50 ttaagtgttt tgccaaaaaa attccaagga aaataangcg gagtttgatt 100 tttcagagtt caacaggaaa aangngaaca aanngccngg agntttnaaa 150 gttttgggaa agccantttt natntgttca aggaacagtt tttatttgng 200 atgccaatca gaattttgga cccagtataa tcaaggtcag antttcaacc 250 taagcctgga ccngacccat aataacggaa agtttaacaa tgactcacat 300 tntcntaaag tttccagcca gaataggaca cgntcatttg gtcattttcc 350 cggtccagag ttnttggatg tagagaaaan tagcttttcc caggaacaat 400 tttgtgattc cgcaggagaa ggntntgaaa gaatacatca agattttgaa 450 tttggtgatg aanttagcag cagctccact gaacagataa gggcaaccac 500 acctccaaat caaggaaggc cagattntcc tgtntatgnt aaccttnnag 550 aantgnaaat ntcccagtat ggtcttcccc canttcttgg gagcctggta 600 attnagntta ttggngcntg nganactnat atagacanct nnnggngntg 650 ttannatnan cacagnggga catngnatng aagttggnna cctcttgctt 700 ggantcgggn nnnnnnnnnn nnnnncntcn ccgcngggnc ntttntngng 750 nn 752 <210> SEQ ID NO 9 <211> LENGTH: 478 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 9 agtttgttaa aaataataat gccaataata tatgttattt tacgtatgtt 50 tatacagatg cacgcttatt tatacttatg tgtaagtgaa ataaatggca 100 aaaatgatac aaggcatagg aagaagaaat taggattata tgctatgtaa 150 gaagcagtat agtgtttttt gaaaatagac ttgaattagt tggaaatcca 200 tattgaaaac tctcgggcaa acatttttaa aaaataaaaa aatgatatgc 250 taagaaagaa gagaaaacgg aattacacaa aatgctcaat taaaaccaca 300 aaaggaagca aaagtgtgga aaacaaaaag gggaacaaag aataaggcaa 350 caaacagaaa acagtaacaa atatggtaag cattaatcca actatattaa 400 taatcacttt aaatatcaat ggtctaaata tgtcaattat aagacagaga 450 ttaccagagt ggacacatta tataagct 478 <210> SEQ ID NO 10 <211> LENGTH: 279 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 90 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 10 tttttttttt tttttttttg agacggagtc ttgctctgtt acccaggcgg 50 agtgcagtgg ccatgatctc ggctcactgc actccagccn ggatgacaga 100 atgagactct gtctccaaaa ataaaataaa ataaaataaa agtgatatga 150 acataaaagt accttaggtc caaacaatga taacaactaa tatttattgg 200 gcgcttactg tggtatgcat tgtgttaagc atttcacatg tatttactca 250 tttaatcctc acaaccatcc taaaaggtc 279 <210> SEQ ID NO 11 <211> LENGTH: 171 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 11 gttccacgtt gcttgaaatt gaaaatcaag ataaaaatgt tcacaattaa 50 gctccttctt tttattgttc ctctagttat ttcctccaga attgatcaag 100 acaattcatc atttgattct ctatctccag agccaaaatc aagatttgct 150 atgttagacg atgtaaaaat t 171 <210> SEQ ID NO 12 <211> LENGTH: 615 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 53, 62, 104, 109-110, 134, 147, 159, 170-171, 209, 275, 304 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 12 cggaattact gttccagccg gctcgggtgg ttttccttgc gttcccgcca 50 cgnggcggct cntcactaaa aggctgccct tctcccccac agctccaggt 100 cccnagagnn gccgcaccgt cgggttggag atcncgctca agggtgncct 150 ctgggtctnc atctgccccn ncatcggcca caggaaaagc cctggtcccc 200 taggcacgnt cgtggttcga gcttttcgtt ctctcgcaca ttgaggtatt 250 cgctcagccc accacgttgt ccctncgggg ttattaggcc ccagtcacaa 300 gccntatgga tgttttccag acttcccagg tggagataag gaaaatttta 350 ctatttctgc agaacttctg ttgatgtaca gccattgtat ttagcaactt 400 cgtgtagatc tgaaaataaa tacattacca attgttagtt gcgtttttat 450 taatataaat cttagagtac ttgattttgc tgttagcttt acttaggtaa 500 attatgtggc actctagcat ttttgttgtt gcatgttcca ttgaactttg 550 ctctgtgttt tccatttatt ccaaattcaa aatagactgt aacttcccaa 600 tttattctat gttcc 615 <210> SEQ ID NO 13 <211> LENGTH: 1207 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 567, 675, 710, 733, 831-833, 1036 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 13 aacggacata gctcagaggg gttaagtgat cagtgcaggt tcacataact 50 aagtaatgac acagatggga cctgaacctg ggtctcagga ggctctggtc 100 cctggccaaa ctatgtgact atgtacatcc acctggtttc tgctcatggg 150 ttagtgtgtg acaggaacat tccatgatgg ctgcagcctc catcccaggg 200 gcacttggag aagccattcc actcagcccc cttgaccaga agaacccttg 250 ggatggaaaa gggaatcctg attctgcaac tacgtgctcc catgagatct 300 gattttcagc cagggctgat ccgtggctgc cagcaaggaa gccacatcat 350 ctcattgtta ctagactggc ccggctgaaa gattagacaa caacgtttac 400 tttgccatta gccctgcctg gcactcagta tggtattgcc tggctttcag 450 gggcactggt tacagtgtct ccgatgcagg gcagcccctg ccaagggcac 500 aggtgttcat aaatattcca tgaaccaatc aaatcagcca tggaatgaga 550 tctaaggaac ctattcncgg caagcctgag acgaacactt aagcatgata 600 atgttatcaa cctggtctga taggcattgg ggcactggtc cctcgcattt 650 tcaatcaggg tctcacccag ggacngatct ccaacaccaa aaaaacttgg 700 tttttccatn cccattccaa actgggctct ccnccaaatg cccttagggc 750 attgggggca agctggtccc cttggcaggt tttttcattc gaggttctca 800 cccccggggg accggggatc ttccaacacc nnnggggaac cttgtgtttt 850 ccactcccca gtcccagacg tgggctgctt ctccagagat gcccgcaggt 900 tttaaaagtt aaattgatga taactttttt ggctcaagta tagaagtaat 950 acattatcca ttgtagatta tttataggta aataaaattt tttaaatgac 1000 ttttaacccc actacccaga actaaccacc actggnggta gtaaatgaat 1050 atattgattt acttacaaat ataggaccac aagatatggc acatgttttg 1100 caaccaacct gttttgatag gcccagcttg cttctgctgc gctactttat 1150 ttgcaaccca aacccgcttt taaaagaaaa atcatggtct tgtattttac 1200 aagtgat 1207 <210> SEQ ID NO 14 <211> LENGTH: 789 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 552, 576 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 14 atcgattata aaagcagaaa tttcacctgg ctgcccaccc caatttcagt 50 tttcctctaa gagttagcca ctattatccc ttcagagtgg atattcaggc 100 ttttctttcc tggcatggac atacatatgt aaatgtacat atataaaaat 150 aattagtgac accatgcatg gtagctcacg cctgtaatcc cagcactttg 200 ggacgctgag gtgagagaat tgcttgaggc catcagtttg aagctgcagt 250 gatctatgat tgtgcctcta cactccagcc tgggtgacag ggtgagaccc 300 tgtctcttaa aaaaaaattc gtatttgggg ttagtagtag tacctacctc 350 ataggttatt atgggatcag tacagtaggc cagacaaagt gcgtatgcta 400 ttattttgca tgtagtaagt accagcatat actacctgtt atccagaaat 450 ttgctgaaat gtcccttgta ttttctctct ttcgattttg atcagtcttc 500 ctagaagtca tcagtttgag ttttttcaaa gaaccagtgg ttggtttaat 550 gnatttggtt tgttttcttt tccaangatt tctgctttac tccttaataa 600 ttcccttttc tgctggcttt gggttccatt tgttcttctg tctcttctag 650 tttcttaagg taaaggctta gatcattgac ttcagatttt ttgtcttttc 700 taacaagtgt tcaaaactat aatataaatt tccctctaag cattgtttag 750 ccacatttca caaatttgga aatgtttatt cattttcac 789 <210> SEQ ID NO 15 <211> LENGTH: 294 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 15 ttttattaat tttatttttt ttttaataca gattttccag tgaggggctt 50 tttcaacccc attggttcta ttttcttgta tttttccatt taatttgctt 100 cataacttaa accaagtctc ttctagtctt aggtattatt tctcgatttt 150 gtgctgatgg gcatgtttat aagaactgga gaggtgattt attggaatga 200 actaactgac ttcctccatt cccctcttcc tttttgacat gaattttact 250 acttcacaaa tgaagaatga tgttatgaag ttaccgtggc aaag 294 <210> SEQ ID NO 16 <211> LENGTH: 514 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 16 cccacgcgcc gctaacccaa tgttcttttt tagaatttca ggttgtggca 50 tccactgagt atgcagctac tatggttttt gtatgggacg tataaatact 100 tgattatata cgacagattt taatgtcttt aaagacttcc tgctgtatta 150 acatattgta atggagtctt ttaaatacta ggttgaattt aattgaagtc 200 acacacatct tgaagtggta actgcatagt aaatactacc aagagttttt 250 ttcacgtggg agtatcctaa aactctgcca tgggtgtaaa tgttttacat 300 taatttcata attggacaga ccctgcattt agcgaaaaca ttttgttttg 350 aaagtgtgtt ctttttgtcg cactgttact gcgtaacact tctcaacatt 400 ctgtaagtta aattatttta aaataactat ggtgaattca tgtttatttt 450 tttttacttt gaaaattgta gtactcaggt ggtatttaat gggaaaggat 500 cctttgggta taaa 514 <210> SEQ ID NO 17 <211> LENGTH: 501 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 57, 60, 97 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 17 aatgtccttt tttaggaatt ccaggttntg gcatccacgg gggttgccgc 50 ctactanggn ttttgtaagg ggaccgtata aataactgga ttatatncga 100 cagattttta atgtctttaa agacttcctg ctgtattaac atattgtaat 150 ggatctttta aatactaggt tgaatttaat tgaagtcaca cacatcttga 200 agtggtaact gcatagtaaa tactaccaag agtttttttc acgtgggagt 250 atcctaaaac tctgccatgg gtgtaaatgt tttacattaa tttcataatt 300 ggacagaccc tgcatttagc gaaaacattt tgttttgaaa gtgtgttctt 350 tttgtcgcac tgttactgcg taacacttct caacattctg taagttaaat 400 tattttaaaa taactatggt gaattcatgt ttattttttt ttactttgaa 450 aattgtagta ctcaggtggt atttaatggg aaaggatcct ttgggtataa 500 a 501 <210> SEQ ID NO 18 <211> LENGTH: 197 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 42, 57 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 18 cttcataact taaaccaagt ctcttcnagt cttaggtatt anttctcgat 50 tttgtgntga tgggcatgtt tataagaact ggagaggtaa tttattggaa 100 tgaactaact gacttcctcc attcccctct tcctttttga catgaatttt 150 actacttcac aaatgaagaa tgatgttatg aagttaccgt ggcaaag 197 <210> SEQ ID NO 19 <211> LENGTH: 526 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 60, 74, 97, 111, 165, 208, 221, 225, 227, 356, 371, 398 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 19 tggggccccc ccaaccccgg cnggtatcca aggaaaaaat tttttattat 50 ggggtttccn ggaactattt gggncctatg gaaatagccc ttaaagngct 100 tacattcatg ngctacttta acatgaatgg agaaaatccg tttatggaag 150 tacagtgaca attgncccaa tcactctgtc catcaaacca ctcaggctag 200 tttgtacnag tagagttttg nttcnanttt tatttttatt aattttattt 250 tttttttaat acagattttc agtgaggggc tttttcaacc ccattggttc 300 tattttcttg tatttttcca tttaatttgc ttcataactt aaaccaagtc 350 tcttcnagtc ttaggtatta nttctcgatt ttgtgctgat gggcatgntt 400 ataagaactg gagaggtaat ttattggaat gaactaactg acttcctcca 450 ttcccctctt cctttttgac atgaatttta ctacttcaca aatgaagaat 500 gatgttatga agttaccgtg gcaaag 526 <210> SEQ ID NO 20 <211> LENGTH: 379 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 40, 103, 125, 127, 204, 219, 378-379 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 20 cagctccgga agactatgca cccaagcacc aaacttccan ccagagagag 50 agacgtcctc cgataacaaa aatccttgct tcctctgtct gtgactttac 100 acncagttgt tcaaagttgt taaangncaa gagtcaatca catccctagg 150 actacctccc aactctcctg actcttatgt tattgaaaaa acaaacaaac 200 aaanactcct ttatgatgnt attcaacttg agtggggttt ttttttccac 250 tttggtcctg gatataatga aatgatacat attaggataa attttcactg 300 tgtatagtag caatacgaac acacatgcca atgtatcaac atatctactt 350 ggttacattt tggtttatga taatcgann 379 <210> SEQ ID NO 21 <211> LENGTH: 408 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 102, 153, 167, 230, 251 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 21 tggaataact ggaaatttat tggatccagg ttccacattg gcagtttgga 50 aactactacc aaaaagattt caccaattta caactccatc attagtaaga 100 angcctgttt gcctatagtc tgccaacctg aacccttaaa aatttttgcc 150 aanctggtag gcaaaantct ttcttttctt tgaatattaa tgaggaggaa 200 catcttttca tgtttcttgg ccatttgcan ttcctattat gaattgcttc 250 nggcccattt tccttttttt aattatgaaa gtctaatgac taccttctca 300 ttgtataaaa aacacagttc tttgaataga gagacccttt tctccaatgc 350 taccaatcac attccactta ccacagttta acatacatcc tctagtcacc 400 tttcccga 408 <210> SEQ ID NO 22 <211> LENGTH: 453 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 31, 87, 175, 263, 297-298 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 22 tagggtccta ttggttgcct aagcatactt nttaacttgt gccattggcc 50 tttactttta tggagttttc aggaaactat tttatancat ctagttattt 100 agtctacgta tctctattta gtggagcctt ttcccctcaa ataatatatt 150 ttatcatttt tggacttata taaancataa ttaaataaat tttttcttaa 200 tactgttgga ctttgtatat acaagttcag ataacttttt cgaagatagt 250 ttcttatata aangtaattt aatttttttt actcttctat acagttnntt 300 agatgtaaag gaattagcac aatctctggc agttttataa aagctgttga 350 agctcttgtc ctgcactgtc tttaggtatc ataggtatca ggtttgcttt 400 gtgttaatgc cacttcaagt cattatttgg tttctgctat ttttttacct 450 gag 453 <210> SEQ ID NO 23 <211> LENGTH: 356 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 42, 45, 201-202 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 23 atacatatat atgtgtgtgt gtgtgtgtgt gtgtatgtat anatntaatc 50 atttacactc ttttgggggt caagaatttg aatgaagaaa aacaaatcca 100 attaattttg gcttccagtt acttctgata aaatcagtga aggttcttgg 150 attttgaaat ctcagttgtg cattgctttt tttagatcct gccaggttac 200 nnttttttaa ataacatgta caaattcatc tttttcagta tagactattg 250 taagtttttg gaaattgtta tagtcataga accatgatca ctaacaagat 300 atattccccc actccaaagt cctatgtgtt ccttttgtag ttaacctgtc 350 acccac 356 <210> SEQ ID NO 24 <211> LENGTH: 498 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 49, 102, 141, 147, 171, 324-325, 339-341 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 24 acccttgacc caacgcggcc ccccgaccgn ttcatggcca aacgcgggnc 50 tccagctgtt gggcttcatt ctccccttcc tgggatggac cggcgcccat 100 cntcagcact gccctgcccc agtggaggat ttactcctat nccggcnaca 150 acatcgtgac cgcccaggcc ntgtacgagg ggctgtggat gtcctgcgtg 200 tcgcagagca ccgggcagat ccagtgcaaa gtctttgact cccttgctga 250 atctgagcag cacattgcaa gcaacccgtg ccttgatggt ggttggcatc 300 ctcctgggag tgatagcaat cttnntggcc accgttgtnn ntgaagtgta 350 tgaagtgctt ggaagacgat gaggtgcaga agatgaggat ggctgtcatt 400 gggggcgcga tatttcttct tgcaggtctg gctattttag ttgccacagc 450 atggtatggc aatagaatcg ttcaagaatt ctatgaccct atgaccga 498 <210> SEQ ID NO 25 <211> LENGTH: 466 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 304 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 25 ttttcttttt tctctttttt aaattacctt tgttttgcgg taaggagttg 50 gggaatttgt ggtggcaggg aagtaatgta agttgcttta taactcactg 100 tctaacaaag ttttgaaaat ttgtctgata tgtaattagg tactttaggg 150 ttattaggtt ttcataaaaa ttctggttag ggctcttgcc ctgctcccaa 200 tgaaagcctt tccacagggc aaatataaaa gagagagtag agggaatccc 250 cctgaggttt aaataagtca aaccagtaag taatagtgct aagtttgtca 300 gtgncctctc tttcttactg tacttaacat ctaaagggca cctcatttat 350 tttcagctaa ttatgttctt tatgagtgac tgtcaaatca gggaagggtg 400 tgacgatcat gtggagatac cttttctaat taatagctgc cttgctcctc 450 aagattctga cgaacc 466 <210> SEQ ID NO 26 <211> LENGTH: 409 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 36, 68, 77, 119, 235, 248, 250-252 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 26 cttcttgaca ctgccctttc ccttcccccn tcccancctg cccgacccat 50 gcccgcgggc gtgcccangt cccaccntac ttgaaaaatg ttcgccagcc 100 agtctccttg gcccatgtnc gcaggggcag aagtggtgcc acaggtacta 150 ccgaccggac ctgacaatac ctgaaattcc caccaaagcg tggagaactc 200 aaaacggagc ttttgggact gaaagaaaga aaacncaaac ctcaagtntn 250 nncaacagga ggaacttaaa taactacgtc caagaattct gtgaataata 300 taagtcttaa atatgtattt cttaatttat tgcatcaaac tacttgtcct 350 taagcactta gtctaatgct aactgcaaga ggaggtgctc agtggatgtt 400 tagccgcga 409 <210> SEQ ID NO 27 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 37, 42, 62, 79, 81, 129, 132-133, 176, 179, 229-230, 248, 375 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 27 cgtgaaacac ccctttattt ccttcataac tactcantat gnctatttcc 50 ttcaccagat gnaagctcct gagctcagnc nctgactgtc tttttcaaca 100 ctgactagta cataacaggc acccaatant tnnttaattg tggtaaaata 150 tacataacaa agttaccatt ttaagnatnt aattcagcag cgttacatac 200 attcaaattg ttgtgcaacc atcaccacnn tccatctccg gaactttnta 250 tcttcccaag ctaaggctct tggcccatta aacaataact tctaattgca 300 cccttccctg tccaccctgg tgaccatcat tctgcactct atgaatttgg 350 ctactttatg tcccccaaat aagtngaatc ataccgaccc 390 <210> SEQ ID NO 28 <211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 43, 105, 115, 245-246 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 28 tggcatgtgg gcccatttca gtttccctac atgttcccaa aanttattta 50 aattactgtg tccaaaatta tgaggacagt gtcattcatt caccatagtt 100 tatantctta gttanatatc aaacttcctt ggcacctagg ataagaacat 150 ttcttttgaa gttatccaat ttttttttat ttttacttga cttgaaggaa 200 agttggaaaa tatggtggaa aaaatcttcc gcattaaaag ggtcnntaaa 250 acacaaccat ttacgatctc agtcagcaga tttactctac tcaaggaaaa 300 aaagaaacaa tcttattgga agcagatgtt gacactgtgt cagttattga 350 agacggaagg agttcacttg agccattgca gttacaaagg ggtattgatc 400 ga 402 <210> SEQ ID NO 29 <211> LENGTH: 300 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 39, 47, 112, 134, 142, 144, 149, 177, 183, 234, 251, 257, 287, 297 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 29 tctgcccctg aaatatacaa gggtcatgcc caaattaana caggttnacc 50 tttgtagagg taaatatgtt ggcattattt attgacattt atgcttcaag 100 catgtcttat tntatgtaat tttaagaaat actntattta antngtgana 150 tatacctaaa agcatactag ttagctntta gantctcact tagggagggt 200 aaagaaacat cactgatgcc aatatgaaga tttntaaaca aatcctttgt 250 ntagaanttt tttcttttcg tgcacctcac aacacantta ccatcgnacc 300 <210> SEQ ID NO 30 <211> LENGTH: 540 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 85, 106, 114, 146, 153, 169, 178, 227, 231, 235, 253, 256, 268, 343, 373, 443, 486, 531 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 30 ggccggttct tttaagatct ttgacctgan ccaaagtttc ggggaagggg 50 gggttgccca ggtggagtgc atgggggatt ttggnttaat gcaagttccc 100 cttccngtgt taangccatt ttcctgcttc agcttttttg agtagntgga 150 aanacaggcg cccgccaana cacctggnta attttttgta ttttcagtag 200 agacggggtt tcaccgtggt ttcaatntcc ngacnttgtg atccgcccgc 250 ctnggnttgc caaagtgntg ggattataag cgtgagccac cgcgcccggc 300 cgagatgttt tgatacaggc atgcaatgtg aaataatcag atnatagaca 350 atgaggtatc catcccctcg aanttttatc ctttgtgtta ctaacaatcc 400 cgtgaacact tttttagtta ttttaaaatg tataattagt tantactgac 450 tatagtcaac cctgttatgc tgtcaaataa tagatnttat tcattcttac 500 tgtttttttt gtactcatta actgttctca ncgccgaacc 540 <210> SEQ ID NO 31 <211> LENGTH: 168 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 56, 61, 112, 156, 165 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 31 gttttttttt tttgaagcga acttttgcta tattgctaag gctagttttg 50 aactcntggg ntcaagcaat actgccttga cctcctaaag tgcttggatt 100 acaggcatga gntactgcgc ctggcctgca atatgtattt taagctactt 150 tttttnttat tccgnacc 168 <210> SEQ ID NO 32 <211> LENGTH: 534 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 98, 118, 504, 513 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 32 tgtcgacgcg aatgccccgc gggcggagaa ctgggctccc accgaggagg 50 ctggaggcag gttcgctgtg gttccccctc ccgacctggc agagctgncg 100 ggagctctct gaggtccntc gagagtaccg gaaggagcac cagactacgt 150 gttccctgct cttctgcggc gcctacctct acaaacaggg ctttgccatc 200 cccggctcca gcttcctgaa gttttagctg gtgcccttgt ttgggcccat 250 ggctggggct tctgctgtgc tgtgtgttga cctcggtggg tgccacatgc 300 tgctacctgc tctccagtat ttttggcaaa cagttggtgg tgtcctactt 350 tcctgataaa gtggccctgc tgcagagaaa ggtggaggag aacagaaaca 400 gcttgttttt tttcttattg tttttgagac ttttccccat gacaccaaac 450 tggttcttga acctctcggc cccaattctg aacattccca tcgtgcagtt 500 cttnttctca gtncttatcg gtttgatccc cgga 534 <210> SEQ ID NO 33 <211> LENGTH: 361 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 33 aaaaaaaaaa aaaactgcct ttcttcccct cagtcaactt ttgtgctcca 50 gaaaattttc tattctgtaa gtctgagcgt aaaacttcag tattaaaata 100 atttgtacat gtagagagaa aaatgacttt ttcaaaaata tacaggggca 150 gctgccaaat tgatgtatta tatattgtgg tttctgtttc ttgaaagaat 200 ttttttcgtt atttttacat ctaacaaagt aaaaaaatta aaaagagggt 250 aagaaacgat tccggtggga tgattttaac atgcaaaatg tccctggggg 300 tttcttcttt gcttgctttc ttcctcctta ccctaccccc cactcacaca 350 cacacacaca c 361 <210> SEQ ID NO 34 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 81, 107, 357 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 34 acccggcatt agggaggcga ggtgngcaat gtcttaaccc cgggctcaac 50 cagtcctccg gcttctgctt cccaaggtgt ngggattgcc aggctggagc 100 ccattgngcc cagtctattg tatagtttta aaaaaacaaa accaaaaggc 150 taataaatgg cacccctttg caagctcttc cccctccctt tctttttcct 200 tcccagtgtc tcctacttct ctgacctagt tgacagcatt atacttttgg 250 atgttggtag catgtataaa gtacattatt acataacaag ttaatataac 300 ataatagttt caagggtttt gccacttaat tatactaagt tacttaacct 350 ctcaatncct tatctgtaga ttttgttttt gatagggtgg gatagtaata 400 gtaactacaa ggtttcacaa ggttgtgaaa ttgaatgaga aatacatggc 450 actttaacaa gtcactatgg attatttaat ttcttttctt cttcttctgc 500 tgctgcttct ccc 513 <210> SEQ ID NO 35 <211> LENGTH: 445 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 35 actatggtaa atagttatac tgtattggtt taggaaataa tggccatttt 50 taaaagtctg tacatgttca gtacagacac agtctttttg aagtattttt 100 tatccctcct ttgttgaatc ccatggatgc agaaccatgg atatgaaggg 150 ctgactatat tctcacagtt atattcaagt tgtattttga atgattttat 200 gacaatcttt taccaaaggg ccaactgtat tctcatgttt attattcaag 250 ttgtatgaca atttcatatc agccccccag agagttggca tttggattga 300 aatcatactg agtctctaga ttaatttagg gagaagtgac atctttataa 350 ttttgaatct tcctatccat gtatatgcga gtgttttgta tttcagtggc 400 attttcaaat tttcttcagg taggtctctt agtgtttatt cccga 445 <210> SEQ ID NO 36 <211> LENGTH: 526 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 50, 60, 123, 127, 370, 395, 397-398, 402-403, 405-407 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 36 attctcccct cctggatgga tcgcnccacc gtcacattgc cttcccccan 50 tggaggattn actcctatgc tggcgacaac atcgtgaccc cccaggccat 100 ttaccgaggg gctttggatg tcntgcntgt cgcagagcac cgggcagatc 150 ccagtgcaaa gtctttgact ccttgctgaa tctgagcagc acattgcaag 200 caacccgtgc cttgatgggg ttggcatcct cctgggagtg atagcaacct 250 ttgtggccac cgttggcatg aagtgtatga agtgcttgga agacgatgag 300 gtgccagaag atgaggatgg ctgtcattgg gggcgcgata tttcttgttg 350 caggtctggc tattttagtn gccacagcat ggtatggcaa tagantnntt 400 cnngnnntct atgaccctat gaccccagtc aatgccaggt acgaatttgg 450 tcaggctctc ttcactggct gggctgctgc ttctctctgc cttctgggag 500 gtgccctact ttgctgttcc tgtccc 526 <210> SEQ ID NO 37 <211> LENGTH: 375 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 220 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 37 ttttttttct tgtttaagct gactctttgc tctaattttg gaaaaaaaga 50 aatgtgaagg gtcaactccc acgtatgtgg ttatctgtga aagttgcaca 100 gcgtggcttt tcctaaactg gtgtttttcc cccgcatttg gtggattttt 150 tattattatt caaaaacata actgagtttt ttaaaagagg agaaaattta 200 tatctgggtt aagtgtttan catatatatg ggtactttgt aatatctaaa 250 aacttagaaa cggaaatgga atcctgctca caaaatcact ttaagatctt 300 ttcgaagctg ttaatttttc ttagtgttgt ggacactgca gacttgtcca 350 gtgctcccac ggcctgtacg gacac 375 <210> SEQ ID NO 38 <211> LENGTH: 493 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 64, 159 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 38 cccaacttgg aggtggagac tatggagntg atcggatggg cccggggcag 50 actttcccct tggngctgtt ctcgtgatag tgaataaggc tcaccagatc 100 aggtttaaaa gtgtgtagcc tccccattct ctctcttcct catccagcca 150 tgtaagacnt gcctgcttcc ccctcacctt ctgccagggt tgtaagtttt 200 ctgaggcctc ccagccatgc ttccctgtac agcctgtaga accatgagcc 250 aattaaacct attttcttta taaattatcc agtctcaggc atttctttat 300 agcagtgtga gagtggacta atagagctag ttattagtag agccaagatt 350 taaattcgag cttgctggct cccgagttct actttctcaa accctatgtt 400 aagctattgt ccacagcatt caacattgtt gaattatctt tgtcaactaa 450 ccttggaagt cttaaatttt gtcctaatcc tgtcccctat tcc 493 <210> SEQ ID NO 39 <211> LENGTH: 123 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 39 tttttttttt ttttttcttt tgtactgagc tcagcataga ctaatactac 50 cttaatgtta aaatctgaat ttcttttagc attttgctta aaagcaatat 100 gctatttgct tattccgtgc gaa 123 <210> SEQ ID NO 40 <211> LENGTH: 119 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 40 tttttttttt ttttttcttt tgtactgagc tcagcataga ctaatactac 50 cttaatgtta aaatctgaat ttcttttagc attttgctta aaagcaatat 100 gctatttgct tattccgtg 119 <210> SEQ ID NO 41 <211> LENGTH: 398 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 61, 91, 144, 238-239, 262, 265-266, 271, 274 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 41 agagcaccgg cagatcccag tncaaagtct ttgacccttg ctgaatctga 50 gcagcacatt ncaagcaacc ccttgccttg aaggtggttg ncatcccccc 100 tgggagtgaa tagcaatctt tgtggccacc gttggcatga agtntatgaa 150 gtgcttggaa gacgatgagg tgcagaagat gaggatggct gtcattgggg 200 gcgcgatatt tcttcttgca ggtctggcta ttttagtnnc cacagcatgg 250 tatggcaata gnatnnttcg nggnttctat gaccctatga ccccagtcaa 300 tgccaggtac gaatttggtc aggctctctt cactggctgg gctgctgctt 350 ctctctgcct tctgggaggt gccctacttt gctgttcctg tccccgaa 398 <210> SEQ ID NO 42 <211> LENGTH: 437 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 87, 97 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 42 aggtagtcct taaaaaaaag tctcctctct gtacccttct tcacccaatc 50 tacaactagg ttttttggta ggaattttat tattagntac caaacanggt 100 aacatcttta catgccagat tccaaagata ccctagaaga gccagagggt 150 tgcacttcct ctctctcact ttgcattccc tcctaagaaa tacttgcccc 200 taactcaaag ggcagaagga gtccagggct ctttcagcat taaaattctc 250 tatagttttc tgggagaggc acatgttctg agtgtgagga gaactgttct 300 ggttattgtt tataaattgt tttcatcttc tatttcttat aacagattat 350 aaatttatgt tttctgatgc ttcatactat tatgaggatt tggttggcaa 400 attatcttac aataaccacc catatattca tgcatgg 437 <210> SEQ ID NO 43 <211> LENGTH: 499 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 81, 93, 150, 340 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 43 ccaccaagag cctgaaggca gtcnctgtgt tccccttccg acctggcaga 50 gctgcgggag ctctctgagg tccttcgaga ntaccggaag gancaccagg 100 cctacgtgtt cctgctcttc tgcggcgcct acctctacaa acagggcttn 150 gccatccccg gctccagctt cctgaatgtt ttagctggtg cttgtttggg 200 ccatggctgg ggcttctgct gtgctgtgtg ttgacctcgg tgggtgccac 250 atgctgctac ctgctctcca gtatttttgg caaacagttg gtggtgtcct 300 actttcctga taaagtggcc ctgctgcaga gaaaggtggn ggagaacaga 350 aacagcttgt tttttttctt attgtttttg agacttttcc ccatgacacc 400 aaactggttc ttgaacctct cggccccaat tctgaacatt cccatcgtgc 450 agttcttctt ctcagttctt atcggtttga tcccatataa tttcatcga 499 <210> SEQ ID NO 44 <211> LENGTH: 494 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 37 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 44 gggttttcca ggactccccc cnacccccgg ccactcnact ggtggaaatg 50 cctctgccca atagacttgc tgtcctaacc ctcgtttagg acttctcatt 100 tactgcagat attggtacac ataggtagtg ggcggctgcc tgagagagac 150 catttggtac ttcttttctt atctcaaagc tgcttcagtc tttgtgcaca 200 ggggatgctc agaagcgtgc cttctttcag ggagactggc catgcgcctg 250 agttagatga taacatggag gttcatcaca cgctgtctac ttgagtgtgt 300 ttttggaatt ctccataata aaaagttaaa aaatacaatt gataggtaag 350 agtaattgaa gtagtttcaa attggttagc tataaaatgc aactatgaag 400 aggattgtag gtaattaaaa tactaagatt gtattgagga gaaatatatt 450 attcagaaca atacctgtga catggcatta gtgacaaata tgac 494 <210> SEQ ID NO 45 <211> LENGTH: 561 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 35, 73, 88, 153, 198, 292 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 45 ttcagagcca gaagggcctc gagctgcnag ccccntggaa tgaagcaggc 50 ctgggctgag gctggaaggg aancccctct aagctggncc gggggcggga 100 aaacttacca ccaggggact cgagatgggg aaggaaaggt cagaaagagg 150 agnaggccca ggcacggggt gtgggcggcc tgcagagctg gagccagntg 200 ctccgcccag agccaggcat gcacactcag agtaggtggc ctgtgccacc 250 ggggaagagg ggcgggtcgg cgtgctgctg aagatgccag gnagctgccg 300 gcctgctctg tgcgtgctga aaggtgtggt gagaagcact tacaaaaaga 350 aatggactgt gttaggattg cacattttac tttgtttctc ccaaatacgt 400 tctctttgaa tttttttcct tccagggcca ggactggagt gatggttgag 450 acaggcacgc actgggtctt gtctgcattt acattttgag attttgttca 500 gcatggattt tatggcgttt ttttgtttgt ttgtttgttc gttttcaaaa 550 tactgcaccg a 561 <210> SEQ ID NO 46 <211> LENGTH: 511 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 9, 25, 43-72, 178, 180, 355-356 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 46 ccagatttng tttctttctt ttttnaaaaa aagaaaaaaa aannnnnnnn 50 nnnnnnnnnn nnnnnnnnnn nnatccttgg gtgtgggctg atcaccttga 100 cctcaggtct ttgtgctatt gccctctctg cttttgggca ccttgacctc 150 aggtctttgt gctattgccc tctctgcntn cgggcacctt gacctcaggt 200 ctttgtgctg ttgccctctc tgctttgggc accttgacct caggtctttg 250 tgctgttgcc ctctctgctt tgggcacctt gacctcaggt ctttgtgcta 300 ttgccctttc tgctttgggc accttgacct caggtctttg tgccgttgcc 350 ctctnngctt tgggcacctt gacctcaggt ctttgtgctg ttgccctctg 400 tgctttgggc actcttcctc agacctgtgc atcacattcc ctctcttcag 450 ctctctgctc aaatgtcacc tccttcctga catcttccct gaccatccta 500 gccaaaatac c 511 <210> SEQ ID NO 47 <211> LENGTH: 470 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 113, 450 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 47 cgccctagcc ctctgtgatt tcataatgct ggaagtatgc ttttttaaaa 50 agtttaaatt cttgcccaat tttactgtag cgggaataaa tacatgctag 100 tattctgaga gtnttatgaa actagacata aaacaagtta aaattaatgg 150 ggaaatggct agatgtccat gactgtcaga gtcagtacat tgtcagtatc 200 ctccagaaat gtcactgata ttaagcaagc tgagttattt ccggcgttga 250 atccatgaag aatgataaat gttttctcat catacttatt cttagaatgt 300 tgtgatactt ttgatatttc agttactcgt ctttaaaagg ggagtgccct 350 tccctgggcc ttgcctaaga gaagaaagaa agactatatt aagacagaaa 400 acatggacat tttaaagaga cgaatacact gctatgtgaa ataccagttn 450 tactcagtaa actccctcga 470 <210> SEQ ID NO 48 <211> LENGTH: 543 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 46, 65-66, 80, 144 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 48 gcaggcccaa agaagaagct caggctgaaa tgaaccgtac cgcctnccga 50 gggagaaaga attcnnggcc aaggaagctn cggcattggg atcccttggc 100 agttgcagcc actgaagtgg agaaggagac ccaggagaag atgncctcct 150 ccagacatac ttccggcaga acgggatgaa gtctggacaa cctcttggct 200 tttgtctgtg acattcggcc agaatccctg aaaactaccg cataaatgga 250 tagaagagag aagcacctgt gctgtggagt ggcattttag atgccctcac 300 gaatatgagc ttagcacagc tctagttaca tcttatgata tggcattaaa 350 ttatttccat atattatata ataggtcctt ccactttttg gagagtagca 400 aatctagctt ttttgtacag acttagaaat tatctaaaga tttcatcttt 450 ttacctcata tttcttagga atttaatggt tatatgttgt ctttttttcc 500 tatgtctttt ggctcaagca acatgtatat cagtgttgac cga 543 <210> SEQ ID NO 49 <211> LENGTH: 485 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 14, 484 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 49 cggacgcttg ggcngcgcca gcggccagcg ctagtcggtc tggtaagtgc 50 ctgatgccga gttccgtctc tcgggtcttt tcctggtccc aggcaaagcg 100 gagcggagat cctcaaacgg cctagtgctt cgcgcttccg gagaaaatca 150 gcggtctaat taattcctct ggtttgttga agcagttacc aagaatcttc 200 aaccctttcc cacaaaagct aattgagtac acgttcctgt tgagtacacg 250 ttcctgttga tttacaaaag gtgcaggtat gagcaggtct gaagactaac 300 attttgtgaa gttgtaaaac agaaaacctg ttagaaatgt ggtggtttca 350 gcaaggcctc agtttccttc cttcagccct tgtaatttgg acatctgctg 400 ctttcatatt ttcatacatt actgcagtaa cactccacca tatagacccg 450 gctttacctt atatcagtga cactggtaca gtanc 485 <210> SEQ ID NO 50 <211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 255, 319-334 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 50 catggtggtg cgcaactgta gtcccaggta cttgagaggc tgaggtggga 50 ggatcatctt aaccccgggg agatggaggc taaaatgagc tgtgttcaca 100 ccactgtacc ccagcctggg caacagaata agacgctgtt tcaaacaaaa 150 atgtgtaact caaaaacagc aaaatgctta gttctttgta aatgcaacat 200 tttaggctac tgtttatttg ccaatagaac ttttttttct ctctctctcc 250 ttatntgtaa acttagctat atatgtttct cactcttggg tctgtgtact 300 tcaaaatctt ttagaaatnn nnnnnnnnnn nnnnaaaaaa aaaaatggaa 350 taatacaaaa ttatactaag attcattcat gttatttttt gtggctgcag 400 tgcattcatt tccactatat agtatttcat tgtctgatgt accagaattt 450 atccactctc tttttgatgc atgtttggat ttgcagtctt ttgctttatg 500 aaaagtgctg ctgtaaaaat tatta 525 <210> SEQ ID NO 51 <211> LENGTH: 150 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 51 tttttttttt tttttttggt ttgttgttgt tgtagtagtc tggtgctggc 50 cacatttaag tcttaaaaat ttttaaattt tgttgttgat gtttgtagac 100 agccctgttg ttgaaatcat ggctttattc attttattta ttttcgaacc 150 <210> SEQ ID NO 52 <211> LENGTH: 179 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 31, 43, 133, 162 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 52 tttaatagtt attcgtcttc tgttgtatag ncatttaagt tgnttatatg 50 tttctgttat taaccctttg tcccacgtat gatttgcaaa tattttctcc 100 catttttttt cagttgtctc attttgttga ttntatcaga ttccatgaag 150 cagcttttta anttcaagaa aaacgaatc 179 <210> SEQ ID NO 53 <211> LENGTH: 324 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 53 cggaagtccc ttgaggagcg tcagaagcgg cttccctacg tcccagagcc 50 ctattacccg gaatctggat gggaccgctc cgggagctgt ttggcaaaga 100 tgaacagcag agaatttcaa aggaccttgc taatatctgt aagacggcag 150 ctacagcagg catcattggc tgggtgtatg ggggaatacc agcttttatt 200 catgctaaac aacaatacat tgagcagagc caggcagaaa tttatcataa 250 ccggtttgat gctgtgcaat ctgcacatcg tgctgccaca cgaggcttca 300 ttcgttcatg gctggcgccg aacc 324 <210> SEQ ID NO 54 <211> LENGTH: 391 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 54 cccactcaga tctactgaaa ctgaaaacct gggagcaggg cccagcaatc 50 aagagttttt aacaaaccct cctggtcatt ttgatgcaca cgcaagtttg 100 agaacctgtg ccctttagga ggatttcctt ttcctcacta aaagccccct 150 gaaagatgcc tccagggtat gcctctgtgc cctactgccc actgctgctt 200 tcctgtttcc taggaatccc ctttatgaag tacccatcct ccagaaagat 250 ttcttaccta ccttgaaagg atcttggctt ctccacaagg ttactccatc 300 ctctgagcag ttatttccga ttctactttt gaatggtttc ttttcagatc 350 ttcctcagtg ctttctcttt ctggctaccc ctcaagcccg a 391 <210> SEQ ID NO 55 <211> LENGTH: 280 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 55 atatatatat aaatatagaa atatatatat agaaatatat atatatctct 50 ctccatatcc aaaagcaaga ttacaaattt cagttgaggg taatagcact 100 taaagtagga acagagattc tttatgtgtt agcataattc ttttttatta 150 caattctgtt actaaagaat caggtgtcat taaaggtgaa catggttacc 200 ttcaccttct gcacagcagt ttttcatata cttgaagaca ttaaatcccc 250 ttccccatcc aacttaatct tttccagcga 280 <210> SEQ ID NO 56 <211> LENGTH: 485 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 56 cggacgcgtg ggcggacgcg tgggtggcct tagagtagtt ttttgagcat 50 ttattgtgct tggtgttctc tgaacttcct tagatctgtg gtttggtgtc 100 tgacattaat ttggataaat tttcagtcat tgttgtttta aatatttctt 150 ctcttccttt cttctcctct tggtactttc atgtgtttat attacacctt 200 ttgtacctgt cccagagttc ttgggtatta tcttctgttt ttttttgggc 250 cttttttttt tccctttggt tttcagtttg tattgataca tccttaagct 300 cagagattat tctttttttc agcggtgtcc actctcctaa tgagcccatc 350 agtggcattc ttcatttctg tcaccatgct ttgctctctg gcacttcttt 400 tcattttttt cttagaattc ctatctccct gctcatgctg cccacctgtt 450 cctgcaagct gcctactttc tccattagag tcctt 485 <210> SEQ ID NO 57 <211> LENGTH: 260 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 42, 53, 93 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 57 tggtgtcttt cccaccacag cccngagagt cagtcatttt tncaaagaag 50 ccntggttgg ctttgtggag aatgatatat gttattatta ttntccgcag 100 ccaacatgac cgctcctctg gtgtctttcc caccacagcc cgagagtcag 150 tcatttttca aagaagcctg gttggctttg tggagaatga tatatgttat 200 tattattttt tgttttgtta tgttgtgttt tttagacagt ctcgctcttt 250 gcccagccga 260 <210> SEQ ID NO 58 <211> LENGTH: 344 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 66, 76, 92, 148, 174, 178 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 58 ggagtaaaaa gactgtnaaa catttttttt taaaaaatta tttttacatt 50 acgacaatat atttanggat gtgttnagat caaaaattaa anttctgtgt 100 cccagatcta ctttcaaagt gagattttca cttgtcagct taaatttntg 150 actagaacta acatttgtgt attnttgngc ttagtcggaa tacaaatttc 200 acagtggatt tttgaagttt gtccttaaat tggataaaat caagtgatta 250 aagttactaa agagataaaa atggtaattt ccatttttaa aagtaatttg 300 gttgtgttta tagttatttg tacaagtatt tatcacagcg aacc 344 <210> SEQ ID NO 59 <211> LENGTH: 495 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 39, 58, 130, 234, 314, 364, 427, 450, 461, 476 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 59 agcaatgccc tgcccccagt ggaggattaa ttcctatgnt ggggacaaca 50 ttgtgacngc ccaggccatg tacggggggc tgtggatgtc ctgcgtgtcg 100 cagagcaccg ggcagatcca gtgcaaagtn tttgactcct tgctgaattt 150 gagcagcaca ttgcaagcaa cccgtgcctt gatggtggtt ggcatcttcc 200 tgggagtgat agcaatcttt gtggccaccg tggnaatgaa gtgtatgaag 250 tgcttggaag acgatgaggt gcagaagatg aggatggctg tcattggggg 300 cgcgatattt cttnttgcag gtctggctat tttagttgcc acagcatggt 350 atggcaatag aatngttcaa gaattttatg accctatgac cccagtcaat 400 gccaggtacg aatttggtca ggctttnttc actggctggg ctgctgcttn 450 tttctgcctt ntgggaggtg ccctantttg ctgttcctgc gaacc 495 <210> SEQ ID NO 60 <211> LENGTH: 266 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 37, 56, 116, 190, 210 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 60 aacttgtcag aggcaagtgt ccagagtttt gctatanatt cattatggaa 50 ggtttnacct tattgaaatg acagttcccc acctttagca ttttatattg 100 ttccattaac tgtcanacaa acattcctgc aaaatatcag ttcaggaacc 150 aaacttactt tccctgagat ggtaaccgtt tcacagcctn tcatattgct 200 gcttcattan gtgatgaagt ctaaacacgt aaatggtgac cagttaaaac 250 acacacctgc cgaacc 266 <210> SEQ ID NO 61 <211> LENGTH: 421 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 3, 5, 22, 142, 147, 186, 198-200, 205, 260, 296, 306, 314 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 61 ccnangggtc cggttttttt gnatttttag tagagacggg gtttcaccat 50 gcaagcccag ctggccacgt aggttttaaa gcaaggggcg tgaagaaggc 100 acagtgaggt atgtggctgt tctcgtggta gttcattcgg cntaaanaga 150 cctggcatta aatttcaaga aggatttggc atattntttt cttgaccnnn 200 ctctntaaag ggtaaaatat caatgtttag aatgacaaag atgaattatt 250 acaataaatn tgatgtacac agagtgaaac atacacacat acaccntaat 300 caaaangttg gggnaaaatg tatttggttt tgttcctttc atcctgtctg 350 tgttatgtgg gtggagatgg ttttcattct ttcattactg ttttgtttta 400 tcctttgtat ctgaacgaac c 421 <210> SEQ ID NO 62 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 35, 37, 79, 91, 98, 155, 162, 170 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 62 agagacgggg tttcaccatg caagcccagc tggcnangta ggttttaaag 50 caaggggcgt gaagaaggca cagtgaggna tgtggctgtt ntcgtggnag 100 ttcattcggc ctaaatagac ctggcattaa atttcaagaa ggatttggca 150 ttttntcttc tngacccttn tctttaaagg gtaaaatatt aatgtttaga 200 atgacaaaga tgaattatta caataaattt gatgtacaca gactgaaaca 250 tacacacata caccctaatc aaaacgttgg ggaaaaatgt atttggtttt 300 gttcctttca tcctgtctgt gttatgtggg tggagatggt tttcattctt 350 tcattactgt tttgttttat cctttgtatc tgaacgaacc 390 <210> SEQ ID NO 63 <211> LENGTH: 448 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 61, 77, 80, 93, 147, 175-176, 234 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 63 tctttagaga tctttgactt gaccnaaggg tccgcaaagg gttcgggttt 50 tttgtatttt nagtagagag gggtttnacn atgcaagcca agntggcaaa 100 gtaggtttta aagcaagggg cgtgaagaag gaaacagtga ggaatgnggc 150 tgttttcgtg gtagttcatt cggcnnaaat agacctggca ttaaatttca 200 agaaggattt ggcatttttt tttcttgacc cttntcttta aagggtaaaa 250 tattaatgtt tagaatgaca aagatgaatt attacaataa atttgatgta 300 cacagactga aacatacaca catacaccct aatcaaaacg ttggggaaaa 350 atgtatttgg ttttgttcct ttcatcctgt ctgtgttatg tgggtggaga 400 tggttttcat tctttcatta ctgttttgtt ttatcctttg tatctgaa 448 <210> SEQ ID NO 64 <211> LENGTH: 245 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 73, 114, 120, 122, 184, 205 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 64 gtgtgtgtgt gtgtgtgtgt gtgtatgtgt atatatatat acatatatat 50 acacatatgt atgtatacct aantcctaaa gtggaacagt aagagtcatt 100 atttatagat tatntgattn tntatgtgga aagagaaaag aatcatatta 150 agtactttgg actgaacaat gacccccaaa attngtatga tgatgaagct 200 ctctntaaat attttcttgc tttactggac tgattttaac ccgct 245 <210> SEQ ID NO 65 <211> LENGTH: 381 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 59, 65, 80, 116, 155, 180, 188, 202, 223, 236, 246, 341, 361 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 65 agggatccag gttggtagag naatcccggc cggtttccca gagatgttta 50 accagcacnt gcttntgaga cttcgttttn tgttccagca accctggttg 100 gggggtcaga cttganacac tttcaggttg ggagtggacc caccccaggg 150 cctgntgagg acagagcagc caggccgtcn tggctaantt tgcagttggc 200 antgggttgg ggaggaagag agntgatgag tgtggnttcc ctgagntggg 250 gtttccctgc ttgtccagtt gtgagctgtc ctcggtgtta ccgaggctgt 300 gcctagagag tggagatttt tgatgaaagg tgtgctcgct ntctgcgttc 350 tatcttctct ntcctccttg ttcctgcaaa c 381 <210> SEQ ID NO 66 <211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 36, 144, 146, 161, 170, 205, 210, 213 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 66 acttaaaaat attgttgagt tctaaacnga tttttngtat atatcataca 50 tagaaaatat taaatttttg ttctaaaaca accaaaaatg gagcatacat 100 ttagagtggc atttgttgca tattattaaa caaatgaaac tgantntttt 150 ttcatcctga ngcagattan atcccatttt aatctttttc ctctctcctt 200 ttctnaaccn acntcagagt atcctgtaac agctgtccct atagttttca 250 aggaaagtga taataatgag attacttctt ctttcatcgt ttattttttt 300 gggaggatgg ggaaaccaca c 321 <210> SEQ ID NO 67 <211> LENGTH: 123 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 53, 75, 100, 110 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 67 tcccctgaat attcaggagg gagaagcaat cgccccagga cagagacggg 50 ganatcccag gagcagggta caggntttag caatatccat cttgcggtan 100 tccctccctn acaacaacca gac 123 <210> SEQ ID NO 68 <211> LENGTH: 521 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 66, 73, 97, 116, 134, 182, 187, 262, 364, 432, 477, 507 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 68 aaatgaccta taaataagtt ggtttgggan attattattt ttttagcatt 50 atttttaaaa tagatnatgg ttnatattta attggaattc cataatntaa 100 tgtactgata ggtaanttgt gtggaaattg tttngcagac ataaattact 150 aaataaatgt tctgttttca gatagtttag tntttgngac attaagtatt 200 gggacagatt gttttgactc caattaatat tctgaaattt ttctcctttc 250 attacctacc tntccattat gcctcagttg taacggtgag taaaactatt 300 tttgtgtctc atactttctt tatctttaaa ctttgtttta cacagtaatt 350 attttcaacc attntttgct aactgcacct cgctgcatgg ttccttcctg 400 tgtcccacca accagccgcc acattttacc anatgttccc agtgttcatg 450 ggccctttcc acccttgtct caaaatntcc ctattgattt tattttgctt 500 ttgttantcc cttcaaacgc c 521 <210> SEQ ID NO 69 <211> LENGTH: 382 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 155, 170 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 69 agagacgggg tttcaccatg caagcccagn tggccaagta ggttttaaag 50 caaggggcgt gaagaaggca cagtgaggta tgtggctgtt ctcgtggtag 100 ttcattcggc ctaaatagac ctggcattaa atttcaagaa ggatttggca 150 ttttnttttc ttgacccttn tctttaaagg gtaaaatatt aatgtttaga 200 atgacaaaga tgaattatta caataaattt gatgtacaca gactgaaaca 250 cacacacata caccctaatc aaaacgttgg ggaaaaatgt atttggtttt 300 gttcctttca tcctgtctgt gttatgtggg tggagatggt tttcattctt 350 tcattactgt tttgttttat cctttgtatc tg 382 <210> SEQ ID NO 70 <211> LENGTH: 405 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 33, 43, 58, 98, 110, 122, 125, 191, 226, 232, 234, 251, 321 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 70 acaccaatgc agtgaggtcg gggattcccc aantggatcc atngcaccag 50 gttcaagnta acccccaagg cagttttttc ttccaaaaca ttaacagnta 100 agtgtttgtn tgggccaatt tntcntacca agtttaaatt aaccaacatt 150 ttttttttaa aaccaaaaca caaggaagac taaccacgtg nttccaggaa 200 tggcctgtat ttacccaacc actttntata cntnttttcc aaccaaaagt 250 nttaatatgg gaatatccct caccacgatc ctaatactgt cagtagctgt 300 cctgctgtcc acagcagccc ntccgagctg ccgtgagtgt tatcagtttt 350 tgcactacag aggggagatg caacaatact ttacttacca tactcatata 400 gaaag 405 <210> SEQ ID NO 71 <211> LENGTH: 526 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26, 44, 54, 143, 244, 351, 504 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 71 gttcaggacc aagcggtaag aaggcntgag gacccaggcc ccantggagc 50 agtntgtcct tatgccgaat caaggcggaa catgggtgaa agacgagtaa 100 ggggcaaatc acagaatatt ccacagcgcc ctccagagtt acntggggag 150 gaccgaggcc acacgccact gcccccgagg ccagagtgta agtaaaggat 200 aaccaggact cgctgggaga gatggattct gtcctcagca acantccaca 250 gcagaaaggg gtagcaggta ccccttttta tcagcggtaa aaatgcattt 300 acaacctttc atttaaccga aaaacacaga ccgctttaac ctttttattt 350 ntgtccccca ctgcatgaac atttatacaa ttttaaaaat acttcctcat 400 aggatgcttt ggcccttcat ctatttaatc atagctacat acctattttt 450 tataagtagc agtacacatt caaaggggta ttcctagctc aatgcttggt 500 gttntagttc aacttttatc ctgcag 526 <210> SEQ ID NO 72 <211> LENGTH: 366 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 274, 348 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 72 tagaaataac ccttttcctt attngatttt agtcatcaaa catagtatga 50 tatgggaaaa gtcagccatt taccagaaat tatcttattt tgattttaaa 100 aactcatttc tatatgtagt tattgtaatg tctatttttt tagacttaaa 150 gatttataga agactatagt tatctgattt gttatttggc attttttcat 200 tctgtaaatc tttgcttatg gcacattgtg ctctctgttt tccatggttt 250 tattcattta tctcctccta tttngagggg acaacatggg tagttaaatc 300 tttgtcaata gtattggaga taacactaac tgctattatc ataacatntt 350 catttttact gcatgc 366 <210> SEQ ID NO 73 <211> LENGTH: 634 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 10, 59, 62 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 73 ggactgaatn cacttgtaat ggtgaccact gaaagctgca gagggacagt 50 aggtatttna tnaaatgcct tatatggcat tctatatgaa gaacctctga 100 acccaaagta tattatttag aaagaaagat aaagagatat aagcaaagta 150 agaatatatc ttaaaagtat cttataaacc attaacttat agtggtaaga 200 taaaccctct atcagcagga aaatacctgc atatgcatac ataaggaaga 250 ctgtgcacct aatctaggga tacataataa ggtggactct gtattagtag 300 taagtatttt tataaaataa tacttagaac aaattatata agataattat 350 aaatattaag atctttatat tgcattgctt ctgacttaaa aaatgaataa 400 ataaatgggg tcttgctatg ttacccaggc tggaatgcag tggctattta 450 caggcacaat catagtgcac tacagcccca aactcctggg ctcgagcaat 500 cctgttgccc agcctcccag gtagctggga ctatatataa gcaggcacca 550 ctgtgcctgg ctgcttctga ctaatccaag taagaataat aaatctatga 600 caaagttata cacaatctcc tacccctacc tcag 634 <210> SEQ ID NO 74 <211> LENGTH: 493 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 31, 42, 60, 114 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 74 atggaaccca gttggaaacc actcttcacg nttatttatc cnggggaact 50 tcccccaacn tagccaaggc ttcggttgag ttctcactcc aaaggtggga 100 actggaccat gggnacactt ggacacggat ggggaactca cacaccgggc 150 ctgtcttggg gtggcggtag ggcgtagcga tagcatagga gatacaccta 200 atgtaatgac gagttatggg tgcagcacac caaatggcac tgtatacgta 250 tgtaacaaac ctgcacttgt gcacatgtac tctagaactt aaagtataat 300 ataaaaattt taaaaatttt aaaaaaataa aaaaatcact gggctaaagt 350 aaataagtat tttactggtt ctaagattgt ttttcagaga gaaaaacaat 400 agaagtgtag aagcaattcg ataaagaaag gagtcttttc aacaaatgtt 450 gctgcaacag tcaaatgtct gtatgcaaaa aaatgaacct cca 493 <210> SEQ ID NO 75 <211> LENGTH: 255 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 75 tggaaaaaaa aaaaaaaagc cccttttcag tttgtgccac tgtgtatggt 50 ccgtgtagat tgatgcagat tttctgaaat gaaatgtttg tttagacgag 100 atcataccgg taaagcagga atgacaaagc ttgcttttct ggtatgttct 150 aggtgtattg tgacttttac tgttatatta attgccaata taagtaaata 200 tagattatat atgtatagtg tttcacaaag cttagacctt taccttccag 250 ccacc 255 <210> SEQ ID NO 76 <211> LENGTH: 627 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 47, 56, 66, 144, 163, 169, 294, 367, 395, 583 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 76 tttagggttc cttgacttgn accaaggttt cggggaaatt taaaggntta 50 aggaanggga ggaaangttt cttaaatttg gaattaacag taataatttt 100 tggaaattcc aataaaattg gcaaaagatt gggaaatttt ggangaataa 150 gggaaacaga tanttttcng ggtattcagg taaagtttaa aaaaggtttt 200 aaaagagagt ttttctaaca ttttgaaaag caacatgaaa aatgaaaaca 250 gttttaacag atatacaata tggatgactt atatacaaat gacnttaaaa 300 tatattaaat tcattatagt agttatattt aagtaaaata tgatgaaatt 350 taatagagat tcactcntcc caaaagcacc ttcatggaag attcntcatt 400 aacaggcagt cctttagtat gctgatttat acaaaatgct gaaaagaaga 450 gaaatacccc aagttcttga aaaaaaattt tttgatatga ctactctaac 500 agtaataact ataaatctca ctttaaataa tttaaaacaa attaaagtga 550 tatatgagtt aaatgaccaa gcagacttga ttntaggaat gttaaggaat 600 gttcattatt tgttttggat aatgaag 627 <210> SEQ ID NO 77 <211> LENGTH: 507 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 58, 60, 98, 107, 116, 240, 276, 432, 500, 502 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 77 tttgaaaagt ttaaaaggga ggaagtggtt tttatgattt ggccgtttcc 50 ggttgccntn cagagagttc cttgccttcc ctgcccttga aggtgacntg 100 tggcccnttt gggtgntgat ggacctgtgt tcccaccctg gttcaaaaag 150 caaagaaaag ggagtggtat cagaaaatgg aagaagagag taaagaagac 200 agtgctggct tgagagaagc agtggcttca ggtaaaaggn tactgccagc 250 gatatggacg ggagacagag aaatgntaga agagggcggt tccccaacaa 300 aggccccacc cacaagcctg gacacctgtg gccctaaatg agaacaggca 350 ttcctgtttt tgcacccaaa aagtggtttt ttggtatgcc acacccccta 400 tcctataccc atataaaccc tgaaccccag gntccagctc agaccagcag 450 aggaggagac gagacaagca gacaatgcag aacagtgcag cagagagaan 500 tngagag 507 <210> SEQ ID NO 78 <211> LENGTH: 478 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 78 ccacggtgtc cgttcttcgc ccggcggcag ctgtccccga ggcgggagga 50 gcccgagggg cgcgagcccc gcatgaatca ttgtagtcaa tcattttcca 100 gttctcagcc gttcagttgt gatcaaggga cacgtggttt ccgaactgcc 150 agctcagaat aggaaaataa cttgggattt tatattggaa gacatggatc 200 ttgctgccaa cgagatcagc atttatgaca aactttcaga gactgttgat 250 ttggtgagac agaccggcca tcagtgtggc atgtcagaga aggcaattga 300 aaaatttatc agacagctgc tggaaaagaa tgaacctcag agaccccccc 350 cgcagtatcc tctccttata gttgtgtata aggttctcgc aaccttggga 400 ttaatcttgc tcactgccta ctttgtgatt caacctttca gcccattagc 450 acctgagcca gtgctttgtg gagctcac 478 <210> SEQ ID NO 79 <211> LENGTH: 637 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 54, 66, 113, 124, 160, 163, 165, 170, 179, 204, 259, 299, 382, 384, 487, 634 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 79 gtttgtccct ttttccngtt ttttttggac aaattcagta taccaagcaa 50 catnaattcc agtttnggtg gattcccggg gtcttttggg atccttgact 100 tgaccaaggg tcnggccctt ttcngttggg acgtttgtaa gttttgggca 150 gtttccgggn gantngggan tcgggtttng ctttctgtgt tccattcgcc 200 cggngcggtg gtgcaggttt tcgggctagt catgggtccc cgtttcggag 250 actgcagant aaaccagtca ttacttgttt caagagcgtt ctgctaatnt 300 acacttttat tttctggatc actggcgtta tccttcttgc agttggcatt 350 tggggcaagg tgagcctgga gaattacttt tntnttttaa atgagaaggc 400 caccaatgtc cccttcgtgc tcattgctac tggtaccgtc attattcttt 450 tgggcacctt tggttgtttt gctacctgcc gagcttntgc atggatgcta 500 aaactgtatg caatgtttct gactctcgtt tttttggtcg aactggtcgc 550 tgccatcgta ggatttgttt tcagacatga gattaagaac agctttaaga 600 ataattatga gaaggctttg aagcagtata actntac 637 <210> SEQ ID NO 80 <211> LENGTH: 294 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 42, 105, 198, 205, 266 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 80 ggcggtatct tttttgcnag ttgcaattgg gggcaaaggt gnccctggag 50 aataattttt ttttttaaaa tgagaaggcc accaagtccc cttggtgatc 100 attgntactg gtaccgtcat tatttttttg ggcacctttg gttgttttgc 150 tacctgccga gtttttgcat ggatgctaaa actgtatgca atgtttcnga 200 ctctngtttt tttggtcgaa atggtcgctg ccatcgtagg atttgttttc 250 agacatgaga ttaagnacag ctttaagaat aattatgaga aggc 294 <210> SEQ ID NO 81 <211> LENGTH: 436 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 53, 58, 78, 148, 162, 253, 281, 336, 399 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 81 gtatggcaga ggataaggcg ttatgagaag ctgccaagct tcagatgtgc 50 agntgggntg aataccgacg ccagcgcnta gcgcccatta ctttgcaccc 100 acacttagga aacaacccac gcctcaccgc gggacccgga cccagccntc 150 cagcacccag cntccggttc cgacgtccgc gcgtgacctc cgggtaccgg 200 aggaccttgg gacgaggagg tccctccgct ttccggtagg atatatctgc 250 atnttgaaag gaagataaaa caaaagcctt ntttggaata gatggatttt 300 tgtcactttc tgtgtgaact aaagtgattc aatgtntctt ttggattgct 350 tctgcacttc aagaacacaa gttgaatcac tcagacctga aaaacagtnt 400 gaaaccagta tccatcaata cttggttgat gagcca 436 <210> SEQ ID NO 82 <211> LENGTH: 670 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 82 actgatcaaa ggcaggcgat acttcctgtt gccgggacgc tatatataac 50 gtgatgagcg cacgggctgc ggagacgcac cggagcgctc gcccagccgc 100 cgcctccaag cccctgaggt ttccggggac cacaatgaac aagttgctgt 150 gctgcgcgct cgtgtttctg gacatctcca ttaagtggac cacccaggaa 200 acgtttcctc caaagtacct tcattatgac gaagaacctc tcatcagctg 250 ttgtgtgaca aatgtcctcc tggtacctac ctaaaacaac actgtacagc 300 aaagtggaag accgtgtgcg ccccttgccc tgaccactac tacacagaca 350 gctggcacac cagtgacgag tgtctatact gcagccccgt gtgcaaggag 400 ctgcagtacg tcaagcagga gtgcaatcgc acccacaacc gcgtgtgcga 450 atgcaaggaa gggcgctacc ttgagataga gttctgcttg aaacatagga 500 gctgccctcc tggatttgga gtggtgcaag ctggaacccc agagcgaaat 550 acagtttgca aaagatgtcc agatgggttc ttctcaaatg agacgtcatc 600 taaagcaccc tgtagaaaac acacaaattg cagtgtcttt ggtctcctgc 650 taactcagaa aggaaatgca 670 <210> SEQ ID NO 83 <211> LENGTH: 427 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 131, 150, 225, 352 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 83 aggctttcat tccccaccta nggagttaat tttttggatt aaaaggtttt 50 tagaactttt tgttgatggt tggttttatt aaggcccgga agaaacattc 100 agattcgatt gaggaccagg aaatggcctt ntagggaaga gaaggcattn 150 tgctagatgg cttttaaaaa tatttccgcc agagtcactt gtctcattaa 200 caacagtttt tgtcttagaa gtctntctgt gattttataa actagcatga 250 ttttgttatg aatgcatgct gctctggttc tctaataagc ccaacatgca 300 tttgcatcat gtcggcaata agcacttttt ttgctgtgtt aacaatgtca 350 tnttcattgt tgtgtgcctg tgttttgact gtgacctgtc acatgaggtt 400 gggtgtggaa ttttccactt gtggcaa 427 <210> SEQ ID NO 84 <211> LENGTH: 371 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 178 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 84 tctttggagc tgcaggaggg acggatggcg gaaccttcca gtccccttca 50 gaggcgactg ccactcgccc ggccgtgcct ggactcccta cagtggtccc 100 tactctcgtg actccctcgg cccctgggaa taggactgtg gacctcttcc 150 cagtcttacc gatctgtgtc tgtgactnga ctcctggagc ctgcgatata 200 aattgctgct gcgacaggga ctgctatctt ctccatccga ggacagtttt 250 ctccttctgc cttccaggca gcgtaaggtc ttcaagctgg gtttgtgtag 300 acaactctgt tatcttcagg agtaattccc cgtttccttc aagagttttc 350 atggattcta atggaatcag g 371 <210> SEQ ID NO 85 <211> LENGTH: 324 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 33, 167 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 85 caggaacctc tttaagaaag tntattgtta ctnaaaacac accactgtct 50 tctggatgct tttctggttg cctttgaagt tcatgcaggt ggaggacgtg 100 gacattgacg aagttcagtg tattctggct aacttgatat acatgggaca 150 cgtcaaaggc tacatcncgc atcagcatca gaagctggtg gtcagcaagc 200 agaacccatt tcctcccctg tccacggtgt gttgaaagta cacggagccc 250 cgaggacggg tgagcagttg tttctttcca ctttggttgt gctgatgaga 300 ccggtccggt actgcaacaa ggcg 324 <210> SEQ ID NO 86 <211> LENGTH: 514 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 38, 64, 358 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 86 caacattctg gaccactaan cctctcttgg caacactngt tggacagatc 50 ctgaagatat gggngaccta ttcctagaat gttgctgaag cttttctgga 100 tggtggtgaa tataattctg cacttcccct cctcagtgct cttgtttgct 150 ctgaaagata caaccttgca gtagtttggc ttcgtcatgc agaatgttta 200 aaggccttag gctatatgga gcgagctgct gaaagctatg gcaaggtggt 250 tgatctggcc ccactccatt tggatgcaag gatttcactt tctacccttc 300 agcagcagct gggccagcct gagaaagctc tggaagctct ggaaccaatg 350 tatgatcnag atactttagc acaggatgca aatgctgcac agcaggaact 400 gaagttattg cttcatcgtt ctactctgtt gttttcacaa ggcaaaatgt 450 atggttatgt ggatacctta cttactatgt tagccatgct tttaaaggta 500 gcaatgaatc gagc 514 <210> SEQ ID NO 87 <211> LENGTH: 84 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 87 aaatgtatgt atcatcagtt ggntacgttt tggttctatg ctaaactgtg 50 aaaaatcaga tgaattgata aaagagttcc ctgc 84 <210> SEQ ID NO 88 <211> LENGTH: 588 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 53, 67, 91, 110, 195, 208, 424, 484, 487, 572 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 88 cgggtaactt agtgtttttg cnacaaggga aatttttttt tcagccaggg 50 ggngggggcc ctgtggnatc ataaaaaggt cctggcatgg ntaacagcca 100 ttttggccan tttgccggaa tttgtggttt ataaacttca gatggaagac 150 cagaaataac aagtgtgcat ttagcagaat tcccttcctg ccagntgatg 200 agacattntg gaagcatttt ctgactttaa aaatgaacat ttcggttctt 250 gtcctccccc tatttatttt tacatttctc tatgtgcaaa tgagaaaaac 300 actaaggttc agggagcaga ggtatagcct tttcaagctt gtttttgcca 350 taatggtagt cttccttctg atgtgggcgc cctacaatat tgcatttttc 400 ctgtccactt tcaaagaaca cttntccctg agtgactgca agagcagcta 450 caatttggac aaaagtgttc acatcactaa actnatngcc accacccact 500 gctgcatcaa ccctctcctg tatgcgtttc ttgatgggac atttagcaaa 550 tacctctgcc gctgtttcca tntgcgtagt aacacccc 588 <210> SEQ ID NO 89 <211> LENGTH: 521 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 66, 72 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 89 caggaatctc gaacactggc tcctcccctt agttcccgcc ctcggagtca 50 gcaagcaggg ggagtntgag gnccctggga cagctctgac tctggctgac 100 acacctgcct ctgggcaagg gtggtgcata tctgaggcgg acaggcacac 150 atggagaagt cagagtccac gccctctgct ccatcccagt agccaccgtc 200 tcaactcagc ccctcgtcac ttcacacttt ggcagtggtt tctgtccact 250 cagctggttc agttggctct atcacatctc ccggcctcta gggttggctc 300 aggcccacct ccgtcctctc atagggctgg ccatccaacc atatcactcc 350 tctcacggct tttaaggata aagtttgaag ccttaaggat acgtcacagg 400 tcctctaggc cctgcttacc tcagcttctg cctagaagtt tatgccccag 450 aaacagtgaa acctccatgt ttaccctcac acaacctgtg tgtctcaaca 500 ccatactttt gctcatactg g 521 <210> SEQ ID NO 90 <211> LENGTH: 613 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 43, 120 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 90 tccgggcccc cggggacgct gtccctgaac ttgccgggga gcngcccccg 50 gcgtcccgcg cgtccccgcg tccctggcaa ttcccgactt cccaacgggc 100 tccctgctgg cagcccccgn agccgcacca tgttccgcct ctggttgctg 150 ctggccgggc tctgcggcct cctggcgtca agacccggtt ttcaaaattc 200 acttctacag atcgtaattc cagagaaaat ccaaacaata caaatgacag 250 ttcagaaata gaatatgaac aaatatccta tattattcca atagatgaga 300 aactgtacac tgtgccacct taaacaaaga tattttttag cagataattt 350 tatgatctat ttgtacaatc caaggatcta tgaatactta ttcttcagat 400 attcagactc aatgctacta tcaaggaaat attgaaggat atccagattc 450 catggtcaca ctcagcacgt gctctggact aagaggaata ctgcaatttg 500 aaaatgtttc ttatggaatt gagcctctgg aatctgcagt tgaatttcag 550 catgttcttt acaaattaaa gaatgaagac aatgatattg caatttttat 600 tgacagaagc ctg 613 <210> SEQ ID NO 91 <211> LENGTH: 445 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 45, 68, 107, 113, 118, 405-406, 419 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 91 ttgagctcga tatcccacag agcntccagc agaacggttc ccttntacat 50 cccacgttta cttcaccnaa gagtggcttc ccacccagac ccccggcaaa 100 agccctntac ccnccggntt gccacagtcc acatgtcccg gatgatcaac 150 aatacaagcg cagacgattt cagaaaacca agaaactgct gacaggagag 200 acagaagcgg acccagaatg atcaagaggg ctgaggacta tgggcctgtg 250 gaggtgatct cccattggca ccccaacatc accatcaaca tcgtggacga 300 ccacacgccg tgggtgaagg gcagtgtgcc ccctcccctg gatcaatatg 350 tgaagttcga cgccgtgagc ggtgactact atcccatcat ctacttcaat 400 gactnntgga acctgcagna ggactagggc cccatcaacg agagc 445 <210> SEQ ID NO 92 <211> LENGTH: 398 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 43, 63, 74, 113, 138, 148, 158, 178, 208, 252, 259, 262, 302, 317, 346, 369, 371, 379 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 92 ccctgctgtc ttggggccct ggtttggtgc cctttgccaa aanagcggta 50 ggtcccctgg acngaaccaa aatnatcttc ccaagtgtct tcaaaaagat 100 tttctgccaa ggnggccttc cgggtcgtat actacacnta cctgcganga 150 gggatttntc agcttgtggg gcgggaantc ggccaccatg gtgtgcgtgg 200 tgccctangc cgccatccag ttcagcgcac acgaggagta caagcgcatc 250 cngggcagnt antatggctt cggtggagaa gccctgcccc cttggccttg 300 cnttttcgcc ggcgcantgg ctggaacgac agccggttca ctgacntacc 350 ccctggacct ggtcagagng nggatggcng taaccccgaa ggaaatgt 398 <210> SEQ ID NO 93 <211> LENGTH: 117 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 50, 57, 79, 113 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 93 aacttaatgc aaagggtgtg agatgttccc cccngctgta aaatgaaggn 50 ctattgntat ttattgagct ttgtgggant ggtggaagca ggcccccatg 100 gaccatgccc ccnccct 117 <210> SEQ ID NO 94 <211> LENGTH: 267 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 40, 75, 127, 153, 176, 183, 221 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 94 ggcagccgcg gcatgtctat agcaactttt ttantaccan ccaagtttgt 50 agaacattat ccaatatgtg gactntcaca atcattggga ttggaccgga 100 taagttaata aatttggcct tatttgnttg gaagtgatta taccgaagga 150 atnccaactg tgggttgtgt aaccgnccat ggnaattcta caatgaattc 200 cctgggcatg gccctggaac ntctcctaaa attctcagaa tggtggcatg 250 aagctcaaaa aaatcac 267 <210> SEQ ID NO 95 <211> LENGTH: 149 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 95 gggttttttt tttttggtct ggcctctttc atttagctta atgttttcaa 50 ggttcatcta tgttgtatca cgtatcagta ctttattttt tgtgtggcac 100 gtcatatgga taccccacaa cccgtttatc ttttcattaa ttatgggcg 149 <210> SEQ ID NO 96 <211> LENGTH: 141 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 35 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 96 tttttttttt tttttttttt ttttgagacg gagtntcatt ctgtcgctcg 50 ggctggagtg cagtggcgcc atcttggctc actgcaacct ctgccgccag 100 gttcaagtga ttctcttgcc tcagcctcca gagtagccgg g 141 <210> SEQ ID NO 97 <211> LENGTH: 598 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 79, 82, 132, 146, 187, 317, 371, 380, 383, 386, 473, 503, 554 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 97 gtttttgtta cagtttttgc ccaccatggt tgcagttata atgatgagct 50 gcagtttttg gagaagattc aataaaaant gntggaggat caagaagggt 100 ttgtgcccaa catgcaggtt gaaggtgttt tntatgtgaa tgatgntttg 150 gagaaattga tgtttgagga attaaggaat gcctgtngag gtggtggtgt 200 tggtggttcc tgccagccat gaaacagatt ggcaatgtgg cagccctgcc 250 tggaattgtt catcgattta ttgggcttcc tgatgtccat tcaggatatg 300 ggtttgctat tgggaanatg gcagcctttg atatgaatga ccctgaagca 350 gtagtatccc caggtggtgt ngggtttgan atnaantgtg gtgtccgctt 400 gctaagaacc aatttagatg aaagtgatgt ccagcctgtg aaggagcaaa 450 ttgcccaagc tatgtttgac canattcctg ttggggtggg gtcaaaaggt 500 gtnatcccaa tgaatgccaa agaattggag gaggccttgg agatgggggt 550 ggantggtcc ttaagagaag ggtatgcctg ggctgaagac aaggagcc 598 <210> SEQ ID NO 98 <211> LENGTH: 518 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 67, 111, 147, 152, 175, 219, 221, 224, 244, 259, 272, 285, 307, 309, 326, 368, 395, 477 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 98 aattagaaaa ggaaggttta tttttaanat tcttcttcca attggtttaa 50 tggtgaatta atgaagnggg taagcaaaac caggtgcttg cgttgagggt 100 tttgcagtgg ntgggaggac cccggggttt ccccgtgtct tttccangaa 150 tngttcggcc cctttggaat aaaanacccg cgagccccga gggcccagag 200 gaggccgaag tgcccgagnt nctncggggg tcccgcccgc gagntttttt 250 tttgccttng catttcctcc tngggcgttt tgganatgcc aggaataaaa 300 aggatantna ctgttaccat tttggntttt tgttttccaa gccctgggaa 350 tgcacaggca cagtgcanga atggctttga cctggattgc cagtnaggac 400 agtgtttaga tattgatgaa tgccgaacca tccccgaggc ctgccgagga 450 gaaatgatgt gtgttaacca aaatggnggg tatttatgca ttccccggac 500 aaaccctgtg tattgagg 518 <210> SEQ ID NO 99 <211> LENGTH: 439 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 39, 59, 104, 130, 146, 209, 221, 233, 248, 269, 284, 287, 290, 305, 360, 380, 386 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 99 ataccaagca ggcctttggc atcatgaacg agctgcggnt cagccagcag 50 ctgtgtgang tcacactgca ggtcaagtac caggatgcac cggccgccca 100 gttnatggcc cacaaggtgg tgctggcctn atccagccct gttttnaagg 150 ccatgttcac caacgggctg cgggagcagg gcatggaggt ggtgtccatt 200 gagggtatnc accccaaggt natggagcgc ctnattgaat ttgcctanac 250 ggcctccatt tccatgggng agaagtgtgt cctncangtn atgaacggtg 300 ctgtnatgta ccagattgac agcgttgtcc gtgcctgcag tgaattcctg 350 gtgcagcagn tggaccccag caatgccatn ggcatngcca aatttgctga 400 gcagattggc tgtgtggagt tgcaccagcg tgcccggga 439 <210> SEQ ID NO 100 <211> LENGTH: 395 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 54, 74, 119, 170, 194, 215, 257, 285, 317, 328, 373 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 100 ttggcatatt ttttcccagc ttaattcaat tccagcattg tcatgcagca 50 cggnaatcct ttgattccac aganacatat ccccagcatg cgcagttttt 100 ggatggcacc accagcagnt ttatccccct gtaccgatcc tcagaggaag 150 agaagagagt gacagttatn aaagccccgc attacccagg gatngggccc 200 gtggatgaat ccggnatccc cacagcaatt agaacgacag ttgaccggcc 250 caaggantgg tacaagacga tgtttaagca aattnacatg gtgcacaagc 300 cggatgatga cacaganatg tataatantc cttatacata caatgcaggt 350 ttgtacaacc caccctacag tgntcagtca caccctgctg caaag 395 <210> SEQ ID NO 101 <211> LENGTH: 326 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 33, 82, 112, 144, 185, 190, 204, 215, 235, 238, 292 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 101 ccaatcgccc ggggcggtgg tgcaggtntc ggntagtcat ggggtccccg 50 tttcggagac tgcagactaa accagtcatt anttgtttca agagcgtttt 100 gctaatttac anttttattt tttggatcac tggcgttatc cttnttgcag 150 ttggcatttg gggcaaggtg agcctggaga attanttttn ttttttaaat 200 gagnaggcca ccaangtccc ctttgtgctc attgntantg gtaccgtcat 250 tatttttttg ggcacctttg gttgttttgc tacctgccga gnttttgcat 300 ggatgctaaa actgtatgca atgttt 326 <210> SEQ ID NO 102 <211> LENGTH: 336 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 41, 127, 146, 178, 203, 220, 254, 267, 272, 320 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 102 tgttccctgg tggcagcgag gtgggcggcg gcggagggag ntggacccca 50 tggaagtccg cgggtgagtg agacccggcg cccacggtca atccccgcaa 100 atttcctggg ccctccccga cggcctncct gcccttttgt tttaantttt 150 tattaaaatg cttaggatac agattgantt ttttttgtaa atgactgttt 200 tanttttcct gaagtaggan atatatgcac tttgataaaa cagaatgaga 250 agtnataatt catgggnatt cntatacaag gtgctgatcc tgtgtttgga 300 gctgagctcc tcacagcagn ttttttcagc tatttt 336 <210> SEQ ID NO 103 <211> LENGTH: 355 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 107, 145, 150, 168, 174, 185, 239, 254, 285, 295 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 103 tgccgcgttc atttttttng ccatttggca cattatagca tttgatgagc 50 tgaagactga ttacaagaat cctatagacc agtgtaatac cctgaatccc 100 cttgtantcc cagagtacct tatccacgct ttttttctgt gtcangtttn 150 tttgtgcagc agagtggntt acantgggtt tcaanatgcc ccttttggca 200 tatcatattt ggaggtatat gagtagacca gtgatggang ccccaggaat 250 ttangaccct acaaccatta tgaatgcaga tattntagca tattntcaga 300 aggaaggatg gtgcaaaata gctttttatt ttttagcatt tttttactac 350 ctata 355 <210> SEQ ID NO 104 <211> LENGTH: 453 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 43, 76, 166, 187, 203, 209, 251, 291, 326, 338, 341, 388, 398 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 104 cggtgggaat ttagtttttc caggatgtgg ttgccccttc cgntgtgggg 50 ggaaaggggc ccccagaacc gaccanaccg tggcaagaga cccagaaccc 100 gaggacgaaa aattgtatga gaagaaccca gattcccatg gttatgacaa 150 ggaccccgtt ttggangttt ggaacatgcg aattgtnttc tttctttggc 200 gtntccatna tcctggtcct tggcagcacc tttgtggcct atttgcctga 250 ntacaggatg aaagagtggt cccgccgcga agctgagagg nttgtgaaat 300 accgagaggc caatggcctt cccatnatgg aatccaantg ntttgacccc 350 agcaagatcc agctgccaga ggatgagtga ccagttgnta agtggggntc 400 aagaagcacc gccttcccca ccccctgcct gccattttga ccttttttca 450 gag 453 <210> SEQ ID NO 105 <211> LENGTH: 449 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 39, 72, 75, 123, 153, 164, 191, 227, 233, 251, 254, 314, 341, 353, 356, 365, 379, 434 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 105 aacttcggtg agggtgccgt tanctgctgt tcctgcagng attatgggga 50 tttttttcgg gggtttgtgc gntangaatt tgaggccgac gcccattggt 100 gttcagagag acgcaacaag aanttgagga catggagaac gaattttact 150 atngctaccc aagnttccag gaagtgcaag tgatggtttt ngtgggcttc 200 ggcttcctca tgactttcct gcagcgntac ggntttagcg ccgtgggctt 250 naanttcctg ttggcagcct tcggcatcca gtgggcgctg ctcatgcagg 300 gctggttcca cttnttacaa gaccgctaca ttgttgtggg ngtggagaac 350 ctnatnaacg ctganttttg cgtggcctnt gtttgcgtgg cctttggggc 400 agttttgggt aaagtcagcc ccattcagct gctnatcatg acttttttc 449 <210> SEQ ID NO 106 <211> LENGTH: 394 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 74, 87, 114, 132, 136, 246, 340, 345, 349, 376 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 106 ggggaacttg ggaggaacat gcaggagtgn atttgttttg gtgggggttt 50 tcctggcctg gttcaggcct gccntgagcc ctgggantgt ggggaaaagt 100 atggtttcca gatngccgac tgtgcctacc gngacntaga atccgtgccg 150 cctggttccc ggccaatgtg aatacactga gcctgtcagc caaccggtgc 200 caggcttgcc ggagggtgcc ttcagggagg tgcccctgct gcagtngctg 250 tggctggcac acaatgagat ccgcacggtg gccgccggag ccctggcctt 300 tttgagccat ttcaagagcc tggacctcag ccacaatttn atttntgant 350 ttgcctggag cgacctgcac aacctngttg ctgtccattt tgag 394 <210> SEQ ID NO 107 <211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 10, 23, 41, 71, 95, 158, 166, 196, 361, 367, 414, 499 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 107 cccaagggtn cgaaatttgg aangttcata ggttcttcaa ngtccttcat 50 tccctggtag acaaatccaa natcaaccga cagttggagg tatanacaag 100 cggagggacc ctgagagtgt ggctggggag tatgggcggc attcctttta 150 caaaatgntt ggttanttca gcctggtcgg gtttttccgc ctgcantccc 200 tgttaggaga ttactaccag gccatcaagg tgctggagaa catcgaactg 250 aacaagaaga gtatgtattc ccgtgtgcca gagtgccagg tcaccacata 300 ctattatgtt gggtttgcat atttgatgat gcgttgttac caggatgcca 350 tccgggtttt ngccaanatc ctcctttaca tccagaggac caagagcatg 400 ttccagagga ccangtacaa gtatgagatg attaacaagc agaatgagca 450 gatgcatgcg ctgctggcca ttgccctcac gatgtacccc atgcgtatng 500 atgagagcat tcacctccag ctgcg 525 <210> SEQ ID NO 108 <211> LENGTH: 498 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12, 14, 135, 137, 165, 219, 309, 322, 334, 339, 341, 379, 386, 405, 417, 423, 430, 466, 480 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 108 gacccatccc angngtccgg agatcatgag gatgtttttt aatggccggt 50 acatcctcct gctgatgggg ctgttttcag tgtacactgg cttcatttac 100 aacgatgctt ttcaaagtca gtcaacctgt tcggntntgg gtggaacgtg 150 tcggccatgt acagntccag ccacccaccc gcagagcata agaagatggt 200 gctttggaac gacagcgtng ttagacacaa cagcattttg cagctggatc 250 caagcattcc tggagtgttc cgaggccctt atccccttgg cattgatcct 300 atttggaant tggccacaaa tngcctcact tttntaaant ntttcaaaat 350 gaaaatgtcc gtgattttag gaatcattna tatgantttt ggagtcattt 400 tgggnatatt taaccanttg canttcaggn agaagttcaa catttacctg 450 gtttccatcc cggaanttct tttcatgctn tgtatttttg gataccta 498 <210> SEQ ID NO 109 <211> LENGTH: 573 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 74, 110, 139, 142, 213, 233, 276, 292, 320, 348, 405, 413, 418, 430, 448, 469, 490, 492, 500, 511, 545, 552 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 109 taaggccttc aggtcccctt ccttacccca ggtttttcac agaatggatt 50 cccagcggga aattgcagag gaantgcggc tttaccaatc cacccttttt 100 caggatggtn taaaagattt cctggatgag aaaaaattna tngattgcac 150 cctaaaagca gggacaaaag ttttccttgc cacagattga ttttgtcagc 200 ttgtagtcct tanttccggg agtacttttt atntgaaatt gatgaggcga 250 aaaaaaagga ggtagtgcta gacaangtgg atcctgctat anttgattta 300 atcatcaaat acctgtactn tgccagtatt gatctcaatg acggaaangt 350 gcaagatatt tttgcattgg ccagccgctt tcagatcccc tcagtgttta 400 ctgtntgcgt ttnttatntt cagaaaagan ttgctcctgg taactgtnta 450 gccatcctaa gattaggant tttttttgac tgcccgagan tngccatttn 500 tgcccgtgaa nttgtgtctg atcgctttgt acagatttgt aaggnagagg 550 antttatgca actgtttcca cag 573 <210> SEQ ID NO 110 <211> LENGTH: 530 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 58, 159, 163, 210, 224, 244, 278, 302, 351, 359, 361, 366, 395, 404, 415, 417, 454, 472, 481, 499 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 110 gcattatttg aatgcagcat ggcagctatt atcaccttaa ttgggagtga 50 tcccaggngg ggttctttat attcgttcat gtcgagtatt gatgctttct 100 gactggtaca cgatgcttta caacccaagt ccagattacg ttaccacagt 150 acactgtant cangaagcgt ttacccacta tataccattg tatttattta 200 ttacgcattn tgcttggtat taangatgct gctccgacct cttntggtga 250 agaagattgc atgtgggtta gggaaatntg atcgatttaa aagtatttat 300 gntgcacttt actttttccc aattttaacc gtgcttcagg cagttggtgg 350 nggcctttna naaaangcct tcccatacat tatattagtg ttatntttgg 400 ttantctggc tgtgnanatg tctgcttttg aaatagagaa ctgctatgat 450 tttntggtca gaaagaaaag anttattgtt nttttcagcc actggttant 500 tcatgcctat ggaataattt ccatttccag 530 <210> SEQ ID NO 111 <211> LENGTH: 356 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 42, 87, 99, 101, 286, 303, 329 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 111 ggtcactgtg agcaggtggt attnacagcc tgcatgaccc tnacggccag 50 ccctggggtg ttccccgtca ctgtacagcc accgcantgt gttcctgana 100 ngtacagcaa cgccacgctt tggtacaaga ttttcacaac tgccagagat 150 gccaacacaa aatacgccca agattacaat cctttctggt gttataaggg 200 ggccattgga aaagtttatc atgctttaaa tcccaagctt acagtgattg 250 ttccagatga tgaccgttca ttaataaatt tgcatntcat gcacaccagt 300 tanttccttt ttgtgatggt gataacaang ttttgctatg ctgttatcaa 350 gggcag 356 <210> SEQ ID NO 112 <211> LENGTH: 711 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 46, 73, 91, 128, 134, 145, 151, 192, 205, 216, 218, 239, 356, 386, 409, 415, 448, 471, 496, 506, 562, 568, 599, 671, 675, 684, 698 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 112 aagggtccgg ttggttcatt taangtatat taaattgaaa gggttncttt 50 cagtcattgg aacagtttgt atnattggga acacccaacc natgttagta 100 ggatgggatg tgttacagtg tgtttaanac attntaaatt acagngcatg 150 ngcttatgtc cgttggttat ttgttgagca gtaaatttag gnggaatatt 200 ttttntattt tcctcnangg gataggcaag ctgtggggna gcacaggctt 250 tggagcaagc agatttgatt gtgaccttat ataagtttca atttccctgt 300 ctgtaattag atccccactt tattgggttg ttgtaaggat taaatgaagt 350 aatttntgta aaacataatg actgatacaa agtagnaaat aagtaaattt 400 ttaattttnt ttcanttttg caccagcata cagacatagt atgtttcntt 450 ttgaccaaac agaacagaat nagatgtgta ataatataag agtganttag 500 cagttntagt tatttaccta atagaaatga gtgcatatgt gtgccagaag 550 acatgtatag gnatgttnat agcagcattg cttgtgatag cccaaaaant 600 agaaacaccc acagatttaa caacagtaga atggattaat aaattgtggt 650 atattcataa aatgcaattt nattnaacaa cagnagcgaa cacagtantg 700 gtacacacac c 711 <210> SEQ ID NO 113 <211> LENGTH: 507 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 101, 263, 376, 397, 426 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 113 gctggaaata tggatgtcat ctacgagaaa ctgttttaag ccacagacaa 50 ttaaaagacc tttaaatcct ttggcttctg gtcaagggac aagtgaagag 100 nacacttttt acagttggct agaaggtctc tgtgtagaaa aaagagcatt 150 ctacagactt atatctggcc tacatgcaag cattaatgtg catttgagtg 200 caagatatct tttacaagag acctggttag aaaagaaatg gggacacaac 250 attacagaat ttnaacagcg atttgatgga attttgactg aaggagaagg 300 tccaagaagg cttaagaact tgtattttct ctacttaata gaactaaggg 350 ctttatccaa agtgttacca ttcttngagc gcccagattt tcaactnttt 400 actggaaata aaattcagga tgaggnaaac aaaatgttac ttttggaaat 450 acttcatgaa atcaagtcat ttcctttgca ttttgatgag aattcatttt 500 tttgctg 507 <210> SEQ ID NO 114 <211> LENGTH: 551 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 32, 58, 61, 85, 149, 169, 204, 255, 261, 300, 317, 324, 326, 329, 354, 397, 535 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 114 ccttgaaaat tatggtgtgg ccggaaccaa anaactttgc tttattgggg 50 actgggcntt naagtttcca ggggcacctt ttggngccag ccccatgcag 100 gggatttttg gaagtgtgca ggtgcctgta tggttcagta ccagaagtnt 150 tttgtggctt ttgaagttng aggcaaggcc tgggtgccca ggccggtgcc 200 cgcntggggt tcaagcggac cagttccatg gattccccag gaggtcccct 250 gcccntcccc ntgttcaaag gaggggttgg cggtgcaggg gcaacccctn 300 gaaagcgggg tgttttnttt tttntngang ccttccgggt gaaacccttt 350 ttgntccata tgccctaaaa ttatttggga aggctgggga agtaggnttt 400 gggtccatgc ctaaatttgt accgttttat tcctcaaggc ctatagcctg 450 tcaatccttg aagccttttt tgcctgtccc tccgatcctt gtccaccgtt 500 tatttattgc ccaatttatt gtttatacgg atgantggga ggcaatgcac 550 c 551 <210> SEQ ID NO 115 <211> LENGTH: 404 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 51, 65, 87, 97, 117, 158, 180, 201, 203, 237, 291, 300, 309, 348, 381 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 115 gcagaggttg agcggcagaa anataaaacc cttgaaagtg ccttccctgg 50 ntccagccat catcntcatc ctccctgggg tcgtcangtt catggtntcc 100 ttcattggtg tgctggngtc cctcccgtga caacctgtac cttttcccaa 150 gcattcangt acatccttgg gatttgcctn atcatggagc tcattggtgg 200 ngnggtggcc ttgaccttcc ggaaccagac cattganttc ctgaacgaca 250 acatttgaag aggaattgag aactactatg atgatttgga nttcaaaaan 300 atcatggant ttgttcagaa aaagttcaag tgctgtggcg gggagganta 350 ccgagattgg agcaagaatc agtaccacga ntgcagtgcc cctggacccc 400 tggc 404 <210> SEQ ID NO 116 <211> LENGTH: 274 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 123, 129, 173, 186, 224, 267 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 116 gtcatttccc ccgcttttat atcctgtaca caattttcat gaaaggattg 50 cagatgttat gggctgatgc caaaaagggt agaagaataa agacaaatat 100 gtggaagcac aatataaagt ttnatcaant tccataccgg gagatggagc 150 atttgagaca gttccgccaa gangtcacca agtgtntttt cctaggtatt 200 atttccattc caccttttgc caantacctg gtttttttgc taatgtacct 250 gtttcccagg caaatantga tcag 274 <210> SEQ ID NO 117 <211> LENGTH: 502 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 29, 44, 55, 86, 114, 117, 157, 167, 197, 207, 236, 261, 275, 292, 300, 302, 317, 341, 343, 366, 373, 446, 452, 481, 497 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 117 gggtggaatc ccaatttttg gggggaagnt ttccggaggt tcanttaagg 50 gaagnaattt caaaatgaaa attcaaagta gtgttngccc agagttgatt 100 gtggtcagca tttnganata gcccagagat acaggataag caaataccca 150 aaccttnaaa ttgtttngta aatgggatga tgatgaagag agaatanagg 200 gttcagngat cagtgaaagc attggcagat aacatnaggc aacaaaaaag 250 tgaccccatt naagaaattc ggganttagc agaaatcacc anttttgatn 300 gnagcaaaag aaatatnatt ggatattttg agcaaaagga ntnggacaac 350 tatagagttt ttgaangagt agngaatatt ttgcatgatg actgtgcctt 400 tttttttgca tttggggatg tttcaaaacc ggaaagatat agtggngaca 450 anataattta caaaccacca gggcattttg ntccggatat ggtgtanttg 500 gg 502 <210> SEQ ID NO 118 <211> LENGTH: 236 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 36, 93, 104, 147, 151 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 118 aaagcccaag ttaccagctg ttcaaaaaac agtngngatt tcagtttcac 50 gattgttgac ccggtgattt ccccagtgct gaacattatg gtnattcaaa 100 cagnaacaga ccgacatata acattacatt gcctttcagt caatggntcg 150 ntgcccatca attacacttt ttttgaaaac catgttgcca tatcaccagg 200 tatttccaag tatgacaggg agcccgaacc ccttgc 236 <210> SEQ ID NO 119 <211> LENGTH: 204 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 33, 64, 129, 167, 172, 198 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 119 atatgcagag agactgggtg ntccgagctc cantcaggtg aaagaatttg 50 cggcaattgt tgangtgaaa ggagaatttc attacatttt ggatccaaag 100 caagcactga tgaagctcac cctaggtant gcaggcagtt tatttcccca 150 agcattgtac attttgnttg anttcatatg gagtttttta ttcaaaantt 200 cagc 204 <210> SEQ ID NO 120 <211> LENGTH: 438 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 32, 65, 92, 121, 142, 154, 170, 293, 315, 323 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 120 gttattgtga actttgtgga gatgggaggt cntggggctg tgttccatgg 50 cgagctggat accangtttg tgtggaagtg ccccgtgttt gntatgccga 100 tgctgtccta gtggaaacaa ntccactgta attagattga tntatgcact 150 tttnttgctt gttggagtan gtgtagcttg tgtaatgttg ataccaggaa 200 tggaagaaca actgaataag attcctggat tttgtgagaa tgagaaaggt 250 gttgtccctt gtaacatttt ggttggctat aaagctgtat atngtttgtg 300 ctttggtttg gctangttct atnttcttct ctctttacta atgatcaaag 350 tgaagagtag cagtgatcct agagctgcag tgcacaatgg attttggttt 400 tttaaatttg ctgcagcaat tgcaattatt attggggc 438 <210> SEQ ID NO 121 <211> LENGTH: 229 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 58, 66, 71, 79, 92, 110, 116, 138, 162, 192, 207 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 121 tggagataag aggttacagc aaattacatg atgacctagg agagtttcca 50 tatggatngt ttgaanttgt ngctagtana aaatctttcc tntttttcac 100 tgacatgttn atttantgga ttcacagagg ccttcatnat agactggtat 150 ataagcgcct anataaacct caccatattt ggagattcct antccatttg 200 caagtcntgc ttttcaccct attgatggc 229 <210> SEQ ID NO 122 <211> LENGTH: 273 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 34, 198, 202, 218, 230 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 122 tgcgcctggc ctgatggttc antttttttt aaantttttt atcagtacaa 50 attatgggat aacatatgaa attttattat gtgtatgtaa tgcatagtga 100 taaagtcaag gtatttacgg tgtccataac ccaaatacaa tacatttttg 150 taactatagt caccctgctt ttttatcaaa cattgaattt attccttnta 200 tnttatttat gtgtgtantt tttaacacan ttctcttcat cttcccttct 250 cctcccaatc acccttcccg tcc 273 <210> SEQ ID NO 123 <211> LENGTH: 376 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 61, 73, 130, 219, 343, 351 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 123 agaagggggg gtgaaagtgg ttgcccagta atggccagaa accaaccacc 50 agaggccagg ntgaaagaca agntccgggt gtcctggggc tgacgggcca 100 accatgtggc aggtcccagg ccccacccan tgcgccatcc gcctttgagc 150 tccacagtgg tcccactaat gggaacctcc tttagggaga gtgatactgc 200 accttcaccc gtaggaatna tatttataac aatgtgtaat ggctgtagca 250 aaaagccctt gtttttagat gtaaatggtc aaagaaacaa gcgctttatt 300 gttttgaata aaatagttca aatgagtcct gtatcattgt atntcctatt 350 ntggattagt gccttttgga cgattg 376 <210> SEQ ID NO 124 <211> LENGTH: 437 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 32, 53, 55, 69, 85, 124, 151, 175, 196, 225, 247, 253, 262, 266, 275, 313, 316, 331, 334, 347, 349 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 124 atggaaaatt ttttttaggg gggggtggtt cntgagcgaa ggtgggcgga 50 cgngnggggg atttttttnt ggccctgttc cttcngagcg ttccgccgtt 100 gcccgcctgg cccctacgga gtcnttagcc aggatggagg ctgttgtgaa 150 nttgtaccaa gaggtgatga agcangcaga tccccggatc cagggntacc 200 ctttgatggg gtcccccttg ctaangacct ccattttcct gacctangtg 250 tantttgttt tntcanttgg gcctngcatc atggctaatc ggaagccctt 300 ccagctccgt ggnttnatga ttgtttacaa nttntcactg gtggcantnt 350 ccctttacat tgtttatgag ttcctgatgt cgggctggct gagcacctat 400 acctggcgct gtgaccctgt ggaatattcc aacagcc 437 <210> SEQ ID NO 125 <211> LENGTH: 441 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 177, 227, 251, 367, 370 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 125 aagtagggaa gtgtatttcc agntacagat ttgatcccgt tggagtggat 50 atcacttcga aaggaaaaat gagagcaaga tatgtgaatt acatcaaaac 100 atcagaggtt gtcagactgc cctatcctct ccaaatgaaa tcttcaggtc 150 cacttcttac tttattaaaa gggaatngtg gggctggaca gactttctaa 200 tgaacccaat ggttatgatg atggttnttc ctttattgat atttgtgctt 250 ntgcctaaag tggtcaacac aagtgatcct gacatgagac gggaaatgga 300 gcagtcaatg aatatgctga attccaacca tgagttgcct gatgtttctg 350 agttcatgac aagactnttn tcttcaaaat catttggcaa atttagcagc 400 ggcagcagta aaacaggcaa aagtggggct ggcaaaagga g 441 <210> SEQ ID NO 126 <211> LENGTH: 397 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 84, 86, 96, 101, 112, 153, 220, 225, 297 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 126 ctttccccct ggcggtgaga gtgcagagac gaagtgcgag atgagcatta 50 tgttcgcgga catctcctca tcgtttttat ctcngngtgc acggtntgtt 100 ngcagagggc anaacctggg tcctggttta caggacagac aagtacaaga 150 gantgaaggc agaagtggaa aaacagagta aaaaattgga aaagaagaag 200 gaaacaataa cagagtcagn tggtngacaa cagaaaaaga aaatagagag 250 acaagaagag aaactgaaga ataacaacag agatttatca atggttngaa 300 tgaaatccat gtttgttatt ggcttttgtt ttactgccct aatgggaatg 350 ttcaattcca tatttgatgg tagagtggtg gcaaagcttc cttttac 397 <210> SEQ ID NO 127 <211> LENGTH: 179 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 67, 70, 95, 114, 170, 179 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 127 atttttttag tatatccaca gagttgtgca accatcaatt ttagaacatt 50 ttcatcacaa attttgngcn tgtaatagtt tcctagagct gtttnttaac 100 gaagtaccac aagntgggtg gcttaagaca acagaaatgt attcctggcc 150 gggtgcagtg gctcacgccn gtaatcccn 179 <210> SEQ ID NO 128 <211> LENGTH: 561 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 37, 57, 82, 119, 150, 174, 184, 202, 217, 225, 303, 332, 354, 375, 429, 443, 490, 509, 523, 527, 547 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 128 atttcccttc cttttttccc gcccngtatt ttttttnaac ctttttccca 50 cctttgnttg ggtagccatg gggggagccg tngggggcaa tcagtcccat 100 tccatttcct tgttgtccnt tgggagccga gccgttccgc gcccggtggn 150 ggcgggagcc caggagcctg cccngcctgg ggangaagag tgcagttctt 200 cntggcggtg cacgatntga ttttntggag agatgtgaag aagactgggt 250 ttgtttttgg caccacgctg atcatgctgc tttccctggc agctttcagt 300 gtnatcagtg tggtttctta cctcatcctg gnttttctct ctgtcaccat 350 cagnttcagg atttacaagt ccgtnatcca agctgtacag aagtcagaag 400 aaggccatcc attcaaagcc tacctggang tagacattaa ttntgtcctc 450 agaagctttc cataattaca tgaatgctgc catggtgcan atcaacaggg 500 ccctgaaant cattatttgt ctntttntgg tagaagattt ggttgantcc 550 ttgaagctgg c 561 <210> SEQ ID NO 129 <211> LENGTH: 526 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 57, 59, 68, 174, 185, 332, 343, 366, 369, 375, 388, 405, 465, 492 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 129 tgttcctcaa tccaatttcc ggattttaga atgcccgtaa aaaatttata 50 attttantnt caagaaanat tttaccaggg gcaattgtaa aggttttatt 100 aatttttaac ctttggcctt tttttttaag taaggcaatt aatataaatg 150 taaaatatac aatattaaca aacntggttt ccagnttgta catttagtaa 200 atatttaata ttaattacga gttattgagg tttaaagtag gctgtgcatg 250 tgtaattata ttttattatg ttcagttttc catggcaatt gcctagtttt 300 taaagtttat tataatcctt atgtttgtga tnttttttca tantttatta 350 tttacaggag tccagntant tgctntttta gttcccantt tgatatttta 400 cctgntggat gaaaattttt ttgcctcagc aagttcagct tccaaagatt 450 ttcatgagtt tgcantccag aatttaatgc atattggacc tntgtatcca 500 catgctttca agacagtaat gggggc 526 <210> SEQ ID NO 130 <211> LENGTH: 429 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 267, 330 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 130 aaataaattt ttcatcccat tatgcatttt gtttgtaaat gtaaatttta 50 aaaatatggt taataacatt tcaacctgtt tattacaact taaaaggaat 100 tcagtgaatt tgtttttatt ttttaacaag atttgtgaac tgaatatcat 150 gaaccatgtt ttgatacccc tttttcacgt tgtgccaacg gaatagggtg 200 tttgatattt tttcatatgt taaggagatg cttcaaaatg tcaattgctt 250 taaacttaaa ttacctntca agagaccaag gtacatttac ctcattgtgt 300 atataatgtt taatatttgt cagagcattn tccaggtttg cagttttatt 350 tctataaagt atgggtatta tgttgctcag ttactcaaat ggtactgtat 400 tgtttatatt tgtaccccaa ataacatcg 429 <210> SEQ ID NO 131 <211> LENGTH: 372 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 126, 261, 347 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 131 ggggggggtg aaagtggctg ccagtaatgg ccagaaacca accaccagag 50 gccaggctga aagacaagct ccgggtgtcc aggggctgac gggccaacca 100 tgtggcaggt cccaggcccc acccantgcg ccatccgcct ttgagctcca 150 cagtggtccc actaatggga acctccttta gggagagtga tactgcacct 200 tcacccgtag gactcatatt tataacaatg tgtaatggct gtagcaaaaa 250 gcccttgttt ntagatgtaa atggtcaaag aaacaagcgc tttattgttt 300 tgaataaaat agttcaaatg agtcctgtat cattgtatct cctattntgg 350 attagtgcct tttggacgat tg 372 <210> SEQ ID NO 132 <211> LENGTH: 252 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 33, 37, 58, 95, 154, 204 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 132 ggatatcttt ttccatccct ttattttcag tcnatgngtg tctttatagg 50 tgaaatgngt ttcttgtggg caacagatca atgggtcttg ttttnacatc 100 tattcagcca gtctatgtct tttgtttgga gagtttagtc gatttatggt 150 caangttatt attgataagt aatgatttct cccagttttt tttctggttg 200 tttngtggtc ttctcttctt tctttctttc tttctttcct tcccgctccc 250 ag 252 <210> SEQ ID NO 133 <211> LENGTH: 139 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 57, 118 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 133 gtatgtacat gtgtatggtg tgtgcatgta ggtgtggtgt gcgtgtgcgt 50 ggtgtgngtg catgtgtatg tgtgtggcat gtatgtgtac ggtatgtata 100 tgtgtggtgt gtgtgcangt gtgtgtatgt gtgtttttg 139 <210> SEQ ID NO 134 <211> LENGTH: 366 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 127, 187, 366 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 134 ggggaaaaat atctgttaca aatttataat ttcaagacaa attgaatctt 50 attttataat acttttggaa tttcattaat aaggctaaaa tttgaggaat 100 ataaataatt ttcagcctta agacatntaa gtttggaagt ccttgctatt 150 caacagaata acaagaaaac ttcagaatgt atcactntcc tgaaaagaag 200 atattaataa gcccttttat ttatggttat agttttattt atagtctcaa 250 aattcctaaa gcaatgctac aaccattgaa tttgccatat tttgtatcag 300 tgctgttaat ttgctgttgc ctcaagaaaa agtgcttttt ctccatggat 350 gaggctagac cctcgn 366 <210> SEQ ID NO 135 <211> LENGTH: 179 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 31, 59, 158 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 135 agggggttct tgacattttg ttcaaatcct ngtaacaatc tgtctttagc 50 tttattttnt gagaaactga gcaaacctgt ttccattgcc ttcttagaag 100 ggttcatgta tatagcacta cagaagcata atgaagtttc tcagctccca 150 aaattatngt tattatactg ctattatac 179 <210> SEQ ID NO 136 <211> LENGTH: 483 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 39, 54 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 136 tattcgcgat tgactcctct tnctaagtgt cgcgccccnt ttagagcagc 50 gatntaagag agccgtcccg gtgtcctcgg gtcccagtga ttgtgaagtg 100 ctgccaattg ccactggaca tacttgaaac aaaataggaa aatggcagca 150 aactcttcag gacaaggttt tcaaaacaaa aatagagttg caatcttggc 200 agaactggac aaagagaaaa gaaaactact tatgcagaac cagtcttcaa 250 caaatcatcc tggagctagc attgcactct cgagaccctc tcttaataag 300 gacttccggg atcacgctga gcagcagcat attgcagccc aacagaaggc 350 agctttgcag catgctcatg cacattcatc tggatacttc atcactcaag 400 actctgcatt tgggaacctt attcttcctg ttttacctcg ccttgaccca 450 gaatgaagaa aacatttgcg atggaaaagt gac 483 <210> SEQ ID NO 137 <211> LENGTH: 598 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 137 cttgagcgag ccagttgccg gattattcta tttcccctcc ctctctcccg 50 ccccgtatct cttttcaccc ttctcccacc ctcgctcgcg tagccatggc 100 ggagccgtcg gcggccactc agtcccattc catctcctcg tcgtccttcg 150 gagccgagcc gtccgcgccc ggcggcggcg ggagcccagg agcctgcccc 200 gccctgggga cgaagagctg cagctcctcc tgtgcggtgc acgatctgat 250 tttctggaga gatgtgaaga agactgggtt tgtctttggc accacgctga 300 tcatgctgct ttccctggca gctttcagtg tcatcagtgt ggtttcttac 350 ctcatcctgg ctcttctctc tgtcaccatc agcttcagga tctacaagtc 400 cgtcatccaa gctgtacaga agtcagaaga aggccatcca ttcaaagcct 450 acctggacgt agacattact ctgtcctcag aagctttcca taattacatg 500 aatgctgcca tggtgcacat caacagggcc ctgaaactca ttattcgtct 550 ctttctggta gaagatctgg ttgactcctt gaagctggct gtcttcat 598 <210> SEQ ID NO 138 <211> LENGTH: 320 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 138 ccttagcaga catgcaaaag cttattcttg tgtgacttac tttctttaag 50 ctaataatat aaaaataaat atgtatctta aaaatctata ataaaacatt 100 agaaattaaa gatatgtgct ttttattttg cagatgagtt catttgcttt 150 tgtagatgtg ttttcagagc taggtacaga ggaatgtttg ctacctttag 200 cggtgaaaaa agaaagagag tcaagaattt tgttggattg tgtttgtgtg 250 tgcatatatt tgatatcatc attatatttg taatctttgg acttgtaatc 300 atagcctgtt tattctactg 320 <210> SEQ ID NO 139 <211> LENGTH: 497 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 139 cggacgcgtg ggctgcttgc cgccctcttt ggatacctaa cattttacga 50 acatgttgag tcagaattgc ttcataccta ctcttctatc ttgggaactg 100 atattcttct tctcattgtc cgtctggctg tgttaatggc tgtgaccctg 150 acagtaccag tagttatttt cccaatccgg agttctgtaa ctcacttgtt 200 gtgtgcatca aaagatttca gttggtggcg tcatagtctc attacagtgt 250 ctatcttggc atttaccaat ttacttgtca tctttgtccc aactattagg 300 gatatctttg gttttattgg tgcatctgca gcttctatgt tgatttttat 350 tcttccttct gccttctata tcaagttggt gaagaaagaa cctatgaaat 400 ctgtacaaaa gattggggct ttgttcttcc tgttaagtgg tgtactggtg 450 atgaccggaa gcatggcctt gattgttttg gattgggtac acaatgc 497 <210> SEQ ID NO 140 <211> LENGTH: 105 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 11 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 140 acttcaatgt ntacacatgg ccattgaaaa atacagagtt tacagaatta 50 tttcagagaa gtcattaaag aaacaaacat taacacaccc tgcagagtgg 100 gggag 105 <210> SEQ ID NO 141 <211> LENGTH: 473 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 141 tccccgctgc tgacgcttca tcccccacac ctccagcccc agttacctgg 50 agcttctcag aacccacttt gccggtgcta aaacacaaga gggggtgaaa 100 gtggctgcca gtaatggcca gaaaccaacc accagaggcc aggctgaaag 150 acaagctccg ggtgtccagg ggctgacggg ccaaccatgt ggcaggtccc 200 aggccccacc cactgcgcca tccgcctctg agctccacag tggtcccact 250 aatgggaacc tcctctaggg agagtgatac tgcaccttca cccgtaggac 300 tcatatttat aacaatgtgt aatggctgta gcaaaaagcc cttgtttcta 350 gatgtaaatg gtcaaagaaa caagcgctct attgttttga ataaaatagt 400 tcaaatgagt cctgtatcat tgtatctcct attctggatt agtgcctttt 450 ggacagtaga ctgttctgta aaa 473 <210> SEQ ID NO 142 <211> LENGTH: 578 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 60, 105, 110 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 142 tccatgtgaa ttttgcttaa tggaatgctt tatttaagca tttaggcaga 50 gttgacacan ttaaaggtac aaagcccaga ggaattggta gagcagcacc 100 gtgcntgccn tgaggcagtg gagtcagtag cgttgtcccc agggccttga 150 gtgcctggag gtgcttggcc tccagtagct gcctccattc tcttttaaaa 200 aaagggggtg attctgaggc actgaagtgc ctcccagatg tggaggagtg 250 aagccaccat cgaggccaca ctcagcactc caggatccca gcgatgtcag 300 acactcttga gttgtcaaaa cgttaatttt cagttttaaa taatcagttt 350 atctaagaaa agggaatttt aacttttcta ccttgagcca agccaatgaa 400 gggaaaatta attaacttag taaatttgaa gtgcagctct gttagctcgt 450 acatgtgggt tcttatcctg atcctgtgcc ttaaagtagg aaggtgtttc 500 caagttcaga ttaaaataga agcagctggc cgggtgcggt ggctcacgcc 550 tgtaatccca gcactttggg aggccgag 578 <210> SEQ ID NO 143 <211> LENGTH: 1000 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 64 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 143 caagagtctc gctccagcct ggtgatagag caagactccg tctaaaaaaa 50 aaaccaggag tganaaaaat aagagtcatt gaacttcatt tttttaaaaa 100 agaatatcac tttgctgtcc tttcaaatat agcatttccc caattaggta 150 cctgtttatt gagattttat aatgtaggta aatttttaat cagtttttaa 200 ttgataccta attaacctcg agctcttgtc ctcctgcctt ttttcacttc 250 tttactcttg cagcattcct tcctagtacc ttctgtatgt acactacgtt 300 gatagccatg actggatggt atatggacag gacttccatt gctgtgctgg 350 gagtagcagc tggggctatc ttaggctggc cattcagtgc agctcttggt 400 ttacccattg cctttgattt gctggtcatg aaacacaggt ggaagagttt 450 ctttcattgg tcgctgatgg ccctcatact atttctggtg cctgtggtgg 500 tcattgacag ctactattat gggaaagttg gtgattgcac cactcaacat 550 tgttttgtat aatgtcttta ctcctcatgg acctgatctt tatggtacag 600 aaccctggta tttctattta attaatggat ttctcaattt caatgtagcc 650 tttgctttgg ctctcctagt cctaccactg acttctctta tggaatacct 700 gctgcagaga tttcatgttc agaatttagg ccacccgtat tggcttacct 750 tggctccaat gtatatttgg tttataattt tcttcatcca gcctcacaaa 800 gatgagagat ttcttttccc tgtgtatcca cttatatgtc tctgtggcgc 850 tgtggctctc tctgcacttc agaaatgtta ccactttgtg tttcaacgat 900 atcgcctgga gcactatact gtgacatcga attggctggc attaggaact 950 gtcttcctgt ttgggctctt gtcattttct cgctctgtgg cactgttcag 1000 <210> SEQ ID NO 144 <211> LENGTH: 612 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 49, 66, 73, 81, 91, 217, 318, 447 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 144 aattggtagt ccctgttctt ttcatggttt tctggctcgt cttatttgnt 50 cttcagattt actccntatt tcnagtactt ngagatcagc ntgcataacg 100 tgagaggttt cttttccttt ttctgacaag tattgcggaa tgttgcagca 150 actccttact ctcttttggg tttggtcttc acggtttctt ttgttgcctt 200 gggtgttctc aacactntgc aagttttact tgcagggtta tcgagctttc 250 atgaatgatc ctgccatgaa tcggggcatg acagaaggag taacgctgtt 300 aatcctggca gtgcagantg ggctgataga actgcaggtt gttcatcggg 350 cattcttgct cagtattatc cttttcattg tcgtagcttc tatcctacag 400 tctatgttag aaattgcaga tcctattgtt ttggcactgg gagcatntag 450 agacaagagc ttgtggaaac acttccgtgc tgtaagcctt tgtttatttt 500 tattggtatt ccctgcttat atggcttata tgatttgcca gtttttccac 550 atggattttt ggcttcttat cattatttcc agcagcattc ttacctctct 600 tcaggttctg gg 612 <210> SEQ ID NO 145 <211> LENGTH: 439 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 116, 156, 247, 252, 277, 279, 292, 301, 314, 338, 356 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 145 aaaaaaaaaa accaaaacca aaaaccagaa cgcttgttca agtttgtcct 50 gtcctgtcca tggataggcc agacctttgg tccagaaatt cagtttttca 100 ttgtgtctga catagngact ccataatgtt ggttccattc tcttttcttc 150 ctcaanatca tgtgttttgt gggtctttgt tttgttttgt tttgttttgt 200 tttgttttgt ttttggtaga gttggagtct tgctgtgttg cccaagntga 250 tntccaattc ctgacctcaa acaggtntnt caccttggcc tnccaaagtg 300 ntgggaattc aggngtgaac cacctcaccc agccaagntc acattttgaa 350 tctaantttt tttttgaaac agtgtcttgc attgttgccc aggctggaat 400 gcagtggtgc catcatggct cactgcagcc tcaacttcc 439 <210> SEQ ID NO 146 <211> LENGTH: 479 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 142 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 146 ggcagtctcc tagctgctct tacacactgc atagctgtgt gtgagtactc 50 ttttcatcca tcagtcagcc agggtttgca ggacagatcc ggcaagtggt 100 gccctgtatg aggaatgctg caacggatct ggactgaacc cntcaaaaat 150 aaagtgattg ctcagtcctc tttggatttc tgcgcgacat atgaaaccat 200 accatggcat ggctggaacc caacccggta ccaaaaataa aggaaatgac 250 cctgcaggac ctgcagcccc aaaacgatgc ggcttcctcg gacgacacag 300 gccccggaca ttatgctgaa gaagacaact caggaagctg agcaaatcct 350 gctccagaca caaacaccat tcactccaga taatctgttc cttgctatgc 400 cctccgttgt acattgcaac actcacaggg tattggtttt tcttattctc 450 tcactctgcc tgcaactcgt acctgctac 479 <210> SEQ ID NO 147 <211> LENGTH: 276 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 147 tttttttttt gtgttgtcta taggaattaa cttgggattg ttttgtgggt 50 ttttgtttgt tttaaatgta aattgagaat cttttataag aaataaaagc 100 attattgggt gcctttgttt gtaaaccaaa aagtaataaa tgaatcccta 150 tatttccatt atagtattta ttgtattttt atgttctgaa aattacccat 200 ggaacaatat gcttaggatt acaggaagca gtccttactt acacttcttg 250 tctgttttag gtgtacttgt taattc 276 <210> SEQ ID NO 148 <211> LENGTH: 451 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 148 gttgtatact aatcaaccat tctgcaacct gcttttctga tttaatctag 50 aacaacctca ttcttgtgta tagtacacct cacaccacta tattggcttg 100 gtataataac tttccaactg gcttttgtct cagccatggg cagtttcttt 150 tctgaccatc catctggcct caggttcccc tggagtcttc ctttctccag 200 cagtccttct ctgtctttgt atatctccag gctttagcaa tacgctcact 250 ctatttttct ttttttgatt tcacttttta aattaaagta ttgtaaaact 300 ggctttttgg tgcacagttt tgagaatttc agtacatgaa cacatttgtg 350 ttcccaccac cacaatcaag acagagggcc gttttattgt ccccaaagct 400 ccacatgcta tcctttcagg tctacttcct ttttactgtt tttgtaatca 450 c 451 <210> SEQ ID NO 149 <211> LENGTH: 268 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 167, 213 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 149 agaataattt tttaaacaca aattcaccat gtttctctac taacttggaa 50 tgcttaatgt gttcccattg tacctagaat aaatccaaac ttactttcca 100 gggtctgctc tccaagctgt acatgacctg gcccatagcc acctttctaa 150 actcgtcaca tccattntcc tcattgctca tggtgctgtg gacagtctgg 200 ttcctttctg ttnttctcca ctaccaagct cattcacact gccccttttc 250 caaggccctt ccctacac 268 <210> SEQ ID NO 150 <211> LENGTH: 749 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 72, 99, 114, 127, 132, 222, 373 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 150 gtaggttagg gtccttaaag gaacttactt tggatttatt ggcaaaatta 50 ttgtgggcac cttacccatt gngaaattat ttttagaggc ttgtaaaant 100 ttaaagttta gatnttattt gccttgntaa tntatttaac tttatggaaa 150 gtatttactg cttctgatca ggattttttg tttgctgtca aagtaaaagt 200 cactaccagt gtcactattt gntatggaag ccacaaacct tgtagtcatt 250 tcttaattat tttctttctt ttatttttcc attcccacat tcccttctca 300 tcccctttta attcattagc aagtatgctg ccagttctgc ttagtccgtc 350 tctctccctc cactggtaaa ccntagccca aaccatcttc atctcttatc 400 tgtactaacg caagagcccc ttaactggta tccctccttc catttcttga 450 tctactaaaa tccatacgcc acatagtggc tagaataatt ttttaaacac 500 aaattcacca tgtttctcta ctaacttgga atgcttaatg tgttcccatt 550 gtacctagaa taaatccaaa cttactttcc agggtctgct ctccaagctg 600 tacatgacct ggcccatagc cacctttcta aactcgtcac atccattctc 650 ctcattgctc atggtgctgt ggacagtctg gttcctttct gttcttctcc 700 actaccaagc tcattcacac tgcccctttt ccaaggccct tccctacac 749 <210> SEQ ID NO 151 <211> LENGTH: 105 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 151 ttttgtcatt ttgaaatttt tttttttttc accagccctg aattttagtt 50 catccatgga taaactatta cttttcttat ttttctttaa ctatacaatt 100 aagac 105 <210> SEQ ID NO 152 <211> LENGTH: 631 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 77, 95, 135, 166, 178 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 152 tccttggaac atttttntag ggatatttcc atttgacttt attagattaa 50 tgaaattggg aaacctggac gtatatntaa actatacttt ttgantatga 100 gcataacctt ttatttcctg tattttagaa aaagngacca tgttgtgatg 150 gcaatcattg tgcttntgca tacccagntg aatgtctgtg gaaactcagt 200 tattctttta aatagttatt atcagagata taattattta caaagtagtt 250 tttttgtttg taggtaaact attatagatt ttgctgttct cccaactgtt 300 ttcttggtgt atattttgaa aatataaacc ttaaatgtta gaacaaagaa 350 aacaaaagca aaacccgaaa accttaactg tgcttgtaaa catttaaaat 400 atttttgtta gtttctctca attgagtaag agaacctggc tttcccacag 450 caatgatcca ggctttggta atacccccct ttatgtctct gtacttctgc 500 cattctaaag ttgatttatt gtttgttact tttagtgatt ttaagtgctc 550 aatgaagttc cttggctttc tcatggcttt tcatttccaa ctaaattacc 600 tagcctttct tttaatgtct tccaccctta c 631 <210> SEQ ID NO 153 <211> LENGTH: 522 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 44, 57, 65, 173, 183 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 153 tatttaaagc aatcttagtg gtataccccg cccctttgcc ttanttaaga 50 ggagcantga aatgnatata cttgctgttc agtatttcca agtacccatt 100 tttatatagt agcttatttg accataagtc acacatcaaa aaaagattac 150 cccttagtgt atgtgtttta atnttagaaa atntggcata tgtactttat 200 ttttgaaaag ggaagagatg ggtgtggggt ggcaatagca ttgtgccatt 250 ttgtcataga atgtaaaaat tggttaactt tacaaatgtc agctagtttt 300 gactactaat tgggggaaat tttagataat ttttaaattc aaagttattt 350 ataaaatgct agaatttgtt ttaatttttt tgtattttga gccacttcac 400 atgaagactc agttgcattt ttatcgaata catttttatc aacagttaaa 450 gactatggtg gtttttttca gagtttggct aagaatgttg ttaccatctt 500 ctttgtttgt ggtacaatat tt 522 <210> SEQ ID NO 154 <211> LENGTH: 632 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 36, 65, 94, 147, 152-153, 156, 179, 222 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 154 aatctattta aactttatgg aaagtattta actggnttct ggatcaggat 50 tttttttgtt tgctntcaaa gtaaaagtca cttaccagtg tcantatttg 100 gttatggaag ccaacaaacc ttgtagtcat ttcttaatta tttttcnttc 150 tnntantttt ccattcccac attcccctnt catccccttt taattcatta 200 gcaagtatgc tgccagttct gnttagtccg tctctctccc tccactggta 250 aaccctagcc caaaccatct tcatcttctt atctgtacta acgcaagagc 300 cccttaactg gtatccctcc ttccatttct tgatctacta aaatccatac 350 gccacatagt ggctagaata attttttaaa cacaaattca ccatgtttct 400 ctactaactt ggaatgctta atgtgttccc attgtaccta gaataaatcc 450 aaacttactt tccagggtct gctctccaag ctgtacatga cctggcccat 500 agccaccttt ctaaactcgt cacatccatt ctcctcattg ctcatggtgc 550 tgtggacagt ctggttcctt tctgttcttc tccactacca agctcattca 600 cactgcccct tttccaaggc ccttccctac ac 632 <210> SEQ ID NO 155 <211> LENGTH: 558 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 61, 91, 96, 108, 120, 157, 393, 478 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 155 ttttttatca ttttgaactt tatgganaaa ttgggcagcc aaaacgcttc 50 ccggggaagg ngccagcgaa gaatgcatcc taacgttagt naaggntgcc 100 aaggaggntg tgcaacatgn tcagattaca atggatgttt gtcatgtaag 150 cccagantat tttttgtttc tggaaagaat tggcatgaag cagattggag 200 tatgtctctc ttcatgtcca agtggatatt atggaactcg atatccagat 250 ataaataagt gtacaaaatg caaagctgac tgtgatacct gtttcaacaa 300 aaatttctgc acaaaatgta aaagtggatt ttacttacac cttggaaagt 350 gccttgacaa ttgcccagaa gggttggaag ccaacaacca tantatggag 400 tgtgtcagta ttgtgcactg tgaggtcagt gaatggaatc cttggagtcc 450 atgcacgaag aagggaaaaa catgtggntt caaaagaggg actgaaacac 500 gggtccgaga aataatacag catccttcag caaagggtaa cctatgtccc 550 ccaacaaa 558 <210> SEQ ID NO 156 <211> LENGTH: 695 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 4, 6, 29, 42, 55, 57, 70, 92, 115, 118-119, 585 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 156 atcnangtgg atgcagtctt cattgacana agtaacctgg anatcactcc 50 ggacnanccc cgctggatcn gagcctggtg gggtggcttt cngctctgcg 100 gtgccttaca cttcntcnnt tccctcttga tgtttgggtt tccacagtcc 150 ctgcccccgc actcagaccc cgccatggaa agcgagcagg ccatgctctc 200 cgaaagagaa tacgagagac ccaagcccag caacggggtc ctgaggcacc 250 ccctggagcc agacagcagt gcctcctgtt tccagcagct gagagtgatc 300 ccgaaggtca ccaagcacct gctctcaaac cctgtgttca cctgcatcat 350 cctggccgcc tgcatggaga ttgcagtggt ggctggcttc gctgcctttt 400 tggggaagta cctggagcag cagtttaacc tcaccacctc ttctgccaac 450 cagctgcttg ggatgactgc gatcccgtgt gcttgtctgg gtatcttcct 500 gggaggtctt ttggtgaaga agctcagcct gtctgccctg ggggccattc 550 ggatggccat gctcgtcaac ctggtgtcca ctgcntgcta cgtctccttc 600 ctcttcctgg gctgcgacac tggccctgtg gctggggtta ctgttcccta 650 tggaaacagc acagcacctg gctcagccct ggacccctac tcgcc 695 <210> SEQ ID NO 157 <211> LENGTH: 574 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 53, 66, 73, 85, 90, 124, 216, 429, 444, 474 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 157 tggaaagcca ttaaaggaat ttaaagttat tttacctgca gacctgaaaa 50 atntatagaa ctgttnacat atntttgtat atctnttcan taggtgaact 100 tttcatgggc taaacagtac attngagtga aattctgaag aaacatttta 150 aggaaaaaca gtggaaaagt atattaatct ggaatcagtg aagaaaccaa 200 gaccaacacc tcttantcat tattccttta catgcagaat agaggcattt 250 atgcaaattg aactgcaggt ttttcagcat atacacaatg tcttgtgcaa 300 cagaaaaaca tgttggggaa atattcctca gtggagagtc gttctcatgc 350 tgacggggag aacgaaagtg acaggggttt cctcataagt tttgtatgaa 400 atatctctac aaacctcaat tagttatant gtacactttc attntcatca 450 acactgagac tatcctgtct cacntacaaa tgtggaaact ttacattgtt 500 cgatttttca gcagactttg ttttattaaa tttctattag tgttaagaat 550 gctaaattta tgtttcaatt ttat 574 <210> SEQ ID NO 158 <211> LENGTH: 779 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 58 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 158 ctaattttat caaaggccnt ttttcccaaa gccatccatc atcccattat 50 taatctgnac tgttgcaaca tggctattgt ctgaaatttt atgagttact 100 atcctgggat ttccctttat ctttctgtat tagaccttct gtttcttgga 150 acctatgtca tccatcttga tgtactccct tattttgata gtgtatatcc 200 tttagtggct tcctaagaaa aagtgcatag atagtaaaat tttgagacct 250 tgcatagctg atagttttat tctaatctca ctcttggttg attagtttaa 300 cagggtagaa aatttcaggt tgaataccag ttttcttcag tatttgaagg 350 tgttatttta ttgatttcga actttcaaca ttgctgttga aatctgaagt 400 tattctgatt ctgatctttt gtatataagt ctttatgacc tctaaaagtt 450 ttcagaattc tgtttgttta tggaattctg aaagttgatg atgtaccata 500 gtggaatact tttacattta ttgtactggg tattccaaag gcccttttta 550 tccaaaaact catgtctttt agtgctggaa atttttcttt tgttattttc 600 atatttttct tccccttttt tctcttttcg ctttctggaa tgcctgttgg 650 tcaaatgtca gattttctga ctcattctat acaattagaa agcacaccca 700 agtttcactg tggaactact ccagtgagcc cttcagtgtg gtcatctctg 750 ggcagagata ctatagattt actgctaag 779 <210> SEQ ID NO 159 <211> LENGTH: 358 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 39, 60, 91 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 159 tcaggatgtt cttaattggg gaagaaatca ttttttccnt acaaaaaacc 50 aagcacttcn tggggccgga ttacactgaa acattgtact nacccagagg 100 agaggaaatt accacgaaac ctgagaacat ggaacactgt tactataaag 150 gaaacatcct aaatgaaaag aattctgttg ccagcatcag tacttgtgac 200 gggttgagag gatacttcac acatcatcac caaagatacc agataaaacc 250 tctgaaaagc acagacgaga aagaacatgc cgtctttaca tctaaccagg 300 aggaacaaga cccagctaac cacacatgtg gtgtgaagag cactgacggg 350 aaacaagg 358 <210> SEQ ID NO 160 <211> LENGTH: 362 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 55 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 160 atgctgcgtg ggatctccca gntacctgca gtggccacca tgtcttgggt 50 cctgntgcct gtactttggc tcattgttca aactcaagca atagccataa 100 agcaaacacc tgaattaacg ctccatgaaa tagtttgtcc taaaaaactt 150 cacattttac acaaaagaga gatcaagaac aaccagacag aaaagcatgg 200 caaagaggaa aggtatgaac ctgaagttca atatcagatg atcttaaatg 250 gagaagaaat cattctctcc ctacaaaaaa ccaagcacct cctggggcca 300 gactacactg aaacattgta ctcacccaga ggagaggaaa ttaccacgaa 350 acctgagaac at 362 <210> SEQ ID NO 161 <211> LENGTH: 479 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 160 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 161 gtttgggcta acaggatctc ctcttgcagt ctgcagccca ggacgctgat 50 tccagcagcg ccttaccgcg cagcccgaag attcactatg gtgaaaatcg 100 ccttcaatac ccctaccgcc gtgcaaaagg aggaggcgcg gcaagacgtg 150 gaggccctcn tgagccgcac ggtcagaact cagatactga ccggcaagga 200 gctccgagtt gccacccagg aaaaaaaggg ctcctctggg agatgtatgc 250 ttactctctt aggcctttca ttcatcttgg caggacttat tgttggtgga 300 gcctgcattt acaagtactt catgcccaag agcaccattt accgtggaga 350 gatgtgcttt tttgattctg aggatcctgc aaattccctt cgtggaggag 400 agcctaactt cctgcctgtg actgaggagg ctgacattcg tgaggatgac 450 aacattgcaa tcattgatgc gcctgtccc 479 <210> SEQ ID NO 162 <211> LENGTH: 307 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 65, 204 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 162 tgtcacaggt gggaaagaaa cggactgtgg gccctctctt ggattagcgg 50 cgggcatacc attgntggtg gccacagccc tgctggtggc tttactattt 100 actttgattc accgaagaag aagcagcatt gaggccatgg aggaaagtga 150 cagaccatgt gaaatttcag aaattgatga caatcccaag atatctgaga 200 atcntaggag atcacccaca catgagaaga atacgatggg agcacaagag 250 gcccacatat atgtgaagac tgtagcagga agcgaggaac ctgtgcatga 300 cgttac 307 <210> SEQ ID NO 163 <211> LENGTH: 502 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 188 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 163 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tataggcttt 50 aaaatgtata tgtcttgcca tactgaaccc atgttgaagc catatttcca 100 cagggtaata gctggcagaa ctgagttaag ggttgcccct tttagatgag 150 gcatatgctc tcccatcctc cacagttcac actatgcntg cttatctctt 200 actgatatta gatattagta atagtcacat ttatgcattg tctttattta 250 aaaaaatagt tctctttttt atgacagtag caatagttag aatatgaaag 300 agagaagagg atttatcctt gccctactca attccttgat atcatctgcc 350 tggtaatgag gtgttggagc tggctaatac tgacttatga gagcatattg 400 ttaaatattc aggaatttta ccagcagcaa ccaccattgg tagattggaa 450 tcagccacag tgggagtatt tacaccaggg aaatcaacga acattacaaa 500 tc 502 <210> SEQ ID NO 164 <211> LENGTH: 238 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 164 tttcaaaaaa aaaaaagtgc ttctagtaaa taacacataa cttttgtttt 50 ataacccaat gttacagtcc ctctcttata ggagaaccca atccattcag 100 tttatcagtg atatgcctgt ttttgtgtgt tccatcggac tttgtttcct 150 tttttcgatt ttgttattgt ttccaccttt tcaattttct tacatttgtt 200 ggctctctca agcttctgtt tattcccctt ctccctcc 238 <210> SEQ ID NO 165 <211> LENGTH: 702 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 165 cccgctgctc gggcactgtc tatatacgcc taacacctac atatatttta 50 aaaacattaa atataattaa caatcaaaag aaagaggaga aaggaaggga 100 agcattactg ggttactatg cacttgcgac tgatttcttg gctttttatc 150 attttgaact ttatggaata catcggcagc caaaacgcct cccggggaag 200 gcgccagcga agaatgcatc ctaacgttag tcaaggctgc caaggaggct 250 gtgcaacatg ctcagattac aatggatgtt tgtcatgtaa gcccagacta 300 ttttttgctc tggaaagaat tggcatgaag cagattggag tatgtctctc 350 ttcatgtcca agtggatatt atggaactcg atatccagat ataaataagt 400 gtacaaaatg caaagctgac tgtgatacct gtttcaacaa aaatttctgc 450 acaaaatgta aaagtggatt ttacttacac cttggaaagt gccttgacaa 500 ttgcccagaa gggttggaag ccaacaacca tactatggag tgtgtcagta 550 ttgtgcactg tgaggtcagt gaatggaatc cttggagtcc atgcacgaag 600 aagggaaaaa catgtggctt caaaagaggg actgaaacac gggtccgaga 650 aataatacag catccttcag caaagggtaa cctgtgtccc ccaacaaatg 700 ag 702 <210> SEQ ID NO 166 <211> LENGTH: 365 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 34, 93, 126, 145, 151, 161, 195 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 166 ggattacaac ccccgggagc gcgccctnta tacntggaac aacggccacc 50 aggtgctata caatgtcacc ctgtttcacg tcatcagcac ctntgggggc 100 ccttttcatt cgtgcctgtg tccccncaag ggtgatctct atgtntatgt 150 nacgcccttt ntccccgcct ttttgctggg cttttgttct ctgcntatgt 200 atttctgtct attttttcaa tttcccctct tctcctttat tgatctctgc 250 ttttaataca ccacttcttt ctttctgcct ttttatggat gtctttttct 300 ttttatggct ctggttctcc agttctttcc gtctctgcct ctctctgtct 350 ctctctctct gtcct 365 <210> SEQ ID NO 167 <211> LENGTH: 452 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 167 tcagcaaaac gtggatttaa atctcnttgc acaagcttga gagcaacaca 50 atttatcagg aaagaaagaa agaaaaaaac cgaacctgac aaaaaagaag 100 aaaaagaaga agaaaaaaaa tcatgaaaac catccagcca aaaatgcaca 150 attctatctc ttgggcaatc ttcacggggc tggctgctct gtgtctcttc 200 caaggagtgc ccgtgcgcag cggagatgcc accttcccca aagctatgga 250 caacgtgacg gtccggcagg gggagagcgc caccctcagg tgcactattg 300 acaaccgggt cacccgggtg gcctggctaa accgcagcac catcctctat 350 gctgggaatg acaagtggtg cctggatcct cgcgtggtcc ttctgagcaa 400 cacccaaacg cagtacagca tcgagatcca gaacgtggat gtgtatgacg 450 ag 452 <210> SEQ ID NO 168 <211> LENGTH: 443 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 110-111, 122, 134, 275 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 168 ggagtggctt cccctactgc gtgntttgac gcccatcccg gtgctcacgt 50 ggtttttccc ccatcatcgg ccacatgggc atctgcacat ccacaggagt 100 cattcgggan ntcgcgggcc cntactttgt ctcngaggac aacatggcct 150 ttggaaagcc tgccaagtac tggaagttgg accctgctca ggtctatgct 200 agcgggccca acgcatggga cacggctgtg cacgacgcct ctgaggagta 250 caagcaccgc atgcacaatc tctgntgtga caactgccac tcgcacgtgg 300 cattggccct gaatctgatg cgctacaaca acagcaccaa ctggaatatg 350 gtgacgctct gcttcttctg cctgctctac gggaagtacg tcagcgttgg 400 ggccttcgtg aagacctggc tgcccttcat ccttctcctg ggc 443 <210> SEQ ID NO 169 <211> LENGTH: 319 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 54, 163, 203 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 169 tgggagatgt atgcttactc tccttagcct ttcattcatc ttggcaggac 50 ttantgttgg tggagcctgc atttacaagt acttcatgcc caagagcacc 100 atttaccgtg gagagatgtg cttttttgat tctgaggatc ctgcaaattc 150 ccttcgtgga ggngagccta acttcctgcc tgtgactgag gaggctgaca 200 ttngtgagga tgacaacatt gcaatcattg atgtgcctgt ccccagtttc 250 tctgatagtg accctgcagc aattattcat gactttgaaa agggaatgac 300 tgcttacctg gacttccag 319 <210> SEQ ID NO 170 <211> LENGTH: 383 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 87, 117, 120, 124 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 170 ggaagcaaag gaggaagatc taccacagaa ggttgaggaa aagttcaacc 50 tcacacaagc acagatcaaa cagacagctt ggaattnagc aaacaacagt 100 ttttacacca gtagcangan ttcntattgt taactttgat tatagcatgg 150 aggaaaagtt tgaatccttt tcaagttttc ctggagtaga atcaagttat 200 aatgtgttac caggaaagaa gggacactgt ttggtaaagg gcataaccat 250 gtacaacaaa gctgtgtggt cgcctgagcc ctgcactacc tgcctctgct 300 cagatggaag agttctttgt gatgaaacca tgtgccatcc ccagaggtgc 350 ccccaaacag ttatacctga aggggaatgc tgc 383 <210> SEQ ID NO 171 <211> LENGTH: 636 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 171 actacattgc ctggaggaag cctaaggaac ccaggcatcc agctgcccac 50 gcctgagtcc aagattcttc ccaggaacac aaacgtagga gacccacgct 100 cctggaagca ccagccttta tctcttcacc ttcaagtccc ctttctcaag 150 aatcctctgt tctttgccct ctaaagtctt ggtacatcta ggacccaggc 200 atcttgcttt ccagccacaa agagacagat gaagatgcag aaaggaaatg 250 ttctccttat gtttggtcta ctattgcatt tagaagctgc aacaaattcc 300 aatgagacta gcacctctgc caacactgga tccagtgtga tctccagtgg 350 agccagcaca gccaccaact ctgggtccag tgtgacctcc agtggggtca 400 gcacagccac catctcaggg tccagcgtga cctccaatgg ggtcagcata 450 gtcaccaact ctgagttcca tacaacatcc agtgggatca gcacagccac 500 caactctgag ttcagcacag cgtccagtgg gatcagcata gccaccaact 550 ctgagtccag cacaacctcc agtggggcca gcacagccac caactctgag 600 tccagcacac cctccagtgg ggccagcaca gccacc 636 <210> SEQ ID NO 172 <211> LENGTH: 480 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 99, 162 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 172 tacattgcct tggaggaagc ntaaggaacc caggcatccc agctgcccac 50 gcctgagtcc aagattcttc ccaggaacac aaacgtagga gacccacgnt 100 cttggaagca ccagccttta tctcttcacc ttcaagtccc ctttctcaag 150 aatcctctgt tntttgccct ctaaagtctt ggtacatcta ggacccaggc 200 atcttgcttt ccagccacaa agagacagat gaagatgcag aaaggaaatg 250 ttctccttat gtttggtcta ctattgcatt tagaagctgc aacaaattcc 300 aatgagacta gcacctctgc caacactgga tccagtgtga tctccagtgg 350 agccagcaca gccaccaact ctgggtccag tgtgacctcc agtggggtca 400 gcacagccac catctcaggg tccagcgtga cctccaatgg ggtcagcata 450 gtcaccaact ctgagttcca tacaacctcc 480 <210> SEQ ID NO 173 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 9, 43, 51, 54, 120 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 173 gacaaaggnt catttgtaaa gaagctcctt ccagcacctc ctntcttctc 50 nttntgccca aactcaccca gtgagtgtga gcattttaag aagcatcctc 100 tgcccaagac caaaaggaan gaagaaaaag ggccaaaagc caaaatgaaa 150 ctgatggtac ttgttttcac cattgggcta actttgctgc taggagttca 200 agccatgcct gcaaatcgcc tctcttgcta cagaaagata ctaaaagatc 250 acaactgtca caaccttccg gaaggagtag ctgacctgac acagattgat 300 gtcaatgtcc aggatcattt ctgggatggg aagggatgtg agatgatctg 350 ttactgcaac ttcagcgaat tgctctgctg cccaaaaaac 390 <210> SEQ ID NO 174 <211> LENGTH: 451 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 174 gtttggtaag actccagact ccagctaaca gtccctatgg aaagatggca 50 tcaaaaaaga tagatctata tatatatata aatatatatt ctattacatt 100 ttcagtgagt aattttggat tttgcaaggt gcatttttac tattgttaca 150 ttatgtggaa aacttatgct gatttattta agggggaaaa agtgtcaact 200 ctttgttatt tgaaaacatg tttatttttc ttgtctttat tttaaccttt 250 gatagaacca ttgcaatatg ggggcctttt gggaacggac tggtatgtaa 300 aagaaaatcc attatcgagc agcattttat ttacccctcc cctatcccta 350 ggcacttaac caagacaaaa agccacaatg aacatccctt tttcaatgaa 400 ttttataatc tgcagctcta ttccgagccc ttagcaccca ttccgaccga 450 g 451 <210> SEQ ID NO 175 <211> LENGTH: 692 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 42, 97, 173 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 175 cggattggat ggattgnttg aacggattgg gttgggggaa gnaaagggaa 50 aggagggaga aaggagggaa taactgggct ccatcttttg agagctnttg 100 gttgggcaag ggcagaaaac aggcccacag tgctcaaccc cggacaccct 150 cacgaaggtt cgcaaagtca ctncttgtgg cttcagattg ctctttagga 200 cctggaggga cagacccaga atcagggtcc cctcctttac cccctgagtt 250 ccttactgtt cccccaagcc tgggagcagt ctatccccca accctgccat 300 ctcccttact catccctctt ccacagcttc ccctttctag ccccctctgc 350 cctacctgtc tttcctgagt gtttgagggg agagagagac ccacatctcc 400 ccaaagagat gagcttttgg ggcacaacat cccaccgcag gccccctcac 450 ccgacaacac ctcctacctg gccccttgcc aaatcccaag cagaattagc 500 aacaggaaaa gcagagcccc aggagagaca ctctactata tatactcttc 550 tatatattct gtttctattg tatattcact ctgtacatgt gggtgtaaat 600 gctgttaaat gacaaaccca atattatact gtggctggtg gactattttc 650 atcctcagtg ctgtacagat ctattttcat tgtatatttg at 692 <210> SEQ ID NO 176 <211> LENGTH: 358 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 59 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 176 tggatgggcg gccagcgatg accccattga gaaggtcatt gaagggatca 50 accgagggnt gagcaatgca gagagagagg tgggcaaggc cctggatggc 100 atcaacagtg gaatcacgca tgccggaagg gaagtggaga aggttttcaa 150 cggacttagc aacatgggga gccacaccgg caaggagttg gacaaaggcg 200 tccaggggct caaccacggc atggacaagg ttgcccatga gatcaaccat 250 ggtattggac aagcaggaaa ggaagcagag aagcttggcc atggggtcaa 300 caacgctgct ggacagggca accatcaaag cggattttcc agccatcaag 350 gaggggcc 358 <210> SEQ ID NO 177 <211> LENGTH: 450 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 49, 58, 74, 283 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 177 gaccttccca gcaatatgca tcttgcacgt ctggtcggct cctgctccnt 50 ccttctgnta ctgggggccc tgtntggatg ggcggccagc gatgacccca 100 ttgagaaggt cattgaaggg atcaaccgag ggctgagcaa tgcagagaga 150 gaggtgggca aggccctgga tggcatcaac agtggaatca cgcatgccgg 200 aagggaagtg gagaaggttt tcaacggact tagcaacatg gggagccaca 250 ccggcaagga gttggacaaa ggcgtccagg ggntcaacca cggcatggac 300 aaggttgccc atgagatcaa ccatggtatt ggacaagcag gaaaggaagc 350 agagaagctt ggccatgggg tcaacaacgc tgctggacag gttgggaagg 400 aggcagacaa actgatccat catggggtcc atcacggggc caaccaggcg 450 <210> SEQ ID NO 178 <211> LENGTH: 489 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 8, 64, 66, 68, 149, 302, 461 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 178 attgaatnac agtttttctg gtttttttgt ggagtttttg ttttggtttt 50 tgagatggag tttngntntt gttccccagg ctggagtgtg gtggtgcgat 100 ttcggcttac cgcaacttct gcttcccggg ttcaggcagt tttcctgcnt 150 cggcttcctg agtggctggt attacgggca tgcaccgtcg cgccccactg 200 gttttgtatt tttttagtag agacggggtt tttccgtgtt ggtcaggctg 250 gtctcgaact cccgacctca ggtgatccgc ccgcctcggc ctcccaaggt 300 tntgggattg caggtgtgag ccaccgtgcc cggctgtttt ttgtgggttt 350 tttgtttgtt tgtttgtttt tgagacagag tcttgctctg tcactcaggc 400 tggagtgcag tggcacagtc tcggctcact gcaacctctg cctcctgagt 450 tcaagccatt ntcctgcctc ggccccctca gtagctggg 489 <210> SEQ ID NO 179 <211> LENGTH: 495 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 78, 212, 234, 487 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 179 gggcgagaag taggggaggg cgtgttccgc cgcggtggcg gttgctatcg 50 ttttgcagaa cctactcagg cagccagntg agaagagttg agggaaagtg 100 ctgctgctgg gtctgcagac gcgatggata acgtgcagcc gaaaataaaa 150 catcgcccct tctgcttcag tgtgaaaggc cacgtgaaga tgctgcggct 200 ggcactaact gngacatcta tgaccttttt tatnatcgca caagcccctg 250 aaccatatat tgttatcact ggatttgaag tcaccgttat cttatttttc 300 atacttttat atgtactcag acttgatcga ttaatgaagt ggttattttg 350 gcctttgctt gatattatca actcactggt aacaacagta ttcatgctca 400 tcgtatctgt gttggcactg ataccagaaa ccacaacatt gacagttggt 450 ggaggggtgt ttgcacttgt gacagcagta tgctgtnttg ccgac 495 <210> SEQ ID NO 180 <211> LENGTH: 552 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12, 25, 65, 130, 437, 537 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 180 gggaggctgt gnccgttttg ttttnttggc taaaatcggg ggagtgaggc 50 ggcccggcgc ggcgngacac cgggttccgg gaaccattgc acgacggggt 100 ggactgacct gaaaaaaatg tttggatttn tagagggctt gagatgctca 150 gaatgcattg actgggggga aaagcgcaat actattgctt ccattgctgc 200 tggtgtacta ttttttacag gctggtggat tatcatagat gcagctgtta 250 tttatcccac catgaaagat ttcaaccact cataccatgc ctgtggtgtt 300 atagcaacca tagccttcct aatgattaat gcagtatcga atggacaagt 350 ccgaggtgat agttacagtg aaggttgtct gggtcaaaca ggtgctcgca 400 tttggctttt cgttggtttc atgttggcct ttggatntct gattgcatct 450 atgtggattc tttttggagg ttatgttgct aaagaaaaag acatagtata 500 ccctggaatt gctgtatttt tccagaatgc cttcatnttt tttggagggc 550 g 552 <210> SEQ ID NO 181 <211> LENGTH: 690 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 87, 89, 97, 127, 148, 170, 221, 232, 357, 426, 478, 561 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 181 ttctttttag agattccntt ggaccttgac ccaaggtttc cgacaggttt 50 ttttttgaat tttggaacag acctttatat tttgggncna gaagttngcc 100 cagaaagcag caggggtttt gcctggntgt agagcccagt tcattggntg 150 tccctgggtt tgtttccttn ttccgagtag ttgtgccttt tttcagatca 200 ggttaccaca atgctccccg ntgtgacgtt tnatccccca cacttccagc 250 cccagttacc tggagttttt cagaacccac tttgccggtg ttaaaacaca 300 agagggggtg aaagtggctg ccagtaatgg ccagaaacca accaccagag 350 gccaggntga aagacaagtt ccgggtgtcc aggggctgac gggccaacca 400 tgtggcaggt cccaggcccc acccantgcg ccatccgctt ctgagctcca 450 cagtggtccc actaatggga acctcctnta gggagagtga tactgcacct 500 tcacccgtag gactcatatt tataacaatg tgtaatggct gtagcaaaaa 550 gcccttgttt ntagatgtaa atggtcaaag aaacaagcgt tttattgttt 600 tgaataaaat agttcaaatg agtcctgtat cattgtatct cctattctgg 650 attagtgcct tttggacagt agactgttct gtaattaaaa 690 <210> SEQ ID NO 182 <211> LENGTH: 468 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 59, 95, 149, 331, 364, 438, 446 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 182 aattttcacc gctgtaggaa tccagatgca ggccaagtac agcagcacga 50 gggacatgnt ggatgatgat gggacaccac catgagcctg cattntcaag 100 cttttgccac aattcggcat ccagagcccc ggcgcacaga gcacagggnt 150 cctttttcaa cgtggcgacc agtggccctg accctgctga ctttgtgctt 200 ggtgctgctg atagggctgg cagccctggg gcttttgttt tttcagtact 250 accagctctc caatactggt caagacacca tttctcaaat ggaagaaaga 300 ttaggaaata cgtcccaaga gttgcaattt nttcaagtcc agaatataaa 350 gcttgcagga agtntgcagc atgtggctga aaaactctgt cgtgagctgt 400 ataacaaagc tggaggaact ttgaaggagg gcaaagtntc ctcatntact 450 atacacacac cacttccc 468 <210> SEQ ID NO 183 <211> LENGTH: 227 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 50, 84, 90, 111, 131, 154, 174-175, 189, 201 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 183 tcacagcatg agagagatcc ntggtatagc tgggaccagc cgggcctgan 50 gttgaactgg ggtgaaccga tgcactggca cctngacatn tacaacagga 100 accgtgtgga nacatccccc acacctgttt nttggcatgt catgtgtatg 150 cagntcttcg gtttcctggc tttnntgata ttcatgtgnt gggtggggga 200 ngtgtaccct gtctaccagc ctgtggg 227 <210> SEQ ID NO 184 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 33, 105, 126, 184, 199, 206, 218, 236 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 184 gaaagaagga aataaacaca ggcaccaaac cantatccta agttgactgt 50 cctttaaata tgtcaagatc cagacttttc agtgtcacct cagcgatctc 100 aacgntaggg atcttgtgtt tgccgntatt ccagttggtg ctctcggacc 150 taccatgcga agaagatgaa atgtgtgtaa attntaatga ccaacaccnt 200 aatggntggt atatctgnat cctcctgctg ctggtnttgg tggcagctct 250 tctctgtgga gctgtggtcc tctgcctcca gtgctggctg aggagacccc 300 gaattgattc tcacaggcgc accatggcag tttttgctgt tggagacttg 350 gactctattt atgggacaga agcagctgtg agtccaactg ttggaattca 400 ccttcaaact caaacccctg acctatatcc tgttcctgct ccatgttttg 450 gccctttagg ctcccctcct ccct 474 <210> SEQ ID NO 185 <211> LENGTH: 340 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 185 ccgaaacgcg gtctttctct agacgcgtct tgctgggaga gtgtccgttg 50 cttcccgtcc gtgtcgcggc cctgcggttg gcggcctcct cgtggagcgg 100 agcaaggctg agatctgtat ctgtggacct gaatgttgat ccctcgcttc 150 agattgacat acctgatgcg ctcagtgaga gagacaaagt caaatttaca 200 gtgcacacaa agaccacact gcccacgttt cagagcccag agttttctgt 250 tacaaggcaa catgaagact ttgtgtggct acatgacact cttattgaaa 300 caacagacta tgctgggctt attattccac ctgctctttg 340 <210> SEQ ID NO 186 <211> LENGTH: 411 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 186 ggctggagca aatgctccac agctgccgaa tccagaagtc agatttcagc 50 aacaactgga acagctcaac gcaatggggt tcttaaaccg tgaagcaaac 100 ttgcaggccc taatagcaac aggaggcgac atcaatgcag ccattgaaag 150 gctgctgggc tcccagccat cgtaatcaca tttctgtacc tggaaaaaaa 200 tgtatcttat ttttgataat ggctcttaaa tctttaaaca cacacacaaa 250 atcgttcttt actttcattt tgattctttt aaatctgtct agttgtaagt 300 ctaatatgat gcattttaag atggagtccc tccctcctac ttccctcact 350 ccctttctcc tttgcttatt tttcctacct tcccttcctc ttgtctcccc 400 actcccctcc c 411 <210> SEQ ID NO 187 <211> LENGTH: 277 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 187 cttagcataa acctacaggg ccctgtgtga tcggactcct gcccacttga 50 catgttagtt acttgcccct cgttgcttcg tgctttacct tccagaatca 100 ttaaactgct gatgtttccc aaaaataact atgtacctgg gtcagctcat 150 gctggcatgg agttctcgtc catcaccatg cccaccctgg cttctttgag 200 cgcccgtata atatatatct ctaccatcat acttcatata ttttgttata 250 attgctggtt ttatttgcct ctgtggt 277 <210> SEQ ID NO 188 <211> LENGTH: 294 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 188 aaaaatcctg gttttttttg ggtttttttt ttgctgtgcc ctagaccatt 50 acataactga agactcccac cttcaggcag gtttgggtag tacacgtttg 100 taactacctg gcattgcctt ttgttgaagt aatttcagtt tttattagta 150 gtagtagtag tatactttgg gttctacagt atatgttcac aatgtgcagg 200 tttgttacat atgtatacat gtgccatgtt tgtttgctgc acccattaac 250 tggtcattta cattgggtat ttctcctaat actatccccc ccgc 294 <210> SEQ ID NO 189 <211> LENGTH: 385 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 189 gtaacatttg ggagtgacaa gactgttcat cagcttgggg cctggcagca 50 acttttctag agttagcttt tttctccttt cttgttccat gacttaaaaa 100 taataacttg ttgggcatgg tgcctcattc ttgtaatccc agcactttgg 150 gaggctgagg cacttgtggc caggagttca agactagcct gggcaacgta 200 gtagatgccc tccccgccac catctctaca aaagaaaaaa agttaactct 250 tgatttgctt tctagtagtg ggtgaatttg gagttccaat gattgtcaac 300 ccattaattc ttcatttact gaacatctcc ttatgtttca gatgctgcaa 350 agatgtacaa gactttgttt cctaccctcc ttttt 385 <210> SEQ ID NO 190 <211> LENGTH: 134 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 190 tgcaatctgc cttgtgtgct gttgtaaaca agttagtgtt caaccagtgt 50 ttaaagtgtc tgttttaaaa gctctaatta tggtagtatt tccatttcct 100 tttacaacac cctttatttt gttcctccag gttc 134 <210> SEQ ID NO 191 <211> LENGTH: 245 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 191 ttttaaaaaa aaaaaaaaac aaagaaattc tatgttaact caataccaac 50 atcttgcaga actagagtac aatatcacag ccaggatgtt gaccttgata 100 cgagccatca gtcttattcg ggttttccca aatttacttt gtgtgtgtgt 150 gtgtctgtgt gtagttaggt ctatgctagt ttatgacgtg cagtttcatg 200 tatctcccac cacagccaac acacagaaca gttccatctc ccctc 245 <210> SEQ ID NO 192 <211> LENGTH: 323 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 192 ggtttcgcca tgttgcccaa gctgttcttg aactcccggg ctcaggtgat 50 ccgcctccct cggcctccca gagtgctggg attacaggca cggaccacca 100 tgcccagcct ccacatcttt ttttgcactg tgtatactct tctgagacat 150 gccaacttcc tccaggtcaa gaaaggggta tatagctctc agcttcactc 200 tttcagggct gatgtcgcct ttgccttttc tcacttcact gacctgtcta 250 ttcctacaac tgtctctttc tagagaagcc tcaatgatca ggattgacag 300 gccacactct cccccacctt tct 323 <210> SEQ ID NO 193 <211> LENGTH: 481 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 193 cagcatgagc tccctgtgtg tgcaaggcag ctctatgcgg ttctcggtgt 50 ctcctaggaa gcaactttca gtaccctcct gtgttgagtc cgattttcta 100 aaagctgagc gggcatctag ggacctttct gtcactcagc cgactgtgtg 150 gctgtggcca gctctgggtc tgcctccccc agaactagat gcccatgggg 200 agtccatcag caccaatctc ctgtgatcgt ttatacaaca gaatctccac 250 tcaagtaaaa gtggggcctc ctcctatctt gctgtttgtg tgtgtgttgg 300 cagaccccag cgtggctgga acagatgatt gcacatacca cgtggcggga 350 ccttttttat aaactggctg aagcccatcc agactgtttg atgctgaact 400 tcaccgttaa ggtaggaaga gttctagagt taaggagaaa agtgtttatg 450 aatgtttatt tttggttgtt ggtctgtttg g 481 <210> SEQ ID NO 194 <211> LENGTH: 184 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 128 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 194 atagctctca gcttcactct ttcagggctg atgtcgcctt tgccttttct 50 cacttcactg acctgtctat tcctacaact gtctctttct agagaagcct 100 caatgatcag gattgacagg ccacactntc ccccaccatt tttttctcct 150 ccttcaagcc tcttgtctgt ttcaccctct agtg 184 <210> SEQ ID NO 195 <211> LENGTH: 225 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 195 gtttaattat ggtatgcaac cactcatgta ttcggttcag gaagcattaa 50 atgccagacc atggtggatt cgtatgggga ctgacatttg ttactataaa 100 aatcatttct caagaagttc agttgctgca ggtgggcaaa agggaaaatc 150 ctactataca attacattta ctgtcaattt tccacataaa gatgatgttt 200 gctactttgc ttatcactat ccttt 225 <210> SEQ ID NO 196 <211> LENGTH: 208 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 196 ctgacattca ttgtgatgag ggcagctttc tggtacagga ttctaagctc 50 tatgttttat atacattttc atctgtactt gcacctcact ttacacaaga 100 ggaaactatg caaagttagc tggatcgctc aaggtcactt aggtaagttg 150 gcaagtccat gcttcccact cagctcctca ggtcagcaag tctacttctc 200 tgctatag 208 <210> SEQ ID NO 197 <211> LENGTH: 403 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 112 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 197 atcttggccg tatgaaagta taacactaag aaaaaaattc atttttttca 50 aacgtaacct tccattcttt ctcccttttc ctctaaacta aaaccttctt 100 tcccatcttt tntttcttga accagactaa tctagacaaa gatctcagcc 150 tctgccagac agagttagag gcagatttag aaaaaatgga gacgcttaat 200 aaagcaccca gtgcaaacgt gccacaggta tttcctagtt tttctcatgc 250 catcagttcc ttttcaagct gtgctttgtt ttcttctttg ttctatggtt 300 tttgatgtag ttgaggtgac ggatggtgat gctggctatt ttaggctgca 350 tggctttctg actactgttt tagactcctt cccccacacc tacccagtta 400 gta 403 <210> SEQ ID NO 198 <211> LENGTH: 484 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 62, 150, 158, 195, 236 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 198 gttgaacgcc accgagggtc aagtcacaga caagaagctg tgcagtcacc 50 agtgtttcct cntgcccaga aacaaatcca ccaaaaaccc atacctctgc 100 caagatttac agaaggggga aacccaactg tggatgggcc cctacccagn 150 ttttcatnta attccactat ttcagaacag gaagctggcg ttctntgcaa 200 gccatggtat gctggagcct gtgatcgaaa gtctgntgaa gaggcattgc 250 acagatcaaa caaggatgga tcatttctta ttcggaaaag ctctggccat 300 gattccaaac aaccatatac actagttgta ttctttaata agcgagtata 350 taatattcct gtgcgattta ttgaagcaac aaaacaatat gccttgggca 400 gaaagaaaaa tggtgaagag tactttggaa gtgttgctga aatcatcagg 450 aatcatcaac atagtccttt ggttcttatt gaca 484 <210> SEQ ID NO 199 <211> LENGTH: 442 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 199 ggcggctggg ctgtttggtt tgagcgctcg ccgtcttttg gcggcagcgg 50 cgacgcgagg gctcccggcc gcccgcgtcc gctgggaatc tagcttctcc 100 aggactgtgg tcgccccgtc cgctgtggcg ggaaagcggc ccccagaacc 150 gaccacaccg tggcaagagg acccagaacc cgaggacgaa aacttgtatg 200 agaagaaccc agactcccat ggttatgaca aggaccccgt tttggacgtc 250 tggaacatgc gacttgtctt cttctttggc gtctccatca tcctggtcct 300 tggcagcacc tttgtggcct atctgcctga ctacaggatg aaagagtggt 350 cccgccgcga agctgagagg cttgtgaaat accgagaggc caatggcctt 400 cccatcatgg aatccaactg cttcgacccc agcaagatcc ag 442 <210> SEQ ID NO 200 <211> LENGTH: 756 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 31, 46, 68, 72, 95, 220 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 200 ggtccgaaaa gtaagttctt nttttgggct naacgggatt tccttntttg 50 cagttttgca gccccagnac gntgattccc agcaggcgct ttacngggca 100 gcccgaagat ttcacttatg gtgaaaatcg cctttcaata cccttaccgc 150 cgtgcaaaag gaggaggcgc ggcaagactt ggaggccctt cttgacccga 200 acggtcagaa ctcaggatan tgaccggcaa ggagctccga gttgccaccc 250 aggaaaaaga gggctcctct gggagatgta tgcttactct cttaggcctt 300 tcattcatct tggcaggact tattgttggt ggagcctgca tttacaagta 350 cttcatgccc aagagcacca tttaccgtgg agagatgtgc ttttttgatt 400 ctgaggatcc tgcaaattcc cttcgtggag gagagcctaa cttcctgcct 450 gtgactgagg aggctgacat tcgtgaggat gacaacattg caatcattga 500 tgtgcctgtc cccagtttct ctgatagtga ccctgcagca attattcatg 550 actttgaaaa gggaatgact gcttacctgg acttgttgct ggggaactgc 600 tatctgatgc ccctcaatac ttctattgtt atgcctcaaa aaaatctggt 650 agagctcttt ggcaaactgg cgagtggcag atatctgcct caaacttatg 700 tggttcgaga agacctagtt gctgtggagg aaattcgtga tgttagtaac 750 cttggc 756 <210> SEQ ID NO 201 <211> LENGTH: 445 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 201 gatgggtttc caagcgttca ttcaaaaact tgctgggtaa tccccaggcc 50 tctatagctc agatcattgt cacagtcgta ctgggactgg ttataggtgc 100 catttacttt gggctaaaaa atgattctac tggaatccag aacagagctg 150 gggttctctt cttcctgacg accaaccagt gtttcagcag tgtttcagcc 200 gtggaactct ttgtggtaga gaagaagctc ttcatacatg aatacatcag 250 cggatactac agagtgtcat cttatttcct tggaaaactg ttatctgatt 300 tattacccat gaggatgtta ccaagtatta tatttacctg tatagtgtac 350 ttcatgttag gattgaagcc aaaggcagat gccttcttcg ttatgatgtt 400 tacccttatg atggtggctt attcagccag ttccatggca ctggc 445 <210> SEQ ID NO 202 <211> LENGTH: 700 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 66, 168 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 202 gcggccccct tggggtttgg attcaggatt tgttcctagt gtccaagatt 50 ttgttaggaa cttacngaag ttgatgctta cctacaaatc ttgattgaac 100 aattaaagct ttttgatgac aagcttcaaa actgcaaaga agatgaacag 150 agaaagaaaa ttgaactntc aaagagacaa caaatagcat ggtagaatca 200 attaaacact gcattgtgtt gctgcagatt gccaaagacc agagtaatgc 250 ggagaagcac gcagatggaa tgataagtac tattaatccc gtagatgcaa 300 tatatcaacc tggtcctttg gaacctgtga tcagcacaat gccttcccag 350 actgtgttac ctccagaacc tgttcagttg tgtaagtcag agcagcgtcc 400 atcttcccta ccagttggac ctgtgttggc taccttggga catcatcaga 450 ctcctacacc aaatagtaca ggcagtggcc attcaccacc gagtagcagt 500 ctcacttctc caagccacgt gaacttgtct ccaaatacag tcccagagtt 550 ctcttactcc agcagtgaag atgagtttta tgatgctgat gaattccatc 600 aaagtggctc atccccaaag cgcttaatag attcttctgg atctgcctca 650 gtcctgacac acagcagctc gggaaatagt ctaaaacgcc cagataccac 700 <210> SEQ ID NO 203 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 203 catgcagtgc ttcagcttca ttaagaccat gatgatcctc ttcaatttgc 50 tcatctttct gtgtggtgca gccctgttgg cagtgggcat ctgggtgtca 100 atcgatgggg catcctttct gaagatcttc gggccactgt cgtccagtgc 150 catgcagttt gtcaacgtgg gctacttcct catcgcagcc ggcgttgtgg 200 tctttgctct tggtttcctg ggctgctatg gtgctaagac tgagagcaag 250 tgtgccctcg tgacgttctt cttcatcctc ctcctcatct tcattgctga 300 ggttgcagct gctgtggtcg ccttggtgta caccacaatg gctgagcact 350 tcctgacgtt gctggtagtg cctgccatca agaaagatta tggttcccag 400 gaagacttca ctcaagtgtg gaacaccacc atgaaagggc tcaagtgctg 450 tggcttcacc aactatacgg attttgagga ctcaccctac ttcaaagaga 500 acagtgcctt tcc 513 <210> SEQ ID NO 204 <211> LENGTH: 348 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 204 gaatcgatag aaccgaggtg cagttggacc tgggagtgga caccaagatt 50 ttaaaagctc caatttcaga gcaagagtcg aaaactcaca gataaagtta 100 tagttatttc agggttctga aaagacgcag aacatgaagg gactcagaag 150 tctggcagca acaaccttgg ctcttttcct ggtgtttgtt ttcctgggaa 200 actccagctg cgctccgcag agactgttgg agagaaggaa ctggactcct 250 caagctatgc tctacctgaa aggggcacag ggtcgccgct tcatctccga 300 ccagagccgg agaaaggacc tctccgaccg gccactgccg gaaagacg 348 <210> SEQ ID NO 205 <211> LENGTH: 493 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 202 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 205 tccaggagac gactaaaatg ggctgtcttc atcggtggaa tacaacataa 50 tggagttgga acaagaactt gaaaatgtaa agactcttaa gacaaaatta 100 gagaggcgaa aaaaggcttc agcatgggaa agaaatttgg tgtatcccgc 150 tgttatggtt ctccttctta ttgagacatc catctcggtc ctcttggtgg 200 cntgtaatat tctttgccta ttggttgatg aaacagcaaa tgccaaaagg 250 aacaaggggg cctggaatag gaaatgcctc tctttctacg tttggttttg 300 tgggagctgc gcttgaaatc attttgattt tctatcttat ggtgtcctct 350 gttgtcggct tctatagcct tcgatttttt ggaaacttta ctcccaagaa 400 agatgacaca actatgacaa agatcattgg aaattgtgtg tccatcttgg 450 ttttgagctc tgctctgcct gtgatgtcga gaacactggg aat 493 <210> SEQ ID NO 206 <211> LENGTH: 599 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 38, 48, 191, 261 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 206 ctattagaga ttccccttgg acccttggac ccaacggngt cccggggnac 50 accccctttt ttcagaaacc cagggctgtg taagagctgc ttggagtagg 100 caccccattt aaagaaaaaa atgaagaagc agcaataaag aagttgtaat 150 cgttacctag acaaacagag aactggtttt gacagtgttt ntagagtgct 200 ttttattatt ttcctgacag ttgtgttcca ccatgattac tttctccttc 250 agcgaatagg ntaaatgaat atgaaacaga aaagcgtgta tcagcaaacc 300 aaagcacttc tgtgcaagaa ttttcttaag aaatggagga tgaaaagaga 350 gagcttattg gaatggggcc tctcaatact tctaggactg tgtattgctc 400 tgttttccag ttccatgaga aatgtccagt ttcctggaat ggctcctcag 450 aatctgggaa gggtagataa atttaatagc tcttctttaa tggttgtgta 500 tacaccaata tctaatttaa cccagcagat aatgaataaa acagcacttg 550 ctcctctttt gaaaggaaca agtgtcattg gggcaccaaa taaaacaca 599 <210> SEQ ID NO 207 <211> LENGTH: 578 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 49, 75, 77, 283, 458 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 207 tgccttttcc tctgaccctt caggtccctc accgagtttt gctccaggng 50 tatattgaaa acatacccag tgctntntca agcacccact gcttagaggg 100 cccagatttc ttttccttct ttcccttgca gagctggaga ctgcatcggg 150 catctggtgt ttaaactaaa caggaaaact gactaaaggt ccacagtgct 200 cattgtgtag actagctgcc ctccgatggg tgctctgatt atcagtggtt 250 ccagtgcagg gcctgtcact aaacaggcct canttcctcc ttgggggctt 300 tcccatggga ggtgtggctt tttactctac atggaaatga ctctctgcag 350 ccacagaaca cagtcatttt ctgaattatc ccagtctctc atgcgccctg 400 gattcctcca gatgccttat atctcttgtg caaagttgtc taaaatttgg 450 ttcccagntt ccaagccttg ccttttggcc ttcctggaag tatttttgtt 500 gatgagtcgt ctgtcattat tctctaaaat gatttgcttt ttgtttcttt 550 cattcctatt tccaccccac atatacac 578 <210> SEQ ID NO 208 <211> LENGTH: 588 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 332, 427, 444, 449, 480, 508, 541, 578 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 208 tctttctgta agactcaact gatatatatt atactgatgc aaatattaag 50 tagggcataa aaatatgctt ccataatatg aaatagatta ttcaataatt 100 gagaaacttt atgtgtaatc atgagagtat aagagtctgg attatctaac 150 attgttagcc ctgtgtatgt acagttcaaa aagttcattt ataaaagtag 200 tttcctgttc ctagtgtgat gtatcacaaa ttgtgctgag gttattttag 250 tatgtgtgtt tcattcccgt gcttctgttc tgaagtcctg gaatacagtt 300 ttcagtgtaa ttaattcaac tgcacttaac antaatgtcc gtgttggtat 350 agaaatgtct aaatcctata ctctagttga ggaagatctt ccataatttt 400 atggtattac acagggaaag ctatgantgc aggatcagtc taantatant 450 attaggtgca tgtattctct tttcactaan ttatacttgt ctatctagaa 500 tacaggtntt ccagtcagct ggtcatttac caggtgtgga nttaagttgc 550 tgggcttgca gtaagaattg ccagccantc attgtgcg 588 <210> SEQ ID NO 209 <211> LENGTH: 481 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 84 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 209 cgtgtggccc ccgcggtgcg gagtatgggg cgctgatggc catggagggc 50 tactggcgct tcctggcgct gctggggtcg gcantgctcg tcggcttcct 100 gtcggtgatc ttcgccctcg tctgggtcct ccactaccga gaggggcttg 150 gctgggatgg gagcgcacta gagtttaact ggcacccagt gctcatggtc 200 accggcttcg tcttcatcca gggcatcgcc atcatcgtct acagactgcc 250 gtggacctgg aaatgcagca agctcctgat gaaatccatc catgcagggt 300 taaatgcagt tgctgccatt cttgcaatta tctctgtggt ggccgtgttt 350 gagaaccaca atgttaacaa tatagccaat atgtacagtc tgcacagctg 400 ggttggactg atagctgtca tatgctattt gttacagctt ctttcaggtt 450 tttcagtctt tctgcttcca tgggctccgc t 481 <210> SEQ ID NO 210 <211> LENGTH: 569 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 325 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 210 tttcatatac catggagtta cataaaacat ggcattttgt atctggcttc 50 tttcacttaa tgttttcaag gttcattcag gctggagcgc ataatgatac 100 tttattcctt tctatggttg aataatattc cattgtatga atagaccata 150 ttttgtctat ccattcatca gttgatggac atctgggtta tttctatttt 200 tggctatcgt gaataatgct gccatggaca ttcacgtata agtttttgtg 250 tggatatatg ttttcatttc tttggagtag agttgctggg tcatggggta 300 accctaggtt taagcttttg aggcntacca gatttccaaa gtgactgcat 350 cattttgcat tcccatcaac agtatatgaa ggttctaact tctctacatc 400 ttcaccaata tttgttattg tctgtcttct tgacaaaagt tctcctagtg 450 ggtgtgaact ggtatcattt tgtggttttg atttgcattt cctggatggt 500 tatgaatgtt gattttactt tcatgtgctt attggccatt gtatatcttt 550 gggaaaatag ctattttcc 569 <210> SEQ ID NO 211 <211> LENGTH: 416 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 291 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 211 gtcgaaagaa gcttatctgc aaaagatata atgaaaaatg ggaagagcaa 50 tcatctcaaa cagttccggg ttgctgccct tttggctttc ctaggtgcta 100 cagtagcagg ctgttttccc cttttccata gaggggaata ttctgcatca 150 cccctttgtt tgccatttcc tacaggtgaa acgccatcat taggattcac 200 tgtaacgtta gtgctattaa actcactagc atttttatta atggccgtta 250 tctacactaa gctatactgc aacttggaaa aagaggacct ntcagaaaac 300 tcacaatcta gcatgattaa gcatgtcgct tggctaatct tcaccaattg 350 catctttttc tgccctgtgg cgtttttttc atttgcacca ttgatcactg 400 caatctctat cagccc 416 <210> SEQ ID NO 212 <211> LENGTH: 765 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 55, 63, 76, 81, 389, 626, 761 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 212 ttttggcctg ttggaatttc cccanttttt ttccccagga ggatttgccc 50 aaaantgagc ttntattggg acaggnggca nttggatttt tggagtaggt 100 gggcttttgt ttttggggtc tgcaattggt ttgtcttaga ggttcaggag 150 gggaaattat atggaagggt cccaaattgc attactttac aaactcattg 200 tactctgttt ggccattagt cttccttagg aatcggacga ttagccatta 250 taaaatcaat aggctatcag gaacatttaa cagagtattg gagttcactg 300 gaactttttc tttaccataa tagttgtgaa attgataaca ccactgctgt 350 tgattatttt tcccctaaat aagtcctgga ttattgccnt cggcattact 400 gtattatacc agctagccct tgactttacc tcactgaaga ggttaatatt 450 atatggcact gatggtagtg gcacacgggt tggtctatta aatgccaacc 500 gcgaaggaat aatctctacc ctggggtatg tggcaataca catggctggt 550 gtgcaaacag ggttatatat gcataagaac cgatcacata tcaaagactt 600 gataaaagta gcctgttttc ttttantggc agctattagc ctcttcatat 650 ctctttacgt agttcaagta aatgtagaag cagtatctcg aagaatggca 700 aatttagcct tttgtatttg gatagttgct tctagcctga tccttcttag 750 tagtttatta ntggg 765 <210> SEQ ID NO 213 <211> LENGTH: 500 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 117, 181, 219, 297, 397, 415 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 213 ggcggaactg aagttttttc ttaattatca tgtgacgggt tctggattta 50 atggggggaa aagggcggaa taggacaagg atccaaactg gcgaatttgc 100 tgatcttcgg gtccctntcc gctttccggc cggcagcgct gccagggtat 150 atttcctttt ttccgatcct gcaacagcct ntttaaactg tttaaatgag 200 aatgtccttg gctcagagng tactactcac ctggcttttc acactactct 250 tcttgatcat gttggtgttg aaactggatg agaaagcacc ttggaantgg 300 ttcctcatat tcattccagt ctggatattt gatactatcc ttcttgtcct 350 gctgattgtg aaaatggctg ggcggtgtaa gtctggcttt gaccctngac 400 atggatcaca caatnttaaa aaaaaagcct ggtacctcat tgcaatgtta 450 cttaaattag ccttctgcct cgcactctgt gctaaactgg aacagtttac 500 <210> SEQ ID NO 214 <211> LENGTH: 500 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 1, 15, 24, 49, 94, 126, 158, 196 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 214 nacggtgaat ttttngaagc caangaagga gatttgcaca ggatagaant 50 cccattcaaa ttccacatgt tgcattcagg gttggtccac ggcntggctt 100 tctggtttga cgttgctttc atcggntcca taatgaccgt gtggctgtcc 150 acagcccnga cagagcccct gacccactgg taccaggtgc ggtgcntgtt 200 ccagtcacca ctgttcgcca aggcagggga cacgctctca gggacatgtc 250 tgcttattgc caacaaaaga cagagctacg acatcagtat tgtggcccag 300 gtggaccaga ccggctccaa gtccagtaac ctcctggatc tgaaaaaccc 350 cttctttaga tacacgggca caacgccctc acccccaccc ggctcccact 400 acacatctcc ctcggaaaac atgtggaaca cgggcagcac ctacaacctc 450 agcagcggga tggccgtggc agggatgccg accgcctatg acttgagcag 500 <210> SEQ ID NO 215 <211> LENGTH: 739 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 98, 103, 114, 178 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 215 tggccggatc cctttagaaa tcccttggac cttggaccca aggtgtccgg 50 gcgagagcct tgggatgcac ccggccagag cccatgctgc tgctgctnaa 100 cgnttgcccc tccntggggg gccccacttg ggcagggaag atgtatggcc 150 ctggaggagg caagtatttc agcaccantg aagattacga cccatgaaat 200 cacagggctg cgggtgtctg taggtcttct cctggtgaaa agtgtccagg 250 tgaaacttgg agactccttg ggacgtgaaa ctgggagcct taggtgggaa 300 tacccaggaa gtcaccctgc agccaggcga atacatcaca aaagtctttg 350 tcgccttcca agctttcctc cggggtatgg tcatgtacac cagcaaggac 400 cgctatttct attttgggaa gcttgatggc cagatctcct ctgcctaccc 450 cagccaagag gggcaggtgc tggtgggcat ctatggccag tatcaactcc 500 ttggcatcaa gagcattggc tttgaatgga attatccact agaggagccg 550 accactgagc caccagttaa tctcacatac tcagcaaact cacccgtggg 600 tcgctagggt ggggtatggg gccatttacc gagcggccgc cgtaattggg 650 ccgctggggt atctctcgag aaaagagagg cccaatatga cccacatact 700 caatatggac gaactgatat tgtccacctg ttatgagtg 739 <210> SEQ ID NO 216 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 92, 120, 205, 214, 238, 348, 353, 358 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 216 tttccaaaag ttgtgaagga cacctccatc cattcaaggc agttgtcaaa 50 gcagaaattt tcagtgcaag tcttgatgtt gccccgtccc cnattcccta 100 catcagaagg atccctcatn tggactccag cgttggcttc ttgatgctgc 150 gcgttccccc attccctaca tcagaatgca tcccgcatcc agactccagc 200 gttgntgctc tacntgcacg ctgttgccaa gtccaagnta ccatactcct 250 gcctgagcta tgacaacagc ctcctcactg atctcccctt tcttcccttt 300 gcctcctcca gctcattttt cacagtgtag aatgacattt tgtttgtntg 350 ttntgttntg tttgagatgg agtctcgctc tgttgcccag ggtggagtgc 400 agcggtgcga tctcggctca ctgcaacctc cacctcccgg gttcaagcgg 450 attctcgtgc ctcagcctcc tgag 474 <210> SEQ ID NO 217 <211> LENGTH: 509 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 217 cacagttccc caccatcact cntcccattc cttccaactt tatttttagc 50 ttgccattgg gagggggcag gatgggaggg aaagtgaaga aaacagaaaa 100 ggagagggac agaggccaga ggacttctca tactggacag aaaccgatca 150 ggcatggaac tccccttcgt cactcacctg ttcttgcccc tggtgttcct 200 gacaggtctc tgctccccct ttaacctgga tgaacatcac ccacgcctat 250 tcccagggcc accagaagct gaatttggat acagtgtctt acaacatgtt 300 gggggtggac agcgatggat gctggtgggc gccccctggg atgggccttc 350 aggcgaccgg aggggggacg tttatcgctg ccctgtaggg ggggcccaca 400 atgccccatg tgccaagggc cacttaggtg actaccaact gggaaattca 450 tctcatcctg ctgtgaatat gcacctgggg atgtctctgt tagagacaga 500 tggtgatgg 509 <210> SEQ ID NO 218 <211> LENGTH: 291 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 218 ctcttaggct ttgaagcatt tttgtctgtg ctccctgatc ttcatgtcac 50 caccatgaag ttcttagcag tcctggtact cttgggagtt tccatctttc 100 tggtctctgc ccagaatccg acaacagctg ctccagctga cacgtatcca 150 gctactggtc ctgctgatga tgaagcccct gatgctgaaa ccactgctgc 200 tgcaaccact gcgaccactg ctgctcctac cactgcaacc accgctgctt 250 caaccactgc gaccactgct gctcctacca ctgcaaccac c 291 <210> SEQ ID NO 219 <211> LENGTH: 266 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 219 cgggctttga agcatttttg tctgtgctcc ctgatcttca ggtcaccccc 50 atgaagttct tagcagtcct ggtactcttg ggagtttcca tctttctggt 100 ctctgcccag aatccgacaa cagctgctcc agctgacacg tatccagcta 150 ctggtcctgc tgatgatgaa gcccctgatg ctgaaaccac tgcaactgca 200 accactgcga ccactgctgc tcctaccact gcaaccaccg ctgcttctac 250 cactgctcgt aaagac 266 <210> SEQ ID NO 220 <211> LENGTH: 264 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 220 ggctttgaag catttttgtc tgtgctccct gatcttcagg tcacccccat 50 gaagttctta gcagtcctgg tactcttggg agtttccatc tttctggtct 100 ctgcccagaa tccgacaaca gctgctccag ctgacacgta tccagctact 150 ggtcctgctg atgatgaagc ccctgatgct gaaaccactg caactgcaac 200 cactgcgacc actgctgctc ctaccactgc aaccaccgct gcttctacca 250 ctgctcgtaa agac 264 <210> SEQ ID NO 221 <211> LENGTH: 610 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 64, 185, 201 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 221 tgatttttac acaccccagg attttttgga attgaggaga cggttcaaga 50 gtttagcctt ggantggccc agtatccagg tcgaggttct gcagaaggtt 100 gtgactttag taacattttt cttctttcgg ggacgtggcc tgcatggcta 150 tctgctcctg ccagtgtcca gcagccatgg ccttntgctt cctggagacc 200 ntgtggtggg aattcacagc ttcctatgac actacctgca ttggcctagc 250 ctccaggcca tacgcttttc ttgagtttga cagcatcatt cagaaagtga 300 agtggcattt taactatgta agttcctctc agatggagtg cagcttggaa 350 aaaattcagg aggagctcaa gttgcagcct ccagcggttc tcactctgga 400 ggacacagat gtggcaaatg gggtgatgaa tggtcacaca ccgatgcact 450 tggagcctgc tcctaatttc cgaatggaac cagtgacagc cctgggtatc 500 ctctccctca ttctcaacat catgtgtgct gccctgaatc tcattcgagg 550 agttcacctt gcagaacatt ctttacaggt tgcccatgag gaaattggaa 600 acattctggc 610 <210> SEQ ID NO 222 <211> LENGTH: 612 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 43, 70, 89, 92, 100, 194, 219, 229, 295, 327-328, 330, 334, 338, 344 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 222 cgaaggcttg ggcggangcg tgggcgcggg agtgcatggc agntttggtt 50 cccagacttg cccggacccn tttgcttcac ctccagctnt gntgctcctn 100 tactcttggg tcgagatccc tttggagcca cagcgaggaa ccctgtggtc 150 ctcaggcagg tgtaccttga gtcagcccag gagccctctt ttcntgtgtc 200 aaagcctgcc ctcgggctnt gctcacctnt ggtgaccctc ccaagatgcc 250 cctgccctca gtttcccctc atgatctggc ctctgccccc ttctntagcc 300 acagcctttt agtacacttt agcaatnncn accngaanta gttngagttc 350 cccaattcac caagcaagac atgcagtttc atgcctctgt gccttcgctc 400 atgcttgttt cttccgaact tggaatgcct tcccctgctc ctcctgcctt 450 gtctgcctgg caagttcatc tctcacgatc ccctcaaagg ccccctcctc 500 caggaaggca acccctgtgc ccctcccctc caggctacct ctgcactttg 550 tcaatgcttc tcttgtggca cttatcacac tgtattttac ttgtttacat 600 gtttgtctcc cc 612 <210> SEQ ID NO 223 <211> LENGTH: 616 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 1, 21, 224 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 223 nccaatgcag ccctccggtt ntccgcgaag aagttccttg ccccgatgag 50 cccccgccgt gcgtccccga ttatccccag gcgggcgtgg ggcaccgggc 100 ccagcgccga cgatcgctgc cgttttgccc ttgggagtag gatgtggtga 150 aaggatgggg cttctccctt acggggctca caatggccag agaagattcc 200 gtgaagtgtc tgcgctgcct gctntacgcc ctcaatctgc tcttttggtt 250 aatgtccatc agtgtgttgg cagtttctgc ttggatgagg gactacctaa 300 ataatgttct cactttaact gcagaaacga gggtagagga agcagtcatt 350 ttgacttact ttcctgtggt tcatccggtc atgattgctg tttgctgttt 400 ccttatcatt gtggggatgt taggatattg tggaacggtg aaaagaaatc 450 tgttgcttct tgcatggtac tttggaagtt tgcttgtcat tttctgtgta 500 gaactggctt gtggcgtttg gacatatgaa caggaactta tggttccagt 550 acaatggtca gatatggtca ctttgaaagc caggatgaca aattatggat 600 tacctagata tcggtg 616 <210> SEQ ID NO 224 <211> LENGTH: 639 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 102, 105, 107, 157, 167 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 224 taagttcctg cattaaaacc atgctgtngc aattgagagc ttagctccac 50 ggttctcaaa gggaggtccc tggccaacag catcagcatc accttgagga 100 cntantngca atgcaaatta tcagggccct tcttcagact cactgaatca 150 gaaaccntgg gataggncca gcacgctgtg ctttaacaag ctctaggtga 200 tgcccaattc atactcaagt gtgaggctga ctggcttatt tgaagggaga 250 gaaaggaaca ggcacatggc gacatatcag catttacaca aggcgtgctg 300 ggtaaccata ggaacacctt tattacggtt aaataggaaa caggcatcaa 350 tgcagagggc ccccaggaga atcaggaagg tcgcgactgt cactgtctga 400 gggcactgtt gtgaaacgat ggccgaaggt gacaaccaca gcaaagtttc 450 aaggaagttc actgaaacgt ggaaaaaccc actcaatgtc ctgctctcat 500 ttatattgag tggcttaagt atttattttc ttggtttttt agaggaaggg 550 agggttggag gattctcaaa gcattcaaaa ggacaccata tgctggcagg 600 aaatattcaa gcttttaatg gaataatgca atggaggtg 639 <210> SEQ ID NO 225 <211> LENGTH: 704 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 45, 89, 96, 105, 115, 121, 141, 147, 178, 194, 205, 209, 233, 236, 245, 256, 284 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 225 tacccttggc cacttaagtt ggagaaattt gaaatcaaga agttntcatt 50 ttgaagaagc acgagttcgg aagactttaa catgggttnt tccttnttgc 100 agccngtata ctttntgtca nccagaaact gtattttcat ntcagcntag 150 tgacgatgaa tcaagtagtg atgaaccngt aatcagccca gtcntgcctt 200 tagangacnc cgtgttagga agaagaccgt ttntgnttca gaatntgaag 250 accggntagt tgctgaacaa gaaactgaac cttntaagga gttgagtaaa 300 cgtcagttca gtagtggtct caataagtgt gttatacttg ctttggtgat 350 tgcaatcagc atgggatttg gccatttcta tggcacaatt cagattcaga 400 agcgtcaaca gttagtcaga aagatacatg aagatgaatt gaatgatatg 450 aaggattatc tttcccagtg tcaacaggaa caagaatctt ttatagatta 500 taagtcattg aaagaaaatc ttgcaaggtg ttggacactt actgaagcag 550 agaagatgtc ctttgaaact cagaaaacga accttgctac agaaaatcag 600 tatttaagag tatccctgga aaaggaagaa aaagccttat cctcattaca 650 ggaagagtta aacaaactaa gagaacagat tagaatattg gaagataaag 700 ggac 704 <210> SEQ ID NO 226 <211> LENGTH: 627 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 46, 51, 66, 90, 95, 179 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 226 ggtccccaac gggccccccg ggtcggtttn ccgcgttggc catgantgcg 50 nccgtgttct ttcggntgcg ccttcatttg ccttcgggcn tgcgntcgcc 100 ctttatgtct tcaccatcgc catcgagccg ttgcgtatca tcttcctcat 150 cgccggagct ttcttctggt tggtgtctnt actgatttcg tcccttgttt 200 ggttcatggc aagagtcatt attgacaaca aagatggacc aacacagaaa 250 tatctgctga tctttggagc gtttgtctct gtctatatcc aagaaatgtt 300 ccgatttgca tattataaac tcttaaaaaa agccagtgaa ggtttgaaga 350 gtataaaccc aggtgagaca gcaccctcta tgcgactgct ggcctatgtt 400 tctggcttgg gctttggaat catgagtgga gtattttcct ttgtgaatac 450 cctatctgac tccttggggc caggcacagt gggcattcat ggagattctc 500 ctcaattctt cctttattca gctttcatga cgctggtcat tatcttgctg 550 catgtattct ggggcattgt attttttgat ggctgtgaga agaaaaagtg 600 gggcatcctc cttatcgttc tcctgac 627 <210> SEQ ID NO 227 <211> LENGTH: 647 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 36, 42, 65, 67, 101, 107, 112, 147, 224, 292 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 227 gaccaagggt ccgggtagnt tacctatatt tggttnatgg tntaattata 50 gaccaggaaa gagcntntta tgtctccatc ttgatttccg tggcagccaa 100 ntgcctntat gnatatctcc acatcccagc tttttcataa taaatantac 150 atgctggttg ctcgtggatt gttgggaatt ggagcaggaa atgtagcagt 200 tgttagatca tatactgctg gtgntacttc ccttcaggaa agaacaagtt 250 ccatggcaaa cataagcatg tgtcaagcat taggttttat tntaggtcca 300 gtttttcaga cttgttttac attccttgga gaaaaaggtg tgacatggga 350 tgtgattaaa ctgcagataa acatgtatac aacaccagtt ttacttagcg 400 ccttcctggg aattttaaat attattctga tccttgccat actaagagaa 450 catcgtgtgg atgactcagg aagacagtgt aaaagtatta attttgaaga 500 agcaagtaca gatgaagctc aggttcccca aggaaatatt gaccaggttg 550 ctgttgtggc catcaatgtt ctgttttttg tgactctatt tatctttgcc 600 ctttttgaaa ccatcattac tccattaaca atggatatgt atgcctg 647 <210> SEQ ID NO 228 <211> LENGTH: 697 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 72, 75, 81, 92, 116, 135, 153, 157, 170, 248, 267, 271, 332, 498, 570 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 228 tgaaattatt aaaccaaaca aacaaacaaa aacccggaat gcattgtata 50 ggattgcatg tgaagtcttt tntantgaat ntatatttcc anttgaagtg 100 attttaagtt aacatntgaa ggcaggaaat gattnccttt ccagtaaaaa 150 gtntagntaa tttaattaan ttagtgacac caccaagtgt tttgatataa 200 ctaaatttgt ggtaataaga ttgtctgcac ctgtattcat tgtggaantt 250 cctctttcat tggaaanttt nttactcaag aatgacggca gtattgtttt 300 cttatatgtg caatgaagtg gaatggttaa cngtatgccc ttaaatttaa 350 aatgggttcc ttgttctgat gttgtttcct gaaatgattt ttcttcctaa 400 ctgtggtttt cgggtatgca agcctaaatc tttgtacact ttgtctcaca 450 gaatagttct gaggctccat gacagggttt tgtcattgtt gatgttantg 500 ttgcttcgtt ttataaaaaa gccaaaattt ttttccaatc caaacgttca 550 cctgtttcct ttcctcaagn tataccagtg taataccagt taccctgtgg 600 atccatttaa tatgttatcc ccactaatta attttcgtat attatttcca 650 atatttggaa agctctttat agccatttgg tatttcctat tacccac 697 <210> SEQ ID NO 229 <211> LENGTH: 621 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 90, 145, 189, 249 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 229 ttttcaattt gccagtttgt ggatgatgaa ttgacttaaa tcgaactaaa 50 ttggaatgtg aatctgcatg tacgaagcat attcccaatn tgatgagcaa 100 tatgcttgcc atcttggttg ccagaatcag ttccattcgc tgaantggac 150 aagaacaact tatgtccctg atgccaaaaa tgcacctant ctttcctcta 200 actcttggtg aggtcattct ggagtgacat gatggactcc gcacagagnt 250 tcataacctc ttcatggact ttttatcttc aagccgatga cggaaaaata 300 gttatattcc agtttaagcc agaaatccca gtacgcacca catttggagc 350 aggagcctac aaatttgaga gaatcatctc taagcaaaat gtcctatctg 400 caaatgagaa attcacaagc gcacaggaat tttcttgaag atggagaaag 450 tgatggcttt ttaagatgcc tctctcttaa ctctgggtgg attttaacta 500 caactcttgt cctctcggtg atggtattgc tttggatttg ttgtgcaact 550 gttgctacag ctgtggagca gtatgttccc tctgagaagc tgagtatcta 600 tggtgacttg gagtttatga a 621 <210> SEQ ID NO 230 <211> LENGTH: 864 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 654, 711, 748, 827 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 230 tcctgctgat gcacatctgg gtttggcaaa aggaggttgc ttcgagccgc 50 cctttctagc ttcctggccg gctctagaac aattcaggct tcgctgcgac 100 tagacctcag ctccaacata tgcattctga agaaagatgg ctgagatgac 150 agaatgcttt attttggaaa gaaacaatgt tctaggtcaa actgagtcta 200 ccaaatgcag actttcacaa tggttctaga agaaatctgg acaagtcttt 250 tcatgtggtt tttctacgca ttgattccat gtttgctcac agatgaagtg 300 gccattctgc ctgcccctca gaacctctct gtactctcaa ccaacatgaa 350 gcatctcttg atgtggagcc cagtgatcgc gcctggagaa acagtgtact 400 attctgtcga ataccagggg gagtacgaga gcctgtacac gagccacatc 450 tggatcccca gcagctggtg ctcactcact gaaggtcctg agtgtgatgt 500 cactgatgac atcacggcca ctgtgccata caacctttgt gtcagggcca 550 cattgggctc acagacctca gcctggagca tcctgaagca tccctttaat 600 agaaactcaa ccatccttac ccgacctggg atggagatca ccaaagatgg 650 cttncacctg gttattgagc tggaggacct ggggccccag tttgagttcc 700 ttgtggccta ntggaggagg ggcgaacccc ttgcggcgca aggggttngc 750 gaaccccttg cggccgctgg ggtatctctc gagaaaagag aggcccaata 800 tgacccacat actcaatatg gacgaantgc tattgtccac ctgtttgagt 850 ggcgctgggt tgat 864 <210> SEQ ID NO 231 <211> LENGTH: 595 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 59, 62, 82, 121, 425, 446, 523, 563 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 231 tagagcgaca gtggaagggg catgaccctc aatgaggacg gccttgtttc 50 ctgggaggng tntaaaaatt ccaacctacg gntacgtttt agatgatcca 100 gatcctgatg atggattcaa ntataaacag atgatggtta gagatgagcg 150 gaggtttaaa atggcagaca aggatggaga cctcattgcc accaaggagg 200 agttcacagc tttcctgcac cctgaggagt atgactacat gaaagatata 250 gtagtacagg aaacaatgga agatatagat aagaatgctg atggtttcat 300 tgatctagaa gagtatattg gtgacatgta cagccatgat gggaatactg 350 atgagcccag aatgggtaaa gacagagcga gagcagtttg ttgagtttcg 400 ggataagaac cgtgatggga agatngacaa ggaagagacc aaagantgga 450 tccttccctc agactatgat catgcagagg cagaagccag gcacctggtc 500 tatgaatcag accaaaacaa ggntggcaag cttaccaagg aggagatcgt 550 tgacaagtat ganttatttg ttggcagcca ggccacagat tttgg 595 <210> SEQ ID NO 232 <211> LENGTH: 460 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 90, 99, 147, 222, 234, 271, 412 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 232 accgccttca gttactccag gtagccccgt agcatttaaa gaacaaaatc 50 tgtccagtca aagtgatttt cttcaagagc cgttacaggn tacttcttnt 100 ccagttactt gtagctcaaa tgcttgcttg gttactaccg atcaggnttc 150 ttctggatct gaaacagagt ttatgacctc agagactcct gaggcagcaa 200 ttcccccagg caagcaaccg tnttcactag cttntccaaa tcctcccatg 250 gcaaagggct ctgaacaggg nttccagtca cctccagcaa gtagtagttc 300 agtaaccatt aacacagcac cctttcaagc catgcagaca gtatttaacg 350 ttaatgcacc tctgcctcca cgaaaagaac aagaaataaa agaatcccct 400 tattcacctg gntacaatca aagttttacc acagcaagta cacaaacacc 450 accccagtgc 460 <210> SEQ ID NO 233 <211> LENGTH: 660 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7, 13, 31, 107, 127, 129, 131, 159 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 233 cgggaanccc ganccggttg ccccggggaa nccgtgcggc cccttccgtc 50 ccgttcccat ccttgccggg gttccagcac ctttgaagtt tttgcagcgc 100 ccgaaangga ggcgaggaag gagggantnt ntgagaggag ggagcaaaaa 150 gcttcaccnt aaaacattta tttcaaggag aaaagaaaaa gggggggcgc 200 aaaaatggct ggggcaatta tagaaaacat gagcaccaag aagctgtgca 250 ttgttggtgg gattctgctc gtgttccaaa tcatcgcctt tctggtggga 300 ggcttgattg ctccagggcc cacaacggca gtgtcctaca tgtcggtgaa 350 atgtgtggat gcccgtaaga accatcacaa gacaaaatgg ttcgtgcctt 400 ggggacccaa tcattgtgac aagatccgag acattgaaga ggcaattcca 450 agggaaattg aagccaatga catcgtgttt tctgttcaca ttcccctccc 500 ccacatggag atgagtcctt ggttccaatt catgctgttt atcctgcagc 550 tggacattgc cttcaagcta aacaaccaaa tcagagaaaa tgcagaagtc 600 tccatggacg tttccctggc ttaccgtgat gacgcgtttg ctgagtggac 650 tgaaatggcc 660 <210> SEQ ID NO 234 <211> LENGTH: 564 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 71 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 234 tttgtttccc gggaccttgg tggcagttct gcagccacag aggcagtggc 50 gattttgaca gccacatacc ntgtgggtca catgccatac ggctggttga 100 cggaaatccg tgctgtgtat cctgctttcg acaagaataa ccccagcaac 150 aaactggtga gcacgagcaa cacagtcacg gcagcccaca tcaagaagtt 200 caccttcgtc tgcatggctc tgtcactcac gctctgtttc gtgatgtttt 250 ggacacccaa cgtgtctgag aaaatcttga tagacatcat cggagtggac 300 tttgcctttg cagaactctg tgttgttcct ttgcggatct tctccttctt 350 cccagttcca gtcacagtga gggcgcatct caccgggtgg ctgatgacac 400 tgaagaaaac cttcgtcctt gcccccagct ctgtgctgcg gatcatcgtc 450 ctcatcgcca gcctcgtggt cctaccctac ctgggggtgc acggtgcgac 500 cctgggcgtg ggctccctcc tggcgggctt tgtgggagaa tccaccatgg 550 tcgccatcgc tgcg 564 <210> SEQ ID NO 235 <211> LENGTH: 461 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 196-197, 307 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 235 cggacgcgtg ggtttaaaaa ttactcataa tcgntccatt gataatacta 50 aatttagttt cccctgtctt tagtgtctaa ttgtcagcca gaaaattagg 100 aatctgttgc acttgatttt taagtaactt atctaaaact atgtgccatt 150 ttaacagtga gcattactta gttgcatttt ccaaatttat tatttnntca 200 tttcttaact gtagactatt atttcaaaat tttaaattta gtttttgatg 250 ttttagagaa atgaagccac agtggcttag cacatctttg tgtttctatt 300 atttatntat ttttttgaga cagagtcttg ctgtgttgct caggctggag 350 tgcagtggtg cgatctcagc tcactgcaac ctctgcctcc cgggttcaag 400 tgattttcct gcctcagcct cccaagtagc tgggattaca gacacctgcc 450 accatgtccg g 461 <210> SEQ ID NO 236 <211> LENGTH: 307 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 93 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 236 gaggtcatct ccatttcatc ccggataaat gagtatgcaa ggaacgtttt 50 tataggcatt ttggagatca aagatgggta gaaaagatgc tgntactata 100 aaacttcctg ttgatcagta cagaaaacaa attggtaaac aggattataa 150 aaaaactaaa cctattttac gagctaccaa attaaaagca gaagcaaaga 200 aaacagcaat aggcataaag gaagttggcc ttgtacttgc agctatattg 250 gcactactac tggctttcta tgctttcttt tatctcagac tcaccacgga 300 aatgttg 307 <210> SEQ ID NO 237 <211> LENGTH: 468 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 53, 67 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 237 cgggggaacc cgagccggtt gcgccggggg aatccgtgcg ggcgccttcc 50 gtnccggtcc catcctngcc gcgctccagc acctttgaag ttttgcagcg 100 cccagaaagg aggcgaggaa ggagggagtg tgtgagagga gggagcaaaa 150 agctcaccct aaaacattta tttcaaggag aaaagaaaaa gggggggcgc 200 aaaaatggct ggggcaatta tagaaaacat gagcaccaag aagctgtgca 250 ttgttggtgg gattctgctc gtgttccaaa tcatcgcctt tctggtggga 300 ggcttgattg ctccagggcc cacaacggca gtgtcctaca tgtcggtgaa 350 atgtgtggat gcccgtaaga accatcacaa gacaaaatgg ttcgtgcctt 400 ggggacccaa tcattgtgac aagatccgag acattgaaga ggcaattcca 450 agggaaattg aagccata 468 <210> SEQ ID NO 238 <211> LENGTH: 490 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 110, 128, 151, 215, 229, 268, 274, 282, 343, 363, 383, 489 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 238 tccataatga ccgtgtggnt gtccacagcc ccgacagagc cccctgaccc 50 aattgtacca ggtgcggtgc ctgttccagt caccattgtt cgccaaggca 100 ggggacacgn tttcagggac atgtttgntt attgccaaca aaagacagag 150 ntacgacatc agtattgtgg cccaggtgga ccagaccggc tccaagtcca 200 gtaacctcct ggatntgaaa aaccccttnt ttagatacac gggcacaacg 250 ccctcacccc cacccggntc ccantacaca tntccctcgg aaaacatgtg 300 gaacacgggc agcacctaca acctcagcag cgggatggcc gtngcaggga 350 tgccgaccgc ctntgacttg agcagtgtta ttnccagtgg ctccagcgtg 400 ggccacaaca acctgattcc tttagggtcc tccggcgccc agggcagtgg 450 tggtggcagc acgagtgccc actatgcagt caacagccng 490 <210> SEQ ID NO 239 <211> LENGTH: 583 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 37, 53, 71, 79, 89, 100, 166, 258, 260, 302, 327, 334 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 239 ttcccctaat gggttgtttg acccccattc cggttgntaa gtggtttttc 50 ccnatcatcg gccaaattgg nattttcana tccacaggng tcattgggan 100 tttgggggcc cctaatttgt ttcagacagg ccgggaggca gtttgccaga 150 aggattctta agtaantgac ccagcccttt gcccccaccc ctggggtacc 200 gagacatggg tagggattag agcaagagtt gagagtcaga ccatccagga 250 accacatntn tggaccttca gaaggaggac aacatggcct ttggaaagcc 300 tnccaagtac tggaagttgg accctgntca ggtntatgct agcgggccca 350 acgcatggga cacggctgtg cacgacgcct ctgaggagta caagcaccgc 400 atgcacaatc tctgctgtga caactgccac tcgcacgtgg cattggccct 450 gaatctgatg cgctacaaca acagcaccaa ctggaatatg gtgacgctct 500 gcttcttctg cctgctctac gggaagtacg tcagcgttgg ggccttcgtg 550 aagacctggc tgcccttcat ccttctcctg ggc 583 <210> SEQ ID NO 240 <211> LENGTH: 546 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 57, 97, 254, 341 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 240 tttttcaggg agaattttga ggctntgttg agaatcatgc tttggaggca 50 gctcatntat tggcaactgc tggctttgtt tttcctccct ttttgcntgt 100 gtcaagatga atacatggag gtgagcggaa gaactaataa agtggtggca 150 agaatagtgc aaagccacca gcagactggc cgtagcggct ccaggaggga 200 gaaagtgaga gagcggagcc atcctaaaac tgggactgtg gataataaca 250 cttntacaga cctaaaatcc ctgagaccag atgagctacc gcaccccgag 300 gtagatgacc tagcccagat caccacattc tggggccagt ntccacaaac 350 cggaggacta cccccagact gcagtaagtg ttgtcatgga gactacagct 400 ttcgaggcta ccaaggcccc cctgggccac cgggccctcc tggcattcca 450 ggaaaccatg gaaacaatgg caacaatgga gccactggtc atgaaggagc 500 caaaggtgag aagggcgaca aaggtgacct ggggcctcga ggggag 546 <210> SEQ ID NO 241 <211> LENGTH: 546 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 126 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 241 ggtgatctga aagatagcca aggatttttc agaacacaag aaaaaagagg 50 gatgaaaagt gaaaaagaaa ttagaagata tggataataa atcccaggag 100 aggtaatatg catccaatca aacatntaat agaaaatttc ctacagggaa 150 taaaagaaaa agattcttaa gatcgaaagg gccagttgat agtggtaccc 200 aggaggaagg agtggttttt cacccagata tatcctggtg aaatttctga 250 attctgcagc ttacaagaaa attctgaact cttccaggga agaacaagct 300 atgtacaaag gaataagaat cttattcatt acactaaaga caatgctttt 350 gatcattgtc tatagctatg tgtattttga acctagaatt ccgtactcag 400 cccaactgtc atttatgtat gagaacaaaa ttaacttttt ggaatttgca 450 gactcatatt cttttcgaaa aaaatactgt gggatgtacc aaaacaaaaa 500 aataagtcaa gaagcaacaa ctcaaggcat aagaaacagt agcgag 546 <210> SEQ ID NO 242 <211> LENGTH: 549 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 100, 121 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 242 ttccagagag cccttgagaa gaccaagggc aaagtgagca tgaggttctc 50 ctctctctgc ccaccctcca cgtccactgc ctctggccgc agacccagcn 100 tcgtgatcga tgggagaagc ntggcctacg ctctcgagaa aaacctggag 150 gacaaattcc tcttccttgc caagcagtgc cgctccgtcc tctgctgtcg 200 gtcgacgcct ctgcagaaga gcatggtggt gaagctggtg cggagcaagc 250 tcaaggccat gaccctggcc ataggtgatg gagccaatga tgtcagcatg 300 atccaggtgg cagatgtggg tgtgggaatc tccggccagg agggtatgca 350 ggcagtgatg gccagcgact ttgcagtgcc gaaattccga tacctggaga 400 ggctcttgat tcttcacggg cattggtgct actcccgact tgccaacatg 450 gtgctgtact tcttctacaa aaacacaatg ttcgtgggcc tcctgttttg 500 gttccagttt ttctgtggct tctctgcatc taccatgatt gaccagtgg 549 <210> SEQ ID NO 243 <211> LENGTH: 549 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 97, 120 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 243 ttcccagcga ggatcctgtc cctggaggct gtaatttgga gttcgattta 50 gatattgatc ccaacattta cttggagtat aatttctttg aaacgantat 100 caagtttgcc ccagcaaacn taggctatgc gagaggcgta gatcccccac 150 catgtgacgc tgggacagac caggactcca ggtggaggtt gcagtatgat 200 gtctatcagt attttctgcc tgagaatgac ctcactgagg agatgttgct 250 gaagcatctg cagaggatgg tcagtgtgcc ccaggtgaag gccagtgctc 300 tcaaggtggt taccctaaca gctaatgata agacaagtgt ttccttctcc 350 tccctcccgg gacaaggtgt catatacaat gtcattgttt gggacccgtt 400 tctaaataca tctgctgcct acattcctgc tcacacatac gcttgcagct 450 ttgaggcagg agagggtagt tgtgcttccc taggaagagt gtcttccaaa 500 gtgttcttca ctctttttgc cctgcttggt ttcttcattt gtttctttg 549 <210> SEQ ID NO 244 <211> LENGTH: 448 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 244 attcttaagt cagttgatcc anttattcat tcatcaaata ttgattgaga 50 acctactgtg tgccaagtgt tattttaggc cctgggacca agtaataaat 100 aagaggacac aggccatgca ctcacggagc ttctgttttc cttggcagag 150 cagacatggg gcagggtggt ctgagggtct cctcaggatg gtgtggtctg 200 tgctggttgt ggttgtcttg acaggttggg cctcatgggc agatggtacc 250 tgtcaggcag ggagtgtggg ggcaaccagg atgaacagtt ataagaccat 300 ttctaatact tgtatttttt tttctcctag ggaaaaattg gaagaaaaag 350 ccaaattata tgaaaaaatg actaaaggag actttataga tgaagaagta 400 gaggatatgt accttgtgga tttcacacag aagatcatag acaagcgc 448 <210> SEQ ID NO 245 <211> LENGTH: 567 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 3, 35, 49, 81, 106, 146, 152, 227, 239, 293, 308, 358, 427, 448, 476, 480, 566-567 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 245 ggntacccga aggccaagct ttttaacaat tttgntttgt aatcaatgng 50 taattcatga tgaattattt tgactaatgg ntagccgaag gccaagcttt 100 taattntaat aggtaatgtt cttcttttgt cttattgaaa caatgngaat 150 antctgtgca tttcaaatgc actccgatta tgctgtggtt ttattcacat 200 aagcacaata tgtgttttat ttataanttc ataacaaant tataatataa 250 taatttacct tagcagacat gcaaaagctt attcttgtgt ganttacttt 300 ctttaagnta ataatataaa aataaatatg tatcttaaaa atctataata 350 aaacattnga aattaaagat atgtgctttt tattttgcag atgagttcat 400 ttgcttctgt agatgtgttt tcagagntag gtacagagga atgtttgnta 450 cctttagcgg tgaaaaaaga aagagngtcn agaattttgt tggattgtgt 500 ttgtgtgtgc atatatttga tatcatcatc atacattgta atctttggac 550 ttgtaatcat agcctnn 567 <210> SEQ ID NO 246 <211> LENGTH: 539 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 33, 100, 115, 153, 158, 185, 194, 263, 273, 286, 325, 371, 400, 404, 410, 454, 458, 485, 508, 539 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 246 ttcccactgt aatgccaaat gatccatagc ctnttcagat tccttataaa 50 atttaaacca agagaggaga ggaaagggta aattttctgt aatgaccttn 100 tgcttaatag tcttntagaa aaaggaaagg tgatgagcaa ataaaggaac 150 ttntagantt tacatgacta ggctgataat cttanttttt aggnttctat 200 acagttaatt ctataaattc tctttctccc tctcttctcc aatcaagcac 250 ttggagttag atntaggtcc ttntatctcg tccctntaca gatgtatttt 300 ccacttgcat aattcatgcc aacantggtt ttcttaggtt tctccatttt 350 cacctctagt gatggcccta ntcatatctt ctctaatttg gtcctgatan 400 ttgnttcgtn tcacgttttc ccatttccct gtggctcact gttttacaat 450 cacngctntg gaatcatgat accactttta gctcnttgca tcttccttca 500 gtgtattntt gtttttcaag aggaagtaga ttttaaatn 539 <210> SEQ ID NO 247 <211> LENGTH: 508 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 9, 38, 45, 78, 469 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 247 cggagcctnt gcaggaggag cttttcggtc ctggccgnga ttttntgcag 50 gccccacgag tgggaggtgc tgagccgntc aggttctccc ttttgccact 100 ggaatcagga gaatgttgca gaggaattgc attcctggta acaagataac 150 ccagcaagac tcagactgct aacccaagga tcaactatta aggccagaca 200 gatgggaccg tgttcagaat tcacacaaaa gctgaaggat ttatggatgc 250 ggatatacct ctggaattgg tgttccattt gccagtcaat tatccttcat 300 gtctacctgg tatctcgatt aactctgaac agttgaccag ggcccagtgt 350 gtgactgtga aagagaattt acttgagcaa gcagagagcc ttttgtcgga 400 gcctatggtt catgagctgg ttctctggat tcagcagaat ctcaggcata 450 tcctcagcca accagaaant ggcagtggca gtgaaaagtg tactttttca 500 acaagcac 508 <210> SEQ ID NO 248 <211> LENGTH: 540 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 85, 100, 104, 133, 156, 395, 468 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 248 tcgggttttc ggagcagttt tcgaatggac agctccgtgg aggaggatga 50 acttatgtta aatgaaggta agagttttgg gcatnttatg ccccctttgn 100 tctntgacag ctctgtgtct tgtctttggc ctntatccac ctccttccaa 150 gacaantgat gataagacca gcggctttaa gaaatgtgaa accaagtcaa 200 ttgtgtcatc gtccatcagt gcttttacat tgcctgtgat caaaattaat 250 aactgtgtta ttgatgagcc cagtatagat aacatcactg aagatgctga 300 caacctcaaa agtaggtcaa ggaatttgtc aatggattcc cttgtggttc 350 ctttgcccaa caccagtgaa tccttccagc ccgtcagcac agtgntacca 400 aggaataatt ccattgggga gtcgttgtcg agtcagtaca agtcatctat 450 ggctctcgga cctggggntg gacagctctt gtctcctggg gctgccagaa 500 gacagtttgg gtccaataca tccttgcatt tgctctcgtc 540 <210> SEQ ID NO 249 <211> LENGTH: 618 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12, 66, 90, 187, 263, 311, 508, 511, 547, 555, 610 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 249 tccttacaag gnccgtgtaa catgacactg ttaatgattg catttggctt 50 gctgtggggg catttnttgc ggatcaaacc cacgcagagn gttttcattt 100 tccaagtgtc tgtccttgtc aagcacaccc cttgtgtcca ggttcctcat 150 gggcagtgct cggggtgaca aagaaggcga cattgantac agcaccgtgc 200 tcctcggcat gctggtgacg caggacgtgc agctcgggct cttcatggcc 250 gtcatgccga ctntcataca ggcgggcgcc agtgcatctt ctagcattgt 300 cgtggaagtt ntccgaatcc tggttttgat tggtcagatt cttttttcac 350 tagcggcggt ttttctttta tgtcttgtta taaagaagta tctcattgga 400 ccctattatc ggaagctgca catggaaagc aaggggaaca aagaaatcct 450 gatcttggga atatctgcct ttatcttctt aatgttaacg gtcacggagc 500 tgctggangt ntccatggag ctgggctgtt tcctggctgg agcgctngtc 550 tcctntcagg gccccgtggt caccgaggag atcgccacct ccatcgaacc 600 catccgcgan ttcctggc 618 <210> SEQ ID NO 250 <211> LENGTH: 626 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 33, 35, 67, 70, 91, 114, 133, 143, 177, 267, 394, 421, 447, 484, 536, 540, 561, 569 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 250 caacttacct gaaatgcgct attgaatgca cgngnggaaa atccttgggt 50 tccaggatga cacctantan tgcagtttga ttggcagaat ngtcgatacg 100 atggctggca aatntcctgg tccctttccc aantgtgact ggngattcaa 150 tgagtttccc aacccagttg cccatgntct ccatgttact tgtgtggagc 200 tcatggcctt ggcagtttca ggcaaagaag ttgggaatgc ccttctaaat 250 gttgtcctaa aaagtcngcc tttagtgcca agagagaaca ttgcagcatg 300 gatgaatgca attggtttga tcatcactgc cctaccagag ccatattgga 350 ttgttcttca tgatcgaatt gtgagtgtca tcagcagccc cagnttgacg 400 tctgaaacag agtgggttgg ntatccattc cgcctctttg atttcantgc 450 ctgtcatcag tcctactctg agatgagttg tagntatacg ttagctcttg 500 cacatgctgt gtggcaccat tttagcatcg gacaantttn tctcattcca 550 aagtttctta ntgaagtant tcttcctata gtgaagaccg aattccagtt 600 gctttatgta taccatcttg ttggac 626 <210> SEQ ID NO 251 <211> LENGTH: 602 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 80, 94, 300, 388 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 251 gaagggcatt ttcagggagc agaatgacaa gacntattgt caaccttgct 50 tcaataagct cttcccactg taatgccaan tgatccatag cctnttcaga 100 ttcccttata aaatttaaac caagagagga gaggaaaggg taaattttct 150 gttactgacc ttctgcttaa tagtcttata gaaaaaggaa aggtgatgag 200 caaataaagg aacttttaga ctttacatga ctaggctgat aatcttattt 250 tttaggcttc tatacagtta attctataaa ttctctttct ccctctcttn 300 tccaatcaag cacttggagt tagatctagg tccttctatc tcgtccctct 350 acagatgtat tttccacttg cataattcat gccaacantg gttttcttag 400 gtttctccat tttcacctct agtgatggcc ctactcatat cttctctaat 450 ttggtcctga tacttgtttc ttttcacgtt ttcccatttc cctgtggctc 500 actgtcttac aatcactgct gtggaatcat gataccactt ttagctcttt 550 gcatcttcct tcagtgtatt tttgtttttc aagaggaagt agattttaac 600 tg 602 <210> SEQ ID NO 252 <211> LENGTH: 455 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 48, 251, 266, 352, 391 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 252 atttgtttgt ataatataat acatatagat agaggggcga taatatantg 50 gtagacaaag aatgcaggaa atgcccttat tcatcacacc accaagcagg 100 cctcacccta aagacccagc aaaagtaaca aaagcacatt tggaaaccca 150 ggaagccagt aaaagtaaat ctaaaggctg acagggtgta cattattatg 200 tatgtgcaat ataaatcaaa ttcaaagctg ttttctctta aattttgata 250 nttatagaga cagganttgc catggggaat ttctttcccc ttactatata 300 attttattac tagaaggaaa agtaatagca atgataataa tgaacagact 350 tngtgtcttt attacatttg ctttcctagt tacctttaga ntgtcacttc 400 tgagttcttt ctctgacatg cttttctttt ctcgtgaagc gtcttacatt 450 ctgac 455 <210> SEQ ID NO 253 <211> LENGTH: 461 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 6, 10, 30, 115, 198, 210, 229, 289, 291, 325, 333, 338, 377, 391, 401 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 253 aatttntatn tacatttgtg ataatatagn tagtgcgtaa gaatatttcc 50 ccaaggtcag ttaagcaaga ttttcttatg atcatcattg ccatgaactt 100 tcaaacatag cgatnttgtg aaaacagtgc ctgttaattt acaatgttta 150 ccttgaacag ttgtcaagtg tgatttttat aaggagttgg tatgtttnta 200 agcagttatn tacttgatct ttttaatant ggggttaagg gaaacctgct 250 tacagcatca cctatttttc attcaaatgg cacataatng ngcatgtgta 300 acagttgtgt acctttgtgg ggttnttttg ttntttgntt ttctttttga 350 gacagggttt cgttctgttg cccaagntgg agtacagtgg ntcgatctca 400 ntgcaacctc caccccccag gctcaagtga ttctttcacc tcggcctcct 450 gagtatccgg g 461 <210> SEQ ID NO 254 <211> LENGTH: 497 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 191, 232, 304, 340, 342, 357, 400, 403, 423, 447, 476 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 254 cagcgaatgt tggggaacnt gattcggcct ccatatgaaa ggccagagct 50 ccccacatgt ctctatgtaa ttgggctgac tggcatcagt ggctctggga 100 agagctcaat agctcagcga ctgaagggcc tgggggcgtt tgtcattgac 150 agtgaccacc tgggtcatcg ggcctatgcc ccaggtggcc ntgcctacca 200 gcctgtggtg gaggcctttg gaacagatat tntccataaa gatggcatca 250 tcaacaggaa ggtcctaggc agccgggtgt ttgggaataa gaagcagctg 300 aagntactca cggacattat gtggccaatt atcgcaaagn tngcccgaga 350 ggagatngat cgggctgtgg ctgagggaaa gcgtgtgtgt gtgattgatn 400 ccnctgtgtt gcttgaagcc ggntggcaga acctggtcca tgaggtntgg 450 actgctgtca tcccagagac tgaggntgta agacgcattg tggagag 497 <210> SEQ ID NO 255 <211> LENGTH: 913 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 39 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 255 cattatcaac ccagcgccac tcaaacaggt ggacaatanc agttcgtcca 50 tattgagtat gtgggtcata ttgggcctct cttttctcga gagatacccc 100 agcggccgca aggggttcgg ggtgataata gatcaatgtg ttggaagtga 150 tggggatgga gaggcgagtc ccactggcga tccgcagcag gatgcccatc 200 agagagaagc tggggctttc caggacagca tagaaaggct ccacccgggc 250 tggatgctcc aggaccatcc cttcattctt aaaatgggca acgagaaacc 300 aggagacgtc cacctcacct tggagggaga tgaagtgggg gaggtggatt 350 tcggcgacag cctcctctgg ctctgcagtg acatcaaaca aggggccgcc 400 caccagccac tgttcatggt gctgcaggtc cagggccagg tgctgactcc 450 aggaaccaaa cgcaatcgtc actgtgacct catcccttac caggaagccg 500 aggcctgtgg ctgaccacag ataccagcca gcagtgggga accaaacgct 550 gtatctgttt gtgctcttat caatcaactc aacatccaca tttccttcag 600 gccccagaaa ctgacgattt ttataatctt cttcgatctc aaaacagact 650 ttagaagcat aagaggaaac tatttgattc tcttctgagc aaatgtctcc 700 tgaatcttgt ccctctgaag attcctgctc ttctgataca ctgggaatgt 750 cccccccaga tagttgacac tcaggaacag cacggaacaa taatggctct 800 gcctctgtct catcatcttc ttggaaaaaa tgtgagcgga cgcgtgggtc 850 gaggtcgagg gatctctaga ggatccggcc agtgtggcct atcgatagct 900 tggagttgat tgt 913 <210> SEQ ID NO 256 <211> LENGTH: 518 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 82, 190, 205, 355, 382, 445, 484, 491, 498, 502 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 256 tggggatcct tggaccttgg acccaggngt ccgtggacgc ttggtagaaa 50 gatggcggag caagagcaag gaaaaatccc tntggttcca gaaaatctcc 100 tgaaaaagag gaaggtttat caagccctca aagccaccca ggcaaagcag 150 gcacttttgg caaagaagga gcagaagaaa ggaaaagggn tcaggtttaa 200 gcgantggaa tcattcctac atgattcctg gcggcagaaa cgtgacaagg 250 tgcgtctcag acgactagaa gtgaaacctc atgccttgga attgccagat 300 aaacattcct tggcctttgt tgtacgcatc gaaaggattg atggcgtgag 350 tttantggtg cagagaacca ttgcaagact tngcctaaag aaaattttta 400 gtggtgtctt tgtaaaagtc accccccaga atctaaaaat gctgngtata 450 gtggaacctt atgtgacctg gggatttcca aatntgaagt ntgtccgnga 500 antcattttg aaacgtgg 518 <210> SEQ ID NO 257 <211> LENGTH: 301 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 44, 55, 60, 81, 172, 194, 225, 268, 279 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 257 tggccagaat gtgaatgtat tgaatggagt gagagaagaa atgntgtggc 50 atctnttgtn gcaggtatat tgttttttac nggctggtgg ataatgattg 100 atgcagctgt ggtgtatcct aagccagaac agttgaacca tgcctttcac 150 acatgtggtg tattttccac antggctttc ttcatgataa atgntgtatc 200 caatgctcag gtgagaggtg atagntatga aagcggctgt ttaggaagaa 250 caggtgctcg agtttggntt ttcattggnt tcatgttgat gtttgggtca 300 c 301 <210> SEQ ID NO 258 <211> LENGTH: 545 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 34, 61, 114, 157, 190, 193, 201, 280, 331, 389, 403, 422, 428, 488 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 258 atcatatggg cacaaatntg gtgtccttta tggngaaaac ctcaagtaaa 50 agttttattc ntgcctttga aaatggttcc aaaagtagac cctgtcccca 100 cacaggtcaa gacnacagag aaggctttgt agaaatgtgt cacctatgta 150 cacctgntac ttacacattt cctcttttgg aaaaatgagn tanttagaat 200 nacaagaaaa ttaagacata ctggcctggt gccagcagat ggcttttcta 250 tagacaaact aggttagtgt ggaagatatn ggttaaaata aactatgctg 300 ttttatttat cttcccaacc tgattggcag ntagactttt ttagggtctc 350 atttaatggc cctgtttttt tcattattat atttaatgnt agggcaggat 400 ttngtatgca agctcttgtt tntcaggntg cctgcagaag aagtcgctat 450 aaattatctg ttgtctacat ggtacaaggc ccattgantc atctgatgct 500 tgttttgtta atttctttaa tatttttatc acggggcagt gggag 545 <210> SEQ ID NO 259 <211> LENGTH: 535 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12, 27, 30, 35, 177, 190, 212, 238, 272, 303, 386, 514 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 259 aatggcggtg tntacagtgt tctgganttn gtcgntgatg cttgctctgt 50 caaggcacag cctattgtct cctttgctca gtgtgacatc attcagacgc 100 ttttacagag gtgacagccc aacagattcc caaaaggaca tgattgaaat 150 ccctttgcct ccatggcagg agagaantga tgaatccatn gaaaccaaaa 200 gagcccgcct gntctatgag agcagaaaga ggggaatntt ggaaaagtgc 250 caggtagtgg agtaaaaaag gngacagttt atttttttat tctatgtgca 300 canttacagt atacatatat atttatatca caatttacga aaccaaaaag 350 ttgagtttcc aatggaaccc ttgtttttta ataatngact ttttaaatgt 400 gatcaagact ataatattgt acagttatta tagggctttt ggggaagggg 450 aggatagcga gaagatgctc tgggggtttt gtttttgctt ttccttcagg 500 gttttatttt tgantgtttt gttttcttgt tggcc 535 <210> SEQ ID NO 260 <211> LENGTH: 519 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 11, 69, 150, 224, 229, 254, 354, 371, 396, 420, 429, 433, 475, 483, 486 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 260 tggatttata nttttcttct atgtagttac tataaaagtg tgctggattt 50 gaccaatcct tacccccant ataaagagaa cccgtgatga ctttagttta 100 aaaattgtgg aaattgtgga gcaatttttc tcacaatgtg agaaaaattn 150 taaaccatat tagataatgt ggaagtcata ttgtctatca tatatactgc 200 catttaaaaa taggttttta aaanttagnt aagtcttaag taatttgccg 250 ttgntaataa ttttatctcc ttgagtcggt tgttggggag agatgttata 300 ttcaataatt tttagttatt ttgtaatgca gagtgtttat tcatttcaca 350 gttntgcaat ggatgtagta ntttgggatt gccctgtcca gaaaantttc 400 aggtacacac ctttaaaggn aaatgtttnt atntcagatg aaacatgtaa 450 tttgggatgg ttcttccttt gtcanttaaa ggnagntagg aaaagtctct 500 tacccacttt aaacatgag 519 <210> SEQ ID NO 261 <211> LENGTH: 407 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 40, 58, 102, 104, 148, 171, 190, 201, 226, 243, 295, 302, 332, 360, 380, 383 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 261 tctgtggtca acggggtcat ctttaaatgn ttggccgtgn ttgccctgtc 50 atcccacntg agaaccatgc tcaccgaccc tggggcagta cccaaaggaa 100 angntacgaa agaatacatg gagagcttgc agctgaagcc cggggaantc 150 atttacaagt gccccaagtg ntgctgtatt aaacccgagn gggcccacca 200 ntgcagtatt tgcaaaagat gtattnggaa aatggatcat cantgcccgt 250 gggtgaacaa ttgtgtagga gaaaagaatc aaagattttt tgtgntcttc 300 antatgtata tagctctgtc ttcagtccat gntctgatcc tttgtggatt 350 tcagttcatn tcctgtgtcc gagggcagtn gantgaatgc agtgattttt 400 cacctcc 407 <210> SEQ ID NO 262 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 35, 37, 64, 182, 211, 263, 329, 398, 410 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 262 cattcttgaa ccacttaatc ctctnttgac aacantngta gaacagaatc 50 ctgaagatat gggngaccta tacctagatg ttgctgaagc ttttctggat 100 gttggtgaat ataattctgc acttcccctc ctcagtgctc ttgtttgctc 150 tgaaagatac aaccttgcag tagtttggct tngtcatgca gaatgtttaa 200 aggccttagg ntatatggag cgagctgctg aaagctatgg caaggtggtt 250 gatctggccc cantccattt ggatgcaagg atttcacttt ctacccttca 300 gcagcagctg ggccagcctg agaaagctnt ggaagctctg gaaccaatgt 350 atgatccaga tactttagca caggatgcaa atgctgcaca gcaggaantg 400 aagttattgn ttcatcgttc tactctgttg ttttcacaag gcaaaatgta 450 tggttatgtg gataccttac ttactatgtt agccatgctt ttaaaggtag 500 caatgaatcg agc 513 <210> SEQ ID NO 263 <211> LENGTH: 650 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 37, 62, 71 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 263 ttgagacctg gatgaacaaa tttatatcct ttccttngag gaagaagcac 50 tccagagacg antaaatggg ntgtcttcat cggtggaata caacataatg 100 gagttggaac agaacttgaa aatgtaaaga ctcttaagac aaaattagag 150 aggcgaaaaa aggcttcagc atgggaaaga aatttggtgt atcccgctgt 200 tatggttctc cttcttattg agacatccat ctcggtcctc ttggtggctt 250 gtaatattct ttgcctattg gttgatgaaa cagcaatgcc aaaaggaaca 300 agggggcctg gaataggaaa tgcctctctt tctacgtttg gttttgtggg 350 agctgcgctt gaaatcattt tgattttcta tcttatggtg tcctctgttg 400 tcggcttcta tagccttcga ttttttggaa actttactcc caagaaagat 450 gacacaacta tgacaaagat cattggaaat tgtgtgtcca tcttggtttt 500 gagctctgct ctgcctgtga tgtcgagaac actgggaatc actagatttg 550 atctacttgg cgactttgga aggtttaatt ggctgggaaa tttctatatt 600 gtattatcct acaatttgct ttttgctatt gtgacaacat tgtgtctggt 650 <210> SEQ ID NO 264 <211> LENGTH: 441 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 79, 106, 160 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 264 tttttttggt agagatgggg tttcgccatg ttgcccaagc tgttcttgaa 50 ctcccgggct caagtgatcc gcctccctng gcctcccaga gtgctgggat 100 tacagncacg gaccaccatg cccagcctcc acatcttttt ttgcactgtg 150 tatactcttn tgagacatgc caacttcctc caggtcaaga aaggggtata 200 tagctctcag cttcactctt tcagggctga tgtcgccttt gccttttctc 250 acttcactga cctgtctatt cctacaactg tctctttcta gagaagcctc 300 aatgatcagg attgacaggc cacactctcc cccaccattt ttttctcctc 350 cttcaagcct cttgtctgtt tcaccctctt ccaccttgga ggctgaggtc 400 ttatttgact cttcacctga attgaccttc ttccttccca c 441 <210> SEQ ID NO 265 <211> LENGTH: 201 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 39, 67 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 265 tgagatcttt ttctctaatt ntcagaagtg tttcaatgnt attaattcat 50 tatttcctcc tctctgnttt ttttttaatt ccctgtctgg ggaatcctgt 100 tatcctgata tgagcactct acttctattc tccatagcac ttagctcctt 150 taaaaatatt ctctttgttc tctacttctg ccttctggga gagtttctca 200 g 201 <210> SEQ ID NO 266 <211> LENGTH: 301 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 94, 128, 146, 167, 232, 257 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 266 tttttttttc aagtcttgat ttgtggctta cctcaagtta ccatttttca 50 gtcaagtctg tttgtttgct tcttcagaaa tgttttttac aatntcaaga 100 aaaaatatgt cccagaaatt gagtttantg ttgcttgtat ttggantcat 150 ttggggattg atgttantgc actatacttt tcaacaacca agacatcaaa 200 gcagtgtcaa gttacgtgag caaatactag anttaagcaa aagatatgtt 250 aaagctntag cagaggaaaa taagaacaca gtggatgtcg agaacggtgc 300 t 301 <210> SEQ ID NO 267 <211> LENGTH: 700 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 61, 67, 132, 134, 150, 183, 194, 197, 238, 355, 424, 431, 449, 465, 470, 478, 507, 509, 523, 527, 529, 533, 560, 578, 614, 644 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 267 gggcccagat tgcgaaattg aggcnccaag gcggccgaga cggactgaag 50 catttcaagg ntccggnggg ttcccatgat ttgaacggag tcgtttcccc 100 taatgggtgt tttgaccccc atcccggtgc tnangtggtt tttccccatn 150 atcggccaac atgggcattt gaaatccaca ggngtcattg gganttngcg 200 ggcccctaat ttgtttcaga caggccggga gggcagtntg gccagaagga 250 ttcttaagta actgacccag ccctttgccc ccacccttgg ggtaccgaga 300 catgggtagg gattagaggc aagagtggag agtcagacca tccaggaacc 350 acatntttgg accttcagaa ggaggacaac atggcctttg gaaagcctgc 400 caagtactgg aagttggacc ctgntcaggt ntatgctagc gggcccaang 450 catgggacac ggctntgcan gacgcctntg aggagtacaa gcaccgcatg 500 cacaatntnt gctgtgacaa atnccantng cangtggcat tggccctgaa 550 tctgatgcgn tacaacaaca gcaccaantg gaatatggtg acgctctgct 600 tcttctgcct gctntacggg aagtacgtca gcgttggggc cttngtgaag 650 acctggctgc ccttcatcct tctcctgggc atcatcagcg gccgccgtaa 700 <210> SEQ ID NO 268 <211> LENGTH: 253 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 49, 120, 181 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 268 gaatctgttt ccaaaaaaaa aagctttaag aagtctttag atttacagnt 50 aagcatattc taaatactat gtgatgaatt atttctctta tgttaaaaaa 100 aatattaatt tggacccaan tatgactgtg ggtattctgc ccagggaaga 150 agagctagga ggtttaaacc ttaccttgga nttgctgctt tgttttctat 200 gccttcttga cagaaggatt tatttcactt ccgaaatatt agccataatg 250 ccc 253 <210> SEQ ID NO 269 <211> LENGTH: 659 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 33, 58, 200, 240, 403 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 269 cactaggaaa aattgaaatn ctattggaaa ttnttttggc cacaaaggta 50 aataggtnta ccaggggaaa caggcatcaa gaaaattgcc ccaattttta 100 aaacaatagg gttatttgag tagttgagtt taagaaatga aaaccacaaa 150 ttttggtgga acttaaacac cacagtctat ttgtgtgtaa tttctcaggn 200 tttattatag ttcatgataa aatcaatttt ccatgtctan tttgtttttc 250 ttcaacaagt gatctatctt ttacaaaagg gaatattttg ctggagaaat 300 gctcattgtt tcccttctgt atgtctttga gggtaatgct aaaagcaagc 350 tcaaatttca aaatatgtta tttttaaaat attttatata ggatttgtta 400 aanttatagt tttcaaggat tgtcttttgt ttctttggat tctgattaag 450 tgatttttaa tgtattcctt taaaaatatt tattggcaca ttgtatttgt 500 acatattgat gggataaaat tgatgcttct gtacatatat atttggcata 550 atcatcaaat ttgggtattt agcttattca tcacctcatt catttatcat 600 ttctttatgg tgagaacatt caaaagtctc tcttccagct attttataat 650 atattatac 659 <210> SEQ ID NO 270 <211> LENGTH: 628 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 51, 106, 111, 120, 140, 378, 513 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 270 ttcggaagaa gcacctcaga gggattaagc tcctgagaat gttacctgca 50 ntatacctga tggcgtgcca atagatatca cagtgaagtt gatggtcttc 100 ccttgnacat ntcaacattn ttgaaccact taatcctctn ttgacaacac 150 tagtagaaca gaatcctgaa gatatgggag acctatacct agatgttgct 200 gaagcttttc tggatgttgg tgaatataat tctgcacttc ccctcctcag 250 tgctcttgtt tgctctgaaa gatacaacct tgcagtagtt tggcttcgtc 300 atgcagaatg tttaaaggcc ttaggctata tggagcgagc tgctgaaagc 350 tatggcaagg tggttgatct ggccccantc catttggatg caaggatttc 400 actttctacc cttcagcagc agctgggcca gcctgagaaa gctctggaag 450 ctctggaacc aatgtatgat ccagatactt tagcacagga tgcaaatgct 500 gcacagcagg aantgaagtt attgcttcat cgttctactc tgttgttttc 550 acaaggcaaa atgtatggtt atgtggatac cttacttact atgttagcca 600 tgcttttaaa ggtagcaatg aatcgagc 628 <210> SEQ ID NO 271 <211> LENGTH: 585 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 71, 76, 86, 91, 162, 220, 269, 281 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 271 tggtttttgc cccataaatt ccctcagctt gagcagtttg ttaaggaatg 50 aggttacaga ttcaggaatt ntaggncctc aacctntaga ntttgtccca 100 aatgttctcc gacatgcagt agatgggaga caagaggaga ttcctgtggt 150 catcgctgca tntgaagaca ggcttggggg ggccattgca gctataaaca 200 gcattcagca caacactcgn tccaatgtga ttttctacat tgttactctc 250 aacaatacag cagaccatnt ccggtcctgg ntcaacagtg attccctgaa 300 aagcatcaga tacaaaattg tcaattttga ccctaaactt ttggaaggaa 350 aagtaaagga ggatcctgac cagggggaat ccatgaaacc tttaaccttt 400 gcaaggttct acttgccaat tctggttccc agcgcaaaga aggccatata 450 catggatgat gatgtaattg tgcaaggtga tattcttgcc ctttacaata 500 cagcactgaa gccaggacat gcagctgcat tttcagaaga ttgtgattca 550 gcctctacta aagttgtcat ccgtggagca ggaaa 585 <210> SEQ ID NO 272 <211> LENGTH: 616 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 80, 86 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 272 ccggaaacca tgaggtaatg ccncaatggc atattgtaaa tgtcatttta 50 aacattggta ggccttggac atgatgctgn attacntctc tttaaaatga 100 cacccttcct tcgcctgttg gtgctggccc ttggggagct ggagcccagc 150 atgctgggga gtgcggtcag ctccacacag tagtccccac gtggcccact 200 cccgggccca ggctgctttc cgtgtcttca gttctgtcca agccatcagc 250 tccttgggac tgatgaacag agtcagaagc ccaaaggaat tgcactgtgg 300 cagcatcaga cgtactcgtc ataagtgaga ggcgtgtgtt gactgattga 350 cccagcgctt tggaaataaa tggcagtgct ttgttcactt aaagggacca 400 agctaaattt gtattggttc atgtagtgaa gtcaaactgt tattcagaga 450 tgtttaatgc atatttaact tatttaatgt atttcatctc atgttttctt 500 attgtcacaa gagtacagtt aatgctgcgt gctgctgaac tctgttgggt 550 gaactggtat tgctgctgga gggctgtggg ctcctctgtc tctggagagt 600 ctggtcatgt ggaggg 616 <210> SEQ ID NO 273 <211> LENGTH: 637 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26, 44, 60, 107, 114, 234 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 273 tgaagttgaa ttgaatgata tgaggntttt ctttcccaag gtcnaccagg 50 accaagattn ttttatagtt ataagccttg aaagaaattc ttgcaaggtg 100 ttggacnctt actnaagcag agaagatgtc ctttgaaact cagaaacgaa 150 ccttggtaca gaaaatcagt atttaaggcc cagaacttat tgaaagcgca 200 atgtacttct accgtgccac gggggatccc accntcctag aactcggaag 250 agatgctgtg gaatccattg aaaaaatcag caaggtggag tgcggatttg 300 caacaatcaa agatctgcga gaccacaagc tggacaaccg catggagtcg 350 ttcttcctgg ccgagactgt gaaatacctc tacctcctgt ttgacccaac 400 caacttcatc cacaacaatg ggtccacctt cgacgcggtg atcaccccct 450 atggggagtg catcctgggg gctggggggt acatcttcaa cacagaagct 500 caccccatcg accctgccgc cctgcactgc tgccagaggc tgaaggaaga 550 gcagtgggag gtggaggact tgatgaggga attctactct ctcaaacgga 600 gcaggtcgaa atttcagaaa aacactgtta gttcggg 637 <210> SEQ ID NO 274 <211> LENGTH: 697 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26, 59, 66 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 274 tatgggcata gaaaaccctg gaaagnccca tccaccatta tatatagagt 50 gattgtctnt gcttgntgag ctaacagggg tgtcaagctt ccattttggt 100 atctacttct aaatacactc agaccaggag aaatttggac taattttcaa 150 actacagaca ctttctaatc atgatgcatt tcaaaagtgg actcgaatta 200 actgagttgc aaaacatgac agtgcccgag gatgataaca ttagcaatga 250 ctccaatgat ttcaccgaag tagaaaatgg tcagataaat agcaagttta 300 tttctgatcg tgaaagtaga agaagtctca caaacagcca tttggaaaaa 350 aagaagtgtg atgagtatat tccaggtaca acctccttag gcatgtctgt 400 ttttaaccta agcaacgcca ttatgggcag tgggattttg ggactcgcct 450 ttgccctggc aaacactgga atcctacttt ttctggtact tttgacttca 500 gtgacattgc tgtctatata ttcaataaac ctcctattga tctgttcaaa 550 agaaacaggc tgcatggtgt atgaaaagct gggggaacaa gtctttggca 600 ccacagggaa gttcgtaatc tttggagcca cctctctaca gaacactgga 650 gcaatgctga gctacctctt catcgtaaaa aatgaactac cctctgc 697 <210> SEQ ID NO 275 <211> LENGTH: 621 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 48, 82, 136 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 275 tgggacacgg gttaccccaa gngcagcgct ggcaaggcct tcatgatntc 50 ggtgtgctct acgtgaccaa ttcccacctg gntggggcaa ggtctacttc 100 gcctatttta ccaacacgtc cagttagagt acacgnacgt gcccttccac 150 aaccagtatt cccacatctc gatgctggat tacaaccccc gggagcgcgc 200 cctctatacc tggaacaacg gccaccaggt gctctacaat gtcaccctgt 250 ttcacgtcat cagcacctct ggggacccct gagccaatgc tgtggctcgg 300 gctgctgcct ggggggcctc cgggggctgg gggccctttt cattctgcct 350 gtgtccctca agggtgatct ctctgtctct gtcacgccct ttctccccgc 400 ctttttgctg ggcttttgtt ctctgcctat gtatttctgt ctattttttc 450 aatttcccct cttctccttt attgatctct gcttttaata caccacttct 500 ttctttctgc ctttttatgg atgtcttttt ctttttatgg ctctggttct 550 ccagttcttt ccgtctctgc ctctctctgt ctctctctct ctgtccttcc 600 acccctccct ccttgcctcc c 621 <210> SEQ ID NO 276 <211> LENGTH: 570 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 5, 28, 71, 73, 86, 126 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 276 cgaangcgtg ggtgtgcatc cgggtgtntg aaggctgtgc ccgttttgtt 50 tcttggctaa aatcggggga ntnaggcggg ccggcncggc gcgacaccgg 100 gctccggaac cactgcacga cggggntgga ctgacctgaa aaaaatgtct 150 ggatttctag agggcttgag atgctcagaa tgcattgact ggggggaaaa 200 gcgcaatact attgcttcca ttgctgctgg tgtactattt tttacaggct 250 ggtggattat catagatgca gctgttattt atcccaccat gaaagatttc 300 aaccactcat accatgcctg tggtgttata gcaaccatag ccttcctaat 350 gattaatgca gtatcgaatg gacaagtccg aggtgatagt tacagtgaag 400 gttgtctggg tcaaacaggt gctcgcattt ggcttttcgt tggtttcatg 450 ttggcctttg gatctctgat tgcatctatg tggattcttt ttggaggtta 500 tgttgctaaa gaaaaagaca tagtataccc tggaattgct gtatttttcc 550 agaatgcctt catctttaat 570 <210> SEQ ID NO 277 <211> LENGTH: 642 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 34, 50, 124, 264, 266, 305, 307, 334, 424, 458, 501, 582, 613, 638 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 277 agtttccttt aaattggggt nggggtgtta agcnctgaaa atatctttcn 50 tgattacttt accatgtgga catatgggat aaatactgta tttcagattt 100 acataaaagt agattagtaa tgcncagctt tcagaataaa aactgataaa 150 aaagaccaag cactatcaac tttggacagt aatttcttag gtgttaaaca 200 agttttctga atacaatctg gatgcaaaac ggcctgattt gatgaattca 250 taattttctt ctgnanactt tcattttatt aaatatttta ttacttggtt 300 aaacncnaga attatctatg taaacttcat gggntttttt gttgaaagtt 350 agatgttcag taactaattt cccagttatg gcccagaatt aaacatttat 400 gatcatattt cagaagtcaa aatncaaaac tggattatca aaacggttgg 450 tgtggtcnct ttaaactgga ctatcagtat ggttgccgtg gtcactttaa 500 ncgggattat cagtacggtt ggtgtggtca ctttggttta tcatcaatac 550 agttggtgtg gtcactttaa actggattac cnatatggtt ggtgtggtcg 600 ctttaaagtt tgntttcatt tttttctatt tttaattntt ac 642 <210> SEQ ID NO 278 <211> LENGTH: 434 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 146, 162, 199, 203, 225, 245, 271, 286, 298, 323, 328, 359, 368, 431 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 278 ttggtttttc tgttcctgng ttagtttgct gacttaagag gatacagact 50 tgaggtataa tttgtcttag tcagttttgt gttgctataa cagaatacct 100 gagactaggt aatttataaa aataaagttt atttggctca tgattntgga 150 gctggaaagt cnagattggg cagcccatat gatgagggtt gcacacttnt 200 tcnatttatg gcagaaagtg gaaanggaag caggtgtgtc caaanagaca 250 tgcaggagag gttggagtca ntgctctctc aggaantaat tcattctnta 300 gagagtgaga actcacttaa ctnttgcnag agggcattaa tctattcacc 350 catgaaacna acaccctnca gtagactcca ccatttaaca ctgccatatt 400 gggaatcaaa tttcaacatg agttttggca nggg 434 <210> SEQ ID NO 279 <211> LENGTH: 335 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 140, 178, 241, 244, 247, 264, 314, 321, 326 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 279 cctttggaaa ctgggattaa tgtatgctct agatccattt attagaaatg 50 caaaaatact acaatttttt gatggatgaa aatactcctg taacacaaac 100 agagaactgg aggaactgaa gaataactca ctcatatagn tctgcctcat 150 tctgtgtgtg tgtgcatgtg tgtgttanca gaggtatttt actcagaaaa 200 taggtttcaa agaacattaa tgactttctt ttccctttta ngtntgntta 250 atcagttaaa ctgntatggg aaaagtttta tagaactata taacctgaat 300 gttggtctct ttgnacacat nttttntatg actgc 335 <210> SEQ ID NO 280 <211> LENGTH: 254 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 29, 135, 140, 143, 163, 190, 207, 209, 219, 221, 241 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 280 tgtggtccta atatcataga tcactttana tgtgatttgt ttcagttgtt 50 gacacttgcc tgcacggaca cccacatcct gggcctttta gttaccctca 100 acagtgggat gatgtgtgtg gccatctttc ttatnttaan tgngtcctac 150 acggtcatcc tangctccct gaagttttac agctttaaan ggcggcacaa 200 agccctntnt acctgcagnt nccacctcac ggtggttgta ntgttctttg 250 tccc 254 <210> SEQ ID NO 281 <211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 96, 205, 265, 331, 334, 337 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 281 tggttccagg tcaccatcct tagcntcaaa ttcataaaat ggttgcttct 50 acctccagcc tgatatcctt gtgatgggca ggcagaacca gggctntaag 100 gaaaggagcc agcacctgta tcaagaagcc aaagccttcc ctgaaatctt 150 tagcagacgt ctgcttgtga ctatttggct agaactttgt gacatggcca 200 ctccntgctg caaggacatt tacagttttt cagttgggcc cattgccacc 250 ctgagcaaag ggtcnataag gaagaagacg gagagtggac atgttgggca 300 ttcacctgcc agcactccat ccagacagcc ncanaantgg tgggtaaaca 350 gagacagcat acattcactt atcaactgtt tagtaaattc ctggcatggg 400 ca 402 <210> SEQ ID NO 282 <211> LENGTH: 515 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 56, 176, 217, 231, 253, 282, 287, 337, 350, 352, 364, 403, 452 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 282 agcccagatc caggaaccat tcctatttca ggattttgaa tgcaaaactt 50 accttnttac tctaaagatg aatgtcaggg agagatttat tcaaccctga 100 gatttttgca gtctccttca gagtcacaga atagattaag gcctgatgat 150 actcaaaggc ctgggaaaac tgatgncaaa gaattttcag tgccctggca 200 cctcattgca gtgactnttg ggatcctctg nttacttctt ctgatgatag 250 tcncagtgtt ggtgacaaat atctttcagt gnattcnaga aaaacatcaa 300 cggcaggaaa ttttaagaaa ctgtagtgaa aagtacntca tgcaaaatgn 350 cnactactta aaanagcaga ttttgacaaa taagacttta aaatatgacg 400 ttntcaaaaa tagctttcag cagaaaaagg aactggattc acgccttata 450 cnaaagaaca gatgtcatag agaaaatgag atcattttta aagttttgca 500 aaatacaggc aaatt 515 <210> SEQ ID NO 283 <211> LENGTH: 433 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 283 aggaatgacc ttcctcaggg ggctgaggat accccacagg cctcctttct 50 ctccagctcc agggtttgac tatgcaccta tttaggggct gcttgctcaa 100 gggagagagg tacaggaggt ggtctgggaa aaacaaaatt gatcttccta 150 tcaattgtat ttttgtttag cggaatctat acacacccat ttctttggat 200 attatttcca gttactccag ctaatccaaa taatgatatt tgccctcagt 250 taagaacaga ttttattttt aggaacagaa gtctagtagc agttttgctt 300 tttattaacg ttttaaggaa catttacctt agatatcatg attcttgggc 350 atttgcaaaa tgcagtcaat atcaaacagc aatggttgct tgttttatga 400 tcggtcagaa tttgtccctt atattaattt cag 433 <210> SEQ ID NO 284 <211> LENGTH: 496 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 83 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 284 gccccgagtt tctgtcgcag gttgcgagga aaggccccta ggctgggtct 50 gggtgcttgg cggcggcggc ttcctccccg ctngtcctcc ccgggcccag 100 aggcacctcg gcttcagtca tgctgagcag agtatggaag cacctgacta 150 cgaagtgcta tccgtgcgag aacagctatt ccacgagagg atccgcgagt 200 gtattatatc aacacttctg tttgcaacac tgtacatcct ctgccacatc 250 ttcctgaccc gcttcaagaa gcctgctgag ttcaccacag tggatgatga 300 agatgccacc gtcaacaaga ttgcgctcga gctgtgcacc tttaccctgg 350 caattgccct gggtgctgtc ctgctcctgc ccttctccat catcagcaat 400 gaggtgctgc tctccctgcc tcggaactac tacatccagt ggctcaacgg 450 ctccctcatc catggcctct ggaaccttgt ttttctcttc tccaac 496 <210> SEQ ID NO 285 <211> LENGTH: 566 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 285 atttagattt gnatctcttc ccatcaatca tgaatacata aggtaatatt 50 ttatagttgg aaagcattgc ttaatatatt gaatcaataa aaatattgat 100 ttcatatatt taatttttat aatctttaca gattacaata ctgtgatgag 150 actgttcctg taacttttga tccacacaca gaatttcttg gtcctcagaa 200 gaaaacagaa caagtccaaa gagacattgg attttggtgt ccaaggcatc 250 ttaagacttc tgggggacaa ggatataagt ttctgggaat tgaccagtgt 300 gcgcctccat gccccaacat gtattttaaa agtgatgagc tagagtttgc 350 aaaaagtttt attggaacag tttcaatatt ttgtctttgt gcaactctgt 400 tcacattcct tactttttta attgatgtta gaagattcag atacccagag 450 agaccaatta tatattactc tgtctgttac agcattgtat ctcttatgta 500 cttcattgga tttttgctag gcgatagcac agcctgcaat aaggcagatg 550 agaagctaga acttgg 566 <210> SEQ ID NO 286 <211> LENGTH: 570 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7, 46, 111, 121, 176, 185, 212, 221, 236, 239, 267, 308, 329, 371, 393, 399, 405, 412, 417, 423, 427, 486, 490, 495, 517, 524, 531, 533, 544 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 286 cgttaanacg agcctgccag taaatgtagc catcatgttc agtaanggcc 50 ttgcaaaaca gattacccct tcaccttttc acttaattgt ctacctatga 100 atcattaatg ntttggtttg nttttaattc tgtgataggt aggaaaggat 150 ggaactcctt ggcagactag tgttanaaag ttttngaagc agggtgagtc 200 ttgtaccttt gnggtcctgt ntcacagaca cctgtntant ccctgaccct 250 tttaaatggt aactttntgc ctgtaggaaa tcttcccttt gtgcttaggt 300 ctttttcntc tgtgagcttt agataaacna cctagtgttt aaacttttta 350 ataagggatt cattttttaa nacatgagaa ttcatttcaa aantttggnt 400 ttagntattt antttantct acntggntct ttttcagaca gatgttctct 450 cctggattgt aaaagtcgaa ttcaaaggat ttttanttgn aatanactta 500 acctttctct tgtaagntgc catntgtgta nanacagctt tgantgcctg 550 acaagaggaa aatgtttccc 570 <210> SEQ ID NO 287 <211> LENGTH: 556 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 40, 80, 179, 195, 203, 263, 304, 310, 313, 427, 437 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 287 aactgtcttt aatggcccag ttttaccagg gcttgttgtn taaggacatt 50 aacttgtgct cccctcaggg atgggtttan tactagctgt cagaaagcta 100 ttgggtatcc taatgtgtta atagctgaaa ctcagctgta atttctccta 150 aatacttcag cattttgcat tctgtacant gtggtgcttt ttccnccttg 200 tantgttcta actgtaagct cctagggggc agcaatttgg ataaatcttt 250 tggtaagtag ttntcaataa aatatcttcc ctccccatac ccctacccga 300 aatnttatan tgntctttac aaaactttgg tcaagagtag aaatatatcc 350 aggcagatgt atatgccata caatagcaag aacagtaaag cccaactaat 400 gattttgagt tttaaaaata gaaggcnatt aaaatgnact caaagttaca 450 ttaagaaaag ctttcacggg ggtaatattg aaacagtcac aaaggttaag 500 aaaatactga tagcagtttt tgtctatttt aacattgtag tcatttgtac 550 tttgat 556 <210> SEQ ID NO 288 <211> LENGTH: 594 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 73, 113, 215, 252, 257, 263, 267, 269, 277, 287, 293, 297, 302, 310, 457, 506, 521, 554, 584, 591 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 288 ggattttcgt aagtagttta gagatagtca cattttaaaa atttaagatc 50 aagcaaatga agcttatttt tangtattca tagtataaaa gaccttcagt 100 aaataggtaa tanttttgtt ttattctaga aaacagctcc ttgaacacag 150 tgagctggct tttcacacat tgcagttgtt agtgtttact gcccttgcca 200 ttttaattat gaggntaaag atgtttttga caccgcacat gtgtgttatg 250 gnttccntga tangctntng acagctnttt ggctggnttt ttngcanagt 300 tngttttgan aaggttatct ttggcatttt aacagtgatg tcaatacaag 350 gttatgcaaa cctccgtaat caatggagca taataggaga atttaataat 400 ttgcctcagg aagaactttt acagtggatc aaatacagta ccacatcaga 450 tgctgtnttt gcaggtgcca tgcctacaat ggcaagcatc aagctgttta 500 cacttnatcc cattgtgaat natccacatt acgaagatgc agacttgagg 550 ggtnggacaa aaatagttta ttttacatat agtngaaaat ntgc 594 <210> SEQ ID NO 289 <211> LENGTH: 713 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 70, 96, 106, 113, 119, 134, 227, 299, 384, 421, 430, 454, 464, 546, 556, 561, 597, 616, 622, 667, 673, 712 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 289 tcccttaatt ccatagaccc cgaagggggt ttcccgggtt ggaatccatt 50 aaatccgggc cagggcttgn tcccgtggtt taggattggg ggttanaaat 100 aaaaantcag gtntatttnt taccagtcag tacnattttt aaagaatgta 150 cttggtatat aatatatgga cttcaggaac tttattgggg tggggggtta 200 attttgcctt accctgttca ctttcanatg attaggcttt tgcactttag 250 aatgagaaac ttgtgacgtt agtgtgttct tactagcttt aatttgtang 300 tagcaatgaa ttgtgaatct tagtgcagtg ggttttttta aaaaactcaa 350 aaagctggga attaagtggt ttcagtaata atgntatacc gaggtgcttg 400 cattgtattt cataattttg ntacaaaccn aaattatttt taatgagaac 450 agtnttgggt tcanaggtgt gatgccagaa tgtattttcg tactgttagg 500 cccttggaac agatatcggt gctttttgaa agatgaaaga aatgcnatgg 550 gtgctnttca ngcaaggttg caaacctacc aagaatgcat aatagtntca 600 cttttcccca ataaanagat gngtgtgact agttttggac ttttaacctt 650 aatgggggtt gcatgtntcc tantgttaat cattgtcagc tgcagtgaca 700 tgatccacag tnc 713 <210> SEQ ID NO 290 <211> LENGTH: 687 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26, 38, 49, 71, 81, 191, 257, 270, 276, 323, 343, 385, 407, 416, 436, 463, 468, 501, 533, 544, 557, 569, 576, 579, 588, 591, 594, 600, 605, 649, 682 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 290 gacttggaag aattggacct agtggntaga cccaaggncc aaagccaana 50 attcgtgggg ggcccaggaa ncaggaggtc ncatgggatt ccagacataa 100 gatcaggttt taaccccctt tggcccaaat tttggctgaa aatgttgaat 150 tatcaactct gaaattaaaa agaaagttta tattaaaaca ntgcaatttt 200 ccttagaatt tctgtatata ttaacatcat gaatgataaa ttctcttcaa 250 tgtgcangtc aggtttttgn acttgnatat caaatctatc tgtgtgtatg 300 aagtgtatgt ttattgaaat acnagatatt taagaagctg atntggaaag 350 ttggattttc attctagttc ctaattccca gaggnttttt taaaggaagg 400 gaatgtntgt ggtacnccag ttgtcagctg ggtggntact ggatcatctt 450 tcttttatca acnagatnaa ctatcaactt caccagcatc atgaaccttg 500 ntgccgtaaa aaggagttca ctacttctgt tcnctttgag tctnttcaaa 550 tggattntgt gtcctcctnt ggagtntgng ccatttantg nttntgactn 600 ttccnctaag ccagagaatg atgatggagg aaattatgaa atgttcacnc 650 gaaaatttgt ttttcgacct gaactgtttg angtcac 687 <210> SEQ ID NO 291 <211> LENGTH: 673 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 34, 66, 97, 187, 229, 263, 309, 314, 346, 397, 448, 451, 463, 487, 491, 536, 563, 575, 608, 618, 625, 636, 656, 666 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 291 aacccatggg gccaagtcaa aagcccncag gttntccagg caagggcatg 50 ggcatggggt taggancagt gaacctggaa gtaatcccag ccctgcngtc 100 attagtgtgt tacctcaggt aaaggggggg aaccctacag gactgttaca 150 aggattaaat gaaggaattt aagtgtgtgc atgtatntgg catgtagaaa 200 atacagtgtg gtggggagag aacagattnt agaaccagac tgcctgagtt 250 caaatcccag ttntgctgct tcctggctgt gtgaccctgg gcaaatcact 300 tagcctgtnt gggnttcaga tttctcatct gacaatgaag ataatnaaat 350 acctatcttt atggttgtag taaggattaa atgaattgaa ataaagnttt 400 tagattaata cttgatatgc tacataggtg tcagccattg ttaatcantg 450 ntgtcattat agntattatc aacatgatta tttgctntaa naggaactca 500 ggcatttgca gggtgtgggg aaccctgagc tgggtntccc ctgttgggtg 550 ttgtgtcccc atnataccct taggncaacc caggtcaggt cagggggatg 600 tgcccttntt ttcctggncc aggtntgtaa ggccancagc tttgcctcat 650 acgtgngcag caggtngtta tgg 673 <210> SEQ ID NO 292 <211> LENGTH: 663 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 54, 71, 73, 89, 104, 137, 142, 177, 308, 409, 423, 430, 451, 468, 503, 551, 558, 581, 598, 622, 629, 632, 660 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 292 ctaaccccag ttgaattttt ggagcttgtt ggatttgccc attgccagcc 50 caantatgtt ggggaaaagt ntntgagtgt cattttgcnt gttgaagctc 100 tggntaatgt gattattgat ctgagaatga atctttntta gntattccaa 150 acttagttat ttttgcagtt ttggtanttt tttcctcatt ggaactccca 200 aaaatccgat tgcttttgcg tgttttttta tttgcctgat aactgatcct 250 ttccttgaca tttattttag tggactttca gtaactgaaa gatggaaacc 300 ctttttgnac cgtggaagaa tttgcagaag actttcagtc gtttttgctg 350 gaatgattga gcttacattt tttattcttt ccgcattcaa acttagagac 400 actcacctnt ggtattttgt aanacctggn ttttccattt ttggaatttt 450 ntggatgatt tgtcatanta tttttctttt aactctttgg ggattccata 500 ccnaattaaa tgactgccat aaagtatatt ttactcacag gacagattac 550 natagccntg atagaatcat ggcatccaaa nggatgcgcc atttttgntt 600 gatttcagag cagttggtgt tntttagtnt tnttgcaaca gcgattttgg 650 gagcagtttn ccg 663 <210> SEQ ID NO 293 <211> LENGTH: 603 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 44, 90, 108, 124, 171, 351, 376, 378, 389, 396, 453, 477, 507, 518, 524, 541, 587 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 293 tccaggattt ttctccctgg tntaaggtcc tggttcacac ccanaggaac 50 cagtttggtc ctgggcaagc cactgcctat aggataaggn aagatcaaat 100 aaatcatntc agggagaaca aggnccagcc ttcctcctct attcactcaa 150 acacaccacc caagcaccca ntttggccag actctgtgat ggtccctgcc 200 ctcaaaggac tgttcatggt ctagagatga aagagcccag tcaacagtta 250 tactgtgtgg tggcggcggg agggtaatca cagggtattt atgggtacaa 300 aaaggaggca ccctgacctc accagaaata gctaccctgt gccataggct 350 ntaggcagac tttactgaca ttgaanancc ttttgcagnc aattancaaa 400 aagactacat gtgtaaatgt gacagaacag ggattcagag cctgaatgtt 450 tangcctgct ttatcctcat tttgtcnctg tggaggcaga ggtgggaaaa 500 ctaagtntag aagccatntg agtntgggtg ggagccacct ntatatttgt 550 cataagtctc tgatggtcct ttggtttcta gctatanctg tgtccactag 600 tgc 603 <210> SEQ ID NO 294 <211> LENGTH: 704 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 33, 42, 94, 99, 106, 122, 147, 187, 198, 458, 482, 484, 497, 560, 609, 626, 665, 679, 691 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 294 ttaaggcctt ttaaaatggt ggaaattttt ggnacaatta tncggaaatt 50 tttaattttt aaggaatttt ggaaagtagt ttaaagatag cccnttttna 100 aaattntaag atcaagcaaa tnaagcttat ttttaaggat tcaaagnata 150 aaagccttca gtaaataggt aaaattttgg tttattntag aaaacagntc 200 cttgacacag tgagtggctt ttcacacatt gcagttgtta atggtttact 250 gcccttgcca tttttaatta tgaggctaaa gatgtttttg acaccgcaca 300 tgtgtgttat ggcttccttg atatgctctc gacagctctt tggctggctt 350 tttcgcagag ttcgttttga gaaggttatc tttggcattt taacagtgat 400 gtcaatacaa ggttatgcaa acctccgtaa tcaatggagc ataataggag 450 aatttaanaa tttgcctcag gaaaaacttt tncnagtgga tcaaatncag 500 taccacatca gatgctgtct ttgcaggtgc catgcctaca atggcaagca 550 tcaagctgtn tacacttcat cccattgtga atcatccaca ttacgaagat 600 gcagacttna ggcctggttg cagtangctt gaaatctggg atgtggaaga 650 cccttccaat gcagntaacc cttccttang tagcgtcctg ntcgaagacg 700 ccag 704 <210> SEQ ID NO 295 <211> LENGTH: 504 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 89, 104, 139, 152, 165, 171, 211, 223, 278, 313, 351, 374, 386, 389, 446, 482, 485, 493 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 295 tccaaaaaaa aaataatgga aaactggaaa gagaaaaatt gtttcaaaaa 50 ctatagcaca cctgttgtta gattcttgtc ttgcctaang tttttcaatt 100 ttantatttt ctacagtttg gaccgaattc taatttttnt tgactacaag 150 tnttcaaaat aatgntttca nttttttctt cttttttcca tttttttcca 200 atttggagtc nctgaaaact aanctgtgct ttcataaagc cctgcaaact 250 gaatctagac aacttcagaa gaaaaatnac agcaacctat ttacatacat 300 aagccacttt canacctgcc taccgatgta tggacttcag agtaatgtgg 350 nttatagcaa ttttccagga ttgntctttt gtttgntgnt gttctccctt 400 cctcccccta ttttgtcttt atgggacatg acacttcaca accttntaaa 450 aatgagtttt cctaataact caggacctac tngtntagaa atnaaccatc 500 ctag 504 <210> SEQ ID NO 296 <211> LENGTH: 557 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 48, 104, 163, 201, 212, 228, 244, 251, 257, 293, 365, 444, 458, 465, 495, 526, 538, 552 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 296 tttttttttc ccctttgggc caggtcgggg tatgataggt cggggaanag 50 ggggctttgg aggccgaggc cgaggccgtg gacgagggaa aggtgccctt 100 gctngccctg tattgaccaa ggagcagctg gacaaccaat tggatgcata 150 tatgtcgaaa acnaaaggac acctggatgc tgagttggat gcctacatgg 200 ngcagacaga tnccgaaacc aatgattnaa gcctgcccat cctnccatga 250 nagactnttg ttagtcaaca catctgtaaa taaccttgag atnacagatg 300 agaagaaatc tgattgatgc tggatggacc tatcacaata ggctgtggac 350 ttacttgcca ccagnttgtg catttagtgt gttcctttta ctttttgata 400 ctgtgttgta tgaaaccctt ttgtcctttg atttggtttt ttgnttttgt 450 ttttttangg ggganggggg gtttcccctc ctttgcccag acttntcttt 500 gaacacaaat gcattagcct tgtggntaga acaccctntt cctacctctg 550 tntcccc 557 <210> SEQ ID NO 297 <211> LENGTH: 501 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 45 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 297 ggtaatggaa aacccgcaat tacatttgaa ccaacctaat agatntaagg 50 aaaagcgctt tccattcgta gcatcagtct ggccacatcc cttgtgagcc 100 actgcgcccg gcttgttggc cgtatttttg gaatgcattt ggagcttggg 150 tcagtagttt ttgttttcat gtgatgtcac caacatgttg cctatacaga 200 ttgaatatcc cttatccaaa atgcttgcaa ccagaagtgt tttggatttt 250 tggaattttt tttggatttt ggaatatctt catgtaaata atgagatttg 300 ttggggatca gactcaagtc taaacatgaa attcgtttat gtttcatata 350 tactttatac acatacctta aaggcagttt tatacagtat tttcaatggt 400 gtgcatgaaa caaagtttgt gttcattgat ccatcagaaa gcaaagatgt 450 cactgtctca gccacacgtg gacaatctgg ttggttagcg tccccatcgt 500 t 501 <210> SEQ ID NO 298 <211> LENGTH: 515 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 298 ggccccgcgt gccgacatgg gaaagtctct ttctcatttg cctttgcatt 50 caagcaaaga agatgcttat gatggagtca catctgaaaa catgaggaat 100 ggactggtta atagtgaagt ccataatgaa gatggaagaa atggagatgt 150 ctctcagttt ccatatgtgg aatttacagg aagagatagt gtcacctgcc 200 ctacttgtca gggaacagga agaattccta gggggcaaga aaaccaactg 250 gggcattgat tccatatagt gatcagagat taaggccaag aagaacaaag 300 ctgtatgtga tggcttctgt gtttgtctgt ctactccttt ctggattggc 350 tgtgtttttc cttttccctc gctctatcga cgtgaaatac attggtgtaa 400 aatcagccta tgtcagttat gatgttcaga agcgtacaat ttatttaaat 450 atcacaaaca cactaaatat aacaaacaat aactattact ctgtcgaagt 500 tgaaaccgaa cccct 515 <210> SEQ ID NO 299 <211> LENGTH: 481 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 168 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 299 gagcggagcc ggcggagcct ctggaatcac ccgggtcgct gttcctgagc 50 agctgcagag catcgagggc tggagaggag cacatactgt ccatggagct 100 ggtggtcaag gtggacaggg gcggtggtga tggcgcagtt tgacactgaa 150 taccagcgcc tagaggcntc ctatagtgat tcacccccag ggaggaggac 200 ctgttggtgc acgtcgccga ggggagcaag tcaccttggc accatattga 250 aaaccttgac ctcttcttct ctcgagttta taatctgcac cagaagaatg 300 gcttcacatg tatgctcatc ggggagatct ttgagctcat gcagttcctc 350 tttgtggttg ccttcactac cttcctggtc agctgcgtgg actatgacat 400 cctatttgcc aacaagatgg tgaaccacag tcttcaccct actgaacccg 450 tcaaggtcac tctgccagac gcctttttgc c 481 <210> SEQ ID NO 300 <211> LENGTH: 468 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 132, 197, 209, 218, 235, 238, 285, 344, 365, 457 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 300 tatggaacag cctccttttg acancagtta cgggctggtg gtggcagggt 50 ctgttctggt cctgggagcc atcatcggtg actgggtgga caagaatggt 100 agacttaaag tggcccagac ctcgctggtg gnacagaatg tttcagtcat 150 cctgtgtgga atcatcctga tgatggtttt cttacataaa catgagnttc 200 tgaccatgna ccatggangg gttctcactt cctgntanat cctgatcatc 250 actattgcaa atattgcaaa tttggccagt actgntactg caatcacaat 300 ccaaagggat tggattgttg ttgttgcagg agaagacaga agcnaactag 350 caaatatgaa tgccncaata cgaaggattg accagttaac caacatttta 400 gcccccatgg ctgttggcca gattatgaca tttggctccc cagtcatcgg 450 ctgtggnttt atttcggg 468 <210> SEQ ID NO 301 <211> LENGTH: 466 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 301 accgcctgac cgtgctggct ggtgcaatgc ttgccttggg actaatgaca 50 tgcttgtcag ttttgtttgg ctatgccacc acagtcatcc ccagggtcta 100 tacatactat gtttcaactg tattatttgc catttttggc attagaatgc 150 ttcgggaagg cttaaagatg agccctgatg agggtcaaga ggaactggaa 200 gaagttcaag ctgaattaaa gaagaaagat gaagaatttc aacgaaccaa 250 acttttaaat ggaccgggag atgttgaaac gggtacaagc ataacagtac 300 ctcagaaaaa gtggttgcat tttatttcac ccatttttgt tcaagctctt 350 acattaacat tcttagcaga atggggtgat cgctctcaac taactacaat 400 tgtattggca gctagagagg acccctatgg tgtagccgtg ggtggaactg 450 tgggcgaacc ccttgc 466 <210> SEQ ID NO 302 <211> LENGTH: 648 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 10, 15 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 302 tcgaacccan ggggnccgcc gaacgcgtgg gaccatatag agaaatagca 50 tgaatatttt tattaggaga tgtttcaaag actgtattcc aatggttaaa 100 ggaaagtcca aaacctcttt aaggaacact gcaagttgag cctctgctgt 150 tttaataggt aggtgacctt gcctgagtca gtctttttga atttcaattt 200 tctaatcttt aaaatgaggt ttttggtgat ccctcagttt cctttcagct 250 ctggaatttg gtgggtaagt taccttgaat gtgtatcttt tcttgttaaa 300 attttaaaaa acaatataga aggaaacaaa tcctttttac tcctattttt 350 tagaaataac ccctaaacct ggtaatattt tgacgtgttt ttttcaaact 400 tgtctgtgca ttttttaaag gagcttctgt cgtatatagt tatgccctgc 450 ttttgtgtgc atgttaagca tttggtatgt tattttaaag tggaatgcct 500 tgaagaatga atcagtcaga cctactgtta acattttgat gtatttcaga 550 ctgacttaca attttttggt atttgatatt atgtataatt atatcctgca 600 tttacttagc atattaagga tttttttata tgtaatttta aagtggaa 648 <210> SEQ ID NO 303 <211> LENGTH: 444 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 83, 103 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 303 attttttatg tattcatagt ataaaagacc ttcagtaaat aggtaatatt 50 tttgttttat tctagaaaac agctccttga acncagtaag ctggcttttc 100 acncattgcc agtggtaagt gtttactgcc cttgccattt taattatgag 150 gctaaagatg tttttgacac cgcacatgtg tgttatggct tccttgatat 200 gctctcgaca gctctttggc tggctttttc gcagagttcg ttttgagaag 250 gttatctttg gcattttaac agtgatgtca atacaaggtt atgcaaacct 300 ccgtaatcaa tggagcataa taggagaatt taataatttg cctcaggaag 350 aacttttaca gtggatcaaa tacagtacca catcagatgc tgtctttgca 400 ggtgccatgc ctacaatggc aagcatcaag ctgtctacac ttca 444 <210> SEQ ID NO 304 <211> LENGTH: 427 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 81 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 304 atgaaatcct gctttctttt cctcagaact actatattca gtggctaaat 50 ggctccctga ttcatggttg tggaatctgg nttccctttt ttccaacctt 100 tggttaattg gaattgatgc cctttgcctt tttctttctg gaatcagaag 150 gctttgctgg cctgaaaaag ggaatccgag cccgcatttt agagactttg 200 gtcatgcttc ttcttcttgc gttactcatt cttgggatag tgtgggtagc 250 ttcagcactc attgacaacg atgccgcaag catggaatct ttatatgatc 300 tctgggagtt ctatctaccc tatttatatt cctgtatatc attgatggga 350 tgtttgttac ttctcttgtg tacaccagtt ggcctttctc gtatgttcac 400 agtgatgggt cagttgctag tgaagcc 427 <210> SEQ ID NO 305 <211> LENGTH: 600 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 14, 19, 27, 54, 65, 126 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 305 atagtattaa gtcnattgng caagtgnagc cttagaagat ttggagtgtt 50 tttnactctt tttcntggtg gcttagaatt ttctccaaga aaagttaaga 100 aaggtgtgaa gatttcctta caaggnccgt gtacatgaca ctgttaatga 150 ttgcatttgg cttgctgtgg gggcatctct tgcggatcaa acccacgcag 200 agcgtcttca tttccacgtg tctgtccttg tcaagcacac ccctcgtgtc 250 caggttcctc atgggcagtg ctcggggtga caaagaaggc gacattgact 300 acagcaccgt gctcctcggc atgctggtac gcaggacgtg cagctcgggc 350 tcttcatggc cgtcatgccg actctcatac aggcgggcgc cagtgcatct 400 tctagcattg tcgtggaagt tctccgaatc ctggttttga ttggtcagat 450 tcttttttca ctagcggcgg tttttctttt atgtcttgtt ataaagaagt 500 atctcattgg accctattat cggaagctgc acatggaaag caaggggaac 550 aaagaaatcc tgatcttggg aatatctgcc tttatcttct taatgttaac 600 <210> SEQ ID NO 306 <211> LENGTH: 492 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 120, 215 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 306 aacctatata aaatagtttt tagcagttta tagctgtgac catcaagtca 50 gataatttgg gatgttcaca gagagctctg ggtgattatg acagtgacca 100 cccacatctc ttatttgttn tgcttcattt ctctactagg gagaggaggt 150 catataatat atggtatttt tatgttattt tagataaatc catatcaaca 200 cagcacagga gaacnaatta taccccctgg tagattttgg ggtataaacg 250 tcatgaaatg tttctcagaa agtgagaaat atttcttgat tgtatcttta 300 aaattaatgc aaaattgtta tgttactcca taatttattt gtgtgcatta 350 ctgtaaggtt catgtgtatt catattaaat tttttctttt aaaaattggg 400 ttcaatgaat tatctaggat gattgcattg tttgtggcat caagtgttgt 450 ttctcccttt ccataccaag catatcctgc ttttggtaca gg 492 <210> SEQ ID NO 307 <211> LENGTH: 495 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 49, 65, 158, 178, 211, 218, 221, 225 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 307 ttacttgtga gtatcatcnt gtcctttaat cctgtaccct aaaataagna 50 atacattttt gacanaggct taatgtttta acaaaagagt gtggacattt 100 ttattttaaa atttaggcaa aagtcactat caaatggttg cttatttgtc 150 tcacacancc atatagtttt tcctggangg ttttgttttg ttgttgttga 200 aaagactttg nttacagnta natgnaacct ttttatagaa aaaaaaaatt 250 gttgaaaggt ccagttctca gtaccatgtg agttaatgat actacaacta 300 agttcttttt aaaaagtgat taatgtattt tataaattac cttttcacat 350 atgcaaaatc tgtttctact acaatgttat ttttactaat gccttattgt 400 tgcactcttt ttgaaatatc ctgcagtgaa tatatgaatc aatttgggct 450 taaaactgaa agccagttgg ctgaaaggtt tgaaatacgt acccc 495 <210> SEQ ID NO 308 <211> LENGTH: 478 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 43, 154 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 308 ttctttcttt tccccatntc attcattcag gctcctttcg canaagtgag 50 gtatttagat aatcaaaacc ccacacaaga cctcaacagc aaatacagat 100 gaaatgtaat tattatttca attaaaaagg gaataatatt tgtaggccat 150 tgtnaccagt attctctcgt tttaactagt tttgctgcat ttaaattaag 200 tgctgctctt cagcttttgt gtacagctat aagtgcacat tggaatttat 250 atgtatatat atatagagag agagagagag agagaaaatg actgctggtt 300 cagtgtgtgt ccctcagatc ataccactac gagtgcctca gcctggaaaa 350 gctaaccatg aaattgataa caatacgctt ttggaaatga aatcaggtaa 400 gaatcacata tgtttgaaat tgtttaaaat aacattgtca tatttcttgt 450 gttatctggt tgctggttta tctctttg 478 <210> SEQ ID NO 309 <211> LENGTH: 469 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 132, 155 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 309 gtggcccgtc tggctagtcc tgtntaagcg cgcccatttc gagcccaagt 50 ttccagctcg ggtttccggg ctcagaattt tccaggagtg ggttcttggg 100 cagtggctgt ggaacaggaa tggcgcagct anagggttac tgtttctcgc 150 cgccnttgag ctgtaccttt ttagtgtcct gcctcctctt ctccgccttc 200 agccgggcgc tgcgagagcc ctacatggac gagatcttcc acctgcctca 250 ggcgcagcgc tactgtgagg gccatttctc cctttcccag tgggatccca 300 tgattactac attacctggc ttgtacctgg tgtcagttgg agtggtcaaa 350 cctgccattt ggatctttgg atggtctgaa catgttgtct gctccattgg 400 gatgctcaga tttgttaatc ttctcttcag tgttggcaac ttctatttac 450 tatatttgct tttccacaa 469 <210> SEQ ID NO 310 <211> LENGTH: 524 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 4, 15, 206, 227 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 310 cgcntcggcc catgnacgcc ttgtgcggtt ccggggagtc ggctccaagt 50 ctgggactcc aacctgtctg tgcacacaga aaacccggac ctcactccct 100 gcttccagaa ctccctgctg gcctgggtgc cctgcatcta cctgtgggtc 150 gccctgccct gctacttgct ctacctgcgg caccattgtc gtggtacatc 200 atcctntccc acctgtccaa gctcaanaat ggtcctgggt gtcctgctgt 250 ggtgcgtctc ctgggcggac cttttttact ccttccatgg cctggtccat 300 ggccgggccc ctgcccctgt tttctttgtc acccccttgg tggtgggggt 350 caccatgctg ctggccaccc tgctgataca gtatgagcgg ctgcagggcg 400 tacagtcttc gggggtcctc attatcttct ggttcctgtg tgtggtctgc 450 gccatcgtcc cattccgctc caagatcctt ttagccaagg cagagggtga 500 gatctcagac cccttccgcc tcac 524 <210> SEQ ID NO 311 <211> LENGTH: 501 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 311 ccatcaggaa ggtgaaagag gtctttggga caggggccat gagacatgtg 50 gtcatcctct tcacccacaa agaggactta gggggccagg ccctggatga 100 ctatgtagca aacacggaca actgcagcct gaaagacctg gtgcgggagt 150 gtgagagaag gtactgtgcc ttcaacaact ggggctctgt ggaggagcag 200 aggcagcagc aggcagagct cctggctgtg attgagaggc tggggaggga 250 gcgagagggc tccttccaca gcaatgacct cttcttggat gcccagctgc 300 tccaaagaac tggagctggg gcctgccagg aagactacag gcagtaccag 350 gccaaagtgg aatggcaggt ggagaagcac aagcaagagc tgagggagaa 400 cgagagtaac tgggcataca aggcgctcct cagagtcaaa cacttgatgc 450 ttttgcatta tgagattttt gtttttctat tgttgtgcag catacttttt 500 t 501 <210> SEQ ID NO 312 <211> LENGTH: 655 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 85, 118 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 312 tctttgttct cacaagttat ctttacattg gaatgaccct gaattaggaa 50 gttaaagtga acttggttgg atttggatac tgctntaaaa gttagaaaat 100 taggtcattt gacatttntg ctccgtgttt tgccatgttt ggttcctaca 150 tacttttgca aagatcaagg aagacctttg aggcatctct ttatctctta 200 tttctattac tatcacccca attcaagtca tcatcattac cctggacttc 250 tgggatagct tcccactgtt cccactcatc tactcttgct cactgccttc 300 cccccaaacc ccctaaaatt cattctccag atagtgacta gagtgaatcg 350 actatatctt ctcttttcct gctctggata taatttatat cttttcctgc 400 tctggatata atttatatcc ttcattctcc atttctgtgc ccctgtgtgc 450 caactgctat tgtctgcatt agatggactt ccttatcttc tggcttctat 500 tgaatttggt gaactgggga gggtcaagta ggagatcagt gtgtgggaga 550 agaaagaagt ttgagtattt atcacctagg aagggggact tccaggacac 600 tgtttggcag ggatgctggg cctctactgg aggcctagtt ccgactgtgt 650 tgccc 655 <210> SEQ ID NO 313 <211> LENGTH: 239 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 226, 234 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 313 tttttttttt tttttttttg gattaatgag gaaatcattc tgtggctcta 50 gtcataattt atgcttaata acattgatag tagccctttg cgctataact 100 ctacctaaag actcacatca tttggcagag agagagtcgt tgaagtccca 150 ggaattcagg actgggcagg ttaagacctc agacaaggta gtagaggtag 200 acttgtggac aaggctcggg tcccanccgg acgngtggg 239 <210> SEQ ID NO 314 <211> LENGTH: 175 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 314 atttgggttt tttttttcca aaaattgctg aaatattgtt ttgccatttt 50 taaaaagtct caggttatta ccactctgcc attaaatatt tgtatgcctg 100 catttttaaa aattctgtgc atgtacttta tggagtacat tctatttttg 150 ttttcagata ccccggacgc gtggg 175 <210> SEQ ID NO 315 <211> LENGTH: 971 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 262, 355, 369, 486, 539 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 315 cggacgcgtg gggaaacctt gccttcaagg gttttttgtt ttgttttgtt 50 ttgttttttg tttgtttggg tttgttttgt tttggtttgg ttttgaaacg 100 gagtctcgct ctgtcgccca ggctggagtg cagtggcgca atctcggctc 150 actgcaagct ccgcctcccg ggttcacgtc attctcctgc ctcagcctcc 200 cgagtagctg ggactacagg cgtccactac cacgcctgga taattttttg 250 tattttcagt anagacgggg tttcaccgtg ttagccagga tggtcttgat 300 ctcctgacct catgatcccg cctgcctcgg cctcccaaag tgttgggatt 350 acagngcgtg agccaccgng ccgggcacct tcaaggtttt gttaattttg 400 gataatgcta caatccgttg ctgcaaagaa ctcgaaaatg cacacgccaa 450 cataggagtt ctttttatgc ccccaaacat taagtntttc atccaacccc 500 tcaatcgggg cataataaaa gcattcaagg cacactacna caagggagct 550 ttatatgaag gcctgtgagg ctctcaggac caacaaggaa accaccatgc 600 tggactattg gaagtcggtc actacatgca acgttattga ttatgtcagt 650 acagcctggg agagcattgg tcaggctact accaataact gttgggaaaa 700 tgtttggcca gactgcgtgg agaattttga agggtttgaa ggtgttacag 750 aaaatataaa gaacactgtc agagacataa tgcatatggc acagcaggta 800 agtggagagg gctttgatga cgtgaaggaa ggagatgtgg agtacatttt 850 ggcagagaag gcagtggaac caaccaacga agacctggat gagatggcaa 900 aacaaggcat tggagttgat ggccatgaaa gtcggcccaa gacttccaga 950 attgtccctc tcacagcgcc c 971 <210> SEQ ID NO 316 <211> LENGTH: 673 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 67, 115, 126, 132, 135, 274 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 316 aaattctact tcctggattt tggaaggcca aaacattttt tccccatggg 50 atacatcccc atgtttntgg cacaatcctt ctttgaaaat aatatggaac 100 ttagatatat ttagncatta cgttcntctg gntgnatgac atcattcaag 150 agcttttcaa agcatttgtt cagatcttca gtactggcca gttttcatac 200 agtctcgggg ttttaaaact ttgaaatcaa ggacacgacg tctccagtct 250 acctccgaga gattagttga aacncagaat atagcgccat cattcgtgaa 300 ggggtttctt ttgcgggaca gaggatcaga tgttgagagt ttggacaaac 350 tcatgaaaac caaaaatata cctgaagctc accaagatgc atttaaaact 400 ggttttgcgg aaggtttttc tgaaagctca agcactcaca caaaaaacca 450 atgattccct aaggcgaacc cgtctgattc tcttcgttct gctgctattc 500 ggcatttatg gacttctaaa aaacccattt ttatctgtcc gcttccggac 550 aacaacaggg cttgattctg cagtagatcc tgtccagatg aaaaatgtca 600 cctttgaaca tgttaaaggg gtggaggaag ctaaacaaga attacaggaa 650 gttgttgaat tcttgaaaaa tcc 673 <210> SEQ ID NO 317 <211> LENGTH: 557 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 43, 52, 59 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 317 cgcttgggca ggttggggtt gaaactnttc accccttgcg gtntgtactg 50 cntcccaant gagcagccag gagaaggcta gagcctgtgc ctttcagcta 100 gatagctgga ggaactggtc ctccctcctt aggctgtgct ggcctgagct 150 gggagcctga gagctggggc agttgtctct aaagtggctt ctgggattct 200 ggtaagagcg ttacatcctt actattcaaa gtgccatcca cagacctgct 250 gatgggcagc atgagcatca cctgggagct tgctgcgctg tagaatcttg 300 aggggtctcc atccagatca gctgaatcag agtttgcatt gttaacaaga 350 ttctgcttct cagaagatgc actattatag atactctaac gccaaggtca 400 gctgctggta caagtacctc cttttcagct acaacatcat cttctggttg 450 gctggagttg tcttccttgg agtcgggctg tgggcatgga gcgaaaaggg 500 tgtgctgtcc gacctcacca aagtgacccg gatgcatgga atcgaccctg 550 tggtgcc 557 <210> SEQ ID NO 318 <211> LENGTH: 570 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 1, 38, 52, 104 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 318 ntgcagtcaa cgcagcttcc cgggttcagc ctgggaanat gcgcgaatcg 50 gnaaccccag agcccggtgg ttagaccggg gtccgccgct tcccccacag 100 cccntttcct aatcgttcag acggagcctg gtcgacttcg ccggagactg 150 ccagatctcg ttcctcttcc ctgtgtcatc ttcttaatta taaataatgg 200 gggatgaaga taaaagaatt acatatgaag attcagaacc atccacagga 250 atgaattaca cgccctccat gcatcaagaa gcacaggagg agacagttat 300 gaagctcaaa ggtatagatg caaatgaacc aacagaagga agtattcttt 350 tgaaaagcag tgaaaaaaag ctacaagaaa caccaactga agcaaatcac 400 gtacaaagac tgagacaaat gctggcttgc cctccacatg gtttactgga 450 cagggtcata acaaatgtta ccatcattgt tcttctgtgg gctgtagttt 500 ggtcaattac tggcagtgaa tgtcttcctg gaggaaacct atttggaatt 550 ataatcctat tctattgtgc 570 <210> SEQ ID NO 319 <211> LENGTH: 698 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 57, 82, 87, 148 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 319 tcagcgggta agaaaattct acttccnggg atttttgtaa aaggcaaaaa 50 ccttttnttc cccattggca tacattccca angtttntgc ccaatccttc 100 ttttgaaaat taaatatgga acttagatat atttagtcat tacgttcntc 150 tggcttgtat ggacatcatt caagagcttt tcaaagcatt tgttcagatc 200 ttcagtactt ggccagtttt catacagtct cggggtttta aaactttgaa 250 atcaaggaca cgacgtctcc agtctacctc cgagagatta gctgaaacac 300 agaatatagc gccatcattc gtgaaggggt ttcttttgcg ggacagagga 350 tcagatgttg agagtttgga caaactcatg aaaaccaaaa atatacctga 400 agctcaccaa gatgcattta aaactggttt tgcggaaggt ttttctgaaa 450 gctcaagcac tcacacaaaa aaccaatgat tccctaaggc gaacccgtct 500 gattctcttc gttctgctgc tattcggcat ttatggactt ctaaaaaacc 550 catttttatc tgtccgcttc cggacaacaa cagggcttga ttctgcagta 600 gatcctgtcc agatgaaaaa tgtcaccttt gaacatgtta aaggggtgga 650 ggaagctaaa caagaattac aggaagttgt tgaattcttg aaaaatcc 698 <210> SEQ ID NO 320 <211> LENGTH: 443 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 4 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 320 gccnagcgga cgggccgctt aaacgggctg ctcgtgccga ttcttttacc 50 tgagaaatgc tacgaccaac ttttcgttca gtgggacttg cttcacgtcc 100 cctgcctcaa gattctcctc agcaaaggcc tggggctggg cattgtggct 150 ggctcacttc tagtaaagct gccccaggtg tttaaaatcc tgggagccaa 200 gagtgctgaa gggttgagtc tccagtctgt aatgctggag ctagtggcat 250 tgactgggac catggtctac agcatcacta acaacttccc attcagctct 300 tggggtgaag ccttattcct gatgctccag acgatcacca tctgcttcct 350 ggtcatgcac tacagaggac agactgtgaa aggtgtcgct ttcctcgctt 400 gctacggcct ggtcctgctg gtgcttctct cacctctgac gcc 443 <210> SEQ ID NO 321 <211> LENGTH: 477 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 321 gttggcctga ttctccccac cagaggacag acgttgaaag ataccacgtc 50 cagttttcag cagacgcaac tatcatggac attcaggtcc cgacacgagc 100 cccagatgca gtctacacag aactccagcc cacctctcca accccaacct 150 ggcctgctga tgaaacacca caaccccaga cccagaccca gcaactggaa 200 ggaacggatg ggcctctagt gacagatcca gagacacaca agagcaccaa 250 agcagctcat cccactgatg acaccacgac gctctctgag agaccatccc 300 caagcacaga cgtccagaca gacccccaga ccctcaagcc atctggtttt 350 catgaggatg accccttctt ctatgatgaa cacaccctcc ggaaacgggg 400 gctgttggtc gcagctgtgc tgttcatcac aggcatcatc atcctcacca 450 gtgcggacgc gtgggcggac gcgtggg 477 <210> SEQ ID NO 322 <211> LENGTH: 505 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 48, 75 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 322 cagtgccttt agattgtgtt ttgcctcctc caatgtagag ttgacatntg 50 gaccccagag cccagcaggg ctttntgtca gacatgtagg gtggtagaaa 100 tgggccctcc aggtccccct gcagtgcact gggcagagac ctccggaaag 150 ccggcagcgg gagcgcttcc tgggcagctt cccccagcac agtgttccca 200 aaccagtcca tccggaaaac agtctgtaca gcaaatgctg tgtgagatct 250 taggcttttc actttttttt gttttgtttt gtttttgaaa gaaagaaaaa 300 aatacaatta acaagcctct tttgtaaatg ggtttccttt ctatgtataa 350 aatcgtggtg gtcccttgtt tttacatgtt catgctgtgt aattttgaga 400 tgttactgag atatgttctg aacataatgt gcattttttt ctgtacagat 450 gaaatgggag aatttaataa agagtttgca gcccacgcgt ccgcggacgc 500 gtggg 505 <210> SEQ ID NO 323 <211> LENGTH: 632 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 75, 80, 107, 117 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 323 gaagtgttca ctggacaatt ngcaagttag gtccagttcc agttggagga 50 ttcttccatt gttccaaggt gtggnaattn caatggtcct gatctccatt 100 tttgtgncaa tctattncaa tgtcataatt gcctatagtc tttactacat 150 gtttgcttct tttcaaagtg aactaccatg gaaaaattgt tcttcgtggt 200 cagataaaaa ctgtagcaga tcaccaatag taactcactg taatgtgagt 250 acagtgaata aaggaataca agagatcatc caaatgaata aaagctgggt 300 agacatcaac aattttacct gcatcaacgg cagtgaaatt tatcagccag 350 ggcagcttcc cagtgaacaa tattggaata aagtggcgct ccaacggtca 400 agtggaatga atgagactgg agtaattgtt tggtatttag cactttgtct 450 tcttctggct tggctcatag ttggagcagc actatttaaa ggaatcaaat 500 cgtctggcaa ggtggtatat tttacagctc ttttccccta tgtggtccta 550 ctcatcctgt tagtacgagg tgcaactctg gagggtgctt caaaaggcat 600 ttcatactat attggagccc cggacgcgtg gg 632 <210> SEQ ID NO 324 <211> LENGTH: 502 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 9, 24 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 324 cggggggcnt acaccactgc ctgngtcttc accaccgccg ccgtgcagtt 50 ggaattgatc acaccttttc agttgtactt caatcctgaa ttaatcttta 100 aacactttca aatatggaga ttaatcacca acttcttatt ttttgggcca 150 gttggattca attttttatt taacatgatt tttctatatc gttactgtcg 200 aatgctagaa gaaggctctt tccgaggtcg gacagcagac tttgtattta 250 tgttcctttt tggtggattc ttaatgaccc tttttggtct gtttgtgagc 300 ttagttttct tgggccaggc ctttacaata atgctcgtct atgtgtggag 350 ccgaaggaac ccctatgtcc gcatgaactt cttcggcctt ctcaacttcc 400 aggccccctt tctgccctgg gtgctcatgg gattttcctt gttgttgggg 450 aactcaatca ttgtggacct tttgggtatt gcagttggac cggacgcgtg 500 gg 502 <210> SEQ ID NO 325 <211> LENGTH: 375 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 9 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 325 tgcaaattnt gagattcaga gactaaagta atttatttat acatagctaa 50 tcagtgccag agctgtgaat ctaagattat cttgctctta atcacaaaaa 100 tacacagtta ttagttgttt gcatttgatg caaatgactt ggaacccaca 150 cattttacac atttttaatg aatgaaatga ctagtttgat tcattacacg 200 tttgtggaaa ttttgcagct aggttttaaa ttaagaacac cagatttatt 250 taaatacaat ttaaaatcat tgtattccaa atggaagttt tcttctataa 300 gaataccagg ctggatgtgg tggctcacac ttgtaatcct agcactttgt 350 gtggccgagg aagcggacgc gtggg 375 <210> SEQ ID NO 326 <211> LENGTH: 198 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 326 gtcaggattt ttgaagtttt tttttttata gtgagataat ggagttggtc 50 ttagccgctg caggagccct tcttttctgt ggattcatca tctatgacac 100 acactcactg atgcataaac tgtcacctga agagtacgta ttagctgcca 150 tcagcctcta cttggatatc atcaatctat tcctgccgga cgcgtggg 198 <210> SEQ ID NO 327 <211> LENGTH: 489 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 327 caagttaggt gatccagntt ttgtggtctt ttgcaaccct tgtggtcatt 50 gtgcccttga tattaatctt cgtggtgggt cctcgccatg gcagacaaac 100 attcttgtgt acataacaat ctgctctgta atcggcgcgt tttcagtctc 150 ctgtgtgaag ggcctgggca ttgctatcaa ggagctgttt gcagggaagc 200 ctgtgctgcg gcatcccctg gcttggattc tgctgctgag cctcatcgtc 250 tgtgtgagca cacagattaa ttacctaaat agggccctgg atatattcaa 300 cacttccatt gtgactccaa tatattatgt attctttaca acatcagttt 350 taacttgttc agctattctt tttaaggagt ggcaagagat gcctgttgac 400 gatgtcattg gtactttgag tggcttcttt acaatcattg tggggatatt 450 cttgttgcat gcctttaaag acgtcagctt tagtctagc 489 <210> SEQ ID NO 328 <211> LENGTH: 559 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 43, 46 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 328 aaagtggtcc ttttagggta aagagtttta aagagtttaa tgngtntatg 50 gcaggtttgg gaaaggtaag aaatgggtcc tttttcctcc taatgttttt 100 ggcacttaaa acataaaatt cattatccta ttaaaaaatt aaattcagtt 150 tgctaatcca gaaattgttc ccaaatgaaa acttgtttta agtccacccc 200 ttagtttcct tattttacaa ggtctctctt cagggaccaa caggggctta 250 gagagcctta gttagattaa agggagaccc tacctcttaa aaccagtttt 300 catttatgca aacaaggaca attaagggaa ccctgacccc acaggctctc 350 aagtcttccc aaggccagaa tcgaaagaaa attaaaattt gaatgctgaa 400 tattctggct ctactctggc ctttttttct ggttcccttc caaaatgcac 450 aaatcatacc cttgtctgct ccaattcagt ctccaaacct ggtgcctgtg 500 ctcctggccc ccctagcatc atgctatccc aggagtatca ggaccagaca 550 catccacgg 559 <210> SEQ ID NO 329 <211> LENGTH: 523 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 4, 14, 60, 71, 99 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 329 ggcnacggcg gccnaagacg gacatgaagc aatatcaagg ttccggcggg 50 gtccccatgn atgtggaacg nagtcgcttt cccctactgc gtggtgtgna 100 cgcccatccc ggtgctcacg tggtttttcc ccatcatcgg ccacatgggc 150 atctgcacat ccacaggagt cattcgggac ttcgcgggcc cctactttgt 200 ctcagaggac aacatggcct ttggaaagcc tgccaagtac tgaagttgga 250 ccctgctcag gtctatgcta gcgggcccaa cgcatgggac acggctgtgc 300 acgacgcctc tgaggagtac aagcaccgca tgcacaatct ctgctgtgac 350 aactgccact cgcacgtggc attggccctg aatctgatgc gctacaacaa 400 cagcaccaac tggaatatgg tgacgctctg cttcttctgc ctgctctacg 450 ggaagtacgt cagcgttggg gccttcgtga agacctggct gcccttcatc 500 cttctcctgg gcatcatcct cac 523 <210> SEQ ID NO 330 <211> LENGTH: 365 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 83, 124 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 330 tttgatttaa tgttggttgt gtgtctcctc ctggcaactg gattttgcct 50 gttcagaggt ttgattgctt tggattgccc atntgagctc tgccgattat 100 atacgcaatt tcaagagccc tatntaaagg atcctgctgc ttatcctaaa 150 attcagatgc tggcatatat gttctattct gttccttact ttgtgactgc 200 actgtatggc ttagtggttc ctggatgttc ctggatgcct gacatcacat 250 tgatacatgc tggaggtctg gctcaggctc agttttctca cattggtgca 300 tctcttcatg ctagaactgc ttatgtctac agagtccctg aagaagcaaa 350 aatccttttt ttagc 365 <210> SEQ ID NO 331 <211> LENGTH: 441 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 331 gaaaatatct ggaggtactg cacataagga ttccaatttc tattttcaga 50 actttcattt gtaatttatg tacgcatcta acgtctattt acgtgtatac 100 tgagttaggg tgtacaactt ttccctgagg ctgtatctca aaaactttgg 150 aagctgaaga atttgtccaa atctatgttc ctttttgttt gtaaatcacc 200 tgatgatggt gatatagctg tggccaacga aatgtcaagg gaagtctgct 250 ggggaaggta gacgtaggat aggagtatgg gaaaaaatta ttcactcaaa 300 agcatgatgc acagaggagc tatgatcttt tcttgttttc ctcactggat 350 gttgtcatgt ctgtatgtac ttcctggaac tgtggcacca tcttacaacc 400 atgaaaggag ctcacatgaa atcatgttga acatagcaga g 441 <210> SEQ ID NO 332 <211> LENGTH: 627 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 45-46, 52, 71, 173, 226, 275 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 332 aggttggtcc ttttccggtt ttttggccaa tttcaagttt ccagnntcca 50 tnatccaagt ttgaagcccc ntggcggatc cttaaaaatc cctgacctga 100 ccagggtcgc caagggtcgc acaaggcctg ggccaggttc ccacagggag 150 gtgaaaaaac tcccattccg ttnaaaagca gtttcctttg ggacccattt 200 ccttttccct ttggccatgg ccgtgncctc caaaggttcc ggtagtttaa 250 tgcaaatgtt ctaccaatag ccccnagaac tccaccaccc tctctctgtc 300 ttgtggctca agtcgagcaa cctgaaagga tatatttttt caaataagta 350 attcctgtag gcaataaaaa gatacactat cttctgagtg aaatataaag 400 agttcacagc agctgtctcc ccagtttgca ttttcctctg cacctgatgg 450 gaaggacaga taaagataat gggatttttt ctttattttt tatttcacct 500 ccctctctcc ctggaaggtg gaaatgtaac aaattggatt gtgagtgtgt 550 ctgtcctttg tgcttggtgc ctggagcagg gcatccggct gccgggcaga 600 gctgctgcga gagaggtcag agctacc 627 <210> SEQ ID NO 333 <211> LENGTH: 607 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 112-113, 151, 175, 183, 196, 211, 215, 223, 241, 247 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 333 ccaagttgaa gcccatggcg gtccttaaat cctgcctgac cagggtcgcc 50 agggtcgggc aagcaagtgc cagaagaata aagaagatgg acgcaaaaag 100 aagaaaggaa gnnccagaag agacgaagag atgaaacgac agtcagatga 150 natgaggagg aaagaaaggt ttcanaaagc cgncggaaat gaaagncgtc 200 ctggtttgaa ngaanttgcc aanagataaa tccagcagga naggccnaga 250 aagatcgagg tctgcttatc tgctgttacc ttggacacca gagcagctat 300 aggtatctgc cagagctatg aaatcattca gccggatcct cttcctcgtc 350 ttcctcctcg ccggcctgag gtccaagccg ctccctcagc ccctctgcct 400 ttgggctgtg gctttccgga catggcccac ccctctgaga cttcccctct 450 gaagggtgct tctgaaaatt ccaaacgaga tcgccttaac ccagaatttc 500 ctgggactcc ttaccctgag ccttccaagc tacctcatac ggtttccctg 550 gaaaccttcc cacttgactt cactgagccc ctcaaccctg acctccgaga 600 aaccccg 607 <210> SEQ ID NO 334 <211> LENGTH: 417 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 334 ttcagactca ctgaatcaga accntgggat aggccagcac gctgtgcttt 50 accaagctct aggtgatgcc aattcatact caagtgtgag gctgactggc 100 ttatttgaag ggagagaaag gaacaggcac atggcgacat atcagcattt 150 acacaaggcg tgctgggtaa ccataggaac acctttatta cggttaaata 200 ggaaacaggc atcaatgcag agggccccca ggagaatcag gaaggtcgcg 250 actgtcactg tctgagggca ctgttgtgaa acgatggccg aaggtgacaa 300 ccacagcaaa gtttcaagga agttcactga aacgtggaaa aacccactca 350 atgtcctgct ctcatttata ttgagtggct taagtattta ttttcttggt 400 tttttagagg aagggag 417 <210> SEQ ID NO 335 <211> LENGTH: 531 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 40, 76 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 335 gaagcttccg ttgccaagcg acatgttcaa ggtaattcan aggtccgtgg 50 ggccagccag cttgagcttg ctcacnttca aagtctatgc agcaccaaaa 100 aaggactcac ctcccaaaaa ttccgtgaag gttgatgagc tttcactcta 150 ctcagttcct gagggtcaat cgaagtatgt ggaggaggca aggagccagc 200 ttgaagaaag catctcacag ctccgacact attgcgagcc atacacaacc 250 tggtgtcagg aaacgtactc ccaaactaag cccaagatgc aaagtttggt 300 tcaatggggg ttagacagct atgactatct ccaaaatgca cctcctggat 350 tttttccgag acttggtgtt attggttttg ctggccttat tggactcctt 400 ttggctagag gttcaaaaat aaagaagcta gtgtatccgc ctggtttcat 450 gggattagct gcctccctct attatccaca acaagccatc gtgtttgccc 500 aggtcagtgg ggagagatta tatgactggg g 531 <210> SEQ ID NO 336 <211> LENGTH: 446 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 336 ggcggccgag gcggacggcc gcttaaacgg ctgctcgtgc cgattctttt 50 acctgagaaa tgctacgacc aacttttcgt tcagtgggac ttgcttcacg 100 tcccctgcct caagattctc ctcagcaaag gcctggggct gggcattgtg 150 gctggctcac ttctagtaaa gctgccccag gtgtttaaaa tcctgggagc 200 caagagtgct gaagggttga gtctccagtc tgtaatgctg gagctagtgg 250 cattgactgg gaccatggtc tacagcatca ctaacaactt cccattcagc 300 tcttggggtg aagccttatt cctgatgctc cagacgatca ccatctgctt 350 cctggtcatg cactacagag gacagactgt gaaaggtgtc gctttcctcg 400 cttgctacgg cctggtcctg ctggtgcttc tctcacctct gacgcc 446 <210> SEQ ID NO 337 <211> LENGTH: 489 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 16, 67 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 337 cggaacgcgt gggcgnacgc gtgggcaaga tgtccctgtg gactcccaaa 50 ctctactcca gatgggnagg tgcccttaac accaagattt taaaagctcc 100 aatttcagag caagagtcga aaactcacag ataaagttat agttatttca 150 gggttctgaa aagacgcaga acatgaaggg actcagaagt ctggcagcaa 200 caaccttggc tcttttcctg gtgtttgttt tcctgggaaa ctccagctgc 250 gctccgcaga gactgttgga gagaaggaac tggactcctc aagctatgct 300 ctacctgaaa ggggcacagg gtcgccgctt catctccgac cagagccgga 350 gaaaggacct ctccgaccgg ccactgccgg aaagacgaag cccaaatccc 400 caactactaa ctattccgga ggcagcaacc atcttactgg cgtcccttca 450 gaaatcacca gaagatgaag aaaaaaactt tgatcaaac 489 <210> SEQ ID NO 338 <211> LENGTH: 452 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 3 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 338 ccntgcacaa gcagcacttt cttttgccat agcaacatgt gcatcaataa 50 ttctttagtc tgtaatggtg tccaaaattg tgcataccct tgggatgaaa 100 atcattgtaa agaaaagaaa aaagcaggag tatttgaaca aatcactaag 150 actcatggaa caattattgg cattacttca gggattgtct tggtccttct 200 cattatttct attttagtac aagtgaaaca gcctcgaaaa aaggtcatgg 250 cttgcaaaac cgcttttaat aaaaccgggt tccaagaagt gtttgatcct 300 cctcattatg aactgttttc actaagggac aaagagattt ctgcagacct 350 ggcagacttg tcggaagaat tggacaacta ccagaagatg cggcgctcct 400 ccaccgcctc ccgctgcatc cacgaccacc actgtgggtc gcaggcctcc 450 ag 452 <210> SEQ ID NO 339 <211> LENGTH: 354 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 339 aaataaagaa ccatggtatc atgttgntca gtgcttcaga cagaaagatt 50 gttgaagcat caaggagagc ttttgttatg tggcaatgaa ctacgaagag 100 gaaatggcca agaaacccga ttgtctagag aaagtttacc aactacctga 150 tgggaaggtc atccagctcc atgaccagct cttttcttgt ccagaggccc 200 tcttctctcc gtgtcatatg aaccttgagg cccctggcat tgataagata 250 tgcttcagca gcataatgaa atgtgataca ggcctgagga attccttctt 300 ttccaatatt atccttgccg ggggatcaac ctctttccct ggtttagaca 350 agct 354 <210> SEQ ID NO 340 <211> LENGTH: 547 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 77, 101, 142, 151 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 340 tggcggtcct aaaatcctgn cctgaccagg gtccggcggt tcagttggag 50 gaaaagtgta gccttgcagg tggcaantgg tccaggtacc ggtatttggc 100 nggcccgttt ttgcctcctc ctccgtgggt gcggcgggaa tnttggccgg 150 ncggccttgg gacggcccag gtcccggccg caaggtccgg gccaatacat 200 agtcatcagt agaaacttct tgaagttgtt caagaaaaat ttgaaagtag 250 caaaatagaa aataaagaat taacagcaga tacagaggca gcatgaagtg 300 ttgtcttagg aaacagaaca cagcagtgaa aaaacagaca aaatccgctc 350 agatacaact gcagctgata atgttttccg gcttcaatgt ctttagagtt 400 gggatctctt ttgtcataat gtgcattttt tacatgccaa cagtaaactc 450 tttaccagaa ctgagtcctc agaaatattt tagtacattg caaccaggaa 500 aagcctcttt agcttatttt tgtcaagctg attccccaag aaataca 547 <210> SEQ ID NO 341 <211> LENGTH: 374 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 42 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 341 ccgaatcaag ttcgagtcat ccgtgtgggc attngtcccc cntggcacag 50 ttggcttctt tccagaagcc cgttttgttt gttttacgtc taaattcgcg 100 tcggttctta tttctctccc tggcaaggtc tgaagacggg taggagaata 150 acctgtgtca gcgtgttatg atgccgtccc gtaccaacct ggctactgga 200 atccccagta gtaaagtgaa atattcaagg ctctccagca cagacgatgg 250 ctacattgac cttcagttta agaaaacccc tcctaagatc ccttataagg 300 ccatcgcact tgccactgtg ctgtttttga ttggcgcctt tctcattatt 350 ataggctccc tcctgctgtc aggc 374 <210> SEQ ID NO 342 <211> LENGTH: 515 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 342 agttccggca agggtgcatc cggcntgtgt gtggcgcaag gcaaggaaac 50 cggtacccgg gtcctggccc cagcgctgac gttttctctc ccctttcttc 100 tctcttcgcg ggttgcggcg tcgcagacgc tagtgtgagc ccccatggca 150 gatacgaccc cgaacggccc ccaaggggcg ggcgctgtgc aattcatgat 200 gaccaataaa ctggacacgg caatgtggct ttctcgcttg ttcacagttt 250 actgctctgc tctgtttgtt ctgcctcttc ttgggttgca tgaagcagca 300 agcctttacc aacgtgcttt gctggcaaat gctcttacca gtgctctgag 350 gctgcatcaa agattaccac acttccagtt aagcagagca ttcctgtccc 400 aggctttgtt agaggacagc tgccactacc tgttgtattc actcatcttt 450 gtaaattcct atccagttac aatgagtatc ttcccagtct tgttattctc 500 tttgcttcat gctgc 515 <210> SEQ ID NO 343 <211> LENGTH: 509 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 46, 63, 68, 117, 139, 145, 164, 173, 179, 181, 246 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 343 cctgacccag ggtccggngg caattttcca tttatgccct gtggtncggg 50 acatacctag atntcagncc atttcctcca ggttttggcc ttgttttaag 100 gccctgggct gggattncaa gtggcttgat caacccccnt ttggnccagt 150 actaccctta gggnccgtga ccntgactnt ntgcagcatt ttcataccta 200 tcgggttggg cgtcttcatt cgctacaaat acagccgggg gctgantaca 250 ttgtgaaggt ttccctgtgg tctctgctag tgactctggt ggtccttttc 300 ataatgaccg gcactatgtt aggacctgaa ctgctggcaa gtatccctgc 350 agctgtttat gtgatagcaa tttttatgcc tttggcaggc tacgcttcag 400 gttatggttt agctactctc ttccatcttc cacccaactg caagaggact 450 gtatgtctgg aaacaggtag tcagaatgtg cagctctgta cagccattct 500 aaaactggc 509 <210> SEQ ID NO 344 <211> LENGTH: 336 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 344 cctaaatagg gccctggata tattcaacac ttccattgtg actccaatat 50 attatgtatt ctttacaaca tcagttttaa cttgttcagc tattcttttt 100 aaggagtggc aagatatgcc tgttgacgat gtcattggta ctttgagtgg 150 cttctttaca atcattgtgg ggatattctt gttgcatgcc tttaaagacg 200 tcagctttag tctagcaagt ctgcctgtgt cttttcgaaa agacgagaaa 250 gcaatgaatg gcaatctctc taatatgtat gaagttctta ataataatga 300 agaaagctta acctgtggaa tcgaacaaca cactgg 336 <210> SEQ ID NO 345 <211> LENGTH: 380 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 345 ttaagtgcaa accatgcagt gcccgaggat gataccatta gcaatgactc 50 caatgatttc accgaagtag aaaatggtca gataaatagc aagtttattt 100 ctgatcgtga aagtagaaga agtctcacaa acagccattt ggaaaaaaag 150 aagtgtgatg agtatattcc aggtacaacc tccttaggca tgtctgtttt 200 taacctaagc aacgccatta tgggcagtgg gattttggga ctcgcctttg 250 ccctggcaaa cactggaatc ctactttttc tggtactttt gacttcagtg 300 acattgctgt ctatatattc aataaacctc ctattgatct gttcaaaaga 350 aacaggctgc atggtgtatg aaaagctggg 380 <210> SEQ ID NO 346 <211> LENGTH: 364 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 346 gcagcattca gagttactgg ctgtcatttt tcatggtgat gattttattt 50 gtagctttca taacctgttg ggaagaagtt actactttgg tacaggctat 100 caggataact tcctatatga atgaaactat cttatatttt cctttttcat 150 cccactccag ttatactgtg agatctaaaa aaatattctt atccaagctc 200 attgtctgtt ttctcagtac ctggttacca tttgtactac ttcaggtaat 250 cattgtttta cttaaagttc agattccagc atatattgag atgaatattc 300 cctggttata ctttgtcaat agttttctca ttgctacagt gtattggttt 350 aattgtcaca agct 364 <210> SEQ ID NO 347 <211> LENGTH: 752 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 40, 47, 73, 87, 235, 256 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 347 acaatgttgg gtaaaataat tgggggggac ttttgggccn ttcaggntta 50 atagtattaa gtctatgggc aantggagcc ttagganaat ttggggggtt 100 tttaatcttt ttcctggtgg gcttagattt ttctccagaa aagttaagaa 150 aggtgtgaag atttccttac aaggcccgtg ttacatgcca ctgttaatga 200 ttgcatttgg cttgctgtgg gggcatttct tgcgnatcaa acccacgcag 250 agggtnttca tttccaaggt gtctgtcctt tgtcaagcac acccctcgtg 300 tccaggttcc tcatgggcag tgctcggggt gacaaagaag gcgacattga 350 ctacagcacc gtgctcctcg gcatgctggt gacgcaggac gtgcagctcg 400 ggctcttcat ggccgtcatg ccgactctca tacaggcggg cgccagtgca 450 tcttctagca ttgtcgtgga agttctccga atcctggttt tgattggtca 500 gattcttttt tcactagcgg cggtttttct tttatgtctt gttataaaga 550 agtatctcat tggaccctat tatcggaagc tgcacatgga aagcaagggg 600 aacaaagaaa tcctgatctt gggaatatct gcctttatct tcttaatgtt 650 aacggtcacg gagctgctgg acgtctccat ggagctgggc tgtttcctgg 700 ctggagcgct cgtctcctct cagggccccg tggtcaccga ggagatcgcc 750 ac 752 <210> SEQ ID NO 348 <211> LENGTH: 342 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 348 aaaaaaaaaa aaaaaaaaaa agaaccactt ctgccttatc attctctctt 50 tattaccgaa atgcggagac agaaagtcaa cagagaaaga attgttttcc 100 ccaaggccac acagattgct ccaacacttg acttttcctg ctaggaactc 150 aatccaagag atgggctttc ttttgttctc tgactataaa agggtgtcac 200 cttgtcacca tcttctatca cacaggaccc ctatgggctt ggtttggttt 250 tgttctttca tcattattat ttggaaagtt atatttcctt tactgtcctt 300 gaggtgtgag gcttcacctc atcttgtctc catatccctg ag 342 <210> SEQ ID NO 349 <211> LENGTH: 608 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 46, 101, 110, 132, 271 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 349 tggatcccat ggccagggng gcgtccaggt gcaaaccagt agaacncaag 50 gcctgaacct ggggccagac accttgtttt ccccggccat ggtcaagacc 100 ntccagtacn tgccttactg tgggcccaga antgggccaa gtcttggcag 150 cccgtgccgc aggttgttgt gcagtttggg gtgttcttct gcaccatcct 200 ccttttgctc tgggtgtctg tcttcctcta tggctccttc tactattcct 250 atatgccgac agtcagccac ntcagccctg gcatttctac tacaggaccg 300 actgtgattc ctccaccacc tcactctgct ccttccctgt tgccaatgtc 350 tcgctgacta agggtggacg tgatcgggtg ctgatgtatg gacagccgta 400 tcgtgttacc ttagagcttg agctgccaga gtcccctgtg aatcaagatt 450 tgggcatgtt cttggtcacc atttcctgct acaccagagg tggccgaatc 500 atctccactt cttcgcgttc ggtgatgctg cattaccgct cagacctgct 550 ccagatgctg gacacactgg tcttctctag cctcctgcta tttggctttg 600 cagagcag 608 <210> SEQ ID NO 350 <211> LENGTH: 590 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 38, 85, 87, 117, 189 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 350 aaatttgaaa cccataagtt accaagtcta tatcaggngc agtggctttg 50 attaaagccc atttttaaaa cttaaaaact caacncntcc cagattataa 100 tagaaaaaga aatggcntca gtttgatctc gttcagaatg ccccagattg 150 ttctgctttg gggcagctgt ttagttcaga gttatattnc agagaattat 200 tttctgagat aatcttaaac tagaatgttc aaaactaatt gataattgaa 250 gtatcaagat acgtagaaca cctcagagat ttttcttcag gaacttccac 300 aaactttgaa tccttgtatc tttatttggt attcatacta ctagtagcaa 350 aatacaggtt ttttgttttg ttttgttttg ttttggcttc atagagtatc 400 tcaaattgaa acttttctgc acaaagaata aaattaagga ttttataaac 450 tcaaattggc acctactgaa ttaaaataca taaaatcatt taaatataat 500 tcagcatatg ggaagtaaca ttgcactaat atggaaatca ctgccagaga 550 cagtctattt tcttttaatt tgttactact tagtcacaaa 590 <210> SEQ ID NO 351 <211> LENGTH: 517 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 65, 78 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 351 tcagaaggga atgaaatccn cagcggacct ggcatcaaaa actttgggca 50 aagcaattga attgnaagca ataaaacnga ctttatcaag tcctaaatgt 100 acaagagaag aagagaaaat cacttgacaa tgaagttgaa aagacagcaa 150 atcttgtcat tagcaactgg aatcagcaaa ttaaggccaa gaagaaatta 200 atggttagta ccaagaaaca tgaagcactt ttccagcttg tagaaagctc 250 caagcaatct atgactgaga aggagaagcg gaagctcctc aataaactga 300 caaaatcaac tgaaaagttg gaaaaggaag atgaaaatta ctaccaaaaa 350 aacatggcgg gttattctac cagactgaaa tgggaaaaca cactagagaa 400 ctgctaccag agcattctgg agctggagaa ggaaagaatt caacttttat 450 gcaataactt aaaccagtac agccaacata tttctctttt tggccaaacc 500 ctgaccacat gccacac 517 <210> SEQ ID NO 352 <211> LENGTH: 559 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 31, 59, 104, 126 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 352 tttaaagaaa tgggtaaata ctgagccttt ntgcaacctt ttttggaagc 50 accagcccnc agaagattct gtgacttgtg tgcttttagg tgcaccctca 100 gacntctggc tcagtacacc tcgggntgat tgagactgtt gcctcagtct 150 ctcatttggg ttgacattat tcattttaat gaatgaatac atttgtcgca 200 gaaagtggaa ttctctcatt gttgagagaa aattctcagc ttgagtcaag 250 aagtttccat atttaccaga accttctagc tttgatgagc ataatcactg 300 ctaaaataat gtgtcttctg agcagctggg taccagtgcc tgtggcctgt 350 agcattagtt actgcctgag ggatggtgac tgttaccgca gaatggtggg 400 cttcgttgac ttgtcttctc tcctctccct cttacccact tcccggagaa 450 acaggacagc aggcacagcc agtaacaagc tgtggtacgc ctccctggcc 500 ctggtgacgc tcatcatgta ttccattgcc actggaggct tggttttgat 550 ggcagtgtt 559 <210> SEQ ID NO 353 <211> LENGTH: 609 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 48, 163 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 353 gtgggccaat gctgtccaaa ctacaggggg ttaatgtaaa gcttgtgnta 50 acatatgaaa agtatttaga aagagcttgg catgtagtaa ccactcaata 100 aaagttagct actattatga agtgttttcc aatggtttat ttagaagcaa 150 aatagtatca gtntagaagt ccaggcttgt ttttctccca aacatgtttt 200 cacaagtgct tccatggtct ccttctcctt ttcttcttcc tcttcctcta 250 aaaacatatt ttgctgtgtc tgcttggtca tctttcactg ggccagagaa 300 agaatccctg agggttggac aaggggagca gctgagttgg tgagaaaagg 350 agcccagcag gttgaatgcc tcgaaccact gtgatgagct cttgagctgg 400 gtgccaatca aagtgaagca gtggggcttg ccaggtgaga tgttaatttc 450 agcagtcaca cgtgtccctg tctggactct ccctaggact cttgacccta 500 ccctgcagtg gtttgaaatg gattttatta ggctttcatt acattctcat 550 atcatttttt tcacttggta tctaagctac acgagagcca gtgtagtgct 600 ttgtccttg 609 <210> SEQ ID NO 354 <211> LENGTH: 603 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 27, 68, 74, 137 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 354 ccggtaaccc attgggcctg gcntaanaaa gtttttttaa gccattagac 50 gtttttaaag gaattggnag atgncaattg gggaaatatt taaaatttaa 100 gtaaaatata aagcttcctt atttcatgta acccagncaa tctcagtata 150 catgatcagt tgtgtctgac aggtaaatct atttgaggcc ttatcacacg 200 ttacttttaa gaactagaaa ggaaaagtca ctgatcttaa gtatttataa 250 tacttcatgt ggtctaatac tttttacgtt ttgttttgat tcagatttag 300 tccggattcc cggtatctgg cagtaggttc tagtgagaac tcagtggatt 350 tttatgacct aacgctgggc cccactctta acagaatcag ctactgcaaa 400 gacattccaa gctttgtcat tcaaatggac ttctctgcag atagcagtta 450 tctccaggta cagtaccaat actgtatacc caggtggcaa gttcttctgc 500 ttttacattt cgtgttagtg aatgcattta aagttcctga gctccagagc 550 tccagcttct caactcctcc ctttgtacct tctgacctac agctcctctt 600 tcc 603 <210> SEQ ID NO 355 <211> LENGTH: 633 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 79, 101, 115, 122, 135, 161, 192, 204, 252 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 355 tcatggcggt atactttggc aagtggttat cttttaacgg gtttcatttt 50 cccagttgtt aaatttacag ttggttaant aaaagttttt cccagtacga 100 ncagggcgta atcanagatc cntaagtgtt tagtncaggg catgtgcttt 150 ttaaagtggg natggctatt tacagattgg cctacactgt tntggtggga 200 gccntcagtg accaaggagc agaggtactt gaaacccacc cttgaagcca 250 tntggatgct ccgttcattc aaatctgggg tgttctaacc caaagtaact 300 ggccacagac tgcaatgtaa gatacaaatc ttcaggacct agtgtgtgca 350 catgttggct cttatataag atggcatcct tagtacttgt tctatgtaga 400 aaagaatttg tgggctcaca agtccctaca gagtctcaca ctctcatggc 450 caataagtat acagggatac ccggaattag acaaacacag atgagacatt 500 tatttctgta tatgaattta ttttatttat ttatttattt tttgggacag 550 ggtctcgctc tgtcgcccat cctggagtgc ggtggcctgg ctcattgcaa 600 gctccgcctc ccgggtttac accattctgc ctc 633 <210> SEQ ID NO 356 <211> LENGTH: 569 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 41, 64, 83, 86, 115 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 356 ttaattagat aatttaaagt agcgtttttt tctacaatgt ntgaagaagt 50 gacctacgcg acantcacat ttcaggattc tgntgnagca aggaataccc 100 gagatggaaa taacntaaga aaaagagggc atccagctcc atctcccatt 150 tggcgtcatg ctgctctggg tctggtaact ctttgcctga tgttgctgat 200 tgggctggtg acgttgggga tgatgttttt gcagatatct aatgacatta 250 actcagattc agagaaattg agtcaacttc agaaaaccat ccaacagcag 300 caggataact tatcccagca actgggcaac tccaacaact tgtccatgga 350 ggaggaattt ctcaagtcac agatctccag tctactgaag aggcaggaac 400 aaatggccat caaactgtgc caagagctaa tcattcatac ttcagaccac 450 agatgtaatc catgtcctaa gatgtggcaa tggtaccaaa atagttgcta 500 ctattttaca acaaatgagg agaaaacctg ggctaacagt agaaaggact 550 gcatagacaa gaactccac 569 <210> SEQ ID NO 357 <211> LENGTH: 565 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7, 19, 117, 197 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 357 caaaaanagt gcccgtccng ttgttgtaag tgaagggacg gcagtcagtt 50 gaccctgcag tgtgcaggcg agcgcaggga gtacgccatg tcctgagaag 100 gggcgattct caggctntgg cagttacagc ttctcctcac cctgccgagc 150 aaccaggcca cggggctccg tgcatcgcca cctagagtgt taccctnttc 200 cttgttcacg gaggttctcc gcagtgtgtg agaaagaggc cctctctcag 250 atgaatggat aaagaaaatg caggacatat ggggggagga gccaagatgg 300 ccgaatagga acagctccgg tctacagctc ccagtgtgag cgacacagaa 350 gacaggcaag aagaataaat gtctctggtg gaacttttgc tctggtggaa 400 ctgcttttct agaactggtg ttgcagcatc cctggaagtg tcagagagcc 450 ctgggagtat ccaggtggcc cggggtcaga cagcagtcct gccctgcact 500 ttcactacca gcgctgccct cattaacctc aatgtcattt ggatggtcac 550 tcctctctcc aatgc 565 <210> SEQ ID NO 358 <211> LENGTH: 575 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 138, 536 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 358 ggttccctaa agattgaagc tttttaagac tcagcttttg acacatttac 50 taattatact taattgttcc ttggtgattt cacccccgtg ggtttgtttc 100 ccttgaactc cacactcatt acgttcagag cctttttnta cactacttga 150 attattttta tttaggtata taaaatactg gtggcaatag cataaattct 200 aagtgttaaa cttgatgaag taatattgta cacctatgta agcactgccc 250 agactgatat acatttacag cctaaggagg cttctttgtg ctgctttgct 300 attaatattc cattgcccag aaatagcccc tctcctaatt tccataacca 350 gagataagct tacatgtttt tccgcttcat gtaaatggaa tcgtacgctg 400 aacccttttt tgtgtctggt ttcttttgct caacattatt tcatgcaaca 450 ataaggatgg ctctctcaga cataatattc atttttattt atgtagtgtt 500 ttatgggaat tgcactgagt tagagaaact gaagtntgaa ggaatagttt 550 ccacaagact gccctcattt cagac 575 <210> SEQ ID NO 359 <211> LENGTH: 553 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 60, 83, 87, 98, 104, 106, 170 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 359 agtgccgtcc cggtgttgta agtgaaggac ggcagtcagt tgccctgcag 50 tgtgcaggcn agcgcaggag taccgccatg tcntaanaag ggcgattntc 100 aggntntggc agtacagttt ctcctcaccc tgcgagcaaa ccaggccacg 150 gggctccgtg catcgccacn tagagtgtta ccctcttcct tgttcacgga 200 ggttctccgc agtgtgtgag aaagaggccc tctctcagat gaatggataa 250 agaaaatgca ggacatatgg ggggaggagc caagatggcc gaataggaac 300 agctccggtc tacagctccc agtgtgagcg acacagaaga caggcaagaa 350 gaataaatgt ctctggtgga acttttgctc tggtggaact gcttttctag 400 aactggtgtt gcagcatccc tggaagtgtc agagagccct gggagtatcc 450 aggtggcccg gggtcagaca gcagtcctgc cctgcacttt cactaccagc 500 gctgccctca ttaacctcaa tgtcatttgg atggtcactc ctctctccaa 550 tgc 553 <210> SEQ ID NO 360 <211> LENGTH: 502 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 40, 57, 63, 68, 78, 84, 88, 138, 350 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 360 caaaatgtta agaacgtcca ctcctaatct gtgggtggtn tgcattgccg 50 ggccccntgg ttntcttntg gcattttntg cttntgcntc atattcttgt 100 taggccaggt gggcttgttg caggacaccc ccagtgcntg gattacgggc 150 cccctttcca gccccctttg caccttgagt tttgctctga ctatgagtcc 200 ttcggctgct gtgatcagca caaggaccgc cgcatcgctg cccggtactg 250 ggacatcatg gaatattttg atctgaagag acatgagctg tgtggagatt 300 acattaaaga catcctttgc caggagtgct cgccctacgc agcccacctn 350 tacgacgccg aaaacaccca gacgcctctc cggaatctcc cgggcctctg 400 ctctgattac tgctctgcct tccattctaa ctgtcactca gccatttccc 450 tgctgaccaa tgaccgcggc ctccaggagt ctcatggaag ggacggtacc 500 cg 502 <210> SEQ ID NO 361 <211> LENGTH: 459 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 361 cccacgcgtc cggcttgaag actgacaaga tgtccctgtg gactcccaaa 50 ctctactcca gatggggagg tgcccttaac accaagattt taaaagctcc 100 aatttcagag caagagtcga aaactcacag ataaagttat agttatttca 150 gggttctgaa aagacgcaga acatgaaggg actcagaagt ctggcagcaa 200 caaccttggc tcttttcctg gtgtttgttt tcctgggaaa ctccagctgc 250 gctccgcaga gactgttgga gagaaggaac tggactcctc aagctatgct 300 ctacctgaaa ggggcacagg gtcgccgctt catctccgac cagagccgga 350 gaaaggacct ctccgaccgg ccactgccgg aaagacgaag cccaaatccc 400 caactactaa ctattccgga ggcagcaacc atcttactgg cgtcccttca 450 gaaatcacc 459 <210> SEQ ID NO 362 <211> LENGTH: 442 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 53, 59, 70, 357 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 362 aatcacccgg gtcgctgttc ctnaggtggt caaggtggac aggggcggtg 50 gtnatggcnc agtttgacan tgaataccag cgcctagagg cctcctatag 100 tgattcaccc ccaggggagg aggacctgtt ggtgcacgtc gccgagggga 150 gcaagtcacc ttggcaccat attgaaaacc ttgacctctt cttctctcga 200 gtttataatc tgcaccagaa gaatggcttc acatgtatgc tcatcgggga 250 gatctttgag ctcatgcagt tcctctttgt ggttgccttc actaccttcc 300 tggtcagctg cgtggactat gacatcctat ttgccaacaa gatggtgaac 350 cacagtnttc accctactga acccgtcaag gtcactctgc cagacgcctt 400 tttgcctgct caagtctgta gtgccaggat tcaggaaaat gg 442 <210> SEQ ID NO 363 <211> LENGTH: 511 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 363 gtccgaacct gagcaaacac agcagcccga gtgttcccaa ggccaaaatg 50 ctgagaacgt ccactcctaa tctgtgtggt ggtctgcatt gccgggcccc 100 ctggctctct tctggcattc tctgcctctg cctcatattc ttgttaggcc 150 aggtgggctt gctgcaggga cacccccagt gcctggatta cgggccccct 200 ttccagcccc ctctgcacct tgagttttgc tctgactatg agtccttcgg 250 ctgctgtgat cagcacaagg accgccgcat cgctgcccgg tactgggaca 300 tcatggaata ttttgatctg aagagacatg agctgtgtgg agattacatt 350 aaagacatcc tttgccagga gtgctcgccc tacgcagccc acctctacga 400 cgccgaaaac acccagacgc ctctccggaa tctcccgggc ctctgctctg 450 attactgctc tgccttccat tctaactgtc actcagccat ttccctgctg 500 accaatgacc g 511 <210> SEQ ID NO 364 <211> LENGTH: 407 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 364 cccacgcgtc cgtgaacaca caaagagctt attttgttag gcaaatacac 50 attaataaga atgcctagaa gaggactgat tcttcacacc cggacccact 100 ggttgctgtt gggccttgct ttgctctgca gtttggtatt atttatgtac 150 ctcctggaat gtgcccccca gactgatgga aatgcatctc ttcctggtgt 200 tgttggggaa aattatggta aagagtatta tcaagccctc ctacaggaac 250 aagaagaaca ttatcagacc agggcaacca gtctgaaacg ccaaattgcc 300 caactaaaac aagaattaca agaaatgagt gagaagatgc ggtcactgca 350 agaaagaagg aatgtagggg ctaatggcat aggctatcag agcaacaaag 400 agcaagc 407 <210> SEQ ID NO 365 <211> LENGTH: 552 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 42, 85, 93, 103, 129 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 365 tggttggggc ctccaagatt agaatgttac tagggccaaa ancagtggga 50 ttggtaaaag aggcaatgat acccccatga gagcnttcac atncagaacc 100 agncagaact tcaaaggttt tgatgatanc aatgatgatt tcctgacaat 150 ggcagaatgt caattcatta tcaaacatga acttgaaaat cttagagcta 200 aagatgaaaa aatgatccct ggttaccctc aggcaaagtt gtatccagga 250 aaatcattgt tgagaagatt gctcacgtct ggcatcgtga ttcaggtgtt 300 tccactgcat gacagtgaag ccctgaagaa gcttgaggac acctggtaca 350 ctcggtttgc tttgaagtat cagcccatag agaatcacag attggaatct 400 gcctatcaga accatctaat tctgaaagtt ttagtgttca acttcctcaa 450 ttgctttgcc tcactcttct atattgcctt tgtcttgaaa gatatgaagc 500 ttttgcgcca gagcttggcc actctcctaa ttacctccca gatcctcaac 550 cg 552 <210> SEQ ID NO 366 <211> LENGTH: 244 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 74, 199 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 366 atttgattaa attatgaatg agttttacaa attcctttca gagttttact 50 aagatcacac aaataacagc tttnttattc agtgaaaaag atattttatt 100 tctgatgttt tatttgcact cgtggaatat gttaccatta atcagaaaca 150 tcatggcaac ccctaagaat agactaagtt tgtgttggct gagggattnt 200 atttggtttg cttttttttt gctttgttat attttattgc taca 244 <210> SEQ ID NO 367 <211> LENGTH: 448 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 100, 148, 251, 352 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 367 ggctacaact gctcaacatg ggaaaagaca ttccgggcag atcggctttt 50 gaaagcttaa agggagcttg atgctggcaa tgggatcaga gtgtttgacn 100 tgacatcggg atgttcattg ctagtctgac catctggctc ctctgtanaa 150 acattgttca gaaacctgtg acagacgaag cagcacagag taacccggag 200 tttgaaaatg aagaattggc tgaaggagaa aaaattgatt cagaagaggc 250 nctgatctat gaagaggatt tcaatggagg agatggtgtt gaaggcgagt 300 tggaagaaag cacgaagtta aaaatgttcc gcaggcttgc ctctgtggcc 350 tntaagctca aggagttcat tggcaacatg atcaccactg ctgggaaagt 400 cgttgttacc atcttactgg gctcctcggg catgatgttg ccgtcttg 448 <210> SEQ ID NO 368 <211> LENGTH: 636 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 40, 57, 81, 133, 156, 158 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 368 ttaagccgga aaatcccctt gaacccagaa gcggaaggtn cagtcaccca 50 aaatggngcc cattgcattc cagcctcggt ncggagcaag actttgttta 100 aaaaaaaaat ttaaattagc cattacccct agntaatttt taaatttttt 150 gtgaananag ggcctcactg tcttgcccag gctggtctcg aactccaggc 200 ttcaggtgat ccttctgcct tgcctcccaa agggcgggat tacaggtgtg 250 agccactgtg cccaactcat tactttttta aaaaattact ttccatttct 300 agtttatata tgacaggtac ttactttaag tagtaaatat tatgtttaac 350 aataaataaa aatgatcagg atttcccccg acatgctttc ctttcttctc 400 tttttcttcc tttctctctc attttatccc ttctcctgcc ctttttggaa 450 gtccttattg gaggaaaaaa taacttgccc tatttgtttc ctcactaatt 500 gttatcagtc tcgggtatca aggcaagcag attcaaattg ctgtaatata 550 tacagtgcaa ttagattaga gtctactaag aatttaattg gagaatgttc 600 aaaatacttt tctaaagtta atttttttag tattca 636 <210> SEQ ID NO 369 <211> LENGTH: 458 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 38, 57, 73, 118 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 369 tagaaggtcc gtcatggacc ccagatccat ttcntagnaa ggccgtcatg 50 acacccngga tccatttcct agnagggccg tcatgacacc ccggatcctt 100 ttcccctcag aggggctngt catgactcag acacatctcc tcccagagga 150 tccgtcatga ctcctcagac acttcacccc caaggagggc ccgtcatgat 200 tctccagatc cttctccccc aaggaggcct cagcataatt cttcaggtgc 250 atctcctagg agagtccgtc atgattcacc agatccctct cctcctaggc 300 gagcccgtca tggttcctca gatatctctt cccccagaag ggtccataac 350 aactcccctg acacatctag gaggactctt ggctcttcag acacacagca 400 actcagaagg gcccgtcatg actcccctga tttggctcct aatgtcactt 450 attccctg 458 <210> SEQ ID NO 370 <211> LENGTH: 538 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 5, 20, 47, 88 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 370 cggangcgtg gccgaacgcn tggtccaacc atatgccagg ttcaacncgg 50 ataaaagtta ggaaacgtaa ccagcttcat ttttttgnca gcagacttaa 100 agatctgaaa cttggaacta atatcaagga tttatgtgct gctctttgga 150 ttctgatgaa gaatccagtg ctcatatgcc tagctctgtc aaaagctaca 200 gaatatttag ttattattgg agcttctgaa tttttgccta tatatttaga 250 aaatcagttt atattaacac ccactgtggc aactacactt gcaggacttg 300 ttttaattcc aggaggtgca cttggccagc ttctgggagg tgtcattgtt 350 tccacattag aaatgtcttg taaagccctt atgagattta taatggttac 400 atctgtgata tcacttatac tgcttgtgtt tattattttt gtacgctgta 450 atccagtgca atttgctggg atcaatgaag attatgatgg aacagggaag 500 ttgggaaacc tcacggctcc ttgcaatgaa aaatgtag 538 <210> SEQ ID NO 371 <211> LENGTH: 692 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 51, 77, 87, 103, 119, 154, 158, 165, 183, 212, 329, 476 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 371 aataaaaaat ggcttaaaag aacatttccg aaccaaaagg aaccggttcc 50 ngccttaaca aagtgggaca ttggccntca aaggggncct catgggaaca 100 tcntgttttg cgggggcang cacaatggtc aagggcttcc ctaaccgttt 150 gcanaagnag ttaancagca tgtgtcccaa tgncccccgc aggtaaacgt 200 gctgcctgaa anagccagtc cgtgtggacc ggggctccat cctggcctca 250 ttcagggttt ccaaccattg tgggtccacc gctttgagta cgaggaacac 300 gggcctttct tcctctacag aaggtgttnt gaacggcgac aactttggcg 350 tcgtgagatt cttgtgaggc gtctgcctgg aagccggcag caatttttgc 400 ttctttaaag agaaaaagaa ggctagggac tcagattcct ggattctgag 450 atccagacca gctcctccca gacctntcca gaagaagcca tgggaacccc 500 tcgtatccag catttgctga tcctcctggt cctaggagcc tccctcctga 550 cctcgggcct agagctgtat tgtcaaaagg gtctgtccat gactgtggaa 600 gcagatccag ccaatatgtt taactggacc acagaggaag tggagacttg 650 tgacaaaggg gcactttgcc aggaaaccat actaataatt aa 692 <210> SEQ ID NO 372 <211> LENGTH: 399 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 372 gtgcgcataa agaggaggcg cttgccttca gcttgtggga aatcccgaag 50 atggccaaag caactcaact gttcgttgct tccagggcct gctgattttt 100 ggaaatgtga ttattggttg ttgcggcatt gccctgactg cggagtgcat 150 cttctttgta tctgaccaac acagcctcta cccactgctt gaagccaccg 200 acaacgatga catctatggg gctgcctgga tcggcatatt tgtgggcatc 250 tgcctcttct gcctgtctgt tctaggcatt gtaggcatca tgaagtccag 300 caggaaaatt cttctggcgt atttcattct gatgtttata gtatatgcct 350 ttgaagtggc atcttgtatc acagcagcaa cacaacgaga ctttttcac 399 <210> SEQ ID NO 373 <211> LENGTH: 567 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 53, 78, 122, 286, 419, 449 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 373 tttaaggatg ttgccatgna ccatgttttt tcaaatttgc ttttcatttg 50 ggnccgtttt ggagtctttg accgctanga tggttttcgt cgtctgggaa 100 cttgatcaga ctttgaagat tntaaatttg gaagatcagg gtgcactttt 150 gagtgatgat gaaatatttg tagccgccaa attgggaaac atacctgcat 200 ggccttgcgc aaatactttg aggctcacct ggccattaaa ttggaacaag 250 tgaagcagtc acttcagagg actgagggtg gcattnttgt ccacccacaa 300 cccccgtaca aggcatgctc atatactcat gaacagattg tggaaatgat 350 ggaatttttg atagaatatg gcccagcgca gctatattgg gaaccagctg 400 aagttttcct caaactttnt tgtgtgcaac tcttgttgca gcttatttnt 450 attgcctgca attggaagac ctattatgca aggaatgaca ctgtgcgctt 500 tgctttggat gtcctggcta ttcttactgt ggtgccaaaa atccagctcc 550 agttggcaga atcagtg 567 <210> SEQ ID NO 374 <211> LENGTH: 299 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 374 aaatttttta aaaaaactcc ttaataggcc cttttttttt ttaacctgaa 50 agttgactac ctacctttca ggaaatatat attttttggg tttagctagg 100 ttgactttct tctagaaatg gaaaagatgg caccctcggt accaaagtgc 150 tgggactctg cactatgctt gtgtgtatgt gtgtgcctct gtcttgctct 200 cttatctccc agcagtgaga cattggacgt gtttgctcat gaagatgcag 250 tatatggctt gtctgtgagc ccagtgaatg acaacatttt tgccagttc 299 <210> SEQ ID NO 375 <211> LENGTH: 556 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 53, 55, 66, 111, 156, 188, 295, 517, 552 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 375 tttttttggg aggaggaatg tncattcagg gagtagcttt ttgggaaaaa 50 ttntntaggg ctacanacag tcatgggtga ctttctttct gctgtgaaaa 100 ctcccagagt ntctttaggg attttcccta aggtgaccac caggcacacc 150 tcagtntttt tgacccagag cctgaaaact gttttcantg ggttccacca 200 gtcccagcaa aatcctcttt gtatttattt tgctaagtta ttggggtttt 250 gcttacatct catgattgat ataataccaa agttctatag ccttntcttg 300 cagtatttgg atttgcttga aaccgggaaa actgttccca ttaggcttgt 350 taatgtcaga gtgacactat tatgaatctt tctctccctt tcctcggcct 400 gtttcttctc tctttctcct tcaaacttgc tctgcagcta aggaaggtga 450 gtctactttc cctgaggctt tggggtcaga gtatatgttg tttggagaaa 500 gagggcaatc aggactnttc tgggacccag atgagttctt cactagccct 550 tntgaa 556 <210> SEQ ID NO 376 <211> LENGTH: 499 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 38, 68, 191, 193, 196 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 376 aaatgttacc ctatcctcgg anaagggttt gaatcccnct gatgtgtgtg 50 gatccatttt ggtggtgnca atgattctct cgtcctattt tattaacttc 100 atctaccttg caagagcaca aaaaaaccat gctaacttta actttggatg 150 tgcaattaca ttcctccttg ttgcagggac attttttcca nanagntcca 200 atcctggtta atccgaagcc aaagagagtg tttcttcagc atatgactag 250 aacattccat gacttggaag gaaatgcagt taaacgggac tctggaatat 300 ggatcaatgg gtttgattat actggaattt ctcacataac ccctcacatt 350 cctgagatca atgatagtat ccgagctcac tgtgaggaga atgcacctct 400 ttgtggtttt ccttggtatc ttccagtgca ctttctgatc aggaaaaact 450 ggtatcttcc tgccccagaa gtttctccaa gaaatcctcc tcatttccg 499 <210> SEQ ID NO 377 <211> LENGTH: 612 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 61, 63, 173, 419, 475 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 377 tttgactggg tgtaagaata tgctgttcca gcagaccaag gatggcattg 50 ggaaatctgc ntntggggta ggcacatctt catgggctat ttggaaagtg 100 agacttgaaa ctacagaggc catcgatgat gaaggctggt tacactctgg 150 ggatttgggc cagctggacg gtntgggttt cctctatgtc accggccaca 200 tcaaagaaat ccttatcact gctggtggtg aaaatgtgcc ccccattcct 250 gttgagacct tggttaagaa gaagatcccc atcattagta acgccatgtt 300 agtaggagat aaactgaagt ttctgagcat gttgctgacg ctgaagtgtg 350 agatgaatca gatgagcgga gaacctctgg acaagctgaa cttcgaggcc 400 atcaacttct gtcggggtnt gggcagccag gcatccaccg tgactgagat 450 tgtgaagcag caagaccccc tggtntacaa ggccatccag caaggcatca 500 atgctgtgaa ccaggaagcc atgaacaatg cacagaggat tgaaaagtgg 550 gtcatcttgg agaaggactt ttccatctat ggtggagagc taggtccaat 600 gatgaaactt aa 612 <210> SEQ ID NO 378 <211> LENGTH: 282 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 194 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 378 gtggaggaag aagacattat acaaaacaaa tttagaaact gggatcatga 50 gtggaaaaac aaaggcaaga agggctgcca tgttttttag acgttgctct 100 gaagacgcca gcggtagcgc cagtggcaat gctttgttat cagaggacga 150 aaatcctgat gcgaatgggg taactcgatc atggaagatt attntaagta 200 caatgcttac actgactttt cttcttgtag gactcctaaa tcatcagtgg 250 cttaaagaaa cagatgttcc tcagaaatcc ag 282 <210> SEQ ID NO 379 <211> LENGTH: 680 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 35, 71, 77, 173 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 379 agccaaaatc cttggccaaa tttngcattt ccaantccgg aggccaagaa 50 aggaagaaag ttccccaggt ngaaaancaa acttggattt tcagcaatat 100 ggatttatta atcaaatgtg gttaccattt gggcccttcc gggggatttt 150 aagtactttt ccatacctag ctnttataca tactattatt ctcatggcag 200 tagcaacttt tggttcaaat atcccaaaac atgctcaaaa gtagaacatt 250 ttgtttcaat attaggaaag tgctttgaat ccccttggac gacaaaagcg 300 ttgtctgaga cagcatgcga agactcagag gaaaacaagc agagaataac 350 aggtgcccag actctaccaa agcatgtttc taccagcagt gatgaaggga 400 gccccagtgc cagtacacca atgatcaata aaactggctt taaattttca 450 gctgagaagc ctgtgattga agttcccagc atgacaatcc tggataaaaa 500 ggatggagag caggccaaag ccctgtttga gaaagtgagg aagttccgtg 550 cccatgtgga agatagtgac ttgatctata aactctatgt ggtccaaaca 600 gttatcaaaa cagccaagtt catttttatt ctctgctata cagcgaactt 650 tgtcaacgca atcagctttg aacacgtctg 680 <210> SEQ ID NO 380 <211> LENGTH: 660 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 55, 96, 146, 162 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 380 cggatccttt aaaatccctg acctngaccc aagggtccgg taaaatcaat 50 ttgtnttacc caaagaccaa tttttgacat atcttgaata ggatgnctat 100 aaattatgac ttttaaattg ttgtaatttt tgtactatta tctganattt 150 ttatttttat gnattttcgt aagtagttta gagatagtca cattttaaaa 200 atctaagatc aagcaaatga agcttatttt tatgtattca tagtataaaa 250 gccttcagta aataggtaat atttttgttt tattctagaa aacagctcct 300 tgaacacagt gagctggctt ttcacacatt gcagttgtta gtgtttactg 350 cccttgccat tttaattatg aggctaaaga tgtttttgac accgcacatg 400 tgtgttatgg cttccttgat atgctctcga cagctctttg gctggctttt 450 tcgcagagtt cgttttgaga aggttatctt tggcatttta acagtgatgt 500 caatacaagg ttatgcaaac ctccgtaatc aatggagcat aataggagaa 550 tttaataatt tgcctcagga agaactttta cagtggatca aatacagtac 600 cacatcagat gctgtctttg caggtgccat gcctacaatg gcaagcatca 650 agctgtctac 660 <210> SEQ ID NO 381 <211> LENGTH: 652 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 35, 118, 136, 183, 281, 349 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 381 gaataagttg ggatttttna gcaaggattc caatntgatt cttaaaaaag 50 gagttagcca taaagccagt ggttttaatt agattcagat ttgattttta 100 aattttacgg gtttcagntt cagggaatgc tacccncaaa atgagatttc 150 attactatat accagtgaaa tttctactct canattttct gtaatgtcat 200 ttttcatagt taggttttag aaagtatcta atcaggttgt gatggtcaaa 250 taaagggttc aaacacattt ctattttctg nttcaataaa tattttttat 300 attgcttatt cttatctatc tttacctaat ttcttcctat ctttttcgnt 350 aactttcttt ttttttattt tcttctaatg aagattctgc tttcttcatc 400 taaacctgtc ccaaaaacct atgtaccaaa acttggcaag ggtgatgtaa 450 aggataagtt tgaagccatg cagagagcca gggaagaaag aaatcaaagg 500 agatctagag acgaaaaaca aagaagaaaa gaacaatata ttagagagag 550 agaatggaac aggagaaagc aggaggttat tttattttac tttattctcg 600 tgaaaatatt tgtttgcatt ttttcattta aattgtattt attcacatta 650 ac 652 <210> SEQ ID NO 382 <211> LENGTH: 397 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 345 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 382 gtccatggag ctggtggtca aggtggacag gggcggtggt gatggcgcag 50 tttgacactg aataccagcg cctagaggcc tcctatagtg attcaccccc 100 aggggaggag gacctgttgg tgcacgtcgc cgaggggagc aagtcacctt 150 ggcaccatat tgaaaacctt gacctcttct tctctcgagt ttataatctg 200 caccagaaga atggcttcac atgtatgctc atcggggaga tctttgagct 250 catgcagttc ctctttgtgg ttgccttcac taccttcctg gtcagctgcg 300 tggactatga catcctattt gccaacaaga tggtgaacca cagtnttcac 350 cctactgaac ccgtcaaggt cactctgcca gacgcctttt tgcctgc 397 <210> SEQ ID NO 383 <211> LENGTH: 573 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 38, 85, 121, 432 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 383 ggatgggaag gatcgattaa aggattggct tttggaanac ttactggtgg 50 gaataaggtt ggccttgtgc aaagtcccca aggcntgaca ttagtttgct 100 ggcaaggcaa ttgattcctc ntttcaacat cgcttatgca gctttctgtt 150 cttcggtaat ctatgaattt ttggatcgtg tcatcaaatg tccattggtt 200 ccttcttcct ggtgagtgct ctgctgatca acgttctgaa agtgagccca 250 ttcaacaacg gtcaactggt catgggatct ttcgtcaaga atgagttttc 300 ggccccctcc taccttatgg gctataataa atccttgagt gtggtggcaa 350 ccacaacttt tctgactggg attattcagc taataatggg cgtattgggt 400 ttgggcttca ttgccactta ccttccggag tntgcaatga gtgcttacct 450 ggctgctgtg gcacttcata tcatgctgtc ccagctgact ttcatctttg 500 ggattatgat tagtttccat gccggtccca tctccttctt ctatgacata 550 attaattact gtgtagctct ccc 573 <210> SEQ ID NO 384 <211> LENGTH: 561 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 40, 73, 120, 487 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 384 tgtttatgtc acctaccttc ncctttttaa gttttgtccn agcaaacctt 50 gcagaatttt agatgaacat ggnaaaaatg ttacaatctg tgggcctgac 100 tttggtcaag acctgtacan agatgaaaac ttggtgacta tactggggac 150 cagcttctta atcggatgta tcttgtattc atgtttgaca tcaacaacaa 200 gatcgagttc tgacgctctg caggggcgat acgcagctcc tgaattggag 250 atagctcgct gttgtttttg cttcagtcct ggtggagagg acactgaaga 300 gcagcagccg gggaaggagg gaccacgggt catttatgac gagaagaaag 350 gcaccgtcta catctactcc tacttccact tcgtgttctt cctagcttcc 400 ctgtatgtga tgatgaccgt caccaactgg ttcaactacg aaagtgccaa 450 catcgagagc ttcttcagcg ggagctggtc catcttntgg gtcaagatgg 500 cctcctgctg gatatgcgtg ctgttgtacc tgtgtacgct ggtcgctccc 550 ctctgctgcc c 561 <210> SEQ ID NO 385 <211> LENGTH: 562 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 77 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 385 aacagggggg ccgcttgntc cagaaatgtt tcccctgggg aaagtggcat 50 cacttaatga cattcagcca acttacngaa tcctgaaacc atggtggaat 100 gtgtttatgg attacctagc tgttgttatg ttaatggtag ccatctttgc 150 aggaaccatg caactttacc aaagatcagg tggtctgttt gccagtattg 200 ccatctcctg taaattcaaa ggcacataca ccaccaggaa atgccgaggt 250 caccaccaac atcccaaaga tggaagcagc caccaaccaa gaccaagatg 300 ggcggacaac aaacgacatt tcctttggga catctgctgt gacacctgac 350 atacctctca gagccacata tcctcgcaca gatttcgcac ttccaaatca 400 ggaggcaaag aaagagaaga aagatccaac aggtcgaaaa acaaacttgg 450 attttcagca atatgtattt attaatcaaa tgtgttacca tctggccctt 500 ccgtggtatt ctaagtactt tccataccta gctcttatac atactattat 550 tctcatggtc ag 562 <210> SEQ ID NO 386 <211> LENGTH: 265 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 386 atcaagttgg tgaagaaaga acctatgaaa tctgtacaaa agattggggc 50 tttgttcttc ctgttaagtg gtgtactggt gatgaccgga agcatggcct 100 tgattgtttt ggattgggta cacaatgcac ctggaggtgg ccattaattg 150 gcaccactca aactcaaact cagtccatct gatgccagtg ttgagtaaac 200 tcaactacta tgaaatttca cctaatgttt tcagtttcac ttccttttga 250 agtgcagatt cctcg 265 <210> SEQ ID NO 387 <211> LENGTH: 457 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 33, 50, 75, 92, 124, 173, 177, 218, 223, 235, 247, 285, 290, 325, 437 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 387 tggatttaat ggggggaaag ggcggaaaan ggncaaggat ccaaactggn 50 gaatttggtg attttcgggt ccctntccgc tttccggccg gncagcgctg 100 ccaagggtat atttcctttt ttcngatcct gcaacaagcc tctttaaact 150 gtttaaatga gaatgtcctt ggntcanaga gtactactca cctggctttt 200 cacactactc ttcttganca tgntggtgtt gaaanggatg agaaagncct 250 tggactggtt cctcatattc attccagttg gaaanttgan actatccttc 300 ttgtcctgct gattgtgaaa atggntgggc ggtgtaagtc tggctttgac 350 cctcgacatg gatcacacaa tattaaaaaa aaagcctggt acctcattgc 400 aatgttactt aaattagcct tttgcctcgc actctgnggt aaactggaac 450 agtttac 457 <210> SEQ ID NO 388 <211> LENGTH: 617 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 55, 80, 88, 107, 161, 181, 198, 203, 219, 233, 259, 272 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 388 gttaggtgat ccaggttttg gggtttttgc aacccttggg gtcattgggc 50 ccttnaaatt aatcttcggg gggggtcctn gccatggnca gccaaacatt 100 tttgggnaca taccatttgg ttctgtaatc ggggcgtttt cagtttcctg 150 tgtaaagggc ntgggcattg ctatcaagga nctgtttgca gggaagcntg 200 tgntgcggca tcccctggnt tggattctgc tgntgagcct catcgtctgt 250 gtgagcacnc agattaatta cntaaatagg gccctggata tattcaacac 300 ttccattgtg actccaatat attatgattc tttacaacat cagttttaac 350 ttgttcagct attcttttta aggagtggca agatatgcct gttgacgatg 400 tcattggtac tttgagtggc ttctttacaa tcattgtggg gatattcttg 450 ttgcatgcct ttaaagacgt cagctttagt ctagcaagtc tgcctgtgtc 500 ttttcgaaaa gacgagaaag caatgaatgg caatctctct aatatgtatg 550 aagttcttaa taataatgaa gaaagcttaa cctgtggaat cgaacaacac 600 actggtgaaa atgtctc 617 <210> SEQ ID NO 389 <211> LENGTH: 365 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 44, 50, 96, 107, 180, 185, 211, 289 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 389 aaaaaaaaaa aaaaagaatn tgactatata ccatggaaaa gccnccactn 50 tgccacttaa ataaacatca ggatcagaga ttccaagagg acaatntgca 100 tcaagtnttc accaagtgtt ttttaagcga aataatgaaa tagggagcag 150 aatatgcctg ttgcccatag aaacgaggtn tattnttgtc ctcaattagg 200 cttttttttt nttcatagtt acaccagaac taaagtaaaa gtggtttttc 250 tgttctttct acttctcccc atgaaatggg catatcatnt caacacttca 300 ctccaagtcg ccacgggcaa ccttatgacc ctaggtcctc cacccctaat 350 gtatcatcat tgcca 365 <210> SEQ ID NO 390 <211> LENGTH: 442 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 209, 233 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 390 agggcgccca tttcgagccc aagtttccag ttcgggtttc cgggctcaga 50 attttccagg agtgggttct tgggcagtgg ctgtggagca ggaatggcgc 100 agtagagggt tactgtttct cggccgcctt gagctgtacc tttttagtgt 150 cctgcctcct tttctccgcc ttcagccggg cgctgcgaga gccctacatg 200 gacgagatnt tccacctgcc tcaggcgcag cgntactgtg agggccattt 250 ctccctttcc cagtgggatc ccatgattac tacattacct ggcttgtacc 300 tggtgtcagt tggagtggtc aaacctgcca tttggatctt tggatggtct 350 gaacatgttg tctgctccat tgggatgctc agatttgtta atcttctctt 400 cagtgttggc aacttctatt tactatattt gcttttccac aa 442 <210> SEQ ID NO 391 <211> LENGTH: 587 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 74, 103, 117 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 391 ccagtttttc atggacatag aaaattccaa aagaataata atattgaatt 50 taaatttggg ggggttaaaa aaanaaaact taactttata aaattattta 100 ttntatttta agccttntat catattttcc ccatccaatt gtttggtttc 150 agtggtccag cttttattta caggcatata aaagaaattg tgagatgttt 200 tgcaagcttt tttttacttt gagagctttt aatttgtatg tttttatgtg 250 gatgaagagc attttttatg tttttgtgca ataggttcca atatgcattt 300 attagacatc tgtttaaatg gtaatgtagc atttattttg ctaaattgaa 350 agggaacata gatggaattc caaaatatgt acattcagct gtttggtttt 400 tcgtttttca ttgttattat tgtgagaatg ctgttattgg ggttgtgtgt 450 gagtgcccgt cagccagtga tgcctcgggc cacgctgtgg ggccacctca 500 gtcctgctgg gtcctggtgc cttggacccc acgtgcttgt ggccaggctg 550 cccctgggcg gggccatgtg gcctcagacc acaagag 587 <210> SEQ ID NO 392 <211> LENGTH: 444 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 392 cgtctccagt ctacctccga gagattagct gaaacacaga atatagcgcc 50 atcattcgtg aaggggtttc ttttgcggga cagaggatca gatgttgaga 100 gtttggacaa actcatgaaa accaaaaata tacctgaagc tcaccaagat 150 gcatttaaaa ctggttttgc ggaaggtttt ctgaaagctc aagcactcac 200 acaaaaaacc aatgattccc taaggcgaac ccgtctgatt ctcttcgttc 250 tgctgctatt cggcatttat ggacttctaa aaaacccatt tttatctgtc 300 cgcttccgga caacaacagg gcttgattct gcagtagatc ctgtccagat 350 gaaaaatgtc acctttgaac atgttaaagg ggtggaggaa gctaaacaag 400 aattacagga agttgttgaa ttcttgaaaa atcccgaacc cctt 444 <210> SEQ ID NO 393 <211> LENGTH: 284 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 95, 109, 186, 244 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 393 ggtcaagttc agtagtggtc tcaataagtg tgttaaactt gctttgggtg 50 attgcaatca gcatgggatt tggccatttc tatggcccaa ttcanattca 100 gaagcgtcna cagttagtca gaaagataca tgaagatgaa ttgaatgata 150 tgaaggatta tctttcccag tgtcaacagg aacaanaatc ttttatagat 200 tataagtcat tgaaagaaaa tcttgcaagg tgttggacac ctantgaagc 250 agagaagatg tcctttgaaa ctcaggaacc cctt 284 <210> SEQ ID NO 394 <211> LENGTH: 481 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 47, 94, 130, 192 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 394 gcagtgggtg atcataggca ctaaccctca aactcctgaa gttcaanaga 50 ttgtcccatg tcagcctccc aagtagctgg gactatagac aggngccatc 100 atgcccagct aattattttt ttaattttan agaagagtct tgctaggttc 150 cccaggctgg tctcgaactc ctgacctcaa ataatcctcc cnccctcaac 200 ctctgaagta gctgcaatga caggtgcaag cccactgtgt ttggctagag 250 tctcatgttt ttctaattcc aaaaaagttc cataatgatt ttgattcaga 300 ttgtattgag tttacacatt aatttaagaa gtgacatctt cataatacta 350 actttcccca aaaagaaaca gggtatgttt ttccatttat atgagtgggg 400 ttttttttgt tttgttttta cgttttgtag ttttcttcat ataggttttg 450 ccagaggttc ccaaactttc ttggttcatg g 481 <210> SEQ ID NO 395 <211> LENGTH: 508 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 69, 473 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 395 agcatgggaa aggtaggaac cnagggaaag gggccccccg agcgcaaggt 50 gtcggtgccc accttcagnt ggaggagatt caaaagcata acctgcgcac 100 cgacaggtgg ctggtcattg accgcaaggt ttacaacatc accaaatggt 150 ccatccagca cccggggggc cagcgggtca tcgggcacta cgctggagaa 200 gatgcaacgg atgccttccg cgccttccac cctgacctgg aattcgtggg 250 caagttcttg aaacccctgc tgattggtga actggccccg gaggagccca 300 gccaggacca cggcaagaac tcaaagatca ctgaggactt ccgggccctg 350 aggaagacgg ctgaggacat gaacctgttc aagaccaacc acgtgttctt 400 cctcctcctc ctggcccaca tcatcgccct ggagagcatt gcatggttca 450 ctgtctttta ctttggcaat ggntggattc ctaccctcat cacggccttt 500 gtccttgc 508 <210> SEQ ID NO 396 <211> LENGTH: 519 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 38, 50, 74, 160 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 396 aatggtacaa cagtccctta atggttgccn caatggcntg aaatccaagn 50 attacagact tttgtgataa ggtnaagctt ggggcatcgt cctagaaacg 100 gtggccacaa gtggggttgt gacctcggtg gccttcatgc tcactctccc 150 gatcctcgtn tgcaaggtgc aggactccaa caggcgaaaa atgctgccta 200 ctcagtttct cttcctcctg ggtgtgttgg gcatctttgg cctcaccttc 250 gccttcatca tcggactgga cgggagcaca gggcccacac gcttcttcct 300 ctttgggatc ctcttttcca tctgcttctc ctgcctgctg gctcatgctg 350 tcagtctgac caagctcgtc cgggggagga agcccctttc cctgttggtg 400 attctgggtc tggccgtggg cttcagccta gtccaggatg ttatcgctat 450 tgaatatatt gtcctgacca tgaataggac caacgtcaat gtcttttctg 500 agctttccgc tcctcgtcg 519 <210> SEQ ID NO 397 <211> LENGTH: 526 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 96 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 397 gacctcgacc ccagggtccg gttntacttt gtcctgcctg ctgctggggt 50 ccctgggtct atgtgcatcc tcttcactat ctactggatg cagtantggt 100 gtggggcttt gcctggaatg gcagcattta catgttcaac tggcacccag 150 tgcttatggt tgctggcatg gtggtattct atggaggtgc gtcactggtg 200 taccgcctgc cccagtcgtg ggtggggccc aaactgccct ggaaactcct 250 ccatgcagcg ctgcacctga tggccttcgt cctcactgtt gtggggctgg 300 ttgctgtctt tacgtttcac aaccatggaa ggactgccaa cctctactcc 350 cttcacagct ggctgggcat caccactgtc ttcctcttcg cctgccagtg 400 gttcctgggc tttgctgtct tcctcctgcc ctgggcgtcc atgtggctgc 450 gcagcctcct aaaacctatc cacgtctttt ttggagccgc catcctctct 500 ctgtccatcg catccgtcat ttcggg 526 <210> SEQ ID NO 398 <211> LENGTH: 773 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 398 agaggagctg ccggtgcctc ctcagaacat ctcctgatcg ctacccagga 50 ccaggcacca aggacaggga gtcccaggcg cacacccccc attctgggtc 100 ccccaggccc agacccccac tctgccacag gttgcatctt gacctggtcc 150 tcctgcagaa gtggcccctg tggtcctgct ctgagactcg tccctgggcg 200 cccctgcagc ccctttctat gactccatct ggatttggct ggctgtgggg 250 acgcggtccg aggggcggcc tggctctcag cgtggtggca gccagctctc 300 tggccaccat ggcaaatgct gagatctgag gggacaaggc tctacagcct 350 cagccagggg cactcagctg ttgcagggtg tgatggagaa caaactatgt 400 acctacacac cgtcagcgac tgtgacacca gctccatctg tgaggattcc 450 tttgatggca ggagcctgtc caagctgaac ctgtgtgagg atggtccatg 500 tcacaaacgg cgggcaagca tctgctgtac ccagctgggg tccctgtcgg 550 ccctgaagca tgctgtcctg gggctctacc tgctggtctt cctgattctt 600 gtgggcatct tcatcttagc agtgtccagg ccgcgcagct cccctgacga 650 cctgaaggcc ctgactcgca atgtgaaccg gctgaatgag agcttccggg 700 acttgcagct gcggctgctg caggctccgc tgcaagcgga cctgacggag 750 caggtgtgga aggtgcagga cgc 773 <210> SEQ ID NO 399 <211> LENGTH: 546 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 74, 80, 159 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 399 atcctggact tgacccaggn gtccgttgat tggaaccggt ggtcggcaaa 50 acaagtccgc tgggcagcag gagnagcagn aggattatta aataacgcag 100 ttggactctg gcaactggga gtgaagagga gcccaacagc cgagaaggga 150 aggaggcana ggagggggac cagaaggaca cccccgtgcc ccgaagacat 200 aaatccctga gtgcccggga ggagccttaa caagcgcacg gagccctcaa 250 ggtgcaaagt tggctttcac agtgcaagcc tttgattccc aatgggggac 300 tcaggatcaa gacgatctac cctggtctcc cggttgccaa tattcagaag 350 aagtattaac agaagacatg attctcttcc ttcttcacct tcttccagta 400 atacagttgg tgtccacagt tcctctcctt ccagcactaa ctcaagctca 450 ggtagcacag gtaaacggag gagcatattc cgtactcctt ccattagctt 500 ccaccataag aaggggagtg agcctaagca agagcctacc aaccag 546 <210> SEQ ID NO 400 <211> LENGTH: 562 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 26 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 400 ggcttccctc gcgccccacc gncctnttcc ggaaggcggc tccctccctg 50 cgcagcccgg agcccctgag atcagcctcg agcaggcgcc cgagcgagac 100 tatccctaaa cgggaacggc ggtggccgac tcgcgagtga ggaaaagaag 150 gaaagggcag actggtcgcg aagagaagat ccaggcctca gaggaggaga 200 aaggccggag ccagccgagc tgtcacgacc ggagggggga ctcgcagcct 250 taccaggggg gtgatgtttt acaggcactt aagtattcat cgaagagtca 300 ccccagtagc ggtgatcaca gacatgaaaa gatgcgagac gccggagatc 350 cttcaccacc aaataaaatg ttgcggagat ctgatagtcc tgaaaacaaa 400 tacagtgaca gcacaggtca cagtaaggcc aaaaatgtgc atactcacag 450 agttagagag agggatggtg ggaccagtta ctctccacaa gaaaattcac 500 acaaccacag tgctcttcat agttcaaatt cacattcttc taatccaagc 550 aataacccaa gc 562 <210> SEQ ID NO 401 <211> LENGTH: 536 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 99, 114 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 401 taacaaccac agaaactgga ntagtggtcc tacagtagct gcagctgata 50 ccactgaaac taatttccct gaaactgcta gcaccacagc aaatacacnt 100 tctttcccaa cagntacttc acctgctccc cccataatta gacacatagt 150 tcctccacaa ttcctacacc tgctcccccc ataattagta cacatagttc 200 ctccacaatt cctataccta ctgctgcaga cagtgagtca accacaaatg 250 taaattcatt agctacctct gacataatca ccgcttcatc tccaaatgat 300 ggattaatca caatggttcc ttctgaaaca caaagtaaca atgaaatgtc 350 ccccaccaca gaagacaatc aatcatcagg gcctcccact ggcaccgctt 400 tattggagac cagcacccta aacagcacag gtcccagcaa tccttgccaa 450 gatgatccct gtgcagataa ttcgttatgt gttaagctgc ataatacaag 500 tttttgcctg tgtttagaag ggtattacta caactc 536 <210> SEQ ID NO 402 <211> LENGTH: 470 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 402 ccacagtatg gaagaatatc cctgacttct agccctgtgc gccttctttt 50 gtttctgctg ttgctactaa tagccttgga gatcatggtt ggtggtcact 100 ctctttgctt caacttcact ataaaatcat tgtccagacc tggacagccc 150 tggtgtgaag cgcaggtctt cttgaataaa aatcttttcc ttcagtacaa 200 cagtgacaac aacatggtca aacctctggg cctcctgggg aagaaggtaa 250 atgccaccag cacttgggga gaattgaccc aaacgctggg agaagtgggg 300 cgagacctca ggatgctcct ttgtgacatc aaaccccaga taaagaccag 350 tgatccttcc actctgcaag tcgagatgtt ttgtcaacgt gaagcagaac 400 ggtgcactgg tgcatcctgg cagttcgcca ccaatggaga gaaatccctc 450 ctctttgacg caatgaacat 470 <210> SEQ ID NO 403 <211> LENGTH: 509 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 29, 39, 124 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 403 gtcgggtggt acggccgctc cctgcaggng agttcgtgna cgacgacgtg 50 tgggcgatcg tgaacaaacc ccgacgtgcg ggcccggcgc cccgctccgt 100 tggggcatct tcaccaacga cttntggggc aagggcatgg ccgagaacac 150 cagccacaag tcctaccgcc gctttgcgtc ctcaccttca agctaaacat 200 atttttgact ggtatgaacc cattctactt tcatgcagta aatataattt 250 tacactgctt agtgactctt gtgctgatgt acacctgtga taaaactgtc 300 ttcaagaatc gtggacttgc ttttgtaacg gcattgcttt ttgctgtaca 350 tcctattcat actgaggcgg tggctgggat cgttggcaga gcggacgtgt 400 tagcgtgtct gctgtttcta ttggcctttc tctcgtacaa caggagtctg 450 gatcagggct gtgttggggg aagtttccct tccacggtgt ctcccttctt 500 cttgctgct 509 <210> SEQ ID NO 404 <211> LENGTH: 400 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 404 cttgtttggt cggtggaata tgttgggatt tatgtttgcc tctgaacaag 50 tgtcttgctc acatcgtaaa tgactttctc tccgaaacgc taaatattct 100 ttcccgcagg agctcatatc cttattttcc atgacagatc ttaacggaca 150 atatatgcaa aagatatata aagatgataa ctaatatagt tatactgagc 200 ctgatcattt gcatttcgtt agctttctgg attatatcaa tgactgcaag 250 cacctattat ggtaacttac gacctatttc tccgtggcgt tggctgtttt 300 ctgttgttgt tcctgttctg atcgtctcta atggccttaa aaagaaaagt 350 ctagatcaca gtggggctct aggagggcta gtcgttggat ttatcctaac 400 <210> SEQ ID NO 405 <211> LENGTH: 370 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 36, 118, 138, 163, 179 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 405 aatgccccca agttaaatac ctcctcnacc tttacntaag ttgctccttt 50 atttttattt tattattatt attattatta ttattttttg agatggagtc 100 tcactttgta acccaggntg gaatgcaatg gcatgatntc agctcactgc 150 aacctccgcc tcntgggttc aagcaagtnt cctgcctcag cctccgagta 200 gctgggacta caggtgcacg ccaccacgcc tggctaattt tttgtatttt 250 agtagagacg gggtttcacc gtgttgccca ggctggtcgc gaactcctga 300 gctcaggcaa tccgcccacc tcagcctccc aaagtgttgg gattacaggc 350 atgagccacc atgcccagct 370 <210> SEQ ID NO 406 <211> LENGTH: 473 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 72 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 406 gggcttgaaa atctaaatac tttgaaatta gaataatatc ttgtgtttta 50 gagctttaaa ttttcaaata tntgctgtcc acacacccca ttggaggagg 100 acctgtgtca ctaacccaaa tttgtagctg agaaaacaga ggcagagaga 150 ggttaagtaa aaaaccccaa gagagttcac ctaatattgt gaagaaagca 200 aacccagggt ttcactaact tgtccatgtg tgtatgtgtg tggctgcgtt 250 cacccctgtg tgtgtgtgta ctgtgtgcat gcctgtgtgt ttgtgcacac 300 ccatgtgtat gtacctgcat acacacccaa gtgtgtgtgt taccacaacg 350 aaagcgcaga tttattgaaa agaaagtgca ctccacagag tgggagcagg 400 ctagagccag tggctcagga gcctggttac agcattttct ggagtttaag 450 tgccctccag agttttccca ttg 473 <210> SEQ ID NO 407 <211> LENGTH: 539 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 35, 51, 98 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 407 cagccaggcc agagagggag ccgagccagg ccatntccaa ccatgtccga 50 ngaggcctcg gccatcactt cctacgagaa gtttcttaac ccccgagnag 100 cccttcccac tcctgggacc ttcctcgcgg gggggcacct gcccgagcaa 150 ggagccgggc tgcctggaca tcaagcgact tcgggtgcca gctgtcctcc 200 tgccatcgca ccgacccgct ccaccgcttc cacaccaaca ggtggaacct 250 aacttcttgt ggaacaagtg ttgccagctc agaaggcagt gaggagctgt 300 tttcatctgt gtctgttgga gatcaagatg attgctattc cctgttagat 350 gatcaggact tcacttcttt tgatttattt cctgagggga gtgtctgcag 400 tgatgtctct tcttctatta gcacttactg ggattggtca gatagcgagt 450 ttgaatggca gttaccaggc agtgacattg ccagtgggag tgatgtactt 500 tctgatgtca tacccagtat tccaagttca ccttgcctg 539 <210> SEQ ID NO 408 <211> LENGTH: 545 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 55, 93, 146 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 408 tcaaaaaggt tgcattcntt ttgcataaac agggacttta tatagttaac 50 tcccnttata taaattctcc tatagtaatc tcaaagagta ttntagactt 100 ctcaatgctt tttattgttg ctgaaaagca aaaagacttg ctgtgnaagt 150 ggagaagact tcaacatcaa agtgattttt tctactctcc taggaatgaa 200 aggaacacaa agggacccgg aagcatttct tgtccagatt gtgtcaaaat 250 ctcaattgcc atctgagaat agagaaggta aagtgctgtg gactggctgg 300 ttctgctgtg tatttggaga cagtcttctg gagactgttt cagaagattt 350 cacctgtctg cccttattcc ttgcaaatgg agcagagtct aacacagcaa 400 taattggaac ttggtttcag aaaacctttg actgttattt cagtccttta 450 gcaatcaatg catttaatct ttcctggatg gctgccatgt ggactgcatg 500 caaaatggac cattatgtgg ctactactga atttctttgg tctgt 545 <210> SEQ ID NO 409 <211> LENGTH: 585 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 45, 77, 118, 121, 203 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 409 gacatttatt tttcatccat tgcaacccat tgccataaga acatncccat 50 ggccttgaag cgcttcacag cagcatngtg gaatgcagaa ttggagccaa 100 gcaattttca aagcaagntt nctgaaaatg aaaaaaaata cttatattga 150 aaaacttttt gagcgttatg gtgaaaatgg aagattatcc ttttttggtt 200 tgnagaaact tttaacaaac ttgggccttg gagagagaaa agtagttgag 250 attaatcatg aggatcttgg ccacgatcat gtttctcatt tagatatttt 300 ggcagttcaa gagggaaagc attttcactc acataaccac cagcattccc 350 ataatcattt aaattcagaa aatcaaactg tgaccagtgt atccacaaaa 400 agaaaccata aatgtgatcc agagaaagag acagttgaag tgtctgtaaa 450 atctgatgat aaacatatgc atgaccataa tcaccgccta cgtcatcacc 500 atcgtttgca tcatcatctt gatcataaca acactcacca ttttcataat 550 gattccatta ctcccagtga gcgtggagcg gccgc 585 <210> SEQ ID NO 410 <211> LENGTH: 446 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 45, 56, 67, 221, 289, 446 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 410 tacctattcc caggtttaat gttgattatt tatatttgaa aaaanttgat 50 ttgtanaaac tgggtanatt actttcaaat taatcattta ttcctaattg 100 accagggatg agtgagatgt ttatttagaa aacaaataat tttagatagg 150 aaaattgaat ctttaaaaaa taatggtgat ttaatatatc aatgtgtggt 200 ttttgtgtgt atgtgtgtaa nattggagca tccaggagtg tgcggtgtgt 250 atatgacctt atttttctac tgtatcttag aggttgccnc ttccatgggt 300 ataaaactta attggatttc tcgattttta ttttgtttat gcacttttac 350 aacttatgtc attttaggtt gtttattaat gccagttttg tataataaaa 400 ttattagaga agttatgaag gaggatggca tgagtggggc ggccgn 446 <210> SEQ ID NO 411 <211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 67, 95 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 411 acgcagagcg ttttcatttt ccacgggtct gtccttgtca aagcacaccc 50 ctcggtgtcc aggttcntca tgggcaagtg ctcggggtga caaanaaggc 100 gacattgact acagcaccgt gctcctcggc atgctggtga cgcaggacgt 150 gcagctcggg cttttcatgg ctgtcatgcc gactctcata caggcgggca 200 ccagtgcatc ttctagcatt gtcgtggaag ttctccgaat cctggttttg 250 attggtcaga ttcttttttc actagcggcg gtttttcttt tatgtcttgt 300 tataaagaag tatctcattg gaccctatta tcggaagctg cacatggaaa 350 gcaaggggaa caaagaaatc ctgatcttgg gaatatctgc ctttatcttc 400 ttaatgttaa cggtcacgga gctgctggac gtctccatgg agctgggctg 450 tttcctggct ggagcgctcg tctcctctca gggccccgtg gtcaccgagg 500 agatcgccac ctccatcgaa ccccc 525 <210> SEQ ID NO 412 <211> LENGTH: 457 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 37, 114, 213 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 412 cagttttttt atagtgaata ccaaaancat cagcaancac tggactgtca 50 acccaaggct tattgatatt tgcggagttg atttctgcga ttaagagacg 100 ttggctcgcc ttcntcgtga tcattgtgag cctgggctat ggcattgtga 150 agcctcgttt aggaacagtc atgcaccggg tgatcggact ggggcttcta 200 tacttaatct ttncagctgt tgaaggcgtg atgagagtca ttgggggttc 250 taaccattta gctgttgttc ttgatgacat tattttagca gttattgact 300 ccatttttgt gtggttcatt tttattagtt tggcacaaac tatgaagacc 350 ctaaggctaa gaaagaacac tgtgaaattt tcattatata gacattttaa 400 aaatactctg atctttgctg tgctggcttc tatagtgttt atggggtggg 450 cggccgc 457 <210> SEQ ID NO 413 <211> LENGTH: 541 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 51, 54, 80 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 413 acgtggtctg cctgttattg gaaagatata ttaagatcca gttctggatt 50 ncanctgttt atttttttgg gaaatgcttn aaaaagcagt ttttttatag 100 tgaataccaa aacatcagca acactggact gtcaacccaa ggcttattga 150 tatttgcgga gttgatttct gcgattaaga ggacgttggc tcgccttctc 200 gtgatcattg tgagcctggg ctatggcatt gtgaagcctc gtttaggaac 250 agtcatgcac cgggtgatcg gactggggct tctatactta atctttgcag 300 ctgttgaagg cgtgatgaga gtcattgggg gttctaacca tttagctgtt 350 gttcttgatg acattatttt agcagttatt gactccattt ttgtgtggtt 400 catttttatt agtttggcac aaactatgaa gaccctaagg ctaagaaaga 450 acactgtgaa attttcatta tatagacatt ttaaaaatac tctgatcttt 500 gctgtgctgg cttctatagt gtttatgggg tgggcggccg c 541 <210> SEQ ID NO 414 <211> LENGTH: 523 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 172 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 414 accggcccgt gagccggccn tgcgccggca ggtcgcggga catactgtgg 50 cgcgttttgg gctggaggat agttgcaagt attgtttggt cagtgctatt 100 tctacccatc tgcaccacag tatttataat tttcagcagg attgatttgt 150 ttcatcctat acagtggctg tntgattctt tcagtgacct gtatagttcc 200 tatgtaatct tttacttcct gctgctgtca gtggtaataa taataataag 250 tattttcaat gtggagttct atgcagttgt gccttctatt ccttgctcca 300 gactagctct gatagggaag atcattcatc ctcagcaact catgcactca 350 tttattcatg ctgcaatggg aatggtgatg gcctggtgtg ctgcagtgat 400 aacccagggc cagtacagct ttcttgtggt tccctgcact ggtactaaca 450 gctttggtag ccctgctgcg caaacctgct taaatgaata tcatcttttt 500 ttcctactga ctggagcggc cgc 523 <210> SEQ ID NO 415 <211> LENGTH: 544 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 2, 30, 40, 117 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 415 gnccacactg gccaaacggg gcatcatggn cacactgccn aaatagggcc 50 gccatgttgc agcaggatag taatgatgac cctgaagatg tttcactgtt 100 tgatgcggaa gaggagncga ctaatagacc aaaaaagcca aaatcagaca 150 tccagtagca tcgtttttcc actttattct ttcgagtcag tgcaatcatc 200 gtctatcttc tctgtgagtt gctcagcagc agctttatta cctgtatggt 250 gacaattatc ttgttgttgt cgtgtgactt ttgggcagtg aagaatgtca 300 caggtagact aatggttggc ctacgttggt ggaatcacat tgatgaagat 350 ggaaagagcc attgggtgtt tgaatctaga aaggagtcct ctcaagagaa 400 taaaactgtg tcagaggctg aatcaagaat cttttggttg ggacttattg 450 cctgtccagt actgtgggtg atatttgctt ttagtgcact cttctccttc 500 agagtaaagt ggttggcggt ggttatcatg ggtgtggcgg ccgc 544 <210> SEQ ID NO 416 <211> LENGTH: 473 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 35, 46, 62, 69, 142, 185, 252 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 416 cagcagtcct tatgattatg gaggaaagtg gaggnccctt atagcnaaac 50 aggtatgctg gntatgacnt attcgcagca aaggcagatt tgtcccctcc 100 agacatgatg cagccacaac agccatacac cgggcagatt tnccagccaa 150 ctcaggcata tactccagct tcacctcagc ctttntatgg aaacaacttt 200 gaggatgagc cacctttatt agaagagtta ggtatccaat tttgaccaca 250 tntggcaaaa aacactaaca gtattacatc cgttaaaagt agcagatggc 300 agcatcatga atgaaactga tttggcaggt ccaatggttt tttgccttgc 350 ttttggagcc acattgctac tggctggcaa aatccagttt ggctatgtat 400 acgggatcag tgcaattgga tgtctaggaa tgttttgttt attaaactta 450 atgagtatga caggtgcggc cgc 473 <210> SEQ ID NO 417 <211> LENGTH: 417 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 31, 53, 80, 96, 110, 130, 227 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 417 taattgttta ttgggaaatg gaggattaag nacatttttc aatttgtgca 50 tgnagaggaa gacctgaagg ttcagcatan tagctacaag acagangggc 100 ccggctgttn aaggaccagc tctccctggn aaatgtgcac tttcagatca 150 caagatgtga aattgcagga tgcaggggtg taccgctgca tgatcaagct 200 atggtggtgc cgactacaag cgaattnctg tgaaagtcaa tgccccatac 250 aacaaaatca accaaagaat tttggttgtg gatccagtca cctctgaaca 300 tgaactgaca tgtcaggctg agggttaccc caaggccgaa gtcatctgga 350 caagcagtga ccatcaagtc ctgagtggta agaccaccac caccaattcc 400 aagggagagg cggccgc 417 <210> SEQ ID NO 418 <211> LENGTH: 585 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 64, 67, 70, 78, 109, 152 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 418 aggtgcttgt gctcgaaccc agtggttggg gcggtgctcc tcaagcttgt 50 gtgcctgcta accntcntgn gtccgggntg gcaagagtgt gggactttcc 100 ccctggcgnc cgtggacaac atgatggtca gaaaagggga cacggcgggt 150 gnttaggtgt tatttgaaag atggagcttc aaagggtgcc tggctgaacc 200 ggtcaagtat tatttttgcg ggaggtgata agtggtcagt ggatcctcga 250 gtttcaattt caacattgaa taaaagggac tacagcctcc agatacagaa 300 tgtagatgtg acagatgatg gcccatacac gtgttctgtt cagactcaac 350 atacacccag aacaatgcag gtgcatctaa ctgtgcaagt tcctcctaag 400 atatatgaca tctcaaatga tatgaccgtc aatgaaggaa ccaacgtcac 450 tcttacttgt ttggccactg ggaaaccaga gccttccatt tcttggcgac 500 acatctcccc atcagcaaaa ccatttgaaa atggacaata tttggacatt 550 tatggaatta caagggacca ggctggggcg gccgc 585 <210> SEQ ID NO 419 <211> LENGTH: 575 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 419 taaactacac tcagtataca gtgatagtgg gatttgaaca cctgaagctc 50 cccatcaaag ggaatgaact tcacatgaag acttataacc ctgccttctc 100 ccgggttgga aatctggttc cggtttttct ttgtggtgct caccttcatc 150 gtcacttgcc tgtttgcgca ttccctccgg aaattttcca tgagagactg 200 gggcatcgag cagaagtgga tgtctgttct cctgcctctg ctgctacttt 250 acaatgatcc gttcttcccc ctctccttcc tggtcaacag ctggctccca 300 gggatgctgg atgacctctt tcagtccatg ttcctgtgcg ccctgctgct 350 cttctggctg tgcgtgtacc acgggattcg tgtccaggga gaaagaaagt 400 gtttaacttt ctatttgcct aaattcttca ttgttggact attgtggttg 450 gcttctgtta cgctaggaat atggcaaaca gttaacgaat tacatgatcc 500 aatgtaccag tatcgagttg ataccggaaa ttttcaggga atgaaggtct 550 tcttcatggt gggggcagcg gccgc 575 <210> SEQ ID NO 420 <211> LENGTH: 572 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 90 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 420 gtgtctgctc gccctccgac gctgctcagg aatttgcaag aaactgaagt 50 tttgattcag atatattttg aattgaaacc agagatgttn tagagtttag 100 attctttcat ttgattaagg tatggtctga atatgcgttg cttggcagct 150 cgggtcaact ataagacttt gattattatc tgcgcactct tcactttggt 200 cacagtactt ttgtggaata agtgttccag tgacaaagca atccagtttc 250 cacggcgttc gagtagtggc ttcagagtgg atgggtttga aaaaagagca 300 gcagcatctg agagtaacaa ctatatgaac cacgtggcca aacaacagtc 350 tgaggaagca ttccctcagg aacagcagaa agcaccccct gttgttgggg 400 gcttcaatag caatgtggga agtaaggtgt tagggctcaa atatgaagaa 450 attgactgtc tcataaatga tgaacacaca attaaaggga gacgagaggg 500 gaacgaagtc tttcttccat tcacttgggt tgagaaatat tttgatgttt 550 atggaaaggt ggtggcggcc gc 572 <210> SEQ ID NO 421 <211> LENGTH: 581 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 421 aggctcccgt gtctgctcgc cctccgacgc tgctcaggaa tttgacaaga 50 aactgaagtt ttgattcaga tatattttga attgaaacca gagatgttct 100 agagtttaga ttctttcatt tgattaaggt atggtctgaa tatgcgttgc 150 ttggcagctc gggtcaacta taaggctttg attattatct gcgcactctt 200 cactttggtc acagtacttt tgtggaataa gtgttccagt gacaaagcaa 250 tccagtttcc acggcgttcg agtagtggct tcagagtgga tgggtttgaa 300 aaaagagcag cagcatctga gagtaacaac tatatgaacc acgtggccaa 350 acaacagtct gaggaagcat tccctcagga acagcagaaa gcaccccctg 400 ttgttggggg cttcaatagc aatgtgggaa gtaaggtgtt agggctcaaa 450 tatgaagaaa ttgactgtct cataaatgat gaacacacaa ttaaagggag 500 acgagagggg aacgaagtct ttcttccatt cacttgggtt gagaaatatt 550 ttgatgttta tggaaaggtg ggggcggccg c 581 <210> SEQ ID NO 422 <211> LENGTH: 264 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 36, 139, 173, 224, 246 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 422 ttcttttttt tcccccngca attttttcag tgaaanacat ggagtctttc 50 atcttggaga gttgtcagag tcaagatttt gctgttgtag ccagtgcttt 100 aaaacaattc acaaagactt tctaggagag gaagagagnc tgagggaaga 150 agagatacag aaaaagaaaa tgncaggatt gaacctggaa actcacagaa 200 tctctgactc atgctggaaa tgtntttggg tacctcttgc cttttntgtg 250 ttggcggcgg ccgc 264 <210> SEQ ID NO 423 <211> LENGTH: 601 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 31, 36, 78, 88, 207 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 423 tgaaaggacc cctagttccc ctggcaaatg nttttnttca atcccccact 50 tcattttcct taagagccat tccaagtntc ttcctttntc gataccccaa 100 ccagctcaca tcccactcaa ggggtgagat gccctcctca ccattgaaga 150 gatcaagccc ccagggggga accagctcaa cttccccctc tgtctctccg 200 aagagcntcc tgtttgaaaa ctcgaggcag ctgtaccccg tgcgaagttc 250 ttgctcccgt ctccccatgt cttccaggat tttccttcat agtggggatt 300 actcgctaac ctttccttcc tcacctactt ccccttttcc ttcagctttc 350 accgtgttta aatcttctaa taattctttt tatgacatct tgtttttcaa 400 gctcttctcc agtgatccct ccacttctcc aatggccctt ttcactaaac 450 ctccaaattt gtctttgctg acatttattg agctgctatt acatgttcta 500 aatgctttac ttgtcgtatt taatcctaac aacaacctac aaggtaggcc 550 ttgctattat ctccatttta tagttgaaga aactgaggct gccgcggccg 600 c 601 <210> SEQ ID NO 424 <211> LENGTH: 573 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 68, 71, 78, 104, 106, 194, 237, 309, 319, 416, 462 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 424 tatcggcaca ttggcaaaga caacattcag gcccaatggc ccacaaattg 50 gtccgcccaa tgccattntg naaaaggntt cactgcaaat tacaaaagca 100 tccntnatga aaagagattg gaaaggcctc tccaagcaac tggactggga 150 tgttcgaagc attcagcgct ggttcgcaaa gacgcaatca gganaagccc 200 aagcacggct gacgaggttc tgtgagagca tgtgganatt ttcattttac 250 ctttatgtat ttacctacgg agtcagattc ctgaaaaaga ccccctggtt 300 gtggaatang aggcattgnt ggtacaacta cccctatcag ccactcacaa 350 ctgaccttca ctactattac atcctggagc tgtcgtttta ttggtctttg 400 atgttttctc agttcnctga tatcaaaaga aaggactttg gcattatgtt 450 cctgcactac cntgtatcta ttttcttgat taccttttca tatgtcaaca 500 atatggcccg agtaggaacg ctggtccttt gtcttcatga ttcagctgat 550 gctcttctgg aggctgcggc cgc 573 <210> SEQ ID NO 425 <211> LENGTH: 632 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 110 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 425 attttttgaa attaatgcnt gagctttatt ttgtttaatt gttatgccca 50 ctggattggg acaagcatca cctctgaatt ttgaagacct taatgtgtgt 100 tagccattgn aaagctactc aagtgctgtg caagagtcat acccacatcc 150 ctttgatcaa atttactaca cgagctgcac tgacattcta aactggttta 200 aatgcacgcg gcacagagtc agctatcgga cagcctatcg acatggggag 250 aagactatga caggcgcaag tctcagtgtt gtcctggatt ttatgaaagc 300 ggggaaatgt gtgtccccca ctgtgctgat aaatgtgtcc atggtcgctg 350 tattgctcca aacacctgtc agtgtgagcc tggctgggga gggaccaact 400 gctccagtgc ctgcgatggt gatcactggg gtccccactg caccagccgg 450 tgccagtgca aaaatggggc tctgtgcaac cccatcaccg gggcttgcca 500 ctgtgctgcg ggcttccggg gctggcgctg cgaggaccgc tgtgagcagg 550 gcacctatgg taacgactgt catcagagat gccaatgcca gaatggagcc 600 acctgcgacc acatcacggg gctggcggcc gc 632 <210> SEQ ID NO 426 <211> LENGTH: 251 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 426 ttttcaatga aaaaaagaat cccaaaaaaa aaagttgtca gcctcatttg 50 tgcgtcatcc cttattttcc tgggatctca ggacctctgt ccctctcatt 100 tctcacttct gagatctgca catcttttac ccaggagcct cagagctcct 150 gagtctggtg tctgcctatc cccatcttca ctgttagtcc tcctgcagat 200 tctgtgtctc ctttcatgta ggtgctggat ccctgtgtgt ggagcggccg 250 c 251 <210> SEQ ID NO 427 <211> LENGTH: 607 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 56, 99, 150 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 427 acaaagtttc ccaatgactt gttaaaagtc gatggtgtag ctcaagatgg 50 aacccncaat gtacattaat aacaaaagtt cacaacgggc aaaggaccnt 100 cacatgtgca aggaaaatgt gcggagatta ttgggctcac cttgggtacn 150 tgaactacac tcagtataca gtgatagtgg gatttgaaca cctgaagctc 200 cccatcaagg gaatgaactt cacatggaag acttataacc ctgccttctc 250 ccggttggaa atctggttcc ggtttttctt tgtggtgctc accttcatcg 300 tcacttgcct gtttgcgcat tccctccgga aattttccat gagagactgg 350 ggcatcgagc agaagtggat gtctgttctc ctgcctctgc tgctacttta 400 caatgatccg ttcttccccc tctccttcct ggtcaacagc tggctcccag 450 ggatgctgga tgacctcttt cagtccatgt tcctgtgcgc cctgctgctc 500 ttctggctgt gcgtgtacca cgggattcgt gtccagggag aaagaaagtg 550 tttaactttc tatttgccta aattcttcat tgttggacta ttgtggttgg 600 cggccgc 607 <210> SEQ ID NO 428 <211> LENGTH: 583 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 119 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 428 gcatccgctt gactgcatnt gagttttccc agtctgtctt tggggatggg 50 gccatgccat agtcttgatg tcttgtgccg tgtgattttt gcagataaga 100 tgacttggcc catggcccnc agatcactta ttctggggaa gtgtaggaac 150 agtggttgcc taacccaagt tcttacatga tgtacctttt tcctttctaa 200 aaaataactt aaaaatatga aatatactaa tttgtttcag atattacata 250 caattggaaa gtggacaagt tcctgtatat gctgtcactt ttcaagaacc 300 tgagaatgat cctcggaatt gctgttactt gtgggctgtt cagtctacac 350 aagataggta ggtctcatac aaactttgtt ttgttttgtt ttgttttttt 400 ggagacagag tctcgctctg ttgtccaggc tggagtgcag tggcgtgatt 450 tcggctcact gcaacctccg cctcccggat tcatgccatt ctctcgctca 500 gcctcccgag tagctgggac tacaggtgcc tgccaccatg cctggctaat 550 ttttatattt tcagtagaga cgggagcggc cgc 583 <210> SEQ ID NO 429 <211> LENGTH: 462 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 51-52, 54 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 429 ttaatttaaa aatatgaaaa gtaaaaatgg gattttgtct tatttgtgtt 50 nnanagctgg cttttcacac atgcagttgt tagtgtttac tgcccttgcc 100 attttaatta tgaggctaaa gatgtttttg acaccgcaca tgtgtgttat 150 ggcttccttg atatgctctc gacagctctt tggctggctt tttcgcagag 200 ttcgttttga gaaggttatc tttggcattt taacagtgat gtcaatacaa 250 ggttatgcaa acctccgtaa tcaatggagc ataataggag aatttaataa 300 tttgcctcag gaagaacttt tacagtggat caaatacagt accacatcag 350 atgctgtctt tgcaggtgcc atgcctacaa tggcaagcat caagctgtct 400 acacttcatc ccattgtgaa tcatccacat tacgaagatg cagacttgag 450 ggctgcggcc gc 462 <210> SEQ ID NO 430 <211> LENGTH: 546 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 6, 36, 64 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 430 ggcccncact ggccaaaata gttggaatgc cttttnttat tcaccaatgg 50 ggcccaaggg gaanagtggg tgtttggggg gcctttttgc accatcatca 100 catccctgga tacttgtaac caatttgcct gtagtgccat catgactgta 150 atgagtgtgg acaggtactt tgccctcgtc caaccatttc gactgacacg 200 tggagaacaa ggacaagacc atccggatca atttgggcct ttgggcagct 250 tcctttatcc tggcattgcc tgtctgggtc tactcgaagg tcatcaaatt 300 taaagacggt gttgagagtt gtgcttttga tttgacatcc cctgacgatg 350 tactctggta tacactttat ttgacgataa caactttttt tttccctcta 400 cccttgattt tggtgtgcta tattttaatt ttatgctata cttgggagat 450 gtatcaacag aataaggatg ccagatgctg caatcccagt gtaccaaaac 500 agagagtgat gaagttgaca aagatggtgc tggtgctggc ggccgc 546 <210> SEQ ID NO 431 <211> LENGTH: 526 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 56, 64 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 431 aggtgtcacc atggcaaagc ttcccttctt gattctctcg agtttgttga 50 agcgtntacg gttncactga cggattcaga agctcatttt acctcagctt 100 tcattgaaac tacctcctat cttgagtctt cactcatttc ccatgaatcc 150 gcagtcactg cactggtgcc ccccggtctg agtcttttga cattttgact 200 gccgggattc aagcaacatc accattgacc actgtccaca caacgcccat 250 tttaactgag tcttctttgt tctcaactct gacacctcct gacgaccaaa 300 tcagtgctct agacggtcac gtgtctgtcc tggcctcttt ctccaaagcc 350 attcccactg agctgaccgt cgtgggccca tcactcacac ccacagaggt 400 gccactgaac acctccacgg aagtgagcac aaccagcacc ggtgctgcca 450 ctggtggtcc cctcgactcc accctgatgg gtgacgccgc aagtcagagc 500 cccccagaga gtagtgctgc tcctcc 526 <210> SEQ ID NO 432 <211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 93, 107 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 432 acactcagaa caggagnaat ttggactaat tttcaaacta cagacacttt 50 ctaatcatga tgcatttcaa aagtggactc ggaatttaac tgngttgcaa 100 aacatgncag tgcccgagga tgataacatt agcaatgact ccaatgattt 150 caccgaagta gaaaatggtc agataaatag caagtttatt tctgatcgtg 200 aaagtagaag aagtctcaca aacagccatt tggaaaaaaa gaagtgtgat 250 gagtatattc caggtacaac ctccttaggc atgtctgttt ttaacctaag 300 caacgccatt atgggcagtg ggattttggg actcgccttt gccctggcaa 350 acactggaat cctacttttt ctggtacttt tgacttcagt gacattgctg 400 tctatatatt caataaacct cctattgatc tgttcaaaag aaacaggctg 450 catggtgtat gaaaagctgg gggaacaagt ctttggcacc acagggaagt 500 tcgtaatctt tggagccacc tctct 525 <210> SEQ ID NO 433 <211> LENGTH: 558 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 111, 130, 146 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 433 ccaacccaat taccaagcag atncttttgg gggattccag ccatcagaca 50 aggaacccat ggcagctgca gggttttttg cattgtgcaa gcttatgctt 100 tcttgcagat ntgagagccg attaacaaan caagagttcc agaccntttt 150 ctttttgggt gtatcactag ctgcaggtgc tgtgttcctt agtgtcatct 200 atttgactta tacaggttac attgcaccat ggagtggcag gttttattca 250 ttgtgggata ctgggtatgc aaaaatacac attccaatta ttgcatcagt 300 gtctgagcat caacctacga cttgggtgtc tttcttcttt gatctacata 350 ttcttgtatg taccttccca gcaggccttt ggttctgcat caaaaatatc 400 aacgatgaaa gagtatttgt tgctctatat gcaatcagtg ctgtctactt 450 tgctggagtg atggtgcgac tgatgttgac tttgactcca gtcgtgtgta 500 tgctgtctgc aattgccttt tcaaatgttt ttgagcacta tttgggggct 550 gcggccgc 558 <210> SEQ ID NO 434 <211> LENGTH: 490 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 74 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 434 attgcagctg ttattttttt ggaaatgctt gaaaaagcag ttttttatag 50 tgaataccaa aacatcagca acantggact gtcaacccaa ggcttattga 100 tatttgcgga gttgatttct gcgattaaga ggacgttggc tcgccttctc 150 gtgatcattg tgagcctggg ctatggcatt gtgaagcctc gtttaggaac 200 agtcatgccc gggtgatcgg actggggctt ctatacttaa tctttgcagc 250 tgttgaaggc gtgatgagag tcattggggg ttctaaccat ttagctgttg 300 ttcttgatga cattatttta gcagttattg actccatttt tgtgtggttc 350 atttttatta gtttggcaca aactatgaag accctaaggc taagaaagaa 400 cactgtgaaa ttttcattat atagacattt taaaaatact ctgatctttg 450 ctgtgctggc ttctatagtg tttatggggc gagcggccgc 490 <210> SEQ ID NO 435 <211> LENGTH: 536 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 435 ggccacactg gccaaactaa aatttttggt attgcagatg acgctcatat 50 tggcaactta ctaacatcaa aattctttag ttataaggat tttgatactt 100 tattgtatac ctgtgcagcg gagtttgact ttatggaaaa agagactcca 150 ctgagataca caaagacatt attgcttcca gttgttcttg tagtgtttgt 200 tgctattgtt agaaagatta ttagtgatat gtggggtgtc ttagctaaac 250 aacagacaca tgtaagaaaa caccagtttg atcatggaga gctggtttac 300 catgcattgc aattgttagc atatacagcc cttggtattt taattatgag 350 actaaaactc ttcttgacac cacacatgtg tgttatggca tcactgatct 400 gctcaagaca gctatttgga tggctctttt gcaaagtaca tcctggtgct 450 attgtgtttg ctatattagc agcaatgtca atacaaggtt cagcaaatct 500 gcaaacccag tggaatattg taggggaggc ggccgc 536 <210> SEQ ID NO 436 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 40, 57, 66 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 436 agggttttaa taggactanc agtacgatgg gcagtgtctn ttaattttta 50 ttcaggngct ggtaanccgc ctatgtttgg tgattatgaa gctcagagac 100 ctggcaagaa ataacttttt aatttaccgg tcaaacaatg gtattttacc 150 agcagtgata acaatttaca gtattgggga ttggattacc cacctcttac 200 agcttatcat agtctcctat gtgcatatgt ggcaaagttt ataaatccag 250 actggattgc tctccataca tcacggtgga tatgagagtc aggcacataa 300 gctcttcatg cgtacaacag ttttaattgc tgatctgctg atttacatac 350 ctgcagtggt tttgtactgt tgttgcttaa aagaaatctc aactaagaaa 400 aagattgcta atgcattatg catcttactg tatccaggcc ttattcttat 450 agactatgga cattttcaat ataattctgt gagtcttggc tttgctttgt 500 ggggtgcggc cgc 513 <210> SEQ ID NO 437 <211> LENGTH: 570 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 32, 48, 72 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 437 cactggccaa aaaattcgat gcgaggccca gnaagcacgc tgaaaccntg 50 gcggcggcaa gctgtgcgac tnttttgcgg ccggcctggg caggtgtctt 100 cctcgagagg caggcagggg atcccggaca ctagctttat cgtcatctgg 150 gaaattgtta aaaatgcaaa ttcgcaagtt tgagagccat ggttccaaga 200 aactgcataa gcatacgaaa taagttgcag cctcccgact tataccctgg 250 tacttctagt ctaaaacagg atttgactct actaatccag ccttatacag 300 gatgctgtgt tctttgctcc tttgtgaatg tctgttgctg gtagctggtt 350 atgctcatga tgatgactgg attgacccca cagacatgct taactatgat 400 gctgcttcag gaacaatgag aaaatctcag gcaaaatatg gtatttcagg 450 ggaaaaggat gtcagtcctg acttgtcatg tgctgatgaa atatcagaat 500 gttatcacaa acttgattct ttaacttata agattgatga gtgtgaaaag 550 aaaaagaggg gtgcggccgc 570 <210> SEQ ID NO 438 <211> LENGTH: 557 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 33, 51 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 438 agaaaaagaa gaatcaacgt aaataagata aanggattca aaataaagat 50 ntcttgaaga gaaataagaa tcatttacaa aagcagcaga gaaaaatttt 100 acagatgaag gagccagcta tttaagatgg gcatcaaggt tctccagcag 150 tctaaaagcc aaaaacaaaa agaagaagcc tacctacttt ttgccaaagc 200 agctgacatg ggaaacttga aagctatgga gaaaatggct gacgctttgc 250 tatttggaaa ttttggcgtg caaaatataa cagcagctat ccaattatat 300 gagtccttgg ctaaagaagg atcatgtaaa gcccaaaacg cattaggatt 350 tttgtcttct tatggaatag gaatggaata tgatcaagct aaggcactga 400 tatattacac ctttggaagt gctggaggaa acatgatgtc ccagatgatt 450 ttggggtaca gatatttgtc gggaatcaat gttctacaga attgtgaagt 500 tgccctaagt tattacaaga aagtggcaga ttatattgct gacacatttg 550 aaaaaag 557 <210> SEQ ID NO 439 <211> LENGTH: 330 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 116-117, 135, 196, 261 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 439 ttttgttgcc ttgggtgttc tcacactctg caagttttac ttgcagggtt 50 atcgagtttt catgaatgat cctgccatga atcggggcat gacagaagga 100 gtaacgctgt taatcnntgg cagtgcagac tgggntgata gaacatgcag 150 gttgttcatc gggcattctt gctcagtatt atccttttca ttgtcngtag 200 cttctatcct acagtctatg ttagaaattg cagatcctat tgttttggca 250 ctgggagcat ntagagacaa gagcttgtgg aaacacttcc gtgctgtaag 300 cctttgttta tttttattgg tattccctgc 330 <210> SEQ ID NO 440 <211> LENGTH: 549 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 46, 64, 82, 85, 88, 169 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 440 accaccttgc ccatttattt tggcccttgt taaaccaata actgcntatc 50 cagatatgcc acanttttgc ctgctgtggc anccntcntg gataggtgct 100 cttgttaatc acatggatgt tatataagag ttgggccggc ccagcacaca 150 aggtcagcat gtgctcttnt gtcacgctct cgctatagct gttgtccaga 200 tcgttatctt ctcagaaagc tgggcatttg ccaagaacat caacttctat 250 aatgtgaggc ctcctctcga ccctacacca tttccaaata gcttcaagtg 300 ctttacttgt gaaaacgcag gggataatta taactgcaat cgatgggcag 350 aagacaaatg gtgtccacaa aatacacagt actgtttgac agttcatcac 400 ttcaccagcc acggaagaag cacatccatc accaaaaagt gtgcctccag 450 aagtgaatgt cattttgtcg gttgccacca cagccgagat tctgaacata 500 cggagtgtag gtcttgctgt gaaggaatga tctgcaatgt agaattacc 549 <210> SEQ ID NO 441 <211> LENGTH: 303 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 441 atttattttg ctaaattgaa agggaacata gatggaattc caaaatatgt 50 acattcagct gtttggtttt tcgtttttca ttgttattat tgtgagaatg 100 ctgttattgg ggttgtgtgt gagtgcccgt cagccagtga tgcctcgggc 150 cacgctgtgg ggccacctca gtcctgcctg ggtcctggtg ccttggaccc 200 cacgtgcttg tggccaggct gcccctgggc ggggccatgt ggcctcagac 250 cacaagagcg gagctgccct ggcccaagca ctgcagctgc ctgcaccccc 300 ggg 303 <210> SEQ ID NO 442 <211> LENGTH: 559 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 38, 63, 90, 138 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 442 cgaccgccct tcgcggggca gnaaggccag gggtgctnag ttctttcacc 50 tccttttaga ctnaagattt gccaagtttt ccggcattgn tcttgaggat 100 ctcagaaggg ctctttaagc aagactgcaa atgggtgngt atttgtcatg 150 aaccgaatga attccccaga acagtggttt cactcagcgc aggggaatgg 200 ctctttggga ttgttattct tctgcttgtt gatgtgatat gggttgcttc 250 ctctgaactt acttcgtatg tttttaccca gtacaacaaa ccattcttca 300 gcacctttgc aaaaacatct atgtttgttt tgtacctttt gggctttatt 350 atttggaagc catggagaca acagtgtaca agaggacttc gcggaaagca 400 tgctgctttt tttgcagatg ctgaaggtta ctttgctgct tgcacaacag 450 atacaactat gaatagttct ttgagtgaac ctctgtatgt gcctgtgaaa 500 ttccatgatc ttccaagtga aaaacctgag agcacaaaca ttgatactga 550 aaaaacccc 559 <210> SEQ ID NO 443 <211> LENGTH: 559 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 50 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 443 gacctcgacc caagggtccg cggangggtg ggactggtca tggatctttn 50 gtcaagaatg agtttcggcc ccctcctacc ttatgggcta taataaatcc 100 ttgagtgtgg ggcaaccaca acttttctga ctgggattat tcagctaata 150 atgggcgtat tgggtttggg ttcattgcca cttaccttcc ggagtctgca 200 atgagtgctt acctggctgc tgtggcactt catatcatgc tgtcccagct 250 gactttcatc tttgggatta tgattagttt ccatgccggt cccatctcct 300 tcttctatga cataattaat tactgtgtag ctctcccaaa agcgaattcc 350 accagcattc tagtatttct aactgttgtt gttgctctgc gaatcaacaa 400 atgtatcaga atttctttca atcagtatcc cattgagttt cccatggaat 450 tatttctgat tattggcttc actgtgattg caaacaagat aagcatggcc 500 acagaaacca gccagacgct tattgacatg attccttata gctttctgct 550 tcctgtaac 559 <210> SEQ ID NO 444 <211> LENGTH: 547 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 444 acagttgtgg ggaatcactg ttcctggtta gaaatttctg cattttatat 50 tattttcttg gctatattcc caaagcttgg attagcactg ctatgaacct 100 tcacatagat gagcaggttc ataggccact tgacacagtg agtggcctct 150 taaatctctc gttactctac catgtctggc tgtgtggtgt ctttctcctg 200 acgacttggt atgtctcatg gatactcttc aaaatctatg ccacagaggc 250 tcatgtgttt cctgttcaac caccatttgc agaagggtca gatgagtgcc 300 ttccaaaagt gttaaatagc aatcctcccc ccatcataaa gtatttagcc 350 ttgcaggacc tgatgttgct ttctcaatat tctccttcac gaagacaaga 400 agttttcagc ctcagccaac caggtggaca tccccacaat tggacagcca 450 tttcaaggga gtgtttgaat cttttaaatg gtatgactca gaaactgatt 500 ctctatcaag aagctgctgc tacgaatggg gggcatcatg cggccgc 547 <210> SEQ ID NO 445 <211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 40, 69, 176 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 445 ttcatggtaa aaaatgaact accctctgcc ataaagtttn taatgggaaa 50 ggaagagaca ttttcagcnt ggacgtggat ggccgcgttc tggtggtgat 100 agttaccttt ggcataattc tccctctgtg tctcttgaag aacttaggga 150 tcttggctat actagtggat tttccntgag ctgtatggtt tttttcctaa 200 ttgtggttat ttacaagaaa tttcaaattc cctgcattgt tccagagcta 250 aattcaacaa taagtgctaa ttcaacaaat gctgacacgt gtacgccaaa 300 atatgttacc ttcaattcaa agaccgtgta tgctttaccc accattgcat 350 ttgcatttgt ttgccacccg tcagtcctgc caatttacag tgagcttaaa 400 gaccgatcac agaaaaaaat gcagatggtt tcaaacatct cctttttcgc 450 catgtttgtt atgtacttct tgactgccat ttttggctac ttgacattct 500 atgacaacgt gcagtccgcg gccgc 525 <210> SEQ ID NO 446 <211> LENGTH: 510 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 2, 287 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 446 gnccacactg gccaaaaggt tgccgctagc cgcctgggaa tttaagggac 50 ccacactacc ttcccgaagt tgaaggcaag cggtgattgt ttgtagacgg 100 cgctttgtca tgggacctgt gcggttggga atattgcttt tccttttttt 150 ggccgtgcac gaggcttggg ctgggatgtt gaaggaggag gacgatgaca 200 cagaacgctt gcccagcaaa tgcgaagtgt gtaagctgct gagcacagag 250 ctacaggcgg aactgagtcg caccggtcga tctcganagg tgctggagct 300 ggggcaggtg ctggatacag gcaagaggaa gagacacgtg ccttacagcg 350 tttcagagac aaggctggaa gaggccttag agaatttatg tgagcggatc 400 ctggactata gtgttcacgc tgagcgcaag ggctcactga gatatgccaa 450 gggtcagagt cagaccatgg caacactgaa aggcctagtg cagaagggcc 500 ctgcggccgc 510 <210> SEQ ID NO 447 <211> LENGTH: 551 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 32, 95, 98, 107, 207, 374 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 447 aagttttttt ttaattatca tgggacgggt tntggattta atggggggaa 50 aagggcggaa aaggacaagg atccaaactg gggaatttgt tgatnttngg 100 gtccctntcc gctttccggc cggcagcggc tgccagggta tatttccttt 150 tttccgatcc tgcaacagcc tctttaaact gtttaaatga gaatgtcctt 200 ggctcanaga gtactactca cctggctttt cacactactc ttcttgatca 250 tgttggtgtt gaaactggat gagaaagcac cttggaactg gttcctcata 300 tttattccag tctggatatt tgatactatc cttcttgtcc tgctgattgt 350 gaaaatggct gggcggtgta agtntggctt tgaccctcga catggatcac 400 acaatattaa aaaaaaagcc tggtacctca ttgcaatgtt acttaaatta 450 gccttctgcc tcgcactctg tgctaaactg gaacagttta ctaccatgaa 500 tctatcctat gtcttcattc ctttatgggc cttgctggct ggggcggccg 550 c 551 <210> SEQ ID NO 448 <211> LENGTH: 346 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 448 taattaaaat gcacacacac acacacacac acagaaattt tgagagccat 50 tttaatataa ttgcctccct agaaacatac cttttaggga atttttatca 100 ctaaaccaca tgttatttaa atacgtacat gtttaacata aatacataca 150 taaaattcac atgcatactt aacacttatg ttaaatatat tcaatgtata 200 tacatatgta cacaatatat gcatatatac atgtgggtat gtggtatgtg 250 tgcatgtgtg tgtatggcca gctacataat ttgtgggact aagggcaaaa 300 tgaaactgta cggccctcgt tcaaaaatta ggtgtggggc ggccgc 346 <210> SEQ ID NO 449 <211> LENGTH: 550 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 449 ccagtttgtc aaactactac tcttcaatgc ttctacatag cattctttaa 50 gggcaaattt gtaggctatc caggagaccc cagtttattg gttgggaaaa 100 tacagaaatg aagagtgtga cccaggtggc tgtcttcttg aactgacaac 150 tcagcttgac aataatcatg ggaggaaaag caatctggaa taacatacaa 200 gaagtattat tgccctggat catgaatcta attgggcgat ttcacagagt 250 ttctggatca gaaaagataa ccccacgatg ggaacaggac taccatctgc 300 agcctatggg caaactggga ttattttatg aatatcttga aatgattatt 350 cagtttgggt tcgtcacctt atttgtggcc tcttttccac tggcccctct 400 gttggctctc gtgaacaata tattggaaat aagagtggac gcatggaaac 450 tgaccaccca gtttagacgc ctggtaccag agaaagccca agacattgga 500 gcatggcagc ccatcatgca aggaatagca attctggctg tggcggccgc 550 <210> SEQ ID NO 450 <211> LENGTH: 499 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 57, 65, 68, 100, 146, 160, 177, 194, 237 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 450 ctgttaatga ttgcatttgg ccttgctggg ggggcatttt cttgcggatc 50 aaacccncgc aaagngtntt catttccacg tgtctgtctt gtcaagcacn 100 cccttggtgt ccaggttcct tcatggccag tgctcggggt acaaanaagg 150 cgacattgan tacaagcccc gtgctcntcg gcatgctggt aacncaggac 200 gtgcagctcg ggctcttcat ggccgtcatg ccgactntca tacaggcggg 250 cgccagtgca tcttctagca ttgtcgtgga agttctccga atcctggttt 300 tgattggtca gattcttttt tcactagcgg cggtttttct tttatgtctt 350 gttataaaga agtatctcat tggaccctat tatcggaagc tgcacatgga 400 aagcaagggg aacaaagaaa tcctgatctt gggaatatct gcctttatct 450 tcttaatgtt aacggtcacg gagctgctgg acgtctccat ggagctggg 499 <210> SEQ ID NO 451 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26, 61, 77, 92, 99, 118, 136, 148, 167, 171, 228, 233, 255, 283, 347, 404, 468 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 451 atcccaggcc tttaggcccc ggaatnaaca attgcaatgc acgtttaagg 50 aaaaggccat ntcggattca gaccctnacg gccttcccac antttgtcnt 100 cacttgcaac agggcttngg gtgggcctcc cgtttntaaa gcaccccnct 150 atgaatgcac agcaggncaa nacccaagtc ccaagactgc ctgggcctac 200 tggcccccct agcatttgtg cagaggtntc ctntacaagc tcccatgttg 250 ggaanaagca cagacccacc aggacccctg ttntcctcct cagatcccct 300 tcctgccacc ttttcccact ccggggactc agcccaggac acctcgntga 350 ttcctgcccc ctttacacct gcaagcaggg atgccggcat cagaagaatg 400 tttngtgttt gaaattgttt gaggggtttg ggtttatttt tgttggtttt 450 ttcttttttt ttgcttangt gggc 474 <210> SEQ ID NO 452 <211> LENGTH: 421 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 108, 153 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 452 acggcgctcc ccgcccgaaa tcaaagctcc gagtcatccg tgtggggcat 50 tcgtcccccc tggcacagtt ggcctctttc cagaagcccg ttttgtttgt 100 tttacgtnta aattcgcgtc ggttcttatt tctctccctg gcaaggtctg 150 aanacgggta ggagaataac ctgtgtcagc gtgttatgat gccgtcccgt 200 accaacctgg ctactggaat ccccagtagt aaagtgaaat attcaaggct 250 ctccagcaca gacgatggct acattgacct tcagtttaag aaaacccctc 300 ctaagatccc ttataaggcc atcgcacttg ccactgtgct gtttttgatt 350 ggcgcctttc tcattattat aggctccctc ctgctgtcag gctacatcag 400 caaagggggg gcagaccggg c 421 <210> SEQ ID NO 453 <211> LENGTH: 504 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 84, 117, 121 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 453 gtcatcttta cattctagtc ctcctgcatc tcctcaaggt tcccctcaca 50 aaggttacac acttattcca tcagctaaat ctgncaactt gtctgactcc 100 agccatagtg agatttnttc ncggtccagc atcgtgagca attgttctgt 150 tgactccatg tctgcagctc tacaggatga acggtgttcc tctcaggccc 200 tggcagtccc tgaatccact ggggcattgg aaaagacaga gcacgcttca 250 gggataggag atcatagtca acatggccct gggtggacac tcttgaagcc 300 atctctaatc aagtgtttag ctgtctcatc gtctgtgagc aatgaagaga 350 tttctcaaga gcatatcatt atagaagcag ctgacagtgg tcgtggaagt 400 tggacttcgt gttcaagcag ctcccatgac aacttccaaa gccttccaaa 450 cccaaaaagc tgggattttt tgaactctta cagacatacc catttggatg 500 accc 504 <210> SEQ ID NO 454 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 46, 55, 81, 86, 218, 301 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 454 ttatgctttt cttgcagtat ntgaaaggcc cgattaacaa aacaanagtc 50 ccaanacccc ttttcttttt tgggtgtatc nctagntgca ggtgctgtgt 100 tccttagtgt catctatttg acttatacag gttacattgc accatggagt 150 ggcaggtttt attcattgtg ggatactggg tatgcaaaaa tacacattcc 200 aattattgca tcagtgtntg agcatcaacc tacagacttg ggtgtctttc 250 ttctttgatc tacatattct tgtatgtacc ttcccagcag gcctttggtt 300 ntgcatcaaa aatatcaacg atgaaagagt atttgttgct ctatatgcaa 350 tcagtgctgt ctactttgct ggagtgatgg tgcgactgat gttgactttg 400 actccagtcg tgtgtatgct gtctgcaatt gccttttcaa atgtttttga 450 gcactatttg gggggagcgg ccgc 474 <210> SEQ ID NO 455 <211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 57, 91-92, 98-99, 127, 133, 151, 178, 221, 236, 239, 267, 295, 301, 325, 349, 381, 396, 426, 441, 481, 498, 501, 516 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 455 gccagaaaac ccttaagaaa aaaagcgnag gaaattttcg ccaaagctga 50 aagatcncag cggcctgaga aaaaagtttg ccccaaaaag nntgtttnna 100 aaaggccaag gaggaagccc ccttttntcc ctngggcact tgtatttttt 150 naaccctgct ttccccaaat ccccactnat gaggatcagc ccatggtggt 200 atttttgcga tgatttcctg ngtcctggag tctttntcng gtcaacggtt 250 ttcttgttat atttgcncta tgtagctgat gtcaattcag gagcncggag 300 ngaagtacaa gcttatggat gggtnctcag cccacctttg cggctagtnc 350 ttgtcagcag cccgggccat tggagcatat nttttctgcc agtttncgga 400 gacagcctcg ttgtgctggt ggcccncagt ggtggctctt ntggacatct 450 ggttcatctt agtggctgtt ccagaatcct ntgcatgaga aaatgagncc 500 nggtttcctg gggagntgcg gccgc 525 <210> SEQ ID NO 456 <211> LENGTH: 506 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 94, 139, 162, 195, 257 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 456 tccttgttaa acatgaaggg ccccggtagc catggtttgg ccaccttcat 50 tccaagcacc ccgccccagc aaggcctcct ggtacctttg tcanccactt 100 gttgtagaag gtgatgccga tggagaagca gtagtagana agcaccagcc 150 ccagggtcaa cnccgccttc cacaaaaagc cacatcgagg gcccncctcc 200 ccattcgtgg cggctgcagc accggagctc ctgagtcagc gggggcaggc 250 acccctnttg aatacaatgt gcaggaagag ccggtggagt tagaccacag 300 ctttcaccaa gaacgtctcc aggctggagg agctctctgc agctccatga 350 ttcggaacca tcagcagagc cccaggcaga gtcctcacct aaggggctgg 400 tggctggtgc tgacccttcc catggttaat tggatgcagc gctcacaggt 450 cccaaggtct gctcggccct gggagctcca ggccggaatt tttggccagt 500 gtggcc 506 <210> SEQ ID NO 457 <211> LENGTH: 194 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 36 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 457 tgctcccctc tctcctctcc acaatctcac ccattntgca tgtgccggtg 50 ccctttcctg tcatcccacc tttctctgag actgtgttct tttttcttaa 100 ttctgttttc tgtttgttct ttaggttgca tagtctttat tgatatttct 150 ttgaattcac tgattcttct gccagctcag tctgttgttg agcc 194 <210> SEQ ID NO 458 <211> LENGTH: 480 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 40, 61, 105, 128, 193, 217, 229 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 458 gattacaaaa acaaaaaatg tttaatttaa gtgaaagggn ttaataattt 50 taatctggga nttaataatt cagtggaaat tttaaatgaa tagttactat 100 aatcncaaat aattgagagt caactttntt tttccccaaa acatacatga 150 aaggtctgtg tgtgtaagct ctgattttca ggacccctat ttntggaagc 200 agagtaactg gaaatantaa gtcaagatnt gaaaaccatt tgaagttaac 250 caaaaagcac aggctactaa ggcaggtgca gcatcaatga ttcactacat 300 ggttctgata tcagctcgct tggtactact cactttgtgt ggatgggtac 350 tttgttggac cctcgtcaat ctctttcgaa gccattcagt cctcaatctc 400 cttttccttg gctacccgtt tggtgtttat gttcctcttt gctgttttca 450 tcaagatagt agagcacatc ttcttctcac 480 <210> SEQ ID NO 459 <211> LENGTH: 564 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 57, 73, 84, 93, 105, 147, 150, 156, 235 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 459 cggtccgaat atccggaacc tgacccaatc cttggccttt gaaactttca 50 ttttttngtt gtctgcctca acncgtcagg tggngcccaa acnttggtaa 100 agtcnagatc cgggggaggg tacttcatgg ccttggactc catattnttn 150 tgcatntacg tggtgaaagc cctgctcaag atcatcgccc tgggcctctt 200 ggtacttctt tgacttctgg aacaatttgg acttnttcat tatggccatg 250 gccgtgctgg acttcttgct gatgcagacc cactccttcg ccatctacca 300 ccaaagcctc ttccggatcc tcaaggtctt caagagcctg cgggccctga 350 gggcaatccg ggtcctgcgg aggctcagct tcctgaccag cgtccaggaa 400 gtgacaggga ccctgggcca gtccttgccg tccatcgcag ccatcctcat 450 cctcatgttt acctgcctct tcctcttctc cgcggtcctc cgggcactgt 500 tccgcaaatc tgaccccaag cgcttccaga acatcttcac caccatcttc 550 accctcttca cctt 564 <210> SEQ ID NO 460 <211> LENGTH: 565 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 460 caaagaaaag aaaagggcac ttcggagcaa atcatacact aggcctttga 50 tgctttaatt cttcttcagt tcattaaaag taactactaa ggaaaggtta 100 aaaacttccc ctcaaaaagg aatcaacccc aggaagtaat catttacaac 150 gattttccca aattttgaca atctgtcctg gaaagcaaac cccttttaaa 200 atctaatgtc tgggctttga gtattagctc atttagggtg gacaaatgca 250 ttactgtttt caaactgctc acatttattc agtatttctc caagttgcta 300 tctactcagc cttatgaatg cccctcgctt ttctaaggcc atgtgaaaat 350 cacggcactg cccttagcct tgtgtcatct gctttttcgt tctgcgatat 400 gcccagttcc caaatcaatt ataggtacct gtttaggaga gaggaagatt 450 ttacctctca aagggtgaga tttgaaattt acactaaaaa gacaacttta 500 catttaatgc ttcacttaat gagacattct tttttttata agtctatttt 550 tctactcagt ttcag 565 <210> SEQ ID NO 461 <211> LENGTH: 563 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 461 atgcagttgt taaggtttac tgcccttgcc attttaatta tgaggctaaa 50 gatgtttttg acgctgcaca tgtgtgtatg gcttccttga tatgctctcg 100 cagttctttg gtggcttttt cgcagagttc gttttgataa tgttatcttt 150 ggcattctaa cagtgatgtc aatacaaggt tatgcaaacc tccgtaatca 200 atggagcata ataggagaat ttaataattt gcctcaggaa gaacttttac 250 agtggatcaa atacaatacc acatcagatg ctgtcttcgc aggtgccatg 300 cctacaatgg caagcgtcaa gctgtctaca cttcatccca ttgtgaatca 350 tccactttac gaagatgcag acttgagggc tcggacaaaa atagtttatt 400 ctacatatag tcgaaaatct gccaaagaag taggagagaa attgttggag 450 ttacatgtga attattatgt tttagaagag gcatggtgtg ttgtgagaac 500 taagcctggt tgcagtatgc ttgaaatctg tgatgtggaa gacccttcca 550 atgcagctaa ccc 563 <210> SEQ ID NO 462 <211> LENGTH: 487 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 37, 70, 126, 128, 131, 150, 161, 172, 234, 299, 321, 368 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 462 gaagtgggcc caacatntga caaaactccc aatgaangat tccccgcttg 50 aaacaatggg ggcagggctn ccggcttcga ggggcaagtt tcaagcattc 100 aacaaagggt cccccggaaa atttcnangg ngtccaacac tcagtgcccn 150 cagcccagcc ncagaaccca anacataagg catgtcatcc acaagctctc 200 ctttggggac aacgctacag gtccagaaca tccncggagc tttcaatgct 250 ctcgggggag cagacagact cacctccaac cccctggcct cccacgacnt 300 acatcctgaa gattgtgccc ncggtttatg aggacaagag tggcaagcag 350 cggtactcct accagtanac ggtggccaac aaggaatacg tcgcctacag 400 ccacacgggc cgcatcatcc ctgcaatctg gttccgctac gacctcagcc 450 ccatcacggt caagtacaca gagagacctg cggccgc 487 <210> SEQ ID NO 463 <211> LENGTH: 535 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 59, 66, 82, 227, 440 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 463 tatcaagggg cgggttttgg atttaatggg gggaaaaggg gggaaaaggc 50 caggatccna actggngaat ttggtgattt tngggtccct ttccgctttc 100 cggccgggaa gggctgccag ggtatatttc cttttttccg atcctgcaac 150 agcctcttta aactgtttaa atgagaatgt ccttggctca gagagtacta 200 ctcacctggc ttttcacact actcttnttg atcatgttgg tgttgaaact 250 ggatgagaaa gcaccttgga actggttcct catatttatt ccagtctgga 300 tatttgatac tatccttctt gtcctgctga ttgtgaaaat ggctgggcgg 350 tgtaagtctg gctttgaccc tcgacatgga tcacacaata ttaaaaaaaa 400 agcctggtac ctcattgcaa tgttacttaa attagccttn tgcctcgcac 450 tctgtgctaa actggaacag tttactacca tgaatctatc ctatgtcttc 500 attcctttat gggccttgct ggctggagcg gccgc 535 <210> SEQ ID NO 464 <211> LENGTH: 451 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 57, 59 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 464 aaaaggccaa ttttaagcaa aatataacaa aacgagaagt ggaggatgac 50 ttgggtntna gcatgctgat tgactcccag aacaaccagt atattttgac 100 caagcccaga gattcaacca tcccacgtgc agatcaccac tttataaagg 150 acattgttac cataggaatg ctgtccttgc cttgtggctg gctatgtaca 200 gccataggat tgcctacaat gtttggttat attatttgtg gtgtacttct 250 gggaccttca ggactaaata gtattaagtc tattgtgcaa gtggagacat 300 taggagaatt tggggtgttt tttactcttt ttcttgttgg cttagaattt 350 tctccagaaa agctaagaaa ggtgtggaag atttccttac aagggccgtg 400 ttacatgaca ctgttaatga ttgcatttgg cttgctgtgg ggagcggccg 450 c 451 <210> SEQ ID NO 465 <211> LENGTH: 573 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 33, 79 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 465 cactggccaa accattatat ggcatactct ggntacgtgg tctgcctgtt 50 attggaaaga tatattaaga atccagttnt ggattgcagc tgttattttt 100 ttgggaatgc ttgaaaaagc agttttttat agtgaatacc aaaacatcag 150 caacactgga ctgtcaaccc aaggcttatt gatatttgcg gagttgattt 200 ctgcgattaa gaggacgttg gctcgccttc tcgtgatcat tgtgagcctg 250 ggctatggca ttgtgaagcc tcgtttagga acagtcatgc accgggtgat 300 cggactgggg cttctatact taatctttgc agctgttgaa ggcgtgatga 350 gagtcattgg gggttctaac catttagctg ttgttcttga tgacattatt 400 ttagcagtta ttgactccat ttttgtgtgg ttcattttta ttagtttggc 450 acaaactatg aagaccctaa ggctaagaaa gaacactgtg aaattttcat 500 tatatagaca ttttaaaaat actctgatct ttgctgtgct ggcttctata 550 gtgtttatgg ggtgggcggc cgc 573 <210> SEQ ID NO 466 <211> LENGTH: 506 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 466 tggatggtac cctggcccnt ccagagtccc agggcaatgg gtccattttc 50 agcccaatgt ggtgtacatt accctacgct ccaagcgcag caagccggcc 100 aatatccgtg gcaccgtaag cccaagcgca ggaaaaagca tgcagtggca 150 tcggctgccc cagggcagga ggctttggtc ggaccatccc ttcagccgca 200 ggaagcggca agggaagctg atgctgtagc acctgggtac gctcagggag 250 caaacctggt taagattgga gagcgaccct ggaggttggt gcggggtccg 300 ggagtgcgag ccgggggccc agacttcctg cagcccagct ccagggagag 350 caacattagg atctacagcg agagcgcccc ctcctggctg agcaaagatg 400 acatccgaag aatgcgactc ttggcggaca gcgcagtggc agggctccgg 450 cctgtgtcct ctaggagcgg agcccgtttg ctggtgctgg aggggggtgc 500 ggccgc 506 <210> SEQ ID NO 467 <211> LENGTH: 410 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 467 aacctgtgac gttagtgtgt tcttactagc tttaatttgt atgtagcaat 50 gaattgtgaa tcttagtgca gtgggttttt ttaaaaaact caaaaagctg 100 ggaattaagg gtttcagtaa taatgctata ccgaggtgct tgcattgtat 150 ttcataattt tgttacaaac caaaattatt tttaatgaga acagtcttgg 200 gttcagaggt gtgatgccag aatgtatttt cgtactgtta ggcccttgga 250 acagataccg gtgctttctg aaagatgaaa gaaatgcaat gggtgctctt 300 catgcaaggt tgcaaaccta ccaagaatgc ataatagtct cacttttccc 350 caataaagag atgcgtgtga ctagttttgg acttttaacc ttaatgggga 400 tggcggccgc 410 <210> SEQ ID NO 468 <211> LENGTH: 395 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 468 atggtcctgg gcatccattg acctgctttc tgtccctgta gattagtttt 50 gcctgttcta gaattttatg tatgtaaggg aatgatgact atgtatgttt 100 gtgtttggct tatttttacc agcaagtttt tgaggttcat gttattgtgt 150 gtatcagaag ttagtttcta tttattgctc agtagtattt cattctgtga 200 atttaccatg gtctgtttaa tatattcatc tattgatgat gaacatttag 250 attacttttc gtttttgcct attaaaaata aagttagtat gaatatgcat 300 gtacaagttg tattgtggat atactttgtg ataataacta gaaccaggag 350 tggttcaaaa tttaatttac acatctactc cctgtgttat ttgcc 395 <210> SEQ ID NO 469 <211> LENGTH: 558 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 53, 122, 235 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 469 tggctgaaaa tttttggaaa aaagaatatt ttctttttaa taggtaactt 50 aanatatttt attcattgtc gcccagtgta acaagaggaa tcagttaaac 100 tcctgtgtcc aggccagtac cnccaattaa tgcacttgta gctactgaat 150 tccagccaag ataaatataa ttaaatctag tgcttcagga aatgagttga 200 tcatcaaggg agttagaatg gaaaaacatt tatgnataat tttaaaggac 250 attggactta actgtttgga atgaatgagc ttgatttttt ctatacatat 300 tataagttaa tataaaaaaa ggctttgggt agactccgta tgaccttatg 350 tatttgattt catgagtttc attttctgca gtaactttat cattcatttt 400 tcatctctta ggctggaatg tagtggaaaa agaactgaac taggagttag 450 aagatttaag ttttggctct ggctccatca catactggca gtgatgatct 500 tagccaagtt tgaactgctt atggcggggt cttgtttatt catttcagta 550 tttccaac 558 <210> SEQ ID NO 470 <211> LENGTH: 552 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 470 agttaccctc actttaccaa ggactttgct cggcgtttat tagtgctgtt 50 tgggtagcat tcccattgct cacaaagctc tgtgtgcata aggacttcaa 100 gcagcatggt gcccaaggaa aatttattgc tttttacctt ttggggatgt 150 ttattcctta tctttatgca ttgacctcat ctgggcagta tttgagatgt 200 ttacccctat cctcgggaga agtggttctg aaatcccacc tgatgttgtg 250 ctggcatcca ttttggctgg ctgtacaatg attctctcgt cctattttat 300 taacttcatc taccttgcca agagcacaaa aaaaaccatg ctaactttaa 350 ctttggtatg tgcaattaca ttcctccttg tttgcagtgg aacatttttt 400 ccatatagct ccaatcctgc taatccgaag ccaaagagag tgtttcttca 450 gcatatgact agaacattcc atgacttgga aggaaatgca gttaaacggg 500 actctggaat atggatcaat gggtttgatt atactggaat ttctcacata 550 ac 552 <210> SEQ ID NO 471 <211> LENGTH: 549 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 471 gaggcattgt gaatggttgc agtgnagctt aggtataaca tcatcaagtg 50 tgttcacacg cggggtcggg tttaatggag tgtccacgcg gagataactg 100 cgatattgga acacctgtga gagagattgt tctatagggt ggaatattca 150 gagttacatt cttggaagtt tctgttttta cttgcatcaa acacccctct 200 gttgttctcc atcatcttta atagcaactg gagaccactt tggtcattgg 250 taagggggtg cattctcctc acaaaggggt tttatggact tcctcaggcg 300 gagagcttct gagaacacag gcaggatgga aaaagactac tagccacttt 350 tgctttccca acccccctta atgccatcct tcattgtctt tctggcttct 400 cttcttctgg cacagtacca ttttgggtct gtgccccagt gtggagcaaa 450 acattgcctg tcccattctg atatacttca gaatttgaga gcagaagtta 500 atgtggaaca aaagttttca ccatctctca agccccaagg actggagcc 549 <210> SEQ ID NO 472 <211> LENGTH: 510 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 46, 95, 404 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 472 attaggctgt ttgggagcat tcccattgct cacaaaagct ttgtgngcat 50 aaggacttca agcagcatgg gcccaagaaa atttattgct ttttnccttt 100 tggggatgtt tattccttat ctttatgcat tgtacctcat ctgggcagat 150 ttgagatgtt tacccctatc ctcgggagaa gtggttctga aatcccacct 200 gatgttgtgc tggcatccat tttggctggc tgacaatgat tctctcgtcc 250 tattttatta acttcatcta ccttgccaag agcacaaaaa aaaccatgct 300 aactttaact ttggtatgtg caattacatt cctccttgtt tgcagtggaa 350 cattttttcc atatagctcc aatcctgcta atccgaagcc aaagagagtg 400 tttnttcagc atatgactag aacattccat gacttggaag gaaatgcagt 450 taaacgggac tctggaatat ggatcaatgg gtttgattat actggaattt 500 ctcacataac 510 <210> SEQ ID NO 473 <211> LENGTH: 471 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 70 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 473 gattgcaagg aggattttat atgatagtca tagcttgtct ttaaaagttt 50 ggtatgtgat aatatcagan cagtaaaagg ctatttcaca ttttaaaact 100 aaatctttat taaataatta tttcacaagt tagtaattat tgatattctt 150 cttcagggac tagagttcct atgcttccta aactgacttt taaggaaaga 200 tgagactata ttcagtgcag ttttaatatg acatatttta ttatctctta 250 ttttttaaat tgatatttta tgaaggagtc tatggactat aatacgaaaa 300 ttctggttgg ggaggcagga aacctggctt tcaagtacac tccaatagct 350 tttatataaa attcaggtgt tctttttctc taatacttga aatagctatt 400 ttcattttca tgtcattttc tgtacttttc ctgatacttt taaacattgt 450 tttattttca aatgaacagc c 471 <210> SEQ ID NO 474 <211> LENGTH: 379 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 77, 96, 101, 109, 117, 124, 185 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 474 ttcccgcaat tttcagaaaa atgggantaa aagaaactat tttgtaaaat 50 aaaaaagctt ccatttttaa tgaccancat gtattaagat ggaacntact 100 ntacgaaanc gaagttntat ggtntcgaaa agcccgtgcc tgtttaaaac 150 ttgatcctaa ctaaaaacag acttgagtgg atatnagaat gttggttagt 200 ggcagaagag tcaaaaaatg gcagttaatt attcagttat ttgctacttg 250 ttttttagcg agcctcatgt ttttttggga accaatcgat aatcacattg 300 tgagccatat gaagtcatat tcttacagat acctcataaa tagctatgac 350 tttgtgaatg ataccctgtc tcttaagca 379 <210> SEQ ID NO 475 <211> LENGTH: 446 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 475 tttagaaatg gtatggcaga atccagaaaa tgctttattg aagacagtca 50 ttgatcacca gtacacttga tctccagtac agacatatgg tggaacagaa 100 gcctggatac aggactcaga ctcttactgg ttggtatcat acgtgatcgt 150 ttgattcagt tcatctctaa attgcagttt gccgtgactg tgcttttgac 200 atcatggaca gagaaaaaac aacgtcgaaa aacaactgcc actttatgta 250 tactcaacat tgtcttttct ccattcgtgt tggtcatcat agttttttct 300 acactactct cttctccctt actccctctt ttcacccttc ctgtgttctt 350 ggtggggttt ccccgaccta ttcagagttg gccaggagca gcaggcacca 400 cagcctgtgt gtgtgcagat acagtgtact actaccaaat ggtgcc 446 <210> SEQ ID NO 476 <211> LENGTH: 451 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 37, 43, 81, 83, 126, 206, 244, 256 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 476 gggtgctctt tttcaattca ggaacatcaa catttantaa acngtggggt 50 gggatcctta caaatcatcc tgcttttttg nanatcactg gctactaagg 100 caggtgcagc atcaatgatt cactanatgg ttttgatatc agctcgcttg 150 gtactactca cttttgtgtg gatgggtact ttgttggacc ctcgtcaatc 200 tctttngaag ccattcagtc ctcaatctcc ttttccttgg gtanccgttt 250 ggtgtnttat gttcctcttt gctgttttca tcaagatagt agagcacatc 300 ttcttctcac agactacaaa tatgtggttc agcacgaggc agtagaggaa 350 agtgcctcga ctgtgggagg cttggccaaa tccaaagact ttctctcctt 400 gttgctggag tcgctaaaag aacagtttaa taatgccaca cccatcccca 450 c 451 <210> SEQ ID NO 477 <211> LENGTH: 527 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 477 ggccacnctg gccaaataag ggcaaaaagc tttatttttt tgaacaggaa 50 aacatgtttt ttaaattcac atgttttgta tgagactttt gcgaagcaag 100 gcatgaactg ctaggtatta ttaagaatga atgatttttg catttaagtt 150 gtttgaaggc atgtattttg aaaaatatct gttacaaatt tataatttca 200 agacaaattg aatcttattt tataatactt ttggaatttc attaataagg 250 ctaaaatttg aggaatataa ctaattttca gccttaagac atttaagttt 300 ggaagtcctt gctattcaac agaataacaa gaaaacttca gaatgtatca 350 ctctcctgaa aagaagatat taataagccc ttttatttat ggttatagtt 400 ttatttatag tctcaaaatt cctaaagcaa tgctacaacc attgaatttg 450 ccatattttg tatcagtgct gttaatttgc tgttgcctca agaaaaagtg 500 ctttttctcc atggatgagg cggccgc 527 <210> SEQ ID NO 478 <211> LENGTH: 332 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 75 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 478 cacacacaca cacacacaga aattttgaga gccattttaa tataattgcc 50 tccctagaaa catacctttt agggnatttt tatcactaaa ccacatgtta 100 tttaaatacg gtacatgttt aacataaata catacataaa attcacatgc 150 atacttaaca cttatgttaa atatattcaa tgtatataca tatgtacaca 200 atatatgcat atatacatgt gggtatgtgg tatgtgtgca tgtgtgtgta 250 tggccagcta cataatttgt gggactaagg gcaaaatgaa actgtacggc 300 cctcgttcaa aaattaggtg tggagcggcc gc 332 <210> SEQ ID NO 479 <211> LENGTH: 569 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 479 accaatcaga tgtatttagg gatttgggat attctaccag gtgttgtgaa 50 atgtcaaatg gaacaagcgt ttcatcttga ttttggaact gaattggaac 100 caagaaaaga aatagtgcta tttgataagc caactagagg aactactgta 150 caaaaattta aagaaatggt ctatagtctc tttaaggcaa aattgggtga 200 ccaaggaaac ctctctgaac tggttaatct catcttgacg gtggctgatg 250 gagacaaaga tggccaggtt tccttgggag aagcaaagtc ggcatgggca 300 cttcttcaac tgaatgaatt tcttctcatg gtgatacttc aagataaaga 350 acataccccc aaattaatgg gattctgtgg tgacctctat gtgatggaaa 400 gtgttgaata tacctctctt tatggaataa gccttccttg ggtcattgaa 450 ctttttattc catctgggtt cagaagaagc atggatcagc tgttcacacc 500 atcatggcca agaaaggcca aaatagccat aggacttcta gaatttgtgg 550 aagatgtttt ccatggccc 569 <210> SEQ ID NO 480 <211> LENGTH: 540 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 41 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 480 cccgccatga ctcggagact gaggacatgt atgggacgac ntgctacatg 50 gcccagagtg ccggtcatct gtcaccagtg acagtgaggg ggcccatgtg 100 aatacccttc actcagggcc aaacgtgccc caaagaggat gtttttcagc 150 agaatcattt attctggctt cagaattcaa gtccttcctc tgatcgagtt 200 aggcaataat ctgggagggg aatgagtgca aaaagatgga tatgtctgtg 250 ttggaaataa gtggcatcat catgagcagg gtcaatacct atcagcaagg 300 agtaggttat cagatgctgg gaaatgttgt cactattgga ttagcatttt 350 ttccattctt acatcgactt ttccgtgaga agagccttga ccaactaaag 400 tccatttcag ctgaggagat cttgactctc ttttgtgggg caccacctgt 450 tacacctatt attgttttgt cgataattaa tttttttgaa agattgtgtc 500 ttacttggat gttttttttc atgatgtgtg tggcggccgc 540 <210> SEQ ID NO 481 <211> LENGTH: 77 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 481 ggccacactg gccaaagagc atatttgatc actttgattc tctgttcttt 50 tctctccgcg gtgtgtgtgg cggccgc 77 <210> SEQ ID NO 482 <211> LENGTH: 560 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 482 aaagacccag tcatggcaag cctccaagca tcagttcacc atggggaaag 50 catgtgttca aagccattct gatggtccta agtggccctt atcctcctcc 100 actcagcatt ggcccagtcc cgtcgagact ttgcaccacc aggccaacag 150 aagagagaag ccccagttga tgtcttgacc cagataggtc gatctgtgcg 200 agggacactg gatgcctgga ttgggccaga gaccatgcac ctggtgtcag 250 agtcttcgtc ccaagtgttg tgggccatct catcagccat ttctgtggcc 300 ttctttgctc tgtctgggat cgccgcacag ctgctgaatg ccttgggact 350 agctggtgat tacctcgccc agggcctgaa gctcagccct ggccaggtcc 400 agaccttcct gctgtgggga gcaggggccc tggtcgtcta ctggctgctg 450 tctctgctcc tcggcttggt cttggccttg ctggggcgga tcctgtgggg 500 cctgaagctt gtcatcttcc tggccggctt cgtggccctg atgaggtcgg 550 tagcggccgc 560 <210> SEQ ID NO 483 <211> LENGTH: 581 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 134, 187, 224 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 483 caaaacgatt ttattgccaa accctgtgca ctccgattgg catcgaggac 50 agtggtcctt atcaggccca acccaatgcc atccttgaaa aggtgttcat 100 atctattacc aagtatcctg ataagaaaag gtgnagggcc tgtcaaagca 150 gctggattgg aatgtccgaa aaatccaatg ctggttngcc atcggaggaa 200 tcaggacaag cccccaacgc ttantaaatt ctgtgaaagc atgtggagat 250 tcacatttta tttatgtata ttctgctatg gaattagatt tctctggtcg 300 tcaccttggt tctgggacat ccgacagtgc tggcataact atccatttca 350 gcctctttca agtgggcttt atcactatta tatcatggaa ttggccttct 400 attggtccct tatgttttct cagtttacag acattaaaag aaaggacttc 450 ctgatcatgt ttgtgcatca cttggtcacc attgggctta tctccttctc 500 ctacatcaac aatatggttc gagtgggaac tctgatcatg tgtctacatg 550 atgtctcaga cttcttgctg ggggcggccg c 581 <210> SEQ ID NO 484 <211> LENGTH: 358 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 484 tctaggtcca ttgtcacctt ttctggcacg acagcctccg ccccaccgca 50 ttccccaggc caagctggtg gccatgcttc agacacgaga cccaccaagg 100 gcctccgcca gaccacggtg cctgccaagg gccaccctga gcgccggctg 150 ctgtcagtgg gggatgggac ccgtgttggg atgggagccc gaacccccag 200 gcctggggcg ggcctcaggg accagcaaat ggccccatcc gctgctcctc 250 aggccccaga agccttcaca ctcaaggaga aggggcacct gctgcggctg 300 cctgcggcat tcaggaaagc agcttcccag aactcgagcc tgtgggccta 350 gcggccgc 358 <210> SEQ ID NO 485 <211> LENGTH: 583 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 32, 61, 95, 100, 110, 190, 205, 228 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 485 ctggccaaac atatggggga tgaaaataaa anaattacat atgaagattc 50 aaaaccatcc ncaggaatga attacacgcc ctcccaggca tcaanaagcn 100 caggaggagn cagttatgaa gtcaaaggta tagatgcaaa atgaaccaac 150 aaaaggaagt ttttttttga aaagcagtaa aaaaaagctn caagaaacac 200 ccaantgaag caaatcacgt acaaagantg agacaaatgc tggcttgccc 250 tccacatggt ttactggaca gggtcataac aaatgttacc atcattgttc 300 ttctgtgggc tgtagtttgg tcaattactg gcagtgaatg tcttcctgga 350 ggaaacctat ttggaattat aatcctattc tattgtgcca tcattggtgg 400 taaacttttg gggcttatta agttacctac attgcctcca ctgccttctc 450 ttcttggcat gctgcttgca gggtttctca tcagaaatat cccagtcatc 500 aacgataatg tgcagatcaa gcacaagtgg tcttcctctt tgagaagcat 550 agccctgtct atcattctgg ctcgtgcggc cgc 583 <210> SEQ ID NO 486 <211> LENGTH: 454 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 58, 152, 315 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 486 tgcatcgtgg ggtatgtaca atgtttacgc atgtgagtgt gtgtaaagtg 50 tgtgtatnaa gtgtgtgtgt acatctgtgc agctggtcac cagcatgtac 100 cttcacaagt tagattttgc tggcatatcc acgagctgtc accactgtgc 150 cntgggcatt gagctttttg aggcttgtgt gttggcctgt cccagggctc 200 tgccatcgtc agtattggcc ccactcacag atgttctttc ctgggttggg 250 ccagctcctt ttggacactt ttgagatcca cctcgggccc gtctgcgttt 300 gcgatgctgc ttttntgtgg ctccttccgg ctactgggac tgttcccttc 350 tggcattgcc ttcggcagca cttcgaggaa ctcagcctcc agggcctcct 400 gttgtccttg aaaatgcagt tttatttcat tatttttatt tatttatttt 450 tggg 454 <210> SEQ ID NO 487 <211> LENGTH: 196 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 487 ctcaaaatta aagtatcaaa caggggtcct cagaactgtc tcacttcctc 50 ctgctcccat caatattaaa gcctaaaact caagaatcat tcttagcagt 100 ttttttctct tttttctttc ttttcttttt tttctttttt gagacggagt 150 ctcactctgt cgcccaggct ggagtgcagt ggcgacagag tgagac 196 <210> SEQ ID NO 488 <211> LENGTH: 226 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 124 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 488 gtgtgtgagt gtgtgtgtgt ttaatgtacc taattctgta aaggatttta 50 agtgattttt tcaaagtgga cccaataaaa taaaaacaat atgcgtgcat 100 gtgttttata aaagtaataa aacnagttat tctgcttttt ctagtcttag 150 ttacttactt acatatttat ttggggggtg tgatgttctt tttaaaagga 200 actcctgtga cacctgttac tccggc 226 <210> SEQ ID NO 489 <211> LENGTH: 398 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 53, 61, 143, 260, 293 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 489 gcagctgcct attgcacttg tgaaaaaggt ttgtatgttc aacactgctg 50 ggntggctca nagttgggag tgaatcctcc aagggataag cttggagaac 100 tttttgaaca gtcaatctgt aaaggtgttt gcaatcccaa ggncaatgga 150 ctagattatg aaggctctcg ggtggaccca ctgttcctct ctgtttatta 200 agctttttga aggagagaga tgagggcagg acatgtgaca acggtgcttt 250 tccttatgcn tatatcgctc tccaacagca tcctttccaa atntatagcg 300 cttcaaagat tccaggacag atcgggaaga gccagtgtcc atagaaacct 350 ggggttgttc agaagaacgg tgttctctgt gtttgtgacg gtgcctgt 398 <210> SEQ ID NO 490 <211> LENGTH: 568 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 52, 63, 87 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 490 ggttttgtcc ttcggtatga caactacaaa aaagcaagcc agtggggatt 50 cntgtggggc ccntggacct gccaaacatc tccgggngca tgcaaaaagg 100 tctcctactt tcactgcacc ctcatcggat actttgtagg cctgctcact 150 gctactgtgg cgtctcgcat tcaccgggcc gcccagcccg cccttctcta 200 tttggtgcca tttactttat tgccactcct cacgatggcc tatttaaagg 250 gcgacctccg gcggatgtgg tctgagcctt tccactccaa gtccagcagc 300 tcccgattcc tggaagtatg atggatcacg tggaaagtga ccagatggcc 350 gtcatagtcc ttttctctca actcatggtt tgtttcctct tagagctggc 400 ctggtactca gaaatgtacc tgtgtttaag gaactgccgt gtgactggat 450 ttggcattga aagggagctc gtttgcagga gagaggtgct ggagccctgt 500 ttggttcctt ctcttcctgc ggatgtagag gtggggcccc ttccaagagg 550 gacaggcctc tccccagc 568 <210> SEQ ID NO 491 <211> LENGTH: 552 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 36, 42, 74, 92, 168, 177, 232 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 491 aagactccca aggaagttgt tgaactatat ttgganaaac angccactga 50 atattatcat ttttcctttt aaanagagtt ttgtaagggg gnaaacatgc 100 atttttatcc agacaattta tccaaagcat ttcagaacat gaagtgctga 150 tgagggcacc tcttgtgntg agtcccntaa gctatcaagt gttcttctca 200 aggacacatt tggaaggttt taacattgaa antgagcgga ggacttgggg 250 gcagagcagc acaaagaaac agccttacac tgggcacatg gaggagacgt 300 ccaccctgca gccaggattg gggttcacgt cactgccaga gctacactcg 350 ccttctgctt ccacggtcct gttaattcta gatcagagag caagaaaaaa 400 gtacagaaca tatcctctac ggttatttcc tgctttctaa ttaaaaaaat 450 aataaccatg gcaagagaga aagaaagaga aagtactcag aggctgacac 500 tgacatttca cttcctcgct ctcctaagtt taattacaac agcacgtgca 550 gc 552 <210> SEQ ID NO 492 <211> LENGTH: 579 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 36, 147 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 492 tgcagcattg gcagcaacaa aaatttctag tttggntgat gattttggag 50 aattcagcct ttttggggaa tattttggtc tagcacctgt tggggagcag 100 gatgactttg cagattttat ggctttcagt aatagcttta tttcatntga 150 gcaaaagccg gatgacaaat atgatgccct taaagaggaa gccagtcctg 200 ttcctctaac cagcaacgtg ggcagcacag tgaagggtgg acaaaactcg 250 actgctgcgt ctaccaagta cgatgtcttc agacaacttt ctctggaagg 300 gtctggacta ggtgttgaag acctgaaaga taacactcct tcaggaaaaa 350 gtgatgatga ttttgctgac ttccactcca gtaaattttc ttccataaac 400 tcggacaaat ccctgggaga gaaagcagtg gctttcagac acaccaaaga 450 agactctgca tcagtgaagt ccttagatct cccttccatt ggtggcagca 500 gtgttggcaa ggaggactct gaagatgcac tctctgttca gtttgacatg 550 aaattggctg atgtgggagg agcggccgc 579 <210> SEQ ID NO 493 <211> LENGTH: 574 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 89, 166, 192, 339 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 493 gccctatcca ggttaccctt ccnaagggaa accaggtttc tttaaaaaat 50 taagcagccc ggggccggtg ggctcacgct tgtaatccna gcctttgaag 100 cccgaggcgg cggatcacct agaagatgac tcaagaccgg cctctgcttg 150 ccgtgcagga ggcgtnaaga agtgcttccc cgtggtggag ancagcaggg 200 cctgtgcaga gtgccctgcg ggactgccag cccctcctgt cctccctcag 250 caacctggcg gaacagctgc aggccgcaca gaacctgcgg tttgaggatg 300 tgccggcgct tcgggccttc ccagatttaa aagagcggnt gaggcgtaag 350 cagctggtgg ctggtgacat cgtcctggac aagctagggg aaaggctagc 400 catcctcctc aaggtgcgag acatggtcag cagccatgtg gagcgagtgt 450 ttcagatcta tgagcaacac gcagacacag ttggcattga tgctgtcctg 500 cagccttcag cagtgagccc ctctgtggct gacatgttgg aatggttgct 550 ggatattgag agacgggcgg ccgc 574 <210> SEQ ID NO 494 <211> LENGTH: 545 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 35, 40, 114, 133, 284, 359 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 494 cagcatgaga catcccccca tgcctggggc cattnagatn tttttggagc 50 accagtcact cccaggtttt tattttaggg gtcatcgatt ttacctactt 100 tgtcagactg gtanaagttg ctttgcatat canaaaaact ccattttttt 150 ccacaaaagg gattacagaa aactcttttg tgagtgagtg attggaactt 200 agagactcct gttgccagaa tcagactgcc ctagaacaga atggacaatg 250 cagggaggag aattcacaca aacagcacct gttntgaggc ctgtgccagc 300 ccaccaggcc tgctcaaatg tggtctttac ttcaagtgca cagaggcaca 350 tgaggtttnt ggtgataaac cagcgtctta ccgctgtttt aaagtcccat 400 ccccatggct ttcacaatca gttccgtttt ttttgctgta cttgataaaa 450 tgtttattct catacaggtc aagtacattt acttctattc acagtgagta 500 cccaataaca acaaaagcgc ttacaaattt ggggggggcg gccgc 545 <210> SEQ ID NO 495 <211> LENGTH: 239 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 495 ttttttaaaa aaaaaaaaaa tctcagtata gttctgatta aaatttcctt 50 tctgagtcct aaatgcttta aatcttcttt tcccattctt tttacttctc 100 ctatccatag ttacaagttc ttacgcatga catatctctt ggctgataag 150 tttaactgct taagcacctg tttatgtttc atttttaaca tagccagtta 200 ctattatgct tggatataca caatgagggg agcggccgc 239 <210> SEQ ID NO 496 <211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 34, 85, 89, 105, 108, 115 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 496 tgtggaaaaa acagttattg cancggttgc ttanaaaaac ataaaaatgc 50 atccatgggg cttatttatt caggagaaat ctcanagcnc ctgggagtgc 100 tttanagnca ggggntgctt gcatcctctg tggatgtgtg tgtgtgtgtt 150 tgtgcctagg tgtgtgcgca caggtttgtg tgcctgtgtg tgcatgtgtg 200 tggggtgtgt gtgcatgtgt gtatgcacgt acccgtgtgt gtgtgcacag 250 gtgtgtgtgt gtgtgtgttt gtgtgcctgt gtgtggggtg tgtgtgcatg 300 tatgcacgta ccagtgtgtg tgtgcgcagg tgtttgcgtg cacaaatatg 350 catctgtgtg tatgtgtgtg tgttcacacg tgtgtgtgta tgtggcggcc 400 gc 402 <210> SEQ ID NO 497 <211> LENGTH: 553 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 497 cattataatt aactatagtt actatgctgt atatttgatc acccagaccc 50 atcttataac tgaaagtttg tatcctttga tccaaatccc cacatttttc 100 ccagccactg acaaccacca ctttactctg tttctatgag ttcaactgct 150 ttagactcca catgtaagtg agatcataca gtatttttct ttctgcactg 200 gcttatttca cttaacataa catcctctag gttcatctat gtttcagcga 250 atggcagaat tttcttcttt ttaaaggctg aatagtgttc cctcaggtat 300 atataccaga tacacataca taagggaata tgtgtgtgtc tcgggtacat 350 gtacataagg gaatactatt ttttactcat tcatgtatgt gtaccagata 400 catatacata agggaatata tgtatatgtg tctggtacat atacatgaag 450 gaatgctatt ttttactcat tcatctctca gtggacactt aggttgtttt 500 catatcttgg ctattatgaa tagtgctgca ataaatatgg gagtggcggc 550 cgc 553 <210> SEQ ID NO 498 <211> LENGTH: 576 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 47, 71, 78, 92, 112 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 498 ttattgggag atatccatgt ttttcataaa atcaacaaga gaatccntga 50 ttgttcagaa gaaaacaatt ntgaccgnag aatgctgtta cntgaacccc 100 ttatttcgaa gnatcataag attcacaggg gtgtttgcat ttggactttt 150 tgctactgac atttttgtaa acgccggaca agtggtcact gggcacttaa 200 cgccatactt cctgactgtg tgcaagccaa actacaccag tgcagactgc 250 caagcgcacc accagtttat aaacaatggg aacatttgta ctggggacct 300 ggaagtgata gaaaaggctc ggagatcctt tccctccaaa cacgctgctc 350 tgagcattta ctccgcctta tatgccacga tgtatattac aagcacaatc 400 aagacgaaga gcagtcgact ggccaagccg gtgctgtgcc tcggaactct 450 ctgcacagcc ttcctgacag gcctcaaccg ggtctctgag tatcggaacc 500 actgctcgga cgtgattgct ggtttcatcc tgggcactgc agtggccctg 550 tttctgggaa tgtgtgtggc ggccgc 576 <210> SEQ ID NO 499 <211> LENGTH: 330 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 499 aaaaaaaaaa aaaaaaagct aaaaaacctt gactaaatct accatgtttt 50 ctcatattat taaaaattct aaacgtgggt ttttttgttt tgttttgttt 100 ttctgtttct ccctctgcag agttgttagc ggttctcgag atgccactct 150 tagggtttgg gatattgaga caggccagtg tttacatgtt ttgatgggtc 200 atgttgcagc agtccgctgt gttcaatatg atggcaggag ggttgttagt 250 ggagcatatg attttatggt aaaggtgtgg gatccagaga ctgaaacctg 300 tctacacacg ttgcaggggc aggcggccgc 330 <210> SEQ ID NO 500 <211> LENGTH: 440 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 42, 79, 82, 101 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 500 atcaatggcc acccagcaag accaagttac aaggatcgta tnttggtccg 50 aagggatgaa agtggcccaa gggtctccnt tntcggtgaa cgttcagctg 100 ntgcaggacc acggggaaat tgccaagagt aagcatctcc agggggagat 150 gacctaacgt ttccaaaaga gaaacaggca gcaggttctt aagcagtgaa 200 gatgcggacg agatgttgca tgtggctcct gaggcacagc agtgacttcg 250 tgcccagagc ctggcagaga ggtcgcaggt gtgccagctt ccctgccagt 300 cagggcagcc ttgggtgtgt gtgcaagcat gtgtgcacat attgtgtgat 350 gtgcgtgctc ctgtatgtgt gtgcatatgt gtgtatgcct tgcacaggtg 400 tgcacaggtc tgaatgtgta tacgtggggg gggcggccgc 440 <210> SEQ ID NO 501 <211> LENGTH: 563 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 31, 48 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 501 gaatatcctg caggtatctc tccggcccac ntccttgcct actgagcntc 50 agccctgatt tgtcatcgtc ggtttcgtga ccctcatcat atttaagcgg 100 gagctgcaca cggcccccac acagcagtgg gcaccaagta cgggatgccc 150 tccagccatt cccagtttat gtggttcttc tccgtctatt ccttcctttt 200 cctgtattta agaatgcacc aaacaaacaa cgccaggttc ctggacttgc 250 tgtggaggca cgtgctctcc ctgggactcc tcgctgtggc cttcctagtc 300 tcctacagca gggtctacct gctgtaccac acctggagcc aggtgctcta 350 tggaggcatc gctggaggcc tcatggccat cgcctggttc atcttcaccc 400 aggaggtcct caccccgctg ttccccagga tagcagcctg gcctgtctcc 450 gagttcttcc taatccgaga cacaagcctc attcccaacg tactctggtt 500 tgagtacacg gtaacccggg cagaagccag gaacagacaa cgcaagctgg 550 ggccagcggc cgc 563 <210> SEQ ID NO 502 <211> LENGTH: 583 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 81, 126 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 502 ccctgcccaa agttaagttc aagttttctt ttcagataat gcctgaaatt 50 gcccagaata gtcagaggat ttaaaaattt ntttgaccac aaatgcacta 100 aagttttaag taaagcagtt tcttcnttca ttagcatgtg ttttacacta 150 acatttaata agaagccatt tttagtcttg atcttggcag tgttttcttt 200 aagacttctg atgttatcaa gtatttcatt aaatattaaa ttattattaa 250 ttactgttag tttaaatatc attaggggtt tcaatttggc ttcttaaaat 300 ggactgaact gtggcatcac gtattttgtc tcattcatgt atgaataaag 350 cataaatcag tttgttaatg gatgctcata ccactgttta ttttttcaaa 400 tattttaaca cactttccaa atggtgggat ttgctttata aatacagttt 450 tctacttaca catgaggaaa ataatattat ttgcattatg gatgtacact 500 ttgaaaaact tttcaatgca attatctgtg tatttcacaa tctctggtac 550 ttttctcaga tttaattttg gtggggcggc cgc 583 <210> SEQ ID NO 503 <211> LENGTH: 459 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 503 aagcctgtgt aaatggatca accaatccca gtacatttgc ttcaagattc 50 aaacacattc aggtgggggc ttgggacggg atcagcattc atcatgggga 100 agaaaaccac aggccatcag tggatcatac acagtgctca tcaagaaaga 150 taacgttact tttaaattgt gggctcaaac tggacagcaa ggtgcacagt 200 ggaagagagc agaagtgttt ttaggcattc gttcacatac acagattgtc 250 ttcagagcca aacgtggtat cagttacata ggagatgtag cagtggatga 300 tatttccttc caagattgct cccctttgct tagcccagag agaaagtgta 350 ctgctcatga attcatgtgt gctaataagc actgcgttgc caaagacaag 400 ctgtgtgatt ttgtgaatga ttgtgctgat aattcagatg agactacttt 450 catttgccg 459 <210> SEQ ID NO 504 <211> LENGTH: 218 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 504 aaaaaaaaaa aaaaaaaaaa acctgccaat tttcaaacat accgtagaga 50 ttattttcag gtgccatttt atagtatagc agcagggctt ttactctgtg 100 tatgcacaga tgcagtctgg ggcatggttt gtgtgctgga ctttctcatg 150 gccatcatca gtatgcttat ggatttgatg acaggcatag cctgggcata 200 tcacctcatt ggtaaagg 218 <210> SEQ ID NO 505 <211> LENGTH: 562 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 60, 88 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 505 tttaagtgca aaaaattatt ttattttttt cccagtaatt ttaaattgga 50 attccagccn tggcttattt ttgggagacc cagccatnta ccaaagctga 100 aggcacaaat gcttattctc gtcactgtcc tttttatgtc agcattcaga 150 gttactggct gtcatttttc atgggatgat tttatttgta gctttcataa 200 cctgttggaa gaagttacta ctttggacag gctatcagga taacttccta 250 tatgaatgaa actctcttat attttccttt ttcatcccac tccagttata 300 ctgtgagatc taaaaaaata ttcttatcca agctcattgt ctgttttctc 350 agtacctggt taccatttgt actacttcag gtaatcattg ttttacttaa 400 agttcagatt ccagcatata ttgagatgaa tattccctgg ttatactttg 450 tcaatagttt tctcattgct acagtgtatt ggtttaattg tcacaagctt 500 aatttaaaag acattggatt acctttggat ccatttgtca actggaagtg 550 ctgcttcatt cc 562 <210> SEQ ID NO 506 <211> LENGTH: 485 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 49, 77, 124, 166, 225, 259 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 506 tttttttttg acacgagaca taaaaacttt taatgaagga ggacacagnt 50 cagagccttc cacaatgggg ccaaccntgc cccacggaga ccggccatgg 100 caaccgctca atcagaaggt gttnttgatg cggccggcca ccagcctaag 150 gatgtccccg atcttnttct gccagttggc gatgtccttg gacacggcgc 200 accacagctc cccatgccga ggctntgcac tctcacagcg cttcctcacc 250 tcctcctgnt gctcctcagt gccatgctgc agctcaaact tgtagaagaa 300 ggcccaggca tcccccaggt ccgagtcaat cttcacagtg cggtggaacc 350 actccctggc cttggtgatc ttccgctgac tccaaaacag cttggccacg 400 gccaggagca catgggggtc atgctcacac ttcttcaggg catccacgct 450 cttggtcctc ctctggggcc ttgcctcgag gaaga 485 <210> SEQ ID NO 507 <211> LENGTH: 503 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 47, 63 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 507 accctgtttt ttaagcacac ctcaagcggg gcctcgctta ccaatanttg 50 attaaccaca agnaaaagtg tcaagctcaa gacgtcctcc ttttactgtt 100 tgtaaaactg tcctgaaaac tatgatcgac gttccggaat tagaaggacg 150 tggggcaatg aaaattatgt tcggtctcag ctgaatgcca acatcaaaac 200 tctgtttgcc ttaggaactc ctaatccact ggagggagaa gaactacaaa 250 gaaaactggc ttgggaagat caaaggtaca atgatataat tcagcaagac 300 tttgttgatt ctttctacaa tcttactctg aaattactta tgcagttcag 350 ttgggcaaat acctattgtc cacatgccaa atttcttatg actgctgatg 400 atgacatatt tattcacatg ccaaatctga ttgagtacct tcaaagttta 450 gaacaaattg gtgttcaaga cttttggatt ggtcgtgttc atcgtggtgc 500 ccc 503 <210> SEQ ID NO 508 <211> LENGTH: 564 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 73, 80, 145, 342 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 508 tcgacccacg gggtccggta aagttgatgg tctgccttgt acatctcaac 50 cattcttgaa ccacttaatc ctntttttgn caacactagt agaacagaat 100 cctgaagata tggagaccta tacctagatg ttgctgaagc ttttntggat 150 gttggtgaat ataattctgc acttcccctc ctcagtgctc tttgtttgct 200 ctgaaagata caaccttgca gtagtttggc ttcgtcatgc agaatgttta 250 aaggccttag gctatatgga gcgagctgct gaaagctatg gcaaggtggt 300 tgatctggcc ccactccatt tggatgcaag gatttcactt tntacccttc 350 agcagcagct gggccagcct gagaaagctc tggaagctct ggaaccaatg 400 tatgatccag atactttagc acaggatgca aatgctgcac agcaggaact 450 gaagttattg cttcatcgtt ctactctgtt gttttcacaa ggcaaaatgt 500 atggttatgt ggatacctta cttactatgt tagccatgct tttaaaggta 550 gcaatgaatc gagc 564 <210> SEQ ID NO 509 <211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 49, 54, 110, 162, 221, 263, 275, 292 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 509 acagtatggt cattcatgct ccaaagaaaa ggagattgag ctttaaatna 50 aatntctcac aagttaggtg atccaggttt tgtggtcttt gcaacccttg 100 tggtcattgn gcccttgata ttaatcttcg ggggggtcct cgccatggac 150 agacaaacat tnttgtgaca taacaatctg ctctgtaatc ggggcgtttt 200 cagtctcctg tgtgaagggc ntgggcattg ctatcaagga gctgtttgca 250 ggaaagcctg tgntgcggca tcccntggtt ggattctgtt gntgagcctc 300 atcgtctgtg tgagcacaca gattaattac ctaaataggg ccctggatat 350 attcaacact tccattgtga ctccaatata ttatgtattc tttacaacat 400 cagttttaac ttgttcagct attcttttta aggagtggca agatatgcct 450 gttgacgatg tcattggtac tttgagtggc ttctttacaa tcattgtggg 500 gatattcttg ttgcatgcct ttaaa 525 <210> SEQ ID NO 510 <211> LENGTH: 565 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 46, 79, 104 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 510 ttgcttgtta agctaacagg ggtgcaagct tccattttgg atctantttt 50 aaatacactc agacaggaga aatttggant aattttcaaa ctacagacac 100 tttntaatca tgatgcattt caaaagtgga ctcgaattaa cttgagttgc 150 aaaacatgac agtgcccgag gatgataaca ttagcaatga ctccaatgat 200 ttcaccgaag tagaaaatgg tcagataaat agcaagttta tttctgatcg 250 tgaaagtaga agaagtctca caaacagcca tttggaaaaa aagaagtgtg 300 atgagtatat tccaggtcca acctccttag gcatgtctgt ttttaaccta 350 agcaacgcca ttatgggcag tgggattttg ggactcgcct ttgccctggc 400 aaacactgga atcctacttt ttctggtact tttgacttca gtgacattgc 450 tgtctatata ttcaataaac ctcctattga tctgttcaaa agaaacaggc 500 tgcatggtgt atgaaaagct gggggaacaa gtctttggca ccacagggaa 550 gttcgtaatc tttgg 565 <210> SEQ ID NO 511 <211> LENGTH: 558 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 83, 114 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 511 agtgggcttg aacttcgtga gtttcgcttt aaactgccct tgaaatgaag 50 tggacttgga ggggcatgga atattcacat ggnagagccg catgaggccg 100 cccaccacgc ttcntgaagg atgcccgtgg gaagaatttt gacgtgccag 150 tgtcctcgtt ctacagggtg ttccattctt ccgcaatctc agaaaaatgg 200 gactaaaaga aacttatttt gtaaaataag aagacttcca tttttaatga 250 ccaacatgta ttaagatgga cacctactct acgaaacacg aagttctatg 300 gtctcgaaga agcccgtgcc tgtttgaaac tgatcctaac taaaaacaga 350 cttgagtgga tatgagaatg ttggttagtg gcagaagagt caaaaaatgg 400 cagttaatta ttcagttatt tgctacttgt tttttagcga gcctcatgtt 450 tttttgggaa ccaatcgata atcacattgt gagccatatg aagtcatatt 500 cttacagata cctcataaat agctatgact ttgtgaatga taccctgtct 550 cttaagca 558 <210> SEQ ID NO 512 <211> LENGTH: 544 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 53, 63, 78, 111, 150 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 512 tccggaacaa ttataataaa gccancttta acccattgag agcataagga 50 tgntgcaaag gcncagtgct ggatgganag gacagtgcct ggggcagtca 100 tggaagactt ntttaggagg tgacttttta aggggttttg tgatcaaaan 150 tatggagtct taagtccaac cagtggttat gaattccggt tctgccactt 200 gctataatag ctgtatcacc atgagcgata acttaacctc tttgtgcctc 250 agtttcttca tatataaaat ggggatcatg atagctctgt cccaggggag 300 ttaggaggat taaatgcaac agtaatccaa cccacagtat gaaaagacag 350 gctagcacat acaacacaat ctataaatgt ttgctattat tgtcatcctt 400 tttattagta tatcatggta caagtttgct gggtagaaag atggcgatgg 450 ggaaggggac atttcaggcc aatgtgataa taaaatcaac agacaaaaga 500 agggagagtg tggtgagtag gataaagctc tgtacagatg caag 544 <210> SEQ ID NO 513 <211> LENGTH: 118 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 513 atttaacttt cccctttaaa aggaattggc tatagaactg ctttgtaaag 50 0atgcttcttg atattttact tttgttcctt ttccctaatc attccctttt 100 ttccccactc ctccagaa 118 <210> SEQ ID NO 514 <211> LENGTH: 557 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 56, 60, 82, 85, 115, 122, 152, 185, 187 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 514 tcccgtgggg gacttgggat cccagacgtt aaantaggag ccggaaagag 50 ggaggntttn ttcttgcctg gaagttgcct gngtntttgt accaccccag 100 cccccccacc gtggngggac cntcggcagt gacggcccac agtgccacgt 150 gntcccagaa cccagaggga aagcatcacg gttcntngtt gacagctccc 200 agtcacacaa tccccacgtg tcctgtcatt tcctaaacaa ggtttcatca 250 ccagatttag acccacctgc ttttctctct tttctgcttc ttccagagat 300 ttttttagtg tcttcatttc actggttacc acttctatca tgtttctggc 350 cctttcttta ttctccttag cctcatgttc tgtggtatcc agttctgact 400 tgacagacat gagctttttc tcagctttct ccttcatctt ctccagttgg 450 tctctggatt tgtttagatc ttcaatggct ttagtctgtt ccaaagtttt 500 aatcttcagt tcattggtgt cggccagttt ggctttgagc tcggtgtgca 550 agtctcg 557 <210> SEQ ID NO 515 <211> LENGTH: 348 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 37, 72, 182 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 515 tcagcctttc tatggaaaca actttgagga tgagccncct ttattaaaaa 50 agttaggtat caattttgac cncatctggc aaaaaacact aacagtatta 100 catccgttaa aagtagcaga tggcagcatc atgaatgaaa ctgatttggc 150 aggtccaatg gttttttgcc ttgcttttgg anccacattg ctactggctg 200 gcaaaatcca gtttggctat gtatacggga tcagtgcaat tggatgtcta 250 ggaatgtttt gtttattaaa cttaatgagt atgacaggtg tttcatttgg 300 ttgtgtggca agtgtccttg gatattgtct tctgcccatg gcggccgc 348 <210> SEQ ID NO 516 <211> LENGTH: 428 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 86, 307 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 516 ttcatgggag gacatggaga tcatgggaag catatctatg actataacct 50 aaagctgaag ccgtgtgatg gcccagtctt gattantgag ccagcgctga 100 acccactggc caaccggcaa cagatcacgg aaatgttttt tgagcatctg 150 ggtgttcctg ccttctatat gtccatccag gctgtgctgg ctctctttgc 200 tgctggcttc actactggcc ttgtgctgaa ttcaggtgct ggggttaccc 250 agagtgtgcc catctttgag ggttactgtc tgcctcatgg tgtgcagcaa 300 ctggatntgg caggccttga cctcaccaac tacctcatgg tgctaatgaa 350 gaaccatggt atcatgttgc tcagtgcttc agacagaaag attgttgaag 400 acatcaagga gagcttttgt tatgtggc 428 <210> SEQ ID NO 517 <211> LENGTH: 393 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 155, 159, 191, 255, 297 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 517 atatgtgaaa tattggcagt cgaacatgaa caacggtcaa gatgttccag 50 gcacataaga ggcgattaga gaggccaggt ttatacacaa tataccattt 100 tctgtagtcc ctattgtcat ggttaaatta ttctctaagt gtattctggg 150 tgcanagang catgggctct gtcagtttct gggaaacttt ntgcacccta 200 taaacacaat atttttcttt gttttcacac attcaccatt ttgctggcac 250 ctttntgaag tagtgttgtc ccggtatcag cctttgcaat atgttanaga 300 tgtactgtct gccgcatttt gcactggttt tctcttttca tttatgatta 350 ataatgtgta tacgttattc ctttttatta tctactgtgt aag 393 <210> SEQ ID NO 518 <211> LENGTH: 245 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 518 ccccccgcac cgatttttca aaaaataatt tttctaatta agatatgtgt 50 atatgtttta acatctttca gaaacataaa attgaatgaa aagagtaatt 100 tgcagaaaca catgcaatat aatttattgt gcatttttaa acacacaaag 150 caggactaca tgatgttcat gtgtgcgtgt gtatatatat atatatttaa 200 acacacagac aggccgggca tgatggctca cgcctgtaat cccag 245 <210> SEQ ID NO 519 <211> LENGTH: 585 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 48, 54, 66, 128 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 519 gaccactggc ccacccgcca aggattgcct agatgataat ttacaagnac 50 cacnacttta gatttncctt attgatgtta agataccaaa ccaagtaagt 100 attaaaatca gccaaacctt ggacattntg ggaatatata atcatttgat 150 aatgcataag aataggaaaa aattgaatgt gtttatgact aaagttttat 200 atttgtggta atgttaaaat gtattattaa atatgttaaa attatttcat 250 ttttttcccc tttgagaggt aaagcctaat acttctcccc ttgaatatgg 300 gctagactta tgagcacatt tctaatgaac agagaaagtg gatgtggatg 350 tgacaatgtg tatgttggaa gactagacaa tatcagagat gaacatgatg 400 gtgaaagaaa ataaaagaag aaagctagtt aataaaaggc accattgttt 450 cctcctcttc ctcctcctcc acctctttaa ctctctctcc ctctctctga 500 tcaacagctc tagcaaaagc cagatgctat gcggtgcgga ctttcaggca 550 gctttgcagg gagatacatg tggcaaggaa ctgac 585 <210> SEQ ID NO 520 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 68-69, 214 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 520 tggcttgtag ccccatccaa ataacagcgg ggaggagcgg agcctgtggt 50 acgcaaccca ttaccccnnt gatgagagaa aacttttatc catgacccag 100 gatgactaca aaccatctga tggcctgctg gtgactgtga acggcaaccc 150 cgtggattac cacaccatcc acccaagcct gcccatggag aacggccctg 200 gcaaagccga cctntactcc acccctcagt accggtggga gccctctgat 250 gaatcctcag aaaagcgaga ggaggaagag gaagagaaag aagaatttga 300 agaagaaagg agccgtgagg aaaaaagaag tatcaaagtt catgccatgg 350 tctccgtatt ccaatttatt atgaaacaaa gttacatctg tgccctcata 400 gctatgatgg cctggagcat cacctatcac agctggctga ccttcgtgct 450 gctgatctgg tcgtgcactc tttg 474 <210> SEQ ID NO 521 <211> LENGTH: 626 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 63, 116, 126, 148, 180, 193, 213, 222, 262 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 521 gaattttttc gaaaagctaa tgccccattt tggatgtcat ttaccattca 50 ccttttaata ttngggggca ttttgggatc aaattatcct gatgtttttc 100 aacaaagact tgaganaaaa taaggngcat tacttttttt ggacattntt 150 cttttagacc tattgtgagg tgtttgcccn ccattagaaa ttnccccaaa 200 tggttgaaaa ttnttaaaca gnagaaggaa gagactcaaa gttagcatca 250 caaagagaaa cncgatgctg gaaagggaga ttgcattctc aatccgggat 300 aatttcatgc agcagaaggc tttcaagtac atgtcagtga ttcaggcttt 350 tctcggttct gttccacaat taattttgca gatgtatatc agtctcacta 400 tacgagaatg gcctttgaat agagcattgc tgatgacatt ttccctgtta 450 tcagttactt atggggccat tcgctgcaat atactggcca tccagatcag 500 caatgatgat actaccatta agctaccgcc gatagaattc ttctgtgtcg 550 tgatgtggcg ttttttggag gttatctcac gtgtagtgac tctggcattg 600 ttcattgcat ctctgaaact gaagag 626 <210> SEQ ID NO 522 <211> LENGTH: 566 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 42-43, 100, 103, 116, 142, 216-217, 227, 233 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 522 aaatgttttg acaaatcaca agaaagtttc aaaaatttgg gnntattagt 50 ttgaaaaatt gttttcagtt cacttgtgat ttcttgttta attcactgcn 100 ganaggattc ttttanactt tccaaggatc ttaaagctat cntacctagg 150 aatgagaatt atggtgttcc atgacaactt tgaataagta ttccctaaag 200 ctaagaggaa attctnncaa taatgantcg ggncattgct attttgggaa 250 agtaaaagcg gaaaaagctt gacgacactg aaaggcttgt tgagatggaa 300 caagtcctct cttcacttaa caagatgaga aagacaatag gtggtgtggc 350 tctctggcga cagcaaatct gcgcaattgc aagggttcgc ttgttaaagt 400 taaagcatga aagaaaagct cttttagcac tgctattaat tctaatggct 450 ggattttgcc ctcttcttgt ggagtatacc atggtgaaaa tatatcaaaa 500 cagttacacc tgggaacttt ctcctcattt gtatttcctt gctcctggac 550 aacaaccaca tgaccc 566 <210> SEQ ID NO 523 <211> LENGTH: 503 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 67 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 523 ccttattgat gttaagaaac caaancaagg tatgattaaa aatcagccaa 50 acctttggac attctgngaa tatataaatc atttgataat gcataagata 100 ggaaaaattg aaatgtgttt atgactaaag ttttatattt gtggtaatgt 150 taaaatgtat tattaaatat gttaaaatta tttcattttt ttcccctttg 200 agaggtaaag cctaatactt ctccccttga atatgggcta gacttatgag 250 cacatttcta atgaacagag aaagtggatg tggatgtgac aatgtgtatg 300 ttggaagact agacaatatc agagatgaac atgatggtga aagaaaataa 350 aagaagaaag ctagttaata aaaggcacca ttgtttcctc ctcttcctcc 400 tcctccacct ctttaactct ctctccctct ctctgatcaa cagctctagc 450 aaaagccagc tgctatgcgg tgcggacttt caggcagctt tgcagggaga 500 tac 503 <210> SEQ ID NO 524 <211> LENGTH: 447 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 39, 43, 96, 344, 418 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 524 gagggtagga tccgcaagcc cctttcgcga agcccgagng agncccgggc 50 gacaggcagg cagagaatat gttattccca tcctttggcc cacaanattt 100 atggcagaga tggtggattt ctttattctc ttctttataa aagcaaccat 150 tgtcttaagc attatgcacc tcagtgggat aaaggatatc tctaagtttg 200 ctatgcatta tataatagaa gaaatagatg aagacacatc aatggaagac 250 ttgcagaaaa tgatggttgt ggcacttata tacagattat tagtttgttt 300 ctatgagata atttgcattt ggggagcagg tggagctacc ccanggaagt 350 tcctgctggg gcttcgagtt gtgacatgtg atacatcagt gcttattgca 400 ccaagtcggg ttttagtnat tccttcctca aatgttagca ttacaac 447 <210> SEQ ID NO 525 <211> LENGTH: 539 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 105 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 525 caagataaaa tatatggggg aagatgtaga aatgtgacag tttggcaaaa 50 acaaagttct cccaagattt cagcacgttt gcagcggaaa ttcaggaaac 100 catcncagca ctcagagagc agataaacaa gctggaggca cgcctgaggc 150 aggcagggtg tacagatgtt agaggggttc caaggaaggc cgaggagcgc 200 tggatgaaag aagactgcac tcactgcatt tgtgagagtg gccaggtcac 250 ctgtgtggtg gagatttgtc ccccggctcc ctgtcccagt cctgaattgg 300 tgaaaggaac ctgctgtcca gtttgcagag accgaggaat gccaagtgat 350 tccccagaga agcgctaata aaagttttgt gctgttgagc cccaaatggg 400 aaatttctca ggaagagaca tttaggactt cagaactttt aacttgtagt 450 cacattgttg atatggaaac cactgactta agcaacttag ttcatctaat 500 cttacatata cttacgatct tttatttttt cattttcta 539 <210> SEQ ID NO 526 <211> LENGTH: 456 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 109 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 526 gaagtgagga gaaagtttat ntttttcata taatttaagg gtcgtttctg 50 tgaaccattg cttcatgtct ttttcacttt tttcaattgt ctcattttcc 100 tcaaaatana ggcactgttt atgtattaca gagattaggc ctttgtcatt 150 agtcttttcc tgtgaacgag atcacataga ttatttgttt cttttctggc 200 ttttgaattt cagccatcat tttaaaaaat acttccccat ggtttttgtc 250 cagttctttt gtaacttctt gttctccatt tcaatattgg atgtttggct 300 tttgttcctt tgcgtgtttg gtatgcgata tggatccccc ttagtctttt 350 tgtctagcat caatatattt atttttatac tgtccttcag attgatgatg 400 atttccagag ttcttggggc tttaatgcct gttgcgttta cagactctca 450 tccggg 456 <210> SEQ ID NO 527 <211> LENGTH: 500 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 527 cttgtgtttt cttcccctcc ctaaatttga agaactatgg agaaaatggt 50 acttgatgac agtagtggtt ttaataggac taacagtacg atggcagtgt 100 ctcttaattc ttattcaggt gctggtaacc cgcctatgtt tggtgattat 150 gaagctcaga gacactggca agaaataact tttaatttac cggtcaaaca 200 atggtatttt aacagcagtg ataacaattt acagtattgg ggattggatt 250 acccacctct tacagcttat catagtctcc tatgtgcata tgtggcaaag 300 tttataaatc cagactggat tgctctccat acatcacgtg gatatgagag 350 tcaggcacat aagctcttca tgcgtacaac agttttaatt gctgatctgc 400 tgatttacat acctgcagtg gttttgtact gttgttgctt aaaagaaatc 450 tcaactaaga aaaagattgc taatgcatta tgcatcttgc tgtatccagg 500 <210> SEQ ID NO 528 <211> LENGTH: 512 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 528 ccagaatgaa aaaaaaaagt cttgttggat aatagtgttt gactagcgtt 50 ttaagaactt gagagtaaaa gcaccaataa gattttttca ctttttcctg 100 cttccacccc caaactgaga acatccactc aattgtttgg aagaaactgt 150 aggtctatat aaattttatt tataatgtat gtgtaatata cataatcata 200 atacagttct cagatgcagg gaagaagttt ggcatttaat cattgaggct 250 ttaggttttt gatgtgatca gactgggcca tgtcaaaccc ggaattttca 300 ccaacagttc actcaccctc ctggtacatt gccattccaa ggaattctga 350 gagtaggcaa acaaattttg ccttcatggt acagttctca gtttttctta 400 taggagaaat atggtatatg tttataagaa tcttttatga gattatagat 450 ttcaatgctg tggatagtgt cttgcaccca aacaagaaag tccataatgg 500 aatgatcttc cc 512 <210> SEQ ID NO 529 <211> LENGTH: 479 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 82, 196 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 529 tccaagtcct tgaacatctt tggttttttt ggagtgtcca aacccatgtt 50 cagaaacggc acatggaata ctcatgtaat gnaggaaaag tctatatctg 100 cagctggacc cagccatacc aggagtgatt ttggaaatcc atacccgttt 150 gggattgatc cgatttggaa cttggcttca aacaaactca catttntgaa 200 ctcgtataaa atgaagatgt cggtgatcct gggaattgtc cagatggttt 250 ttggtgtcat cctcagcctt ttcaatcaca tatacttcag aagaactctc 300 aacatcattc tgcaatttat ccctgagatg atttttatcc tgtgtctgtt 350 tggatacctg gttttcatga tcattttcaa atggtgctgc tttgacgtcc 400 acgtatctca gcacgccccc agcatcctca tccacttcat caacatgttt 450 ctgtttaact acagtgactc ttccaacgc 479 <210> SEQ ID NO 530 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 56, 68, 72, 83, 149 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 530 gcctttagtt tccagctact tggaaggtta aggtaaaagg atccctttgg 50 gcccgnaggt tgaggctnca gnagttgaga tcncaccatt gcattccatt 100 ttgggtgaca caagcgagag ctatctcaaa accaaaaagc aagccaaanc 150 ccacccagac caaaaaggtg acttccaggg ctgccccagc taggaacact 200 ccagaaagca gacaaggaaa accgagtgtg aagagtccct ttggagattg 250 tcatggccat gtgacattcc tttggcctga actcagtcac atgtcccctt 300 cgagatgcag gggggacctg ggaaatgtag tttctggctg ggcagctgct 350 ttccagcaat agcactctac tgcagaagag gagcaggagt ctgtggtgca 400 aagccagcca ggcctgccac agatactgca ccatttacaa aaatgctttt 450 acactcattt catttgcttc tcatcacaat ctataccatc agctatactg 500 tcctcatttt tca 513 <210> SEQ ID NO 531 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 35, 53, 454, 461, 482 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 531 gaatggagga aattgctttc acttcaagac tttcnttttt tcactaaaac 50 ttntaaaggt gtacaagggg agggaagggg ggcaaagtcc ttgaacattt 100 tctttggctc ggccatgtta tgatcatata ccttttaaat aaggggaaat 150 agtatcttta aagttaatgt ctagccaaga gtttagtaaa cgaagaatta 200 aactgcactg ttgatcggtg ctttgtgtaa atacatcttt aacatttggg 250 tggagagggg ccttaagaag gacagttcat tgtaggaaag caattctgta 300 catgagttta agcattcttg ttgcattgtc tctgcagatt ctatttttgt 350 ttacaatatt aaaatgtatg ttagcaaaat gggtggattt tcaaataaaa 400 tgcagcttcc acaaaagttt tgttatggta ttctggtctg agatgcattt 450 tcanttttcc nttctctttt tattatcaat antgtcattt ttccctaata 500 aaatataccc agg 513 <210> SEQ ID NO 532 <211> LENGTH: 484 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 35 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 532 gctgtcctga gcagttgcag aagcatcgag ggtgnagagg agcacatact 50 gtccatggag tggtggtcaa ggtggacagg gggcgggtgg tgatggcgca 100 gtttgacatt gaataccagc gcctagaggc ctcctatagt gattcacccc 150 caggggagga ggacctgttg gtgcacgtcg ccgaggggag caagtcacct 200 tggcaccata ttgaaaacct tgacctcttc ttctctcgag tttataatct 250 gcaccagaag aatggcttca catgtatgct catcggggag atctttgagc 300 tcatgcagtt cctctttgtg gttgccttca ctaccttcct ggtcagctgc 350 gtggactatg acatcctatt tgccaacaag atggtgaacc acagtcttca 400 ccctactgaa cccgtcaagg tcactctgcc agacgccttt ttgcctgctc 450 aagtctgtag tgccaggatt caggaaaatg gctc 484 <210> SEQ ID NO 533 <211> LENGTH: 558 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 93 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 533 gggtaagtat attcagtgca ggtaaagact gaatgaatgg gtaccatcaa 50 attggttaaa tgaagatggg ttttggctca ggaacacaaa gtnttatttt 100 atcctgtgcc aaacactcca gttttgcaat gagattgtga ggaaggagaa 150 ggcaaggatt ctgttccaat gtttggtccc agaggaccta gaatagtact 200 ttgaccgggt aagcgcttaa taaaataatg cttactctta tgaatttagc 250 tgcagaaaca tttagtccca tagacaatat gtgtagaatg taaaaaatgc 300 aaatcttact aaaagaatat acaggaaaag ttctccctac tccttcctga 350 aagggagcca gtgttattag ctcgtcatgg agattgtctg tgctcatgca 400 agcatctccc tgcatgtatg tcctcttgct ttcgtgcaaa gaatagcatc 450 ctacacacac cttttagccc cttgcttttc ggttttgtgt attttgcaga 500 ttgggtcatt ttgtgcacac agtgctattt tattcttttt tttgtttgtt 550 tccccctg 558 <210> SEQ ID NO 534 <211> LENGTH: 462 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 55, 91, 156, 193, 215, 281, 395, 399, 444 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 534 atcatagtgt tttcaaactc cccgtgtaaa agttcccaaa atcccatgtc 50 acagntgagt cttggttttg ttgattggtt tgtctcttga nagtgtgtta 100 ttttttgttt cattatgtgt ctcataattt ttggttgaaa gctaaagcct 150 tcttgngaag gctagtggag acttgggtaa acactattta tgngcaaaaa 200 tggacatgcc ttttntttaa ggaggaggca ttgagacaac tctgtcaggt 250 tttgttgtta gtatggttac tctcaaaaag nacataattc aaattcttcc 300 agtattattt ttttgcttag tggctggttt gttggagagt ttttctcagt 350 gtctgttcaa atcacagtta ttggtctttt ctttgtgcct acgtntaana 400 gaggatatct ttctgtgctt ttaccctcac tcttccagca gtanactgct 450 gttacttgtt cc 462 <210> SEQ ID NO 535 <211> LENGTH: 511 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 94, 110, 156 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 535 ctgcccattt ttttgctttt acctggcaag tgtttaaaaa aggcctcaaa 50 gaaaaggggt ttgtgttgct agttaagcta gcttgtattg tggnggcttc 100 cttcgttttn tgctggctgc cattctttac agaaagggac caacccctgc 150 aggttntaag aagactcttc ccggttgatc gtggattatt tgaggataaa 200 gtagccaata tttggtgcag cttcaatgtc tttctgaaga ttaaggatat 250 tttgccacgt cacatccaat taataatgag cttttgtttt acgtttttga 300 gcctgcttcc tgcatgcata aaattaatac ttcagccctc ttccaaagga 350 ttcaaattta cactggttag ctgtgcgcta tcattctttt tattttcttt 400 ccaagtacat gaaaaatcca ttctcttggt gtcactacca gtctgcttag 450 ttttaagtga aattcctttt atgtctactt ggtttttact tgtgtcaaca 500 tttagtatgc t 511 <210> SEQ ID NO 536 <211> LENGTH: 511 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 536 ggtttgtttc cccatctgcc atattataag ttttttgagg catccccagc 50 catgctgaac tggaagtggc actaaggtcc aaaggaagct acatatgggt 100 ggtccctgtt acaccagcct cccaagcctc ccagtgcacc ttctaggaga 150 caagcaagga aggccgctgc ttgtttgtca tcctgctcat ggcggtgtac 200 tggtgcacgg aggccctgcc gctctcagtg acggcgctgc tgcccatcgt 250 cctcttcccc ttcatgggca tcttgccctc caacaaggtc tgcccccagt 300 acttcctcga caccaacttc ctcttcctca gtgggctgat catggccagc 350 gccattgagg agtggaacct gcaccggcga atcgccctca agatcctgat 400 gcttgttgga gtccagccgg ccaggctcat cctggggatg atggtgacca 450 cctcgttctt gtccatgtgg ctgagcaaca ccgcctccac tgccatgatg 500 cttcccattg c 511 <210> SEQ ID NO 537 <211> LENGTH: 441 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 51, 70, 105, 134 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 537 ttggcctaat ttaagtgata taaaaaatga aattttttat gcagtgtggg 50 ngaggggcaa aaaaaaatan atttgaacac ccagatttta gttttggctc 100 tgtgnttgca gctagttaca tggcatccag gacnaaagtt tggaaaacaa 150 aataatggaa ctaaatagta ctaaccaaag tatagggtgc tttatgattt 200 acagaactct cttacaggca gtatgttgtt caggcgccac tagaacccac 250 gtaatggcag aggcttcctg ttccatgttt aaaaaccttt ccaaggcttt 300 tcattatttt cttatctgtg gtacccctag cttcctgtgc tctagacaca 350 ctggcctacc ttcaacttcc ttgaccagtg tagcttacag tgtaagctta 400 ccccacaccc ccacctcctg caataaaata gtagcatcgg c 441 <210> SEQ ID NO 538 <211> LENGTH: 497 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 56, 76, 126, 175 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 538 ggtaatgggc aattaaaatt ttttcgggtc tggattttaa aaatttatat 50 taaggnattg aagttccttt tctccnttag gtttaacagt gaattcacat 100 gagtaatttt taaaagatat cagatncatt ttgctattca aagaaaatta 150 tgatttaaag ccacttttta aaatncgaga aggaaaatag gatggattaa 200 agggttaact tttaaagatt attattggtt aatgttgaca tatttcctct 250 atctcataga tggtaaaagt gttgctttta aaaactggca aatgcactct 300 tcagaaatcc ttttctatct gatccacatg gagaggttaa aggttcaatt 350 tcatgacctc tatgcaggca gcgctctcat tggatgtaag aatattacct 400 gcaaggatag aatgcagttg tgcaacagag acacattctt atttcacttt 450 tttcacaatt ttgttttgtt tttaatgacc cttttattga atattgg 497 <210> SEQ ID NO 539 <211> LENGTH: 362 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure 222> LOCATION: 42, 106, 132, 134, 184, 199, 208, 240, 250, 253, 256, 268, 307, 318, 355 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 539 aaagggtccg gtccccggcc gaaaccactt ttgatctttc cntctttggg 50 ctcaaaaaat gtacaggttt tccagggcag ccttgggatt gggccacttc 100 ctttangatc ctggttcttc ccgttgtctt tnanacggag aagttgcaaa 150 tggagcaaca gcagcaattg cagcagcggc aganactttt aggcctaana 200 cagggctntc aggaggaatg ccaggggctt taccctcacn tcctggaaan 250 atntanattg ttattgcngt ttgagctgtc tcagtgggat aagtttgaaa 300 ttcaagngtt tgaactgntg aaaattggaa tttttttttt aactttggca 350 gcaangggtt cg 362 <210> SEQ ID NO 540 <211> LENGTH: 441 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 42, 44, 47, 67, 341 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 540 ggtttgcttt gggggtgttt ttggaatatt ttgtgactgc gncntcntag 50 ggtcactggc attttgntta gctataaatt ataaacagat ggaactttac 100 cacgccttgc catttttttg ctttttactt ggcaagtgtt ttaaaaaagg 150 cctcaaagga aaggggtttg tgttgctagt taagctagct tgtattgttg 200 tggcttcctt cgttctctgc tggctgccat tctttacaga aagggaacaa 250 accctgcagg ttctaagaag actcttcccg gttgatcgtg gattatttga 300 ggataaagta gccaatattt ggtgcagctt caatgtcttt ntgaagatta 350 aggatatttt gccacgtcac atccaattaa taatgagctt ttgttttacg 400 tttttgagcc tgcttcctgc atgcataaaa ttaatacttc a 441 <210> SEQ ID NO 541 <211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 45, 53, 55, 95 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 541 ccttccactt atgtggtccc acaccacccg cctcccctgc caggntttat 50 ttngngtgtg tgtgagtgtg ttctgttttg tgttttgttt tttgntgttg 100 ttttcagttg tttggttttc ttttctttcc cccctccggt cccatacttc 150 acagcactct ggtgcgggaa gaagcagaag 180 <210> SEQ ID NO 542 <211> LENGTH: 318 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 57 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 542 tctagtttgc ctaagtagaa tttacatggg aatgcactct attctggata 50 ttattgntgg attcctatat accattttaa tcttagctgt cttctatcca 100 tttgtggacc tgattgacaa cttcaaccaa actcacaaat atgctccatt 150 catcatcatc gggcttcatt tagctttggg gatcttttct ttcactcttg 200 acacctggag cacatcccga ggagacacag ccgagatact aggaagtggt 250 gctggaattg catgtggatc tcatgttact tataacatgg gtctagtatt 300 agatccttct ctagatac 318 <210> SEQ ID NO 543 <211> LENGTH: 396 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 543 agaacccccc ggtgaagttt tccgccaata acctaagggg gctttttcca 50 ggacttcaac ccgagtaaat tcctcatcta tgcctgtctg ctgcttgttt 100 tctgtgctgc tggcccttcg tttggatggc atcatacagt ggagttactg 150 ggctgtcttt gctccaatat ggctgtggaa gttaatggtc attgttggag 200 cctcagttgg aactggagtc tgggcacgaa atcctcaata tcgagcagaa 250 ggagaaacgt gtgtggagtt taaagccatg ttgattgcag tgggcatcca 300 cttgctcttg ttgatgtttg aagttctggt ctgtgacaga atcgagagag 350 gaagccattt ctggctcctg gtcttcatgc cgctgttctt tgtttc 396 <210> SEQ ID NO 544 <211> LENGTH: 351 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 544 ttaatgtcta agccaagagt ttagtaaaca aagaattaaa ctgcactgtt 50 gatcggtgct ttgtgtaaat acatctttaa catttgggtg gagaggggcc 100 ttaagaagga cagttcattg taggaaagca attctgtaca tgagtttaag 150 cattcttgtt gcattgtctc tgcagattct atttttgttt acaatattaa 200 aatgtatgtt agcaaaatgg gtggattttc aaataaaatg cagcttccac 250 aaaagttttg ttatggtatt ctggtctgag atgcattttc atttttcctt 300 tctcttttta ttatcaatat tgtcattttt ccctaataaa atatacccag 350 g 351 <210> SEQ ID NO 545 <211> LENGTH: 398 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 298, 323 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 545 agtttcatat atttgggaat gagccttgag ccataaaagg ttttcagcaa 50 gttgtaactt attttggcct aaaaatgagg tttttttgga aagaaaaaat 100 atttgttctt atgtattgaa gaagtgactt ttatataatg attttttaaa 150 tgcccaaagg actagtttga aagcttcttt taaaaagaat tcctctaata 200 tgactttatg tgagaaggga taatacatga tcaaataaac tcagtttttt 250 atggttactg taaaaaagac tgtgtaaggc agctcagcac catgcttntc 300 gtaaaagcag cttcaattat ccnctggggt tatcttttga caacttgcca 350 ttatctgatg ttacacaatt caatagcaag caagtttgag acaatcgc 398 <210> SEQ ID NO 546 <211> LENGTH: 374 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 43, 99, 102, 129 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 546 cataaatata cccaccccaa atggacgact tatgaaggaa ttncttgtga 50 aagctcattg gagtaaaatt tcctctcaaa caatactttt aggtcatang 100 cntgagtcta ttaattattt ttctgttana ccctgccaaa aaagaatttt 150 aaaagttagt ttatgttttg tgtaaccatg ttcttcagaa tgcaggtatg 200 tgagcatcat ggtttctggg taattctgct gctcctgtct ttgaaaatgg 250 agataccact tgcagcttat cccactgctg agtattccag cattggtagt 300 ggtttcactc cattgcatcc atccagaact ttcacacagg cctcccccga 350 accccttgcg gcgcaagggg ttcg 374 <210> SEQ ID NO 547 <211> LENGTH: 251 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 547 aaaaaaaaaa aattaagtga acctctactt tagaatgttg gcttttcata 50 tatgtacaaa acaaaagagg ttgcagtgat ggcgtggata aaggcacctg 100 tgtacttttc caacctatcc aatttcaaga tgtatccttt gtggattaca 150 ttggttcttt tctatggaat catgcacctt agacctggga gaaaccagcg 200 tgacatccag ggtcaaggtt ttccaatcag gtattttggg caaggggttc 250 g 251 <210> SEQ ID NO 548 <211> LENGTH: 331 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 77 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 548 aaaaaaaaaa aaaaaaaagc taaaaaccct tgactaaatc tcccatgttt 50 tctcatatta ttaaaaattc taaacgnggg tttttttgtt ttgttttgtt 100 tttctgtttc tccctctgca gagttgttag cggttctcga gatgccactc 150 ttagggtttg ggatattgag acaggccagt gtttacatgt tttgatgggt 200 catgttgcag cagtccgctg tgttcaatat gatggcagga gggttgttag 250 tggagcatat gattttatgg taaaggtgtg ggatccagag actgaaacct 300 gtctacacac gttgcagggg catgcggccg c 331 <210> SEQ ID NO 549 <211> LENGTH: 228 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 549 aaattatctt tactgatatg cgttgccaaa tcccatgaga aaagacatct 50 catttgaggt tccccttcct ctcatgtggt tgattttttg gaaggtgata 100 cagatgtggg taaccatgca aatgtttatg aataacttta ctgaagtgat 150 tccatccgta ttctgttcta atacttggag aatgaccttc atatttatat 200 attttatttc tttgtttcaa ctatccag 228 <210> SEQ ID NO 550 <211> LENGTH: 461 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 550 tgaagatatg ggagacctat ncttagatgt tgctgaagct tttctgatgt 50 tgggaatata attctgcact tcccctcctc agggctcttg tttgctctga 100 aagatacaac cttgcagtag ttttggcttc gtcatgcaga atgtttaaag 150 gccttaggct atatggagcg agctgctgaa agctatggca aggtggttga 200 tctggcccca ctccatttgg atgcaaggat ttcactttct acccttcagc 250 agcagctggg ccagcctgag aaagctctgg aagctctgga accaatgtat 300 gatccagata ctttagcaca ggatgcaaat gctgcacagc aggaactgaa 350 gttattgctt catcgttcta ctctgttgtt ttcacaaggc aaaatgtatg 400 gttatgtgga taccttactt actatgttag ccatgctttt aaaggtagca 450 atgaatcgag c 461 <210> SEQ ID NO 551 <211> LENGTH: 205 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 41, 66 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 551 tggaccccag ttgtcagctg ggnggtactg gatcatcttt nttctatcac 50 aagataaact atcaanttcc ccagcatcat gaccttgttg ccgtaaaaag 100 gagttcacta cttctgttca ctttgagtct cttcaaatgg attctgtgtc 150 ctcctctgga gtctgtgctg catttattgc ttctgactct tccactaagc 200 cagag 205 <210> SEQ ID NO 552 <211> LENGTH: 331 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 39, 55, 66, 81, 90, 162, 164, 166, 170, 206, 245 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 552 ctaaagggga agaagaaaaa gaaaggattg gtcttgctnt aaggggtaga 50 aaagngcaag gggaancagg aaaggaaggc nccctacggn gtaattatga 100 aaatgcattg gaacttctgt ctgatgtttt gctttttttt tcatttctca 150 aaatatttct anananggtn ttaatccttc ttccaccatt tgctttagtt 200 ttaagngccc tgtgtgatag aagggttcat gttgtaaaat cagtnttgaa 250 taatcagaac acttctacca gattgtctaa tgttgatttg tttctggcac 300 tgcttctaaa tgtcttcctc ctcattctgc g 331 <210> SEQ ID NO 553 <211> LENGTH: 370 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 60, 64, 74, 101, 117, 142, 188, 290 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 553 taaaagaaaa gctaaagttt tactgtggcc aaaaaacccc tacatggtct 50 ggggactggn ggtntctttg accntatctt tgaccacttt tcttttttca 100 nttttctcaa ggcacanctg gcctcctttt tgttcctggc antgggaaga 150 cttgttccta cttcagggtc ttcatgtttg ttcttccntc tgccttgaac 200 acccaccttt ctcccaagtg ttccaggcag atggagtatg cacatggctc 250 actcttttac tttttaagtc tctgctcaaa agcaaatttn tcagccatgg 300 ctttcctgag caccctattt aaaattgctt tcctactcct acatggctgt 350 tctcctttgc ttaccaccac 370 <210> SEQ ID NO 554 <211> LENGTH: 310 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 554 ttaaaatagt aaaaaaaaaa gaatttattt ttgttctttg ttagaatttc 50 tctgcaaaga atgtccaaaa attcatattc acattgatcg tatggcaaaa 100 agatgtccca gaagaacaag aacatatgag aagatggctg catgaacgtt 150 tcgaaatcaa agataagatg cttatagaat tttatgagtc accagatcca 200 gaaagaagaa aaagatttcc tgggaaaagt gttaattcca aattaagtat 250 caagaagact ttaccatcaa tgttgatctt aagtggtttg actgcaggca 300 tgcttatgac 310 <210> SEQ ID NO 555 <211> LENGTH: 202 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 39, 62, 79, 109, 129 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 555 ccttattttc cattccaaat ggcagccagn ataaaattna tttcccacaa 50 tttcccttta anggtaaggg ttgcccttnc cgcaatgccc ctcacatggt 100 tcttttggnc agttcggaag cccttgggnt cttgatggct ttgtgtctag 150 taataatgca gggtgctcaa ggaaataaat tcagtgtgga tatactgaaa 200 ac 202 <210> SEQ ID NO 556 <211> LENGTH: 536 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 159 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 556 ggtccggaat aagccattag caatccttgc tgtatccagg ccttattttt 50 tatagactat ggacattttc aatataattc tgtgagtctt ggctttgctt 100 tgtggggtgt tcttggaata tcttgtgact gcgacctcct agggtcactg 150 gcattttgnt tagctataaa ttataaacag atggaacttt accacgcctt 200 gccatttttt tgctttttac ttggcaagtg ttttaaaaaa ggcctcaaag 250 gaaaggggtt tgtgttgcta gttaagctag cttgtattgt tgtggcttcc 300 ttcgttctct gctggctgcc attctttaca gaaagggaac aaaccctgca 350 ggttctaaga agactcttcc cggttgatcg tggattattt gaggataaag 400 tagccaatat ttggtgcagc ttcaatgtct ttttgaagat taaggatatt 450 ttgccacgtc acatccaatt aataatgagc ttttgtttta cgtttttgag 500 cctgcttcct gcatgcataa aattaatact tcagcc 536 <210> SEQ ID NO 557 <211> LENGTH: 488 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 68, 118 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 557 aaatcttctt gagctttgtt ttgagatgta gttgagttaa cttataaacc 50 gtttcattct tttgggtntt gtttttatga tttattagac agatatgaag 100 gagtgcttag tccagganta attattcctc accactgagg caagactttc 150 tgtggactct gttgaatgtt ccatgaatta atagttttcc cagtttggct 200 agtgggaaca gatactattc ctggctttgt atgagtatca ggccctgttc 250 cctcccattg tttctgatgt tctttttctg gattctcata gtttcctcat 300 atgcatatgc tgatcagtta tctggtgaat gcttgagaga agatctctat 350 agacctctgg ggttcttttc tatgcaactg tctcctctca gcattctgtg 400 cagttattcc ttgctgcttt tttctctcct ggctcttaac tttctctttc 450 caactcagga gtcagctgag atttgcctca gttgccac 488 <210> SEQ ID NO 558 <211> LENGTH: 728 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26, 40, 59, 97, 108, 117, 141, 156, 163, 169, 192, 215, 266, 482, 484, 558 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 558 ttgcccttgg gagtaaacct tgaatnattt taaaaaaacn acggttttaa 50 accttggcna ccgttgggtt gaggccttga ccacctttgg gacaccntgc 100 aagaggantc caacccnaaa caacaaccag gatgtgctcc nagcccagcc 150 cggggnttca gtnccatant ttgccatgtg tctgtccaga tntggggttg 200 agcggggggt ggggntgcaa cccagtggat tgggtcaccc ggcagactta 250 gggaaggtga ggcgangtgg ggagttggca gaatccccat acctcgcaga 300 tttgctgagt ctgtcttgtg cagagggcca gagaatggct tatgggggcc 350 caggttggat ggggaaaggc taatggggtc agaccccacc ccgtctaccc 400 ctccagtcag cccagcgccc atcctgcagc tcagctggga gcatcattct 450 cctgctttgt acatagggtg tggtcccctg gnangtggcc accatcatgt 500 ctaggcctat gctaggaggc aaatggccag gctctgcctg tgtttttctc 550 aacactantt ttctgatatg agggcagcac ctgcctctga atgggaaatc 600 atgcaactac tcagaatgtg tcctcctcat ctaatgctca tctgtttaat 650 ggtgatgcct cgcgtacagg atctggttac ctgtgcagtt gtgaataccc 700 agaggttggg cagatcagtg tctctagt 728 <210> SEQ ID NO 559 <211> LENGTH: 586 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 68, 70, 113, 119, 150, 291, 312 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 559 atccggctgg gatacaattt tcatcttcca tttnactctt gtcaattcca 50 ccttttaaga agacagcntn tcattcctga ggcatgaaaa ttctccaggg 100 acaaagccat gcntcagtna catgtgtgtg cagagagaaa tgcacctgtn 150 tatctaaggg tagatttttg atccctgaat aattcattga ctaaactgac 200 ctcttcctcc tggctaaata aattaatttt gctggcttct ctctcagcgg 250 tttctatttt gtaaattgct gcatgaccaa aatagcccca ntcaaaatca 300 attggattaa tnttaatggt ttggttggat gaatattctt ggatgaatat 350 aaaatgtgct gcccttcaca gatgacacca ctcccctgtc aatcatagca 400 catgtgtact ttttattgtt acttaatagt gatggatttg cacttttcta 450 tcctcatact ctttcctgtt ttcttctttg tacaattgca tgcaggaggg 500 ctggatgcca gggttaagag agaaattcat gacaaggaag gtaaaattgg 550 ttcaaatgag catgtgtccc acagccttag tctccc 586 <210> SEQ ID NO 560 <211> LENGTH: 648 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 71, 102, 113, 149, 157 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 560 ccgggaaatt aagccctttt ttttttttca aataataaaa gcttcgaaat 50 tgaaagggag aagtaaatat nccggatacc atgatttaat atgtagaaat 100 tntaagagat tcncaaacca ttaaagataa aagccagttc accaaagtna 150 aggatgnaag atcagtgtac ataaatctgt tttatttcca tatacttgca 200 aagaggaatc ccaaaactga gattgaggaa agcatatata atagcatcaa 250 aaagtagtac aaaacatata ctctgaaaac tgcagaatgt tgagagaaat 300 taaataagta aatagataat cccatgttca tctagccaga ggactcatgt 350 attttggtta ttaacccctg atcagatgta tggtttgcaa atattttctc 400 ccatttcata cattggctct tcattctgtt gattgttctc ttcctgtaca 450 gaagttttta agtttcatat ataattttag tggtctattt ttgccttcgt 500 tccctatgct gtcggggtca tatctaaaaa aggtcatcgt gcagaccaac 550 gtcatggaga ttttccctgt gtttccagta gttttacagt tttgggtctt 600 acatataagt ttgttttctt tttttcgaga tggaatcttg ctctgcgg 648 <210> SEQ ID NO 561 <211> LENGTH: 322 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <400> SEQUENCE: 561 aaaaaaaaaa aaaaaagggc ggccgcgact ctagagtcga cctgcagggt 50 ttttatccaa aatgaaatgg ttgggcacca aagagacaga aacccacaag 100 tcaaccactt aggtcacaca tggttctgaa agtcctatac tgttctggat 150 tcccaggcac agaactccgg gctgctcagg aagagactat gattcttcca 200 cctgccagct actattggcc atcccttctc attgcttcta gctccagcct 250 tctcatccca attctctatt ctacattgtt atttctaacc cattgtgtgc 300 tgggaaatca aaccactcag ca 322 <210> SEQ ID NO 562 <211> LENGTH: 275 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 13, 206, 237 <223> OTHER INFORMATION: unknown base <400> SEQUENCE: 562 cccacgcgtc cgntggtggc ttcagaagaa attctcaaca cctagctcgc 50 cagagagtct atgtatggga ttgaacaatc tgtaaactaa aggatcctaa 100 tcatgaaaat aagtatgata aattataagt cactattggc actgttgttt 150 atattagcct cctggatcat ttttacagtt ttccagaact ccacaaaggt 200 ttggtntgct ctaaacttat ccatctccct ccattantgg aacaactcca 250 caaagtcctt attccctaaa acacc 275 <210> SEQ ID NO 563 <211> LENGTH: 43 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Synthetic oligonucleotide probe <400> SEQUENCE: 563 tgtaaaacga cggccagtta aatagacctg caattattaa tct 43 <210> SEQ ID NO 564 <211> LENGTH: 41 <212> TYPE: DNA <213> ORGANISM: Homo Sapien <220> FEATURE: <221> NAME/KEY: Artificial Sequence <222> LOCATION: full <223> OTHER INFORMATION: Synthetic oligonucleotide probe <400> SEQUENCE: 564 caggaaacag ctatgaccac ctgcacacct gcaaatccat t 41 

What is claimed is:
 1. An isolated nucleic acid molecule comprising a nucleotide sequence having at least about 80% nucleic acid sequence identity to (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).
 2. The isolated nucleic acid molecule of claim 1 comprising the nucleotide sequence shown in any one of FIG. 1 to 562, or the complement thereof.
 3. The isolated nucleic acid molecule of claim 1 consisting essentially of a nucleotide sequence having at least about 80% nucleic acid sequence identity to (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).
 4. The isolated nucleic acid molecule of claim 1 consisting essentially of the nucleotide sequence shown in any one of FIG. 1 to 562, or the complement thereof.
 5. The isolated nucleic acid molecule of claim 1 consisting of a nucleotide sequence having at least about 80% nucleic acid sequence identity to (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).
 6. The isolated nucleic acid molecule of claim 1 consisting of the nucleotide sequence shown in any one of FIG. 1 to 562, or the complement thereof.
 7. An isolated nucleic acid molecule which hybridizes to (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).
 8. The isolated nucleic acid molecule of claim 7 which hybridizes to the complement of the DNA molecule of any one of FIG. 1 to
 562. 9. The isolated nucleic acid molecule of claim 7, wherein said hybridization occurs under stringent hybridization conditions.
 10. An isolated nucleic acid molecule comprising at least about 10 consecutive nucleotides contained within (a) the DNA molecule of any one of FIG. 1 to 562, or (b) the complement of the DNA molecule of (a).
 11. The isolated nucleic acid molecule of claim 10 comprising at least about 10 consecutive nucleotides contained within the complement of the DNA molecule of any one of FIG. 1 to
 562. 12. The isolated nucleic acid molecule of claim 10 which is from about 10 to about 1000 nucleotides in length.
 13. The isolated nucleic acid molecule of claim 10 which is from about 10 to about 500 nucleotides in length.
 14. The isolated nucleic acid molecule of claim 10 which is from about 10 to about 100 nucleotides in length.
 15. The isolated nucleic acid molecule of claim 10 which is from about 10 to about 50 nucleotides in length.
 16. The isolated nucleic acid molecule of claim 11 which is fully complementary to the DNA molecule of any one of FIG. 1 to
 562. 17. The isolated nucleic acid molecule of claim 10 which is detectably labeled.
 18. A method of detecting the presence of a cDNA molecule which encodes a mammalian polypeptide in a mammalian cDNA library, said method comprising: contacting said cDNA library with an oligonucleotide probe that hybridizes to the DNA molecule of any one of FIG. 1 to 562, wherein said contacting is performed under conditions suitable for hybridization of said probe to a cDNA molecule in said library and wherein hybridization of said probe to a cDNA molecule in said library is indicative of the presence of cDNA molecule which encodes a mammalian polypeptide in said cDNA library.
 19. The method of claim 18, wherein said hybridization is performed under stringent hybridization conditions.
 20. The method of claim 18, wherein said oligonucleotide probe comprises at least about consecutive nucleotides contained within the complement of the DNA molecule of any one of FIG. 1 to
 562. 21. The method of claim 18, wherein said mammalian polypeptide is a human polypeptide.
 22. A vector comprising the nucleic acid molecule of claim
 1. 23. The vector of claim 22, wherein said nucleic acid molecule is operably linked to control sequences recognized by a host cell transformed with the vector.
 24. A host cell comprising the vector of claim
 22. 25. The host cell of claim 24, wherein said cell is a CHO cell.
 26. The host cell of claim 24, wherein said cell is an E. coli.
 27. The host cell of claim 24, wherein said cell is a yeast cell.
 28. An isolated SRT polypeptide encoded by the nucleic acid molecule of claim
 1. 29. An antibody which binds to the isolated SRT polypeptide of claim
 28. 30. The antibody of claim 29 which is a monoclonal antibody.
 31. The antibody of claim 29 which is a humanized antibody. 